Information on EC 2.8.2.1 - aryl sulfotransferase

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY
2.8.2.1
-
RECOMMENDED NAME
GeneOntology No.
aryl sulfotransferase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
isozyme P-PST: sequential ordered bisubstrate reaction mechanism
-
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
isozyme M-PST: ordered bisubstrate reaction mechanism
-
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
Cys70 is not essential for activity
-
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
the overall physiological reaction is a transfer of the sulfate group between 2-naphthol and 4-nitrophenol with the intermediate formation of 3'-phosphoadenylyl sulfate
-
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
Glu146 determines the substrate specificity
-
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
aryl sulfotransferase IV: Cys66 acts as a redox switch, but is not directly involved in the cataytic mechanism; ping-pong mechanism
-
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
Asp86 is located at the active site in the intercalating mobile loop and responsible for substrate binding
-
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
structure modeling to determine Arg residues involved in the catalytic reaction: Arg257 is essential, located very close to 3'-phosphoadenylyl sulfate, the negative charge of Arg78 is not required, Arg130 is not critical
P50225
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
mechanism
-
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
mechanism
Q29476
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
mechanism; mechanism; mechanism; mechanism
-, O00338, O75897
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
mechanism
P52846
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
mechanism; mechanism; mechanism; mechanism
-, O35401, Q80VR3, Q9QWG7
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
mechanism; mechanism
O46503, Q9XT99
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
aryl sulfotransferase IV: Cys66 acts as a redox switch, but is not directly involved in the cataytic mechanism; mechanism; mechanism; mechanism; mechanism; mechanism
P50237, P52847, Q9WUW8, Q9WUW9, -
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
random bi-bi mechanism catalytic mechanism of SULTs, many family members have distinct, but overlapping substrate specificities, the enzymes have a sequential catalytic mechanism that is susceptible to substrate inhibition
-
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
mechanism
Macaca fascicularis ST1A9, Mus musculus ST1a4, Mus musculus ST1c4, Oryctolagus cuniculus ST1A8, Oryctolagus cuniculus ST1C5
-
-
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
sulfate group transfer
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
dopamine degradation
-
melatonin degradation I
-
serotonin degradation
-
thyroid hormone metabolism II (via conjugation and/or degradation)
-
SYSTEMATIC NAME
IUBMB Comments
3'-phosphoadenylyl-sulfate:phenol sulfotransferase
A number of aromatic compounds can act as acceptors. Organic hydroxylamines are not substrates (cf. EC 2.8.2.9 tyrosine-ester sulfotransferase).
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
1-naphthol phenol sulfotransferase
-
-
-
-
2-naphtholsulfotransferase
-
-
-
-
4-nitrocatechol sulfokinase
-
-
-
-
aryl sulfotransferase IV
P17988
-
arylsulfotransferase
-
-
-
-
ASTIV
-
-
-
-
ASTIV
P17988
-
catecholamine-sulfating phenol sulfotransferase
-
-
-
-
cytosolic sulfotransferase
-
-
cytosolic sulfotransferase
-
-
cytosolic sulfotransferase
O00338, O43704
-
cytosolic sulfotransferase
P50224
-
cytosolic sulfotransferase
P50225
-
cytosolic sulfotransferase
P50226, Q9BR01
-
cytosolic sulfotransferase
-, Q9QWG7
-
DOPA/tyrosine sulfotransferase
-
-
-
-
dopamine sulfotransferase
-
-
-
-
dopamine sulfotransferase
-
-
H-PST
-
i.e. hippocampal phenol sulfotransferase
HAST1/HAST2
-
-
-
-
HAST3
-
-
-
-
hippocampal phenol sulfotransferase
-
-
-
-
M-PST
-
-
-
-
M-PST
-
-
minoxidil sulfotransferase
-
-
-
-
monoamine sulfotransferase
-
-
-
-
monoamine-form phenol sulfotransferase
-
-
neuronal SULT
Q9BR01
-
p-nitrophenol sulfotransferase
-
-
-
-
P-PST
-
-
-
-
P-PST
-
-
PAPS-sulfotransferase
-
-
phenol sulfokinase
-
-
-
-
phenol sulfotransferase
-
-
-
-
phenol sulfotransferase
P50227
-
phenol sulfotransferase
P50225
-
phenol sulfotransferase
-
-
phenol sulfotransferase 1
-
-
phenol sulfotransferase 1A1
-
-
phenol sulfotransferase 1A1
P50225
-
phenol sulfotransferase 1A1
P17988
-
phenol sulfotransferase 1A3
-
-
phenol/aryl sulfotransferase
-
-
-
-
Pst
-
-
-
-
PST-P
-
-
ritodrine sulfotransferase
-
-
-
-
ST
Mus musculus BALB/c
-
-
-
ST
Mus musculus ST1a4
-
;
-
ST
Oryctolagus cuniculus ST1A8
Q9XT99
;
-
ST1A2
-
-
-
-
ST1A3
-
-
-
-
ST1A4
-
-
-
-
sulfokinase
-
-
-
-
sulfotransferase
-
-
sulfotransferase
-
-
sulfotransferase 1,3
A0FIP8
-
sulfotransferase 1A1
-
-
sulfotransferase 1A1
-
isoform
sulfotransferase 1A1
P50225
-
sulfotransferase 1A1
-
-
sulfotransferase 1A3
-
-
sulfotransferase 1A3
P50224
-
sulfotransferase, aryl
-
-
-
-
sulfotransferase, monoamine-preferring
-
-
-
-
sulphotransferase
P50225
-
SULT
P50224
-
SULT
P50225
-
SULT1 isoform 4
Q6XZC1
-
SULT1 ST5
-
-
SULT1,3
A0FIP8
-
SULT1A1
P50227
-
SULT1A1
-
isoform
SULT1A1
P50225
isoform
SULT1A1
-
isoform
SULT1A1
P17988
-
SULT1A1
Q6Y0X5
-
SULT1A1*2
-
-
SULT1A2
P50226
-
SULT1A3
P50224
isoform
SULT1B1
-
-
SULT1B1
O43704
-
SULT1B1
Q9QWG7
isoform
SULT1B2
O43704
-
SULT1C*2
O00338
-
SULT1C1
-
-
SULT1C2
-
-
SULT1C3
-
-
SULT4A1
-
-
SULT4A1
Q9BR01
-
thermolabile phenol sulfotransferase
-
-
-
-
thermostable phenol sulfotransferase
-
-
-
-
TL-PST
-
-
-
-
TS-PST
-
-
-
-
tyrosine-ester sulfotransferase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9026-09-9
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
ST1A6
-
-
Manually annotated by BRENDA team
enzyme form SULT1D1
-
-
Manually annotated by BRENDA team
isozymes A and B
-
-
Manually annotated by BRENDA team
P-PST, 100% identical in amino acid sequence with GenBank accession number AY069922; SULT1A1, 100% identical in amino acid sequence with GenBank accession number D29807
SwissProt
Manually annotated by BRENDA team
recombinant
SwissProt
Manually annotated by BRENDA team
recombinant enzyme form SULT1 ST5
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
2 forms
-
-
Manually annotated by BRENDA team
2 forms of P-PST: PI-PST and PII-PST
-
-
Manually annotated by BRENDA team
2 forms of P-PST: PI-PST and PII-PST, differing in their thermostability; 2 forms: simple phenol sulfating P-PST, monoamine sulfating M-PST
-
-
Manually annotated by BRENDA team
2 forms: simple phenol sulfating P-PST, monoamine sulfating M-PST
-
-
Manually annotated by BRENDA team
2 forms: simple phenol sulfating P-PST, monoamine sulfating M-PST
SwissProt
Manually annotated by BRENDA team
2 forms: simple phenol sulfating P-PST, monoamine sulfating M-PST; SULT1A1/2, a P-PST enzyme form; SULT1A3, is a M-PST enzyme form
-
-
Manually annotated by BRENDA team
2 forms: simple phenol sulfating P-PST, monoamine sulfating M-PST; SULT1C1 and SULT1C2
-
-
Manually annotated by BRENDA team
2 forms: thermolabile TL, thermostable TS
-
-
Manually annotated by BRENDA team
; SULT1A1; SULT1A1
SwissProt
Manually annotated by BRENDA team
; SULT1A3; SULT1A3
SwissProt
Manually annotated by BRENDA team
allelic variants of SULT1A1
SwissProt
Manually annotated by BRENDA team
enzyme form PST-P
-
-
Manually annotated by BRENDA team
enzyme form SULT1A1
-
-
Manually annotated by BRENDA team
enzyme form SULT1A1, recombinant; enzyme form SULT1A3, recombinant; enzyme form SULT1E1, recombinant; enzyme form SULT2A1, recombinant
-
-
Manually annotated by BRENDA team
enzyme form SULT1A1; enzyme form SULT1A3
SwissProt
Manually annotated by BRENDA team
enzyme form SULT1A1; enzyme form SULT1A3
-
-
Manually annotated by BRENDA team
female and male
-
-
Manually annotated by BRENDA team
hippocampal enzyme form H-PST
-
-
Manually annotated by BRENDA team
Japanese individuals possessing the polymorphic SULT1A1*2 allele
SwissProt
Manually annotated by BRENDA team
ST1A3 and ST1A5
-
-
Manually annotated by BRENDA team
SULT1A1 allozymes 1 and 2
SwissProt
Manually annotated by BRENDA team
SULT1A1 allozymes 1 and 2; SULT1B1
-
-
Manually annotated by BRENDA team
SULT1A1 is a P-PST enzyme form
SwissProt
Manually annotated by BRENDA team
SULT1A1-A3; thermostable SULT1A1 and thermolabile SULT1A3
-
-
Manually annotated by BRENDA team
SULT1A1; SULT1A1
SwissProt
Manually annotated by BRENDA team
SULT1A2
SwissProt
Manually annotated by BRENDA team
SULT1A3, is a M-PST enzyme form
-
-
Manually annotated by BRENDA team
SULT1A3, is a M-PST enzyme form
SwissProt
Manually annotated by BRENDA team
SULT1B1
SwissProt
Manually annotated by BRENDA team
SULT1B2
SwissProt
Manually annotated by BRENDA team
SULT1C*2
GenBank
Manually annotated by BRENDA team
SULT1C1
GenBank
Manually annotated by BRENDA team
SULT1C2
SwissProt
Manually annotated by BRENDA team
SULT4A1
SwissProt
Manually annotated by BRENDA team
thermostable SULT1A1 and thermolabile SULT1A3
-
-
Manually annotated by BRENDA team
channel catfish
-
-
Manually annotated by BRENDA team
Macaca fascicularis ST1A9
ST1A9
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
Balb/c mice; ST1a4
-
-
Manually annotated by BRENDA team
ST1a4
-
-
Manually annotated by BRENDA team
ST1c4
SwissProt
Manually annotated by BRENDA team
SULT-N or St1d1
O35401
SwissProt
Manually annotated by BRENDA team
SULT1B1
SwissProt
Manually annotated by BRENDA team
Mus musculus BALB/c
Balb/c mice
-
-
Manually annotated by BRENDA team
Mus musculus ST1a4
ST1a4
-
-
Manually annotated by BRENDA team
Mus musculus ST1c4
ST1c4
SwissProt
Manually annotated by BRENDA team
male New Zealand White rabbits; ST1A8
SwissProt
Manually annotated by BRENDA team
SULT1A1
SwissProt
Manually annotated by BRENDA team
Oryctolagus cuniculus ST1A8
ST1A8
SwissProt
Manually annotated by BRENDA team
Oryctolagus cuniculus ST1C5
ST1C5
SwissProt
Manually annotated by BRENDA team
alpha- and beta-enzyme form
-
-
Manually annotated by BRENDA team
aryl sulfotransferase IV
-
-
Manually annotated by BRENDA team
aryl sulfotransferase IV; AST IV; male rats; ST1A1
-
-
Manually annotated by BRENDA team
male and female August-Copenhagen Irish, ACI, rats
SwissProt
Manually annotated by BRENDA team
Sprague-Dawley rats; ST1A1
-
-
Manually annotated by BRENDA team
ST1B1
SwissProt
Manually annotated by BRENDA team
ST1C1
SwissProt
Manually annotated by BRENDA team
SULT1C2 or ST1C6
SwissProt
Manually annotated by BRENDA team
SULT1C2A or ST1C7
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
metabolism
-
sulfonation, catalyzed by PAPS-sulfotransferases, especially SULT2A1,is one major phase II pathways for polychlorobiphenylols conjugation and for elimination of the potentially toxic compounds, overview
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 3'-phosphoadenylyl sulfate + 2 dopamine
2 adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + dopamine 4-O-sulfate
show the reaction diagram
P50224
SULT1A3
-, NMR product structure analysis, dopamine 3-O-sulfate is the main product, overview
-
?
