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Literature summary for 3.1.1.4 extracted from
- The phospholipase A2 activity of peroxiredoxin 6 (2018), J. Lipid Res., 59, 1132-1147 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diethyl 4-nitrophenyl phosphate | - |
Arabidopsis thaliana |  |
| diethyl 4-nitrophenyl phosphate | - |
Bos taurus | |
| diethyl 4-nitrophenyl phosphate | - |
Gallus gallus | |
| diethyl 4-nitrophenyl phosphate | - |
Homo sapiens | |
| diethyl 4-nitrophenyl phosphate | - |
Mus musculus | |
| diethyl 4-nitrophenyl phosphate | - |
Rattus norvegicus | |
| diethyl 4-nitrophenyl phosphate | - |
Trematomus bernacchii | |
| diethyl 4-nitrophenyl phosphate | - |
Xenopus tropicalis | |
| additional information | no inhibition by bromoenol lactone | Arabidopsis thaliana | |
| additional information | no inhibition by bromoenol lactone | Bos taurus | |
| additional information | no inhibition by bromoenol lactone | Gallus gallus | |
| additional information | no inhibition by bromoenol lactone | Homo sapiens | |
| additional information | no inhibition by bromoenol lactone | Mus musculus | |
| additional information | no inhibition by bromoenol lactone | Rattus norvegicus | |
| additional information | no inhibition by bromoenol lactone | Trematomus bernacchii | |
| additional information | no inhibition by bromoenol lactone | Xenopus tropicalis |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Trematomus bernacchii | 5829 | - |
| cytosol | - |
Arabidopsis thaliana | 5829 | - |
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | - |
Bos taurus | 5829 | - |
| cytosol | - |
Gallus gallus | 5829 | - |
| cytosol | - |
Xenopus tropicalis | 5829 | - |
| lysosome | and lysosomal-related organelles | Homo sapiens | 5764 | - |
| lysosome | and lysosomal-related organelles | Mus musculus | 5764 | - |
| lysosome | and lysosomal-related organelles | Rattus norvegicus | 5764 | - |
| lysosome | and lysosomal-related organelles | Bos taurus | 5764 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | Ca2+-independent enzyme | Trematomus bernacchii | |
| additional information | Ca2+-independent enzyme | Arabidopsis thaliana | |
| additional information | Ca2+-independent enzyme | Homo sapiens | |
| additional information | Ca2+-independent enzyme | Mus musculus | |
| additional information | Ca2+-independent enzyme | Rattus norvegicus | |
| additional information | Ca2+-independent enzyme | Bos taurus | |
| additional information | Ca2+-independent enzyme | Gallus gallus | |
| additional information | Ca2+-independent enzyme | Xenopus tropicalis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | Q8S8N6 | - |
- |
| Bos taurus | O77834 | - |
- |
| Gallus gallus | Q5ZJF4 | - |
- |
| Homo sapiens | P30041 | - |
- |
| Mus musculus | O08709 | - |
- |
| Rattus norvegicus | O35244 | - |
- |
| Trematomus bernacchii | - |
- |
- |
| Xenopus tropicalis | B1WAZ6 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,2-dipalmitoyl-sn-phosphatidylcholine + H2O | the catalytic site for aiPLA2 activity is an S32-H26-D140 triad | Trematomus bernacchii | 1-palmitoyl-sn-phosphatidylcholine + palmitate | - |
? | |
| 1,2-dipalmitoyl-sn-phosphatidylcholine + H2O | the catalytic site for aiPLA2 activity is an S32-H26-D140 triad | Arabidopsis thaliana | 1-palmitoyl-sn-phosphatidylcholine + palmitate | - |
? | |
| 1,2-dipalmitoyl-sn-phosphatidylcholine + H2O | the catalytic site for aiPLA2 activity is an S32-H26-D140 triad | Homo sapiens | 1-palmitoyl-sn-phosphatidylcholine + palmitate | - |
? | |
| 1,2-dipalmitoyl-sn-phosphatidylcholine + H2O | the catalytic site for aiPLA2 activity is an S32-H26-D140 triad | Mus musculus | 1-palmitoyl-sn-phosphatidylcholine + palmitate | - |
