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Literature summary for 3.1.1.4 extracted from

  • Boehl, M.; Ketscher, L.; Tietboehl, C.; Gutzeit, H.O.
    Phospholipase A2 inhibition at different substrate concentrations (2006), Anal. Biochem., 359, 280-282.
    View publication on PubMed
Search for more literature for 3.1.1.4

Inhibitors

Inhibitors Comment Organism Structure
aristolochic acid
-
 Sus scrofa
additional information epigallocatechin is a poor inhibitor Sus scrofa
quercetin
-
 Sus scrofa
quercetin-3-beta-D-glucoside
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secretory phospholipase A2 type IB Sus scrofa
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa P00592
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation from pancreas Sus scrofa
-
pancreas commercial preparation Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-dihexadecanoyl-rac-glycero-3-phosphorac-(1-glycerol) + H2O pyrene-modified or unmodified phospholipid substrate Sus scrofa ?
-
 ?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphogylcerol + H2O
-
 Sus scrofa 1-hexadecanoyl-glycero-3-phosphoethanolamine + 1-pyrenedecanoate
-
 ?

Synonyms

Synonyms Comment Organism
secretory phospholipase A2 type IB
-
 Sus scrofa
sPLA2 IB
-
 Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.01
-
 pH 7.4, 37°C, isozyme sPLA2 IB Sus scrofa quercetin
0.01
-
 pH 7.4, 37°C, isozyme sPLA2 IB Sus scrofa aristolochic acid
0.02
-
 pH 7.4, 37°C, isozyme sPLA2 IB Sus scrofa quercetin-3-beta-D-glucoside