3'-phosphoadenosine 5'-phosphosulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenosine 5'-phosphosulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
Q9QWG7
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
best substrate
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
SULT1B1
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
isoform ST4 shows a preference toward 1-naphtol
-
-
?
3'-phosphoadenylyl sulfate + 17alpha-ethinylestradiol
?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, P50226, Q9BR01
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, P50226, Q9BR01
SULT1A1
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, P50226, Q9BR01
SULT1A3
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, P50226, Q9BR01
SULT1A2
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, P50226, Q9BR01
SULT1C*2
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2,3,3',5,5',6-hexachlorobiphenyl-4'-yl
adenosine 3',5'-bisphosphate + 2,2',3,3',5,5'-hexachlorobiphenyl-4'-yl sulfate
show the reaction diagram
O43704
-
-
-
?
3'-phosphoadenylyl sulfate + 2,3,5,5',6-pentachlorobiphenyl-4'-yl
adenosine 3',5'-bisphosphate + 2,2',3,3',5'-pentachlorobiphenyl-4'-yl sulfate
show the reaction diagram
O43704
-
-
-
?
3'-phosphoadenylyl sulfate + 2,6-dichloro-4-nitrophenol
adenosine 3',5'-bisphosphate + 2,6-dichloro-4-nitrophenyl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 2,6-dichloro-4-nitrophenol
adenosine 3',5'-bisphosphate + 2,6-dichloro-4-nitrophenyl sulfate
show the reaction diagram
-, O00338, O43704, O75897
low activity, inhibitory
-
-
?
3'-phosphoadenylyl sulfate + 2,6-dichloro-4-nitrophenol
adenosine 3',5'-bisphosphate + 2,6-dichloro-4-nitrophenyl sulfate
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
low activity, inhibitory
-
-
?
3'-phosphoadenylyl sulfate + 2,6-dichloro-4-nitrophenol
adenosine 3',5'-bisphosphate + 2,6-dichloro-4-nitrophenyl sulfate
show the reaction diagram
-
competitive to 4-nitrophenol
-
?
3'-phosphoadenylyl sulfate + 2-aminophenol
adenosine 3',5'-bisphosphate + 2-aminophenyl sulfate
show the reaction diagram
O43704
-, preferred substrate of SULT1A1
-
-
?
3'-phosphoadenylyl sulfate + 2-methoxyestradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
P17988
-
-
-
r
3'-phosphoadenylyl sulfate + 2-naphthylamine
adenosine 3',5'-bisphosphate + naphthalen-2-ylsulfamic acid
show the reaction diagram
-, Q6XZC1
-
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthylamine
adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate
show the reaction diagram
O00338, P50226, Q9BR01
-
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthylamine
adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate
show the reaction diagram
O00338, P50226, Q9BR01
SULT1A1
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthylamine
adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate
show the reaction diagram
O00338, P50226, Q9BR01
SULT1A3
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthylamine
adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate
show the reaction diagram
O00338, P50226, Q9BR01
SULT1A2
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthylamine
adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate
show the reaction diagram
O00338, P50226, Q9BR01
SULT1B2
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthylamine
adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate
show the reaction diagram
O00338, P50226, Q9BR01
SULT1C*2
-
-
?
3'-phosphoadenylyl sulfate + 3',4',5-trichlorobiphenyl-2-yl
adenosine 3',5'-bisphosphate + 3',4',5-trichlorobiphenyl-2-yl sulfate
show the reaction diagram
O43704
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9QWG7
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3-cyano-7-hydroxycoumarin
?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3-nitro-L-tyrosine
adenosine 3',5'-bisphosphate + 3-nitro-O4-sulfo-L-tyrosine
show the reaction diagram
P50224
sulfation serves as a pathway for the metabolism/regulation of nitrotyrosine, nitrotyrosine O-sulfate is released into the medium of Hep-G2 hepatoma cells
-
-
?
3'-phosphoadenylyl sulfate + 3-nitro-L-tyrosine
adenosine 3',5'-bisphosphate + 3-nitro-O-sulfo-L-tyrosine
show the reaction diagram
P50224
specific reaction of SULT1A3, not performed by other SULT isozymes
-
-
?
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone
adenosine 3',5'-bisphosphate + 3alpha-sulfooxytibolone O-sulfate
show the reaction diagram
-
-, sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis
-
-
?
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone
adenosine 3',5'-bisphosphate + 3beta-sulfooxytibolone O-sulfate
show the reaction diagram
-
-, sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis
-
-
?
3'-phosphoadenylyl sulfate + 4-chlorobiphenyl-3'-ol
adenosine 3',5'-bisphosphate + 4'-chlorobiphenyl-3-yl sulfate
show the reaction diagram
O43704
low activity
-
-
?
3'-phosphoadenylyl sulfate + 4-chlorobiphenyl-4'-ol
adenosine 3',5'-bisphosphate + 4'-chlorobiphenyl-4-yl sulfate
show the reaction diagram
O43704
low activity
-
-
?
3'-phosphoadenylyl sulfate + 4-hydroxytamoxifen
adenosine 3',5'-bisphosphate + 4-(sulfooxy)tamoxifen
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 4-hydroxytamoxifen
adenosine 3',5'-bisphosphate + 4-(sulfooxy)tamoxifen
show the reaction diagram
-
a potent inducer of apoptosis in breast tumor cell lines
-
-
?
3'-phosphoadenylyl sulfate + 4-methylumbelliferone
adenosine 3',5'-bisphosphate + 4-methylumbelliferyl sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
Q9QWG7
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
O43704
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
P50224, P50225
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
O43704
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
P50225
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
P17988
-
-
-
r
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
A0FIP8, -
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
isoform ST3 shows higher sulfating activity toward 4-nitrophenol
-
-
?
3'-phosphoadenylyl sulfate + 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
i.e. aminoflavone, diaminoflavone analogues with potent growth-inhibitory activity against human breast and renal cancer cells in vitro and antitumor activity in mice bearing human tumor xenografts, aminoflavone binds to DNA in tumor cells and induces DNA-protein cross-links, i.e. aminoflavone
-
-
?
3'-phosphoadenylyl sulfate + 5-chloro-7-iodo-8-quinolinol
adenosine 3',5'-bisphosphate + 5-chloro-7-iodo-8-quinolinyl sulfate
show the reaction diagram
-
isoform SULT1A3 is responsible for the 5-chloro-7-iodo-8-quinolinol sulfation in human jejunum
-
-
?
3'-phosphoadenylyl sulfate + 6-hydroxydopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
SULT1A3, specific substrate of SULT1A3, no activity with other SULT isozymes
-
-
?
3'-phosphoadenylyl sulfate + 7-hydroxycoumarin
adenosine 3',5'-bisphosphate + 7-hydroxycoumarin sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 7-hydroxycoumarin
adenosine 3',5'-bisphosphate + 7-hydroxycoumarin sulfate
show the reaction diagram
P50227
-, SULT molecular dynamic, substrate 3'-phosphoadenylyl sulfate, i.e. PAPS, induces a structural change, overview
-
-
?
3'-phosphoadenylyl sulfate + 7-hydroxyserotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
SULT1A3, specific substrate of SULT1A3, no activity with other SULT isozymes
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
-
-
r
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-, P50225
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
O43704
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
P50225
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
P50225
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
r
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-, O00338, O43704, O75897
-
-
r
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
-
-
r
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
r
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
P52847
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
P50224, P50225
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
P50224
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
Q9XT99
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
O46503, Q9XT99
-
-
r
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
Q29476
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
Q29476
-
-
r
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
Q95KM3
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
P52846
-
-
r
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
P50227
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
the alpha-enzyme form catalyzes only the reverse reaction
r
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
SULT1A1/2: preference for straight chain phenol substrates with C1-2 and C4-5 chain lengths, overview, SULT1A3 is not active with short chain alkylphenols
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
Oryctolagus cuniculus ST1A8
Q9XT99
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
Oryctolagus cuniculus ST1A8
-
-
-
r
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
Oryctolagus cuniculus ST1C5
O46503
-
-
r
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
Mus musculus BALB/c
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
Mus musculus ST1c4
Q80VR3
-
-
r
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
Macaca fascicularis ST1A9
P52846
-
-
r
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
Mus musculus ST1a4
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
Mus musculus ST1a4
-
-
-
r
3'-phosphoadenylyl sulfate + acetaminophen
adenosine 3',5'-bisphosphate + 4-(acetylamino)phenylsulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + apigenin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + aristolochic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50225
herbal preparations containing Aristolochia species lead to progressive nephropathy and urothelial cancer in humans, metabolic activation of aristolichic acid, mutagenic effect, overview, in renal target tissue, good substrate of SULT1A1
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
show the reaction diagram
Q9QWG7
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + beta-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
-, Q6XZC1
-
-
-
?
3'-phosphoadenylyl sulfate + bisphenol A
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
isoform ST3 also shows sulfating activity toward bisphenol A
-
-
?
3'-phosphoadenylyl sulfate + butylated hydroxyanisole
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, Q6XZC1
-
-
-
?
3'-phosphoadenylyl sulfate + butylparaben
adenosine 3',5'-bisphosphate + butylparaben sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + caffeic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, P50226, Q9BR01
-
-
-
?
3'-phosphoadenylyl sulfate + caffeic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, P50226, Q9BR01
SULT1A1
-
-
?
3'-phosphoadenylyl sulfate + caffeic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, P50226, Q9BR01
SULT1A3
-
-
?
3'-phosphoadenylyl sulfate + caffeic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, P50226, Q9BR01
SULT1A2
-
-
?
3'-phosphoadenylyl sulfate + caffeic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, P50226, Q9BR01
SULT1C*2
-
-
?
3'-phosphoadenylyl sulfate + catechin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, Q6XZC1
-
-
-
?
3'-phosphoadenylyl sulfate + catechol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, P50226, Q9BR01
SULT1A1
-
-
?
3'-phosphoadenylyl sulfate + catechol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, P50226, Q9BR01
SULT1A3
-
-
?
3'-phosphoadenylyl sulfate + catechol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, P50226, Q9BR01
SULT1A2
-
-
?
3'-phosphoadenylyl sulfate + catechol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, P50226, Q9BR01
SULT1C*2
-
-
?
3'-phosphoadenylyl sulfate + chrysin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
substrate of allozyme SULT1A1*1
-
-
?
3'-phosphoadenylyl sulfate + daidzein
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
A0FIP8, -
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9QWG7
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + despiramine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9QWG7
-
-
-
?
3'-phosphoadenylyl sulfate + despiramine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + DL-3-hydroxyphenylalanine
adenosine 3',5'-bisphosphate + DL-3-(sulfooxy)phenylalanine
show the reaction diagram
P50224
-
-
-
?
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50224, P50225
as dopamine hydrochloride
-
-
?
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
isoform ST1 recognizes dopamine as a substrate
-
-
?
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
show the reaction diagram
P50224, P50225
-
-
-
?
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
show the reaction diagram
P50224
-
-
-
?
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
show the reaction diagram
A0FIP8, -
low activity
-
-
?
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopaminyl sulfate
show the reaction diagram
-
-, specific substrate for isoform SULT1A3
-
-
?
3'-phosphoadenylyl sulfate + epicatechin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + epicatechin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, Q6XZC1
-
-
-
?
3'-phosphoadenylyl sulfate + epigallocatechin gallate
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, Q6XZC1
-
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol sulfate
show the reaction diagram
-
the enzyme also performs the reaction of EC 2.8.2.4, estrone sulfotransferase, with low activity
-
-
?
3'-phosphoadenylyl sulfate + fenoterol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50224, P50225
as fenoterol hydrobromide
-
-
?
3'-phosphoadenylyl sulfate + genistein
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
A0FIP8, -
-
-
-
?
3'-phosphoadenylyl sulfate + isoproterenol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50224, P50225
as isoproterenol hydrochloride
-
-
?
3'-phosphoadenylyl sulfate + isoproterenol
adenosine 3',5'-bisphosphate + isoproterenol sulfate
show the reaction diagram
P50224, P50225
as isoproterenol hydrochloride
-
-
?
3'-phosphoadenylyl sulfate + kaempferol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, Q6XZC1
-
-
-
?
3'-phosphoadenylyl sulfate + L-DOPA
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50224
-
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9QWG7
-
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + L-tyrosine
adenosine 3',5'-bisphosphate + O-sulfo-L-tyrosine
show the reaction diagram
P50224
low activity
-
-
?
3'-phosphoadenylyl sulfate + minoxidil
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + myricetin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, Q6XZC1
-
-
-
?
3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl
adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl 4-amine
show the reaction diagram
O00338, P50226, Q9BR01
-
-
-
?
3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl
adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl 4-amine
show the reaction diagram
O00338, P50226, Q9BR01
SULT1A1
-
-
?
3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl
adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl 4-amine
show the reaction diagram
O00338, P50226, Q9BR01
SULT1A3
-
-
?
3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl
adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl 4-amine
show the reaction diagram
O00338, P50226, Q9BR01
SULT1A2
-
-
?
3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl
adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl-4-amine
show the reaction diagram
O00338, P50226, Q9BR01
SULT1C*2
-
-
?
3'-phosphoadenylyl sulfate + n-propyl gallate
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, Q6XZC1
-
-
-
?
3'-phosphoadenylyl sulfate + nonyl phenol
adenosine 3',5'-bisphosphate + nonyl phenyl sulfate
show the reaction diagram
A0FIP8, -
low activity
-
-
?
3'-phosphoadenylyl sulfate + octyl phenol
adenosine 3',5'-bisphosphate + octyl phenyl sulfate
show the reaction diagram
A0FIP8, -
low activity
-
-
?
3'-phosphoadenylyl sulfate + p-nitrophenol
adenosine 3',5'-bisphosphate + p-nitrophenyl sulfate
show the reaction diagram
P50224, P50225
-
-
-
?
3'-phosphoadenylyl sulfate + pentachlorophenol
adenosine 3',5'-bisphosphate + pentachlorophenyl sulfate
show the reaction diagram
-, O00338, O43704, O75897
low activity, inhibitory
-
-
?
3'-phosphoadenylyl sulfate + pentachlorophenol
adenosine 3',5'-bisphosphate + pentachlorophenyl sulfate
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
low activity, inhibitory
-
-
?
3'-phosphoadenylyl sulfate + phenol
adenosine 3',5'-bisphosphate + phenyl sulfate
show the reaction diagram
O00338, P50226, Q9BR01
-
-
-
?
3'-phosphoadenylyl sulfate + quercetin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, Q6XZC1
-
-
-
?
3'-phosphoadenylyl sulfate + quercetin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
allozyme SULT1A1*1
-
-
?
3'-phosphoadenylyl sulfate + resveratrol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + resveratrol
adenosine 3',5'-bisphosphate + trans-resveratrol-3-O sulfate
show the reaction diagram
-
3,4',5-trihydroxy-trans-stilbene
-
-
?
3'-phosphoadenylyl sulfate + ritodrine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50224, P50225
as ritodrine hydrochloride
-
-
?
3'-phosphoadenylyl sulfate + salbutamol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50224, P50225
as salbutamol hemisulfate
-
-
?
3'-phosphoadenylyl sulfate + serotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + silybin B
adenosine 3',5'-bisphosphate + silybin B 20-O-sulfate
show the reaction diagram
P17988
-
-
-
?
3'-phosphoadenylyl sulfate + terbutaline
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50224, P50225
as terbutaline hemisulfate
-
-
?
3'-phosphoadenylyl sulfate + trans-4-hydroxytamoxifen
adenosine 3',5'-bisphosphate + trans-4-(sulfooxy)tamoxifen
show the reaction diagram
P50225
substrate of the allozymes SULT1A1*2 and SULT1A1*1
-
-
?
3'-phosphoadenylyl sulfate + vanillin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
vanillin is the best substrate for isoforms ST1 and ST3
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9QWG7
-
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + (+/-)isoproterenol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST and M-PST
-
-
?
3'-phosphoadenylylsulfate + (+/-)metoprolol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST, not M-PST
-
-
?
3'-phosphoadenylylsulfate + (+/-)salbutamol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST and M-PST
-
-
?
3'-phosphoadenylylsulfate + (+/-)sotalol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST, not M-PST
-
-
?
3'-phosphoadenylylsulfate + (-)-(1R,2R)-pseudoephedrine
adenosine 3',5'-bisphosphate + 2-(methylamino)-1-phenylpropyl sulfate
show the reaction diagram
-
absolute stereospecificity
-
-
?
3'-phosphoadenylylsulfate + (-)-(1R,2S)-ephedrine
adenosine 3',5'-bisphosphate + 2-(methylamino)-1-phenylpropyl sulfate
show the reaction diagram
-
absolute stereospecificity
-
-
?
3'-phosphoadenylylsulfate + (-)-(S)-2-methyl-1-phenyl-1-propanol
adenosine 3',5'-bisphosphate + 2-methyl-1-phenylpropyl 1-sulfate
show the reaction diagram
-
absolute stereospecificity
-
-
?
3'-phosphoadenylylsulfate + 1,2,3,4-tetrahydro-1-naphthol
adenosine 3',5'-bisphosphate + 1,2,3,4-tetrahydronaphthyl 1-sulfate
show the reaction diagram
-
only the (-)-(R)-enantiomer is active as substrate
-
-
?
3'-phosphoadenylylsulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-, O00338, O43704, O75897
-
-
-
?
3'-phosphoadenylylsulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
M-PST
-
-
?
3'-phosphoadenylylsulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
SULT1C2 and SULT1C2A: no activity
-
-
-
3'-phosphoadenylylsulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-, O00338, O43704, O75897
ST1B2
-
-
?
3'-phosphoadenylylsulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
highest activity among simple phenols tested
-
-
?
3'-phosphoadenylylsulfate + 1-phenylethanol
adenosine 3',5'-bisphosphate + 1-phenylethyl sulfate
show the reaction diagram
-
(+)-(R)- and (-)-(S)-
-
-
?
3'-phosphoadenylylsulfate + 2-amino-4'-hydroxy-1-methyl-6-phenylimidazo[4,5-b]pyridine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + 2-amino-4'-hydroxy-1-methyl-6-phenylimidazo[4,5-b]pyridine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + 2-amino-4'-hydroxy-1-methyl-6-phenylimidazo[4,5-b]pyridine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + 2-amino-4'-hydroxy-1-methyl-6-phenylimidazo[4,5-b]pyridine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 2-chlorophenol
adenosine 3',5'-bisphosphate + 2-chlorophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 2-chlorophenol
adenosine 3',5'-bisphosphate + 2-chlorophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 2-ethylphenol
adenosine 3',5'-bisphosphate + 2-ethylphenyl sulfate
show the reaction diagram
-
SULT1A1/2
-
-
?
3'-phosphoadenylylsulfate + 2-hydroxyestradiol
adenosine 3',5'-bisphosphate + estradiol 2-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 2-hydroxyestrone
adenosine 3',5'-bisphosphate + estrone 2-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 2-methylphenol
adenosine 3',5'-bisphosphate + 2-methylphenyl sulfate
show the reaction diagram
-
SULT1A1/2
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
O00338, O43704, O75897
-
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
-
-
-
r
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
-
-
-
r
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
-
-
-
r
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
P50225
SULT1A1
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
Q29476
SULT1A1
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
SULT-N
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
ST1A1 or AST IV
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
-
ST1A6
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
ST1c4
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
no activity with ST1B1
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthyl sulfate
show the reaction diagram
Mus musculus ST1c4
Q80VR3
ST1c4
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthylsulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 2-naphthol
adenosine 3',5'-bisphosphate + 2-naphthylsulfate
show the reaction diagram
-
recombinant enzyme form SULT1 ST5
-
-
?
3'-phosphoadenylylsulfate + 2-naphthylamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
SULT-N
-
-
?
3'-phosphoadenylylsulfate + 2-nitrophenol
adenosine 3',5'-bisphosphate + 2-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 3,3',5'-triiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O00338, O43704, O75897
-
-
-
?
3'-phosphoadenylylsulfate + 3,3',5'-triiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
-
-
-
?
3'-phosphoadenylylsulfate + 3,3',5'-triiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P52847
low activity
-
-
?
3'-phosphoadenylylsulfate + 3,3',5'-triiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O00338, O43704, O75897
ST1B2
-
-
?
3'-phosphoadenylylsulfate + 3,3',5'-triiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50225
SULT1A1 allozymes 1 and 2
-
-
?
3'-phosphoadenylylsulfate + 3,3',5-triiodo-D-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P52847
-
-
-
?
3'-phosphoadenylylsulfate + 3,3',5-triiodo-D-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
-
-
-
?
3'-phosphoadenylylsulfate + 3,3',5-triiodo-D-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O00338, O43704, O75897
ST1B2
-
-
?
3'-phosphoadenylylsulfate + 3,3',5-triiodo-D-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50225
SULT1A1 allozymes 1 and 2
-
-
-
3'-phosphoadenylylsulfate + 3,3',5-triiodo-D-thyronine
adenosine 3',5'-bisphosphate + 3,3',5-triiodo-D-thyronine 4'-sulfate
show the reaction diagram
-
recombinant enzyme form SULT1 ST5
-
-
?
3'-phosphoadenylylsulfate + 3,3',5-triiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O00338, O43704, O75897
-
-
-
?
3'-phosphoadenylylsulfate + 3,3',5-triiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
-
-
-
?
3'-phosphoadenylylsulfate + 3,3',5-triiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P52847
-
-
-
?
3'-phosphoadenylylsulfate + 3,3',5-triiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
SULT1B1
-
-
?
3'-phosphoadenylylsulfate + 3,3',5-triiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
SULT-N: no activity
-
-
-
3'-phosphoadenylylsulfate + 3,3',5-triiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50225
SULT1A1 allozymes 1 and 2
-
-
?
3'-phosphoadenylylsulfate + 3,3',5-triiodo-L-thyronine
adenosine 3',5'-bisphosphate + 3,3',5-triiodo-L-thyronine 4'-sulfate
show the reaction diagram
-
recombinant enzyme form SULT1 ST5
-
-
?
3'-phosphoadenylylsulfate + 3,3'-diiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O00338, O43704, O75897
-
-
-
?
3'-phosphoadenylylsulfate + 3,3'-diiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50225
low activity
-
-
?
3'-phosphoadenylylsulfate + 3,3'-diiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O00338, O43704, O75897
ST1B2
-
-
?
3'-phosphoadenylylsulfate + 3,3'-diiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50225
SULT1A1 allozymes 1 and 2
-
-
?
3'-phosphoadenylylsulfate + 3,4-dihydroxyphenylacetate
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + 3,4-dihydroxyphenylacetate
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + 3,4-dihydroxyphenylacetate
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + 3,4-dihydroxyphenylacetate
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 3,4-dihydroxyphenylglycol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 3,5-diiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P52847
low activity
-
-
?
3'-phosphoadenylylsulfate + 3,5-diiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50225
no activity with
-
-
-
3'-phosphoadenylylsulfate + 3,5-diiodo-L-thyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O00338, O43704, O75897
no activity: ST1B2
-
-
-
3'-phosphoadenylylsulfate + 3-chlorophenol
adenosine 3',5'-bisphosphate + 3-chlorophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 3-chlorophenol
adenosine 3',5'-bisphosphate + 3-chlorophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 3-ethylphenol
adenosine 3',5'-bisphosphate + 3-ethylphenyl sulfate
show the reaction diagram
-
SULT1A1/2
-
-
?
3'-phosphoadenylylsulfate + 3-hydroxybenzo[a]pyrene
adenosine 3',5'-bisphosphate + benzo[a]pyrene 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 3-hydroxybenzo[a]pyrene
adenosine 3',5'-bisphosphate + benzo[a]pyrene 3-sulfate
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + 3-hydroxybenzo[a]pyrene
adenosine 3',5'-bisphosphate + benzo[a]pyrene 3-sulfate
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + 3-hydroxybenzo[a]pyrene
adenosine 3',5'-bisphosphate + benzo[a]pyrene 3-sulfate
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + 3-hydroxybenzo[a]pyrene
adenosine 3',5'-bisphosphate + benzo[a]pyrene 3-sulfate
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 3-hydroxyindole
adenosine 3',5'-bisphosphate + 3-indoxyl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + 3-hydroxyindole
adenosine 3',5'-bisphosphate + 3-indoxyl sulfate
show the reaction diagram
-
in vivo function may include the production of the normal tryptophan metabolite indican
-
-
?
3'-phosphoadenylylsulfate + 3-methoxy-4-hydroxyphenylethyleneglycol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 3-methoxy-4-hydroxyphenylglycol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 3-methylphenol
adenosine 3',5'-bisphosphate + 3-methylphenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 3-methylphenol
adenosine 3',5'-bisphosphate + 3-methylphenyl sulfate
show the reaction diagram
-
SULT1A1/2
-
-
?
3'-phosphoadenylylsulfate + 3-nitrophenol
adenosine 3',5'-bisphosphate + 3-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 3-nitrophenol
adenosine 3',5'-bisphosphate + 3-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-acetamidophenol
adenosine 3',5'-bisphosphate + 4-acetamidophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-chlorocatechol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
SULT1A1, SULT1A3
-
-
?
3'-phosphoadenylylsulfate + 4-chlorophenol
adenosine 3',5'-bisphosphate + 4-chlorophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-chlorophenol
adenosine 3',5'-bisphosphate + 4-chlorophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-chlorophenol
adenosine 3',5'-bisphosphate + 4-chlorophenyl sulfate
show the reaction diagram
-
SULT1A1, SULT1A3
-
-
?
3'-phosphoadenylylsulfate + 4-ethylphenol
adenosine 3',5'-bisphosphate + 4-ethylphenyl sulfate
show the reaction diagram
-
SULT1A1/2
-
-
?
3'-phosphoadenylylsulfate + 4-hydroxy-3-methoxyphenylglycol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + 4-hydroxy-3-methoxyphenylglycol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + 4-hydroxy-3-methoxyphenylglycol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + 4-hydroxy-3-methoxyphenylglycol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 4-isopropylcatechol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
SULT1A1, SULT1A3
-
-
?
3'-phosphoadenylylsulfate + 4-methoxyphenol
adenosine 3',5'-bisphosphate + 4-methoxyphenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-methoxytyramine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-methylcatechol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
SULT1A1, SULT1A3
-
-
?
3'-phosphoadenylylsulfate + 4-methylphenol
adenosine 3',5'-bisphosphate + 4-methylphenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-methylphenol
adenosine 3',5'-bisphosphate + 4-methylphenyl sulfate
show the reaction diagram
-
SULT1A1, SULT1A3
-
-
?
3'-phosphoadenylylsulfate + 4-methylphenol
adenosine 3',5'-bisphosphate + 4-methylphenyl sulfate
show the reaction diagram
-
SULT1A1/2
-
-
?
3'-phosphoadenylylsulfate + 4-methylumbelliferone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-methylumbelliferone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-methylumbelliferone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + 4-methylumbelliferone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + 4-methylumbelliferone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + 4-methylumbelliferone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 4-methylumbelliferone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST and M-PST
-
-
?
3'-phosphoadenylylsulfate + 4-n-amylphenol
adenosine 3',5'-bisphosphate + 4-n-amylphenyl sulfate
show the reaction diagram
-
SULT1A1/2
-
-
?
3'-phosphoadenylylsulfate + 4-n-butylphenol
adenosine 3',5'-bisphosphate + 4-n-butylphenyl sulfate
show the reaction diagram
-
SULT1A1/2
-
-
?
3'-phosphoadenylylsulfate + 4-n-propylphenol
adenosine 3',5'-bisphosphate + 4-n-propylphenyl sulfate
show the reaction diagram
-
SULT1A1/2
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
P50225
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
r
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
r
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
r
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
r
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
P52847
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
Q29476
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
Q6Y0X5, -
-
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
SULT1A1
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
O00338, O43704, O75897
SULT1A1
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
Q29476
SULT1A1
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
SULT1B1
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
O35401, Q80VR3, Q9QWG7
ST1a4
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
M-PST
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
O43704
M-PST
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
M-PST
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
O46503, Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
O43704
P-PST
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
P-PST
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
SULT-N
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-, O00338, O43704, O75897
ST1B2
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
SULT1C1: specific for
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
O00338, O43704, O75897
SULT1C1: specific for
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-, O00338, O43704, O75897
SULT1A2
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-, O00338, O43704, O75897
SULT1A3: no activity
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
SULT1C2A
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
ST1C1
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
preferred substrate of TS enzyme form
-
-
-
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
SULT1C2
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
O00338, O43704, O75897
SULT1C2
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
SULT1C2
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
O46503, Q9XT99
ST1C5
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
H-PST, preferred substrate
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
SULT1A1/2
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
P50225
enzyme form SULT1A1
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
enzyme form SULT1A1
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
P50225
enzyme form SULT1A3
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
enzyme form SULT1A3
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
enzyme form SULT1D1
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
recombinant enzyme form SULT1 ST5
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
Oryctolagus cuniculus ST1A8
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
Oryctolagus cuniculus ST1A8
-
ST1A8
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
Oryctolagus cuniculus ST1C5
O46503
ST1C5
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
Mus musculus BALB/c, Mus musculus ST1a4
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
Mus musculus ST1a4
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + 4-nonylphenol
adenosine 3',5'-bisphosphate + 4-nonylphenyl sulfate
show the reaction diagram
-
P-PST, M-PST, SULT1C2, not SULT1C1, P-PST: best substrate
-
-
?
3'-phosphoadenylylsulfate + 4-octylphenol
adenosine 3',5'-bisphosphate + 4-octylphenyl sulfate
show the reaction diagram
-
SULT1C2: best substrate, P-PST, M-PST, SULT1C2, not SULT1C1
-
-
?
3'-phosphoadenylylsulfate + 5,7-dihydroxyflavanone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + 5,7-dihydroxyflavanone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + 5,7-dihydroxyflavanone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + 5,7-dihydroxyflavanone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 5-(hydroxyphenyl)-5-(p-tolyl)-hydantoin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + 5-(hydroxyphenyl)-5-(p-tolyl)-hydantoin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + 5-(hydroxyphenyl)-5-(p-tolyl)-hydantoin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + 5-(hydroxyphenyl)-5-(p-tolyl)-hydantoin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 5-hydroxyindole
adenosine 3',5'-bisphosphate + 5-indoxyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 5-hydroxyindole
adenosine 3',5'-bisphosphate + 5-indoxyl sulfate
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + 5-hydroxyindole
adenosine 3',5'-bisphosphate + 5-indoxyl sulfate
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + 5-hydroxyindole
adenosine 3',5'-bisphosphate + 5-indoxyl sulfate
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + 5-hydroxyindole
adenosine 3',5'-bisphosphate + 5-indoxyl sulfate
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 5-hydroxytryptamine
adenosine 3',5'-bisphosphate + 3-(2-aminoethyl)-5-indoxyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 5-hydroxytryptophol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + 5-hydroxytryptophol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + 5-hydroxytryptophol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + 5-hydroxytryptophol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 5-hydroxytryptophol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Oryctolagus cuniculus ST1A8
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + 5-hydroxytryptophol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Mus musculus BALB/c, Mus musculus ST1a4
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + 6-hydroxymelatonin
adenosine 3',5'-bisphosphate + melatonin 6-sulfate
show the reaction diagram
-, O00338, O43704, O75897
-
-
-
?
3'-phosphoadenylylsulfate + 6-hydroxymelatonin
adenosine 3',5'-bisphosphate + melatonin 6-sulfate
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
-
-
-
?
3'-phosphoadenylylsulfate + 6-hydroxymelatonin
adenosine 3',5'-bisphosphate + melatonin 6-sulfate
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + 6-hydroxymelatonin
adenosine 3',5'-bisphosphate + melatonin 6-sulfate
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + 6-hydroxymelatonin
adenosine 3',5'-bisphosphate + melatonin 6-sulfate
show the reaction diagram
O35401, Q80VR3, Q9QWG7
ST1a4
-
-
?
3'-phosphoadenylylsulfate + 6-hydroxymelatonin
adenosine 3',5'-bisphosphate + melatonin 6-sulfate
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + 6-hydroxymelatonin
adenosine 3',5'-bisphosphate + melatonin 6-sulfate
show the reaction diagram
O46503, Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + 6-hydroxymelatonin
adenosine 3',5'-bisphosphate + melatonin 6-sulfate
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + 7-(hydroxymethyl)-12-methylbenz[a]anthracene
adenosine 3',5'-bisphosphate + sulfuric acid mono-(12-methyl-benzo[a]anthracen-7ylmethyl)ester
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 7-hydroxybenzo[a]pyrene
adenosine 3',5'-bisphosphate + benzo[a]pyrene 7-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 9-hydroxybenzo[a]pyrene
adenosine 3',5'-bisphosphate + benzo[a]pyrene 9-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-, O00338, O43704, O75897
-
-
-
?
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
-
-
-
?
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
phase II drug metabolizing or detoxifying enzyme, sulfate conjugation of phenolic biogenic amines, important in the biotransformation of many neurotransmitters, hormones, drugs, and xenobiotic compounds
-
-
-
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
sulfate conjugation of phenolic biogenic amines, important in the biotransformation of many neurotransmitters, hormones, drugs, and xenobiotic compounds
-
-
?
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
sulfation of environmental estrogens, overview
-
-
?
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
enzyme may be considered as detoxification enzyme which catalyzes the conjugation of xenobiotics containing a phenol group or of phenolic compounds generated by endogenous oxidation
-
-
?
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
enzyme may be considered as detoxification enzyme which catalyzes the conjugation of xenobiotics containing a phenol group or of phenolic compounds generated by endogenous oxidation
-
-
?
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
SULTs, especially SULT1A1, are important in xenobiotic and drug metabolism because of their broad substrate specificity and extensive tissue distribution
-
-
?
3'-phosphoadenylylsulfate + acebutolol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST, not M-PST
-
-
?
3'-phosphoadenylylsulfate + acetaminophen
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
SULT1C2 and SULT1C2A: no activity
-
-
-
3'-phosphoadenylylsulfate + acetaminophen
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
M-PST and P-PST
-
-
?
3'-phosphoadenylylsulfate + adrenaline
adenosine 3',5'-bisphosphate + adrenaline sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q29476
SULT1A1
-
-
?
3'-phosphoadenylylsulfate + beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
SULT1C2 and SULT1C2A: no activity
-
-
-
3'-phosphoadenylylsulfate + beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O00338, O43704, O75897
no activity: ST1B2
-
-
-
3'-phosphoadenylylsulfate + bisphenol A
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + bisphenol A
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST, M-PST, SULT1C2, not SULT1C1
-
-
?
3'-phosphoadenylylsulfate + bupivacaine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST, not M-PST
-
-
?
3'-phosphoadenylylsulfate + butylated hydroxyanisole
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
recombinant enzyme form SULT1 ST5
-
-
?
3'-phosphoadenylylsulfate + caffeic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
recombinant enzyme form SULT1 ST5
-
-
?
3'-phosphoadenylylsulfate + catechin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
recombinant enzyme form SULT1 ST5
-
-
?
3'-phosphoadenylylsulfate + catechol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
SULT1A1, SULT1A3
-
-
?
3'-phosphoadenylylsulfate + catecholamine metabolites
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
deaminated and (or) O-methylated
-
-
?
3'-phosphoadenylylsulfate + chlorogenic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
recombinant enzyme form SULT1 ST5
-
-
?
3'-phosphoadenylylsulfate + cinnamyl alcohol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
ST1c4
-
-
?
3'-phosphoadenylylsulfate + cinnamyl alcohol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Mus musculus ST1c4
Q80VR3
ST1c4
-
-
?
3'-phosphoadenylylsulfate + D-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P52847
-
-
-
?
3'-phosphoadenylylsulfate + D-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
-
-
-
?
3'-phosphoadenylylsulfate + D-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
SULT1B1
-
-
?
3'-phosphoadenylylsulfate + D-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O43704
M-PST
-
-
?
3'-phosphoadenylylsulfate + D-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
M-PST
-
-
?
3'-phosphoadenylylsulfate + D-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O43704
i.e. D-Dopa
-
-
?
3'-phosphoadenylylsulfate + D-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
i.e. D-Dopa
-
-
?
3'-phosphoadenylylsulfate + D-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, O43704, O75897
i.e. D-Dopa
-
-
?
3'-phosphoadenylylsulfate + D-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
i.e. D-Dopa
-
-
?
3'-phosphoadenylylsulfate + D-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
preferred isomer, stereospecific
-
-
?
3'-phosphoadenylylsulfate + D-tyrosine
adenosine 3',5'-bisphosphate + D-tyrosyl sulfate
show the reaction diagram
-
no activity with
-
-
-
3'-phosphoadenylylsulfate + D-tyrosine
adenosine 3',5'-bisphosphate + D-tyrosyl sulfate
show the reaction diagram
O43704
M-PST
-
-
?
3'-phosphoadenylylsulfate + D-tyrosine
adenosine 3',5'-bisphosphate + D-tyrosyl sulfate
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
SULT1B1: no activity
-
-
-
3'-phosphoadenylylsulfate + daidzein
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
recombinant enzyme form SULT1 ST5
-
-
?
3'-phosphoadenylylsulfate + daidzein
adenosine 3',5'-bisphosphate + daidzein 4'-sulfate
show the reaction diagram
-
enzyme form SULT1A3
-
-
?
3'-phosphoadenylylsulfate + daidzein
adenosine 3',5'-bisphosphate + daidzein 7-sulfate + daidzein 4'-sulfate
show the reaction diagram
-
enzyme form SULT1A1, ratio of 7-sulfate formation to 4'-sulfate formation is 4.4, enzyme form SULT1E1, ratio of 7-sulfate formation to 4'-sulfate formation is 1.1, enzyme form SULT2A1, ratio of 7-sulfate formation to 4'-sulfate formation is 11.8
-
-
?
3'-phosphoadenylylsulfate + daidzein 4'-sulfate
adenosine 3',5'-bisphosphate + daidzein 4',7-disulfate
show the reaction diagram
-
enzyme form SULT1A1, enzyme form SULT1E1
-
-
?
3'-phosphoadenylylsulfate + daidzein 7-sulfate
adenosine 3',5'-bisphosphate + daidzein 4',7-disulfate
show the reaction diagram
-
enzyme form SULT1A1, enzyme form SULT1E1
-
-
?
3'-phosphoadenylylsulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + dexamethasone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST, not M-PST
-
-
?
3'-phosphoadenylylsulfate + DL-propanolol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST, not M-PST
-
-
?
3'-phosphoadenylylsulfate + DL-tyrosine
adenosine 3',5'-bisphosphate + DL-tyrosyl sulfate
show the reaction diagram
-, O00338, O43704, O75897
-
-
-
?
3'-phosphoadenylylsulfate + DL-tyrosine
adenosine 3',5'-bisphosphate + DL-tyrosyl sulfate
show the reaction diagram
P52847
-
-
-
?
3'-phosphoadenylylsulfate + DL-tyrosine
adenosine 3',5'-bisphosphate + DL-tyrosyl sulfate
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
-
-
-
?
3'-phosphoadenylylsulfate + DL-tyrosine
adenosine 3',5'-bisphosphate + DL-tyrosyl sulfate
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
SULT1B1
-
-
?
3'-phosphoadenylylsulfate + DL-tyrosine
adenosine 3',5'-bisphosphate + DL-tyrosyl sulfate
show the reaction diagram
O43704
M-PST
-
-
?
3'-phosphoadenylylsulfate + dobutamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST and M-PST
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P52847
-
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
-
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, P50225
-
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q29476
-
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
low activity
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, P50225
SULT1A3 is specific for dopamine and other biogenic amines
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
SULT1A1
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q29476
SULT1A1
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
SULT1B1
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
M-PST
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O43704
M-PST
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
M-PST
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
preferred substrate of TL enzyme form
-
-
-
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O46503, Q9XT99
ST1A8: no activity
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
ST1A1: no activity
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
H-PST, no activity with
-
-
-
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
M-PST: best substrate
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
SULT1A3
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, O43704, O75897
SULT1A3
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
SULT1A3
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
ST1B1
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O43704
P-PST
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
SULT1C2 and SULT1C2A: no activity
-
-
-
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O46503, Q9XT99
ST1C5: no activity
-
-
-
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
SULT-N
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O00338, O43704, O75897
SULT1A1 and SULT1A2: no activity
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
ST1a4: no activity
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
accounts for approximately 10% of the enzymic activity directed towards catabolism of dopamine
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50225
enzyme form SULT1A1
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
enzyme form SULT1A1
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50225
enzyme form SULT1A3
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
enzyme form SULT1A3
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
enzyme form SULT1D1
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Oryctolagus cuniculus ST1A8
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Oryctolagus cuniculus ST1A8
-
ST1A8: no activity
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Oryctolagus cuniculus ST1C5
O46503
ST1C5: no activity
-
-
-
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Mus musculus BALB/c, Mus musculus ST1a4
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Mus musculus ST1a4
-
ST1a4: no activity
-
-
?
3'-phosphoadenylylsulfate + epinephrine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50225
enzyme form SULT1A3
-
-
?
3'-phosphoadenylylsulfate + epinephrine
adenosine 3',5'-bisphosphate + epinephrine sulfate
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
-
-
-
?
3'-phosphoadenylylsulfate + epinephrine
adenosine 3',5'-bisphosphate + epinephrine sulfate
show the reaction diagram
-, O00338, O43704, O75897
-
-
-
?
3'-phosphoadenylylsulfate + epinephrine
adenosine 3',5'-bisphosphate + epinephrine sulfate
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
-
-
-
?
3'-phosphoadenylylsulfate + epinephrine
adenosine 3',5'-bisphosphate + epinephrine sulfate
show the reaction diagram
O46503, Q9XT99
-
-
-
?
3'-phosphoadenylylsulfate + epinephrine
adenosine 3',5'-bisphosphate + epinephrine sulfate
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + epinephrine
adenosine 3',5'-bisphosphate + epinephrine sulfate
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + epinephrine
adenosine 3',5'-bisphosphate + epinephrine sulfate
show the reaction diagram
-
M-PST
-
-
?
3'-phosphoadenylylsulfate + epinephrine
adenosine 3',5'-bisphosphate + epinephrine sulfate
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + epinephrine
adenosine 3',5'-bisphosphate + epinephrine sulfate
show the reaction diagram
-
P-PST
-
-
?
3'-phosphoadenylylsulfate + epinephrine
adenosine 3',5'-bisphosphate + epinephrine sulfate
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + epinephrine
adenosine 3',5'-bisphosphate + epinephrine sulfate
show the reaction diagram
-
H-PST, no activity
-
-
-
3'-phosphoadenylylsulfate + epinephrine
adenosine 3',5'-bisphosphate + epinephrine sulfate
show the reaction diagram
Oryctolagus cuniculus ST1A8, Mus musculus ST1a4
-
-
-
-
?
3'-phosphoadenylylsulfate + gallic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
recombinant enzyme form SULT1 ST5
-
-
?
3'-phosphoadenylylsulfate + genistein
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
recombinant enzyme form SULT1 ST5
-
-
?
3'-phosphoadenylylsulfate + genistein
adenosine 3',5'-bisphosphate + genistein 7-sulfate + genistein 4'-sulfate
show the reaction diagram
-
enzyme form SULT1A1, ratio of 7-sulfate formation to 4'-sulfate formation is 8.8, enzyme form SULT1E1, ratio of 7-sulfate formation to 4'-sulfate formation is 1.1, enzyme form SULT2A1, ratio of 7-sulfate formation to 4'-sulfate formation is 8.8
-
-
?
3'-phosphoadenylylsulfate + genistein
adenosine 3',5'-bisphosphate + genistein 4'-sulfate
show the reaction diagram
-
enzyme form SULT1A3
-
-
?
3'-phosphoadenylylsulfate + genistein 4'-sulfate
adenosine 3',5'-bisphosphate + genistein 4',7-disulfate
show the reaction diagram
-
enzyme form SULT1A1, enzyme form SULT1E1
-
-
?
3'-phosphoadenylylsulfate + genistein 7-sulfate
adenosine 3',5'-bisphosphate + genistein 4',7-disulfate
show the reaction diagram
-
enzyme form SULT1A1, enzyme form SULT1E1
-
-
?
3'-phosphoadenylylsulfate + guaiacol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
ST1c4
-
-
?
3'-phosphoadenylylsulfate + harmol
adenosine 3',5'-bisphosphate + harmol sulfate
show the reaction diagram
-, O00338, O43704, O75897
-
-
-
?
3'-phosphoadenylylsulfate + harmol
adenosine 3',5'-bisphosphate + harmol sulfate
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
-
-
-
?
3'-phosphoadenylylsulfate + harmol
adenosine 3',5'-bisphosphate + harmol sulfate
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + harmol
adenosine 3',5'-bisphosphate + harmol sulfate
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + harmol
adenosine 3',5'-bisphosphate + harmol sulfate
show the reaction diagram
O35401, Q80VR3, Q9QWG7
ST1a4
-
-
?
3'-phosphoadenylylsulfate + harmol
adenosine 3',5'-bisphosphate + harmol sulfate
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + harmol
adenosine 3',5'-bisphosphate + harmol sulfate
show the reaction diagram
O46503, Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + harmol
adenosine 3',5'-bisphosphate + harmol sulfate
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + homovanillic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + hydroquinone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + hydroxybiphenyl
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + kaempferol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
recombinant enzyme form SULT1 ST5
-
-
?
3'-phosphoadenylylsulfate + L-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P52847
-
-
-
?
3'-phosphoadenylylsulfate + L-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
-
-
-
?
3'-phosphoadenylylsulfate + L-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
low activity
-
-
?
3'-phosphoadenylylsulfate + L-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O43704
i.e. L-dopa
-
-
?
3'-phosphoadenylylsulfate + L-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
i.e. L-dopa
-
-
?
3'-phosphoadenylylsulfate + L-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, O43704, O75897
i.e. L-dopa
-
-
?
3'-phosphoadenylylsulfate + L-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
i.e. L-dopa
-
-
?
3'-phosphoadenylylsulfate + L-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
SULT1B1
-
-
?
3'-phosphoadenylylsulfate + L-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O43704
M-PST
-
-
?
3'-phosphoadenylylsulfate + L-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
M-PST
-
-
?
3'-phosphoadenylylsulfate + L-3,4-dihydroxyphenylalanine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
SULT-N: no activity
-
-
-
3'-phosphoadenylylsulfate + L-4-hydroxyphenylglycine
adenosine 3',5'-bisphosphate + (2S)-amino[4-(sulfooxy)phenyl]ethanoic acid
show the reaction diagram
-
no activity with the D-isomer
-
-
?
3'-phosphoadenylylsulfate + L-thyroxine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O00338, O43704, O75897
no activity: ST1B2
-
-
-
3'-phosphoadenylylsulfate + L-thyroxine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50225
SULT1A1 allozymes 1 and 2
-
-
?
3'-phosphoadenylylsulfate + L-thyroxine
adenosine 3',5'-bisphosphate + L-thyroxine 4'-sulfate
show the reaction diagram
-
recombinant enzyme form SULT1 ST5
-
-
?
3'-phosphoadenylylsulfate + L-tyrosine
adenosine 3',5'-bisphosphate + L-tyrosyl O4-sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylylsulfate + L-tyrosine
adenosine 3',5'-bisphosphate + L-tyrosyl O4-sulfate
show the reaction diagram
P52847
-
-
-
?
3'-phosphoadenylylsulfate + L-tyrosine
adenosine 3',5'-bisphosphate + L-tyrosyl O4-sulfate
show the reaction diagram
O43704
M-PST
-
-
?
3'-phosphoadenylylsulfate + L-tyrosine
adenosine 3',5'-bisphosphate + L-tyrosyl O4-sulfate
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
SULT1B1: no activity
-
-
-
3'-phosphoadenylylsulfate + lidocaine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
P-PST and M-PST
-
-
?
3'-phosphoadenylylsulfate + minoxidil
adenosine 3',5'-bisphosphate + minoxidil sulfate
show the reaction diagram
-, O00338, O43704, O75897
-
-
-
?
3'-phosphoadenylylsulfate + minoxidil
adenosine 3',5'-bisphosphate + minoxidil sulfate
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
-
-
-
?
3'-phosphoadenylylsulfate + minoxidil
adenosine 3',5'-bisphosphate + minoxidil sulfate
show the reaction diagram
Q29476
SULT1A1
-
-
?
3'-phosphoadenylylsulfate + minoxidil
adenosine 3',5'-bisphosphate + minoxidil sulfate
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + minoxidil
adenosine 3',5'-bisphosphate + minoxidil sulfate
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + minoxidil
adenosine 3',5'-bisphosphate + minoxidil sulfate
show the reaction diagram
O35401, Q80VR3, Q9QWG7
ST1a4
-
-
?
3'-phosphoadenylylsulfate + minoxidil
adenosine 3',5'-bisphosphate + minoxidil sulfate
show the reaction diagram
-
M-PST
-
-
?
3'-phosphoadenylylsulfate + minoxidil
adenosine 3',5'-bisphosphate + minoxidil sulfate
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + minoxidil
adenosine 3',5'-bisphosphate + minoxidil sulfate
show the reaction diagram
O46503, Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + minoxidil
adenosine 3',5'-bisphosphate + minoxidil sulfate
show the reaction diagram
-
P-PST
-
-
?
3'-phosphoadenylylsulfate + minoxidil
adenosine 3',5'-bisphosphate + minoxidil sulfate
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + minoxidil
adenosine 3',5'-bisphosphate + minoxidil sulfate
show the reaction diagram
-
TL- and TS-PST, activation of the substrate
-
?
3'-phosphoadenylylsulfate + myricetin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
recombinant enzyme form SULT1 ST5
-
-
?
3'-phosphoadenylylsulfate + n-propyl gallate
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
recombinant enzyme form SULT1 ST5
-
-
?