? | |
| 1,2-dipalmitoyl-sn-phosphatidylcholine + H2O | the catalytic site for aiPLA2 activity is an S32-H26-D140 triad | Rattus norvegicus | 1-palmitoyl-sn-phosphatidylcholine + palmitate | - |
? | |
| 1,2-dipalmitoyl-sn-phosphatidylcholine + H2O | the catalytic site for aiPLA2 activity is an S32-H26-D140 triad | Bos taurus | 1-palmitoyl-sn-phosphatidylcholine + palmitate | - |
? | |
| 1,2-dipalmitoyl-sn-phosphatidylcholine + H2O | the catalytic site for aiPLA2 activity is an S32-H26-D140 triad | Gallus gallus | 1-palmitoyl-sn-phosphatidylcholine + palmitate | - |
? | |
| 1,2-dipalmitoyl-sn-phosphatidylcholine + H2O | the catalytic site for aiPLA2 activity is an S32-H26-D140 triad | Xenopus tropicalis | 1-palmitoyl-sn-phosphatidylcholine + palmitate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aiPLA2 | - |
Trematomus bernacchii |
| aiPLA2 | - |
Arabidopsis thaliana |
| aiPLA2 | - |
Homo sapiens |
| aiPLA2 | - |
Mus musculus |
| aiPLA2 | - |
Rattus norvegicus |
| aiPLA2 | - |
Bos taurus |
| aiPLA2 | - |
Gallus gallus |
| aiPLA2 | - |
Xenopus tropicalis |
| peroxiredoxin 6 | - |
Trematomus bernacchii |
| peroxiredoxin 6 | - |
Arabidopsis thaliana |
| peroxiredoxin 6 | - |
Homo sapiens |
| peroxiredoxin 6 | - |
Mus musculus |
| peroxiredoxin 6 | - |
Rattus norvegicus |
| peroxiredoxin 6 | - |
Bos taurus |
| peroxiredoxin 6 | - |
Gallus gallus |
| peroxiredoxin 6 | - |
Xenopus tropicalis |
| Prdx6 | - |
Trematomus bernacchii |
| Prdx6 | - |
Arabidopsis thaliana |
| Prdx6 | - |
Homo sapiens |
| Prdx6 | - |
Mus musculus |
| Prdx6 | - |
Rattus norvegicus |
| Prdx6 | - |
Bos taurus |
| Prdx6 | - |
Gallus gallus |
| Prdx6 | - |
Xenopus tropicalis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme has important physiological roles in the repair of peroxidized cell membranes, and in the activation of NADPH oxidase type 2 | Trematomus bernacchii |
| physiological function | the enzyme has important physiological roles in the repair of peroxidized cell membranes, and in the activation of NADPH oxidase type 2 | Arabidopsis thaliana |
| physiological function | the enzyme has important physiological roles in the repair of peroxidized cell membranes, and in the activation of NADPH oxidase type 2 | Xenopus tropicalis |
| physiological function | the enzyme has important physiological roles in the turnover (synthesis and degradation) of lung surfactant phospholipids, in the repair of peroxidized cell membranes, and in the activation of NADPH oxidase type 2 | Mus musculus |
| physiological function | the enzyme has important physiological roles in the turnover (synthesis and degradation) of lung surfactant phospholipids, in the repair of peroxidized cell membranes, and in the activation of NADPH oxidase type 2 | Rattus norvegicus |
| physiological function | the enzyme has important physiological roles in the turnover (synthesis and degradation) of lung surfactant phospholipids, in the repair of peroxidized cell membranes, and in the activation of NADPH oxidase type 2 | Bos taurus |
| physiological function | the enzyme has important physiological roles in the turnover (synthesis and degradation) of lung surfactant phospholipids, in the repair of peroxidized cell membranes, and in the activation of NADPH oxidase type 2 | Gallus gallus |
| physiological function | the enzyme has important physiological roles in the turnover (synthesis and degradation) of lung surfactant phospholipids, in the repair of peroxidized cell membranes, and in the activation of NADPH oxidase type 2. The enzyme has been implicated in acute lung injury, carcinogenesis, neurodegenerative diseases, diabetes and male infertility | Homo sapiens |
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