Cloned (Comment) | Organism |
---|---|
DHEA ST and SULT2A1 cloned and expressed in COS-1 cells | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00136 | - |
tetraiodothyronine | pH 6.0, 37°C, isoform SULT1E1 | Homo sapiens | |
0.00295 | - |
3,3'-diiodothyronine | pH 6.0, 37°C, isoform SULT2A1 | Homo sapiens | |
0.00463 | - |
triiodothyronine | pH 6.0, 37°C, recombinant isoform SULT1E1 | Homo sapiens | |
0.00484 | - |
3,5-diiodothyronine | pH 6.0, 37°C, isoform SULT2A1 | Homo sapiens | |
0.00607 | - |
triiodothyronine | pH 6.0, 37°C, isoform SULT1E1 | Homo sapiens | |
0.00704 | - |
triiodothyronine | pH 6.0, 37°C, recombinant isoform SULT2A1 | Homo sapiens | |
0.00973 | - |
3,3'-diiodothyronine | pH 6.0, 37°C, isoform SULT1E1 | Homo sapiens | |
0.0143 | - |
triiodothyronine | pH 6.0, 37°C, isoform SULT2A1 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylylsulfate + dehydroepiandrosterone | Homo sapiens | sulfation is an important pathway in the metabolism of thyroid hormones, sulfated iodothyronines are elevated in nonthyroidal illnesses and in the normal fetal circulation | adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylylsulfate + 3,3'-diiodothyronine | sulfation inactivates the substrate by addition of a sulfuryl moiety to the 4'-hydroxyl group | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + 3,5-diiodothyronine | sulfation inactivates the substrate by addition of a sulfuryl moiety to the 4'-hydroxyl group | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + dehydroepiandrosterone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate | - |
r | |
3'-phosphoadenylylsulfate + dehydroepiandrosterone | sulfation is an important pathway in the metabolism of thyroid hormones, sulfated iodothyronines are elevated in nonthyroidal illnesses and in the normal fetal circulation | Homo sapiens | adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate | - |
r | |
3'-phosphoadenylylsulfate + diiodothyronine | sulfation inactivates the substrate by addition of a sulfuryl moiety to the 4'-hydroxyl group | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + tetraiodothyronine | sulfation inactivates the substrate by addition of a sulfuryl moiety to the 4'-hydroxyl group | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylylsulfate + triiodothyronine | sulfation inactivates the substrate by addition of a sulfuryl moiety to the 4'-hydroxyl group | Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DHEA-ST | - |
Homo sapiens |
hydroxysteroid sulfotransferase ST2A3 | also variously named as SULT2A1 or human DHEA-ST | Homo sapiens |
iodothyronine sulfotransferase | - |
Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
4 | 43 | 50% inactivation temperature for SULT1E1 41.0°C, for SULT2A1 45.5°C | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
isoform SULT2A1 | Homo sapiens |