3'-phosphoadenylylsulfate + naringenin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + naringenin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + naringenin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + naringenin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + norepinephrine
adenosine 3',5'-bisphosphate + norepinephrine sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + norepinephrine
adenosine 3',5'-bisphosphate + norepinephrine sulfate
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + norepinephrine
adenosine 3',5'-bisphosphate + norepinephrine sulfate
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + norepinephrine
adenosine 3',5'-bisphosphate + norepinephrine sulfate
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + norepinephrine
adenosine 3',5'-bisphosphate + norepinephrine sulfate
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + norepinephrine
adenosine 3',5'-bisphosphate + norepinephrine sulfate
show the reaction diagram
-
i.e. noradrenalin
i.e. noradrenalin sulfate
?
3'-phosphoadenylylsulfate + norepinephrine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50225
enzyme form SULT1A3
-
-
?
3'-phosphoadenylylsulfate + normetanephrine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + normetanephrine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + normetanephrine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + normetanephrine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + phenol
adenosine 3',5'-bisphosphate + phenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + phenol
adenosine 3',5'-bisphosphate + phenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + phenol
adenosine 3',5'-bisphosphate + phenyl sulfate
show the reaction diagram
-
SULT1A1, SULT1A3
-
-
?
3'-phosphoadenylylsulfate + phentolamine
adenosine 3',5'-bisphosphate + phentolamine sulfate
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + phentolamine
adenosine 3',5'-bisphosphate + phentolamine sulfate
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + phentolamine
adenosine 3',5'-bisphosphate + phentolamine sulfate
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + phentolamine
adenosine 3',5'-bisphosphate + phentolamine sulfate
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + quercetin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
recombinant enzyme form SULT1 ST5
-
-
?
3'-phosphoadenylylsulfate + ritodrine
adenosine 3',5'-bisphosphate + ritodrine sulfate
show the reaction diagram
-
enzyme form SULT1A1, enzyme form SULT1A3
-
-
?
3'-phosphoadenylylsulfate + sakuranetin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + sakuranetin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + sakuranetin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + sakuranetin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + salicylamide
adenosine 3',5'-bisphosphate + 2-sulfooxybenzamide
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + salicylamide
adenosine 3',5'-bisphosphate + 2-sulfooxybenzamide
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + salicylamide
adenosine 3',5'-bisphosphate + 2-sulfooxybenzamide
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + salicylamide
adenosine 3',5'-bisphosphate + 2-sulfooxybenzamide
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + salicylamide
adenosine 3',5'-bisphosphate + 2-sulfooxybenzamide
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + serotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
-
-
-
?
3'-phosphoadenylylsulfate + serotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + serotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O00338, O43704, O75897
-
-
-
?
3'-phosphoadenylylsulfate + serotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
-
-
-
?
3'-phosphoadenylylsulfate + serotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O46503, Q9XT99
-
-
-
?
3'-phosphoadenylylsulfate + serotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + serotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + serotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + serotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + serotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-, O35401, Q80VR3, Q9QWG7
SULT-N
-
-
?
3'-phosphoadenylylsulfate + troglitazone
adenosine 3',5'-bisphosphate + troglitazone sulfate
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + troglitazone
adenosine 3',5'-bisphosphate + troglitazone sulfate
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + troglitazone
adenosine 3',5'-bisphosphate + troglitazone sulfate
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + troglitazone
adenosine 3',5'-bisphosphate + troglitazone sulfate
show the reaction diagram
-
ST1A3, not ST1A5
-
-
?
3'-phosphoadenylylsulfate + tyramine
adenosine 3',5'-bisphosphate + tyramine O-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + tyramine
adenosine 3',5'-bisphosphate + tyramine O-sulfate
show the reaction diagram
-
SULT1A1
-
-
?
3'-phosphoadenylylsulfate + tyramine
adenosine 3',5'-bisphosphate + tyramine O-sulfate
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + tyramine
adenosine 3',5'-bisphosphate + tyramine O-sulfate
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + tyramine
adenosine 3',5'-bisphosphate + tyramine O-sulfate
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + tyramine
adenosine 3',5'-bisphosphate + tyramine O-sulfate
show the reaction diagram
-
SULT1A3
-
-
?
3'-phosphoadenylylsulfate + tyramine
adenosine 3',5'-bisphosphate + tyramine O-sulfate
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + umbelliferone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A1
-
-
?
3'-phosphoadenylylsulfate + umbelliferone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1a4
-
-
?
3'-phosphoadenylylsulfate + umbelliferone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9XT99
ST1A8
-
-
?
3'-phosphoadenylylsulfate + umbelliferone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
ST1A3 and ST1A5
-
-
?
3'-phosphoadenylylsulfate + vanillin
adenosine 3',5'-bisphosphate + 3-methoxybenzaldehyde 4-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + vanillylmandelic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
adenosine 2',3'-cyclic phosphate 5'-phosphate + 4-nitrophenyl sulfate
adenosine 2',3'-cyclic phosphate 5'-phosphate 5'-sulfate + 4-nitrophenol
show the reaction diagram
-
sulfation at 5'-position
-
?
adenosine 2',5'-bisphosphate + 4-nitrophenyl sulfate
adenosine 2'-phosphate 5'-phosphate 5'-sulfate + 4-nitrophenol
show the reaction diagram
-
sulfation at 5'-position
-
?
adenosine 3',5'-bisphosphate + 4-methylumbelliferyl sulfate
3'-phosphoadenylyl sulfate + 4-methylumbelliferone
show the reaction diagram
-
-
-
-
r
adenosine 3',5'-bisphosphate + dopamine sulfate
3'-phosphoadenylyl sulfate + dopamine
show the reaction diagram
-
-
-
-
r
AMP + 4-nitrophenyl sulfate
adenosine 5'-phosphate 5'-sulfate + 4-nitrophenol
show the reaction diagram
-
sulfation at 5'-position
-
?
additional information
?
-
Q29476
-
-
-
-
additional information
?
-
-
substrate specificity
-
-
-
additional information
?
-
P50225
substrate specificity
-
-
-
additional information
?
-
-
substrate specificity
-
-
-
additional information
?
-
-
substrate specificity
-
-
-
additional information
?
-
-
substrate specificity
-
-
-
additional information
?
-
-
substrate specificity
-
-
-
additional information
?
-
-
substrate specificity
-
-
-
additional information
?
-
-
estrogens and related compounds are substrate only for P-PST
-
-
-
additional information
?
-
-
isoenzyme B catalyzes the sulfurylation of a wider range of substrates than A which is preferentially active with dopamine
-
-
-
additional information
?
-
-
2 forms, TL: thermolabile, sulfate conjugation of dopamine and other phenolic monoamines, TS: thermostable, sulfate conjugation of simple phenols, e.g. p-nitrophenol
-
-
-
additional information
?
-
-
tyrosine and its derivatives
-
-
-
additional information
?
-
-
sterol-like structures cannot bind to M-PST, hydroxysteroids are no substrates
-
-
-
additional information
?
-
-
the liver aryl sulfotransferase IV has a very broad substrate range
-
-
-
additional information
?
-
-, O35401, Q80VR3, Q9QWG7
no activity with 3-phenylpropan-1-ol
-
-
-
additional information
?
-
-
no activity with 5-hydroxyindole acetic acid
-
-
-
additional information
?
-
Q9XT99
no activity with 5-hydroxyindole acetic acid
-
-
-
additional information
?
-
-
hippocampal H-PST is not active with neuropeptide substrates
-
-
-
additional information
?
-
Q29476
no activity with dehydroepiandrosterone
-
-
-
additional information
?
-
-, O35401, Q80VR3, Q9QWG7
no activity with dehydroepiandrosterone
-
-
-
additional information
?
-
P50237, P52847, Q9WUW8, Q9WUW9, -
no activity with dehydroepiandrosterone
-
-
-
additional information
?
-
-, O35401, Q80VR3, Q9QWG7
different enzyme forms show overlapping substrate specificities, overview
-
-
-
additional information
?
-
-, O00338, O43704, O75897
different enzyme forms show overlapping substrate specificities, overview
-
-
-
additional information
?
-
P50237, P52847, Q9WUW8, Q9WUW9, -
different enzyme forms show overlapping substrate specificities, overview
-
-
-
additional information
?
-
-
different enzyme forms show overlapping substrate specificities, overview
-
-
-
additional information
?
-
O46503, Q9XT99
different enzyme forms show overlapping substrate specificities, overview
-
-
-
additional information
?
-
Q29476
different enzyme forms show overlapping substrate specificities, overview
-
-
-
additional information
?
-
P52846
different enzyme forms show overlapping substrate specificities, overview
-
-
-
additional information
?
-
-
M-PST shows no activity with phentolamine
-
-
-
additional information
?
-
-
biogenic amines: the absence of a meta substituent on the phenolic ring, or the presence of a beta-OH group on the aliphatic amine side chain greatly reduces their binding affinities
-
-
-
additional information
?
-
-
no activity: serotonin
-
-
-
additional information
?
-
-
activity with various substrates at different pH values
-
-
-
additional information
?
-
-
culture of HT-29 cells with TNF-alpha increases activity of SULT1A1, TGF-beta increases activity to a lesser extent, insulin also increases activity of SULT1A1. TNF-alpha, TNF-beta and insulin have little effect on activity of enzyme in neuronal cell line SK-N-SH
-
-
-
additional information
?
-
-
phenolsulfotransferase is a key enzyme in drug metabolism, bile acid detoxification, and the regulation of intratissue active hormone levels. The increased gene expression of phenolsulfotransferase promotes the efficiency of detoxification. Certain antioxidant phenolic acids could induce PST-P activity in HepG2 cells, by promoting PST-P mRNA and protein expression, suggesting a novel mechanism by which phenolic acids may be implicated in phase II sulfate conjugation. Gallic acid, gentisic acid, p-hydroxybenzoic acid, and p-coumaric acid increase PST-P activity, in a dose-dependent manner. A maximum of 4fold and 5fold induction of PST-P activity is observed for both gallic acid and gentisic acid, adverse effect on cell growth at higher concentrations. A 2fold or 2.5fold increase of PST-P activity is found with either p-coumaric or p-hydroxybenzoic acid treatment, no significant effect is found for ferulic acid treatment
-
-
-
additional information
?
-
-
SULT1A1, occurring in liver plays the most important role among the human sulfotransferases in the hepatic cytosolic 7-preferential sulfation of phytoestrogens
-
-
-
additional information
?
-
-, Q6XZC1
no actrivity with: 17beta-estradiol, L-dopa, D-dopa, dopamine, chlorogenic acid, daidzein, gallic acid
-
-
-
additional information
?
-
P17988
estradiol exhibits neuroprotective action in the brain e.g. by activity of SULT1A1 and other phase II antioxidant enzymes, regulation mechanisms, overview
-
-
-
additional information
?
