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Literature summary for 2.8.2.1 extracted from

  • Tabrett, C.A.; Coughtrie, M.W.
    Phenol sulfotransferase 1A1 activity in human liver: kinetic properties, interindividual variation and re-evaluation of the suitability of 4-nitrophenol as a probe substrate (2003), Biochem. Pharmacol., 66, 2089-2097.
    View publication on PubMed
Search for more literature for 2.8.2.1

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics of SULT1A1 allozymes 1 and 2 with 4-nitrophenol Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol SULT1A1 allozymes 1 and 2 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylylsulfate + a phenol Homo sapiens SULTs, especially SULT1A1, are important in xenobiotic and drug metabolism because of their broad substrate specificity and extensive tissue distribution adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 SULT1B1
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Homo sapiens
-
 SULT1A1 allozymes 1 and 2
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Source Tissue

Source Tissue Comment Organism Textmining
liver SULT1A1 Homo sapiens
-
liver SULT1B1 Homo sapiens
-
placenta SULT1A1 alozymes 1 and 2, but no SULT1B1 expression Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 assay development with 4-nitrophenol to distinguish SULT1A1 allozymes and SULT1B1 from liver Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + a phenol
-
 Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?
3'-phosphoadenylylsulfate + 4-nitrophenol SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
3'-phosphoadenylylsulfate + 4-nitrophenol SULT1B1 Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 ?
3'-phosphoadenylylsulfate + a phenol SULTs, especially SULT1A1, are important in xenobiotic and drug metabolism because of their broad substrate specificity and extensive tissue distribution Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
 ?

Synonyms

Synonyms Comment Organism
SULT
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens