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Literature summary for 2.8.2.2 extracted from

  • Ekuase, E.J.; van t Erve, T.J.; Rahaman, A.; Robertson, L.W.; Duffel, M.W.; Luthe, G.
    Mechanistic insights into the specificity of human cytosolic sulfotransferase 2A1 (hSULT2A1) for hydroxylated polychlorinated biphenyls through the use of fluoro-tagged probes (2016), Environ. Sci. Pollut. Res. Int., 23, 2119-2127.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.2

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2'-fluoro-4-hydroxy-3,5-dichlorobiphenyl
-
 Homo sapiens
2-fluoro-4-hydroxy-3,5-dichlorobiphenyl
-
 Homo sapiens
3'-fluoro-4-hydroxy-3,5-dichlorobiphenyl
-
 Homo sapiens
4'-fluoro-4-hydroxy-3,5-dichlorobiphenyl
-
 Homo sapiens
4-hydroxy-3,5-dichlorobiphenyl
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0037
-
 2'-fluoro-4-hydroxy-3,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.0063
-
 3'-fluoro-4-hydroxy-3,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.0085
-
 4-hydroxy-3,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.0121
-
 4'-fluoro-4-hydroxy-3,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.0256
-
 2-fluoro-4-hydroxy-3,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q06520
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + 2'-fluoro-4-hydroxy-3,5-dichlorobiphenyl
-
 Homo sapiens adenosine 3',5'-bisphosphate + 2'-fluoro-4-hydroxy-3,5-dichlorobiphenyl sulfate
-
 ?
3'-phosphoadenylylsulfate + 2-fluoro-4-hydroxy-3,5-dichlorobiphenyl
-
 Homo sapiens adenosine 3',5'-bisphosphate + 2-fluoro-4-hydroxy-3,5-dichlorobiphenyl sulfate
-
 ?
3'-phosphoadenylylsulfate + 3'-fluoro-4-hydroxy-3,5-dichlorobiphenyl
-
 Homo sapiens adenosine 3',5'-bisphosphate + 3'-fluoro-4-hydroxy-3,5-dichlorobiphenyl sulfate
-
 ?
3'-phosphoadenylylsulfate + 4'-fluoro-4-hydroxy-3,5-dichlorobiphenyl
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4'-fluoro-4-hydroxy-3,5-dichlorobiphenyl sulfate
-
 ?
3'-phosphoadenylylsulfate + 4-hydroxy-3,5-dichlorobiphenyl
-
 Homo sapiens adenosine 3',5'-bisphosphate + 4-hydroxy-3,5-dichlorobiphenyl sulfate
-
 ?

Synonyms

Synonyms Comment Organism
sulfotransferase 2A1
-
 Homo sapiens
SULT2A1
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0775
-
 3'-fluoro-4-hydroxy-3,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.219
-
 4'-fluoro-4-hydroxy-3,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.221
-
 4-hydroxy-3,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.259
-
 2'-fluoro-4-hydroxy-3,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
0.323
-
 2-fluoro-4-hydroxy-3,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.3
-
 2-fluoro-4-hydroxy-3,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
4.5
-
 4'-fluoro-4-hydroxy-3,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
5.9
-
 4-hydroxy-3,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
10.2
-
 2'-fluoro-4-hydroxy-3,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
12.4
-
 3'-fluoro-4-hydroxy-3,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens