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Literature summary for 3.1.1.4 extracted from
- The human calcium-independent phospholipase A2 gene (1999), Eur. J. Biochem., 262, 575-585.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| into pcDNA3.1 for later transfections | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ankyrin-iPLA2s | iPLA2-splice variant, contributes to formation of the iPLA2-tetrameric complex but possesses no active site | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Rattus norvegicus | 5737 | - |
| cytoplasm | - |
Homo sapiens | 5737 | - |
| plasma membrane | - |
Homo sapiens | 5886 | - |
| plasma membrane | one isoform of iPLA2 | Rattus norvegicus | 5886 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 88000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phospholipids + H2O | Rattus norvegicus | release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins | ? | - |
? |  |
| phospholipids + H2O | Homo sapiens | release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O60733 | - |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone marrow | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| brain | iPLA2 | Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| leukocyte | peripheral blood | Homo sapiens | - |
| prostate gland | - |
Homo sapiens | - |
| skeletal muscle | - |
Homo sapiens | - |
| spinal cord | - |
Homo sapiens | - |
| stomach | - |
Homo sapiens | - |
| testis | - |
Homo sapiens | - |
| thyroid gland | - |
Homo sapiens | - |
| trachea | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-palmitoyl-2-arachidonoylphosphatidylethanolamine | - |
Homo sapiens | 1-palmitoyl-glycerophosphorylethanolamine + arachidonic acid | - |
? | |
| phospholipids + H2O | release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins | Rattus norvegicus | ? | - |
? | |
| phospholipids + H2O | release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 88000 Da, homologous subunits, iPLA2 | Homo sapiens |
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Release 2023.1 (January 2023)
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