-
-
regulation of human SULT1A genes by glucocorticoids, overview
-
-
-
additional information
?
-
-
SULT is involved in drug metabolism, detoxification and hormone regulation
-
-
-
additional information
?
-
-
SULT1A1 catalyzes the sulfation of small planar phenols such as neurotransmitters, steroid hormones, acetaminophen, and 4-nitrophenol
-
-
-
additional information
?
-
P50225
SULT1A1 is a phase II metabolism enzyme responsible for xenobiotic sulfonation, substrate specificity and catalytic function, including its role in the sulfonation of endogenous substrates such as oestrogens from crystal structure, overview, SULT1A1 can also bioactivate compounds, e.g. sulfonate pro-carcinogens such as hydroxymethyl polycyclic aromatic hydrocarbons leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis, roles of allelic variants, regulation of expression and activities, overview
-
-
-
additional information
?
-
O00338, P50226, Q9BR01
SULT1A1 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview
-
-
-
additional information
?
-
P50224, P50225
SULT1A1 plays important roles in the presystemic inactivation of b2 agonists in the liver
-
-
-
additional information
?
-
-
SULT1A1 sulfates a wide variety of phenolic xenobiotics, as well as iodothyronines, and also certain N-hydroxy heterocyclic and aromatic amines, SULT1A1 is a detoxifying enzyme, overview
-
-
-
additional information
?
-
O00338, P50226, Q9BR01
SULT1A2 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview
-
-
-
additional information
?
-
O00338, P50226, Q9BR01
SULT1A3 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview
-
-
-
additional information
?
-
P50224, P50225
SULT1A3 plays important roles in the presystemic inactivation of b2 agonists in the intestine
-
-
-
additional information
?
-
O00338, P50226, Q9BR01
SULT1C*2 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview
-
-
-
additional information
?
-
-
SULTs play a role in the metabolism of regulatory hormones, drugs, and carcinogens, they catalyze the sulfonation of simple phenols, estradiol, and thyroid hormones, as well as environmental xenobiotics and drugs, overview
-
-
-
additional information
?
-
-
the enzyme plays an important role in the regulation and homeostasis of monoamine neurotransmitters, by serving as substrates for SULT1A3, 7-hydroxyserotonin or 6-hydroxydopamine may interfere with the homeostasis of endogenous serotonin and dopamine
-
-
-
additional information
?
-
-
analysis of binding site similarities between members of the human cytosolic sulfotransferase family, correlation with small-molecule binding profiles, e.g. of 3,5-dibromo-4-hydroxy-benzoic acid (6,8-chloro-4-oxo-4H-chromen-3-ylmethylene)-hydrazide, 3,5-dibromo-4-hydroxy-benzoic acid (6-chloro-4-oxo-4H-chromen-3-ylmethylene)-hydrazide, pyridoxal 5'-phosphate, resveratrol, quercetin dihydrate, and adenosine 5'-(beta,gamma-imino)triphosphate, analysis by combination of computational analysis and experimental data, overview
-
-
-
additional information
?
-
-
DOPA and 6-hydroxy-DOPA are poor substrates for SULT1A3
-
-
-
additional information
?
-
O00338, P50226, Q9BR01
no activity with caffeic acid, catechol, 17beta-estradiol, N-hydroxy-4-aminobiphenyl, DDT, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by SULT1B2
-
-
-
additional information
?
-
O00338, P50226, Q9BR01
no activity with DDT, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by SULT1A1
-
-
-
additional information
?
-
O00338, P50226, Q9BR01
no activity with DDT, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by SULT1A2
-
-
-
additional information
?
-
O00338, P50226, Q9BR01
no activity with DDT, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by SULT1A3
-
-
-
additional information
?
-
O00338, P50226, Q9BR01
no activity with DDT, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by SULT1C*2
-
-
-
additional information
?
-
-
no activity with dopamine
-
-
-
additional information
?
-
A0FIP8, -
no activity with the synthetic estrogens ethynyl estradiol and diethylstilbestrol or endogenous substrates estrone, 17beta-estradiol, dehydroepiandrosterone, and the thyroid hormones 3,3',5-triiodo-L-thyronine T3 and thyronine T4, the enzyme contains two conserved co-substrate binding motifs for 30-phosphoadenosine 50-phosphosulfate: RKGxxGDWKxxFT and YPKSGTxW
-
-
-
additional information
?
-
-
role for 3'-phosphoadenylyl sulfate in priming the conformation of substrate binding loops, overview, substrate specificities and binding structures of SULT1B1, SULT1A1, SULT1A3, SULT1C1, SULT1C2, and SULT1C3, overview
-
-
-
additional information
?
-
-
substrate specifiicty of SULT1A1*1, *2, and *3, allozyme activities against catecholestrogens and dietary flavonoids, overview
-
-
-
additional information
?
-
-
SULT1A1 catalyzes the sulfation of small planar phenolic compounds, substrate specificity of the three allozymes SULT1A1*1, *2, and *3, overview
-
-
-
additional information
?
-
-
SULT1A1 catalyzes the sulfation of the active metabolizes of tamoxifen and endoxifen
-
-
-
additional information
?
-
-
isoform ST4 shows low but not negligible activity toward 20-hydroxyecdysone, no activity toward tyramine and serotonin
-
-
-
additional information
?
-
-
the enzyme is active in conjugating the polychlorobiphenyl alcohols, e.g. 3'-OH-trichlorobiphenyl, 4'-OH-trichlorobiphenyl and 4'-OH-(chlorobiphenyl)112, SULT2A1 is active with 4-OH-(chlorobiphenyl)34 and 4'-OH-(chlorobiphenyl)68, but not with 4'-OH-nonachlorobiphenyl
-
-
-
additional information
?
-
P17988
silybin A is completely resistant to the sulfation reaction
-
-
-
additional information
?
-
Oryctolagus cuniculus ST1A8
Q9XT99
no activity with 5-hydroxyindole acetic acid
-
-
-
additional information
?
-
Oryctolagus cuniculus ST1A8
-
different enzyme forms show overlapping substrate specificities, overview
-
-
-
additional information
?
-
Oryctolagus cuniculus ST1C5
O46503
different enzyme forms show overlapping substrate specificities, overview
-
-
-
additional information
?
-
Mus musculus BALB/c
-
no activity with 5-hydroxyindole acetic acid
-
-
-
additional information
?
-
Mus musculus ST1c4
Q80VR3
no activity with 3-phenylpropan-1-ol, different enzyme forms show overlapping substrate specificities, overview
-
-
-
additional information
?
-
Macaca fascicularis ST1A9
P52846
different enzyme forms show overlapping substrate specificities, overview
-
-
-
additional information
?
-
Mus musculus ST1a4
-
no activity with 5-hydroxyindole acetic acid
-
-
-
additional information
?
-
Mus musculus ST1a4
-
different enzyme forms show overlapping substrate specificities, overview
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2 3'-phosphoadenylyl sulfate + 2 dopamine
2 adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + dopamine 4-O-sulfate
show the reaction diagram
P50224
SULT1A3
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
Q9QWG7
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
isoform ST4 shows a preference toward 1-naphtol
-
-
?
3'-phosphoadenylyl sulfate + 17alpha-ethinylestradiol
?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, P50226, Q9BR01
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-methoxyestradiol
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 2-naphthylamine
adenosine 3',5'-bisphosphate + 2-naphthylamine sulfate
show the reaction diagram
O00338, P50226, Q9BR01
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9QWG7
-
-
-
?
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 3-nitro-L-tyrosine
adenosine 3',5'-bisphosphate + 3-nitro-O4-sulfo-L-tyrosine
show the reaction diagram
P50224
sulfation serves as a pathway for the metabolism/regulation of nitrotyrosine, nitrotyrosine O-sulfate is released into the medium of Hep-G2 hepatoma cells
-
-
?
3'-phosphoadenylyl sulfate + 3alpha-hydroxytibolone
adenosine 3',5'-bisphosphate + 3alpha-sulfooxytibolone O-sulfate
show the reaction diagram
-
sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis
-
-
?
3'-phosphoadenylyl sulfate + 3beta-hydroxytibolone
adenosine 3',5'-bisphosphate + 3beta-sulfooxytibolone O-sulfate
show the reaction diagram
-
sulfation inactivates the hydroxylated metabolite of tibolone, a synthetic steroid used for the treatment for climacteric symptoms and postmenopausal osteoporosis
-
-
?
3'-phosphoadenylyl sulfate + 4-hydroxytamoxifen
adenosine 3',5'-bisphosphate + 4-(sulfooxy)tamoxifen
show the reaction diagram
-
a potent inducer of apoptosis in breast tumor cell lines
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
Q9QWG7
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
O43704
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
isoform ST3 shows higher sulfating activity toward 4-nitrophenol
-
-
?
3'-phosphoadenylyl sulfate + 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
i.e. aminoflavone, diaminoflavone analogues with potent growth-inhibitory activity against human breast and renal cancer cells in vitro and antitumor activity in mice bearing human tumor xenografts, aminoflavone binds to DNA in tumor cells and induces DNA-protein cross-links
-
-
?
3'-phosphoadenylyl sulfate + 5-chloro-7-iodo-8-quinolinol
adenosine 3',5'-bisphosphate + 5-chloro-7-iodo-8-quinolinyl sulfate
show the reaction diagram
-
isoform SULT1A3 is responsible for the 5-chloro-7-iodo-8-quinolinol sulfation in human jejunum
-
-
?
3'-phosphoadenylyl sulfate + 6-hydroxydopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
SULT1A3
-
-
?
3'-phosphoadenylyl sulfate + 7-hydroxyserotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
SULT1A3
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
P50224, P50225
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
P50227
-
-
-
?
3'-phosphoadenylyl sulfate + acetaminophen
adenosine 3',5'-bisphosphate + 4-(acetylamino)phenylsulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + aristolochic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
P50225
herbal preparations containing Aristolochia species lead to progressive nephropathy and urothelial cancer in humans, metabolic activation of aristolichic acid, mutagenic effect, overview
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
show the reaction diagram
Q9QWG7
-
-
-
?
3'-phosphoadenylyl sulfate + beta-estradiol
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + bisphenol A
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
isoform ST3 also shows sulfating activity toward bisphenol A
-
-
?
3'-phosphoadenylyl sulfate + caffeic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
O00338, P50226, Q9BR01
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9QWG7
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + despiramine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9QWG7
-
-
-
?
3'-phosphoadenylyl sulfate + despiramine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
isoform ST1 recognizes dopamine as a substrate
-
-
?
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
show the reaction diagram
-
-
-
-
r
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopaminyl sulfate
show the reaction diagram
-
specific substrate for isoform SULT1A3
-
-
?
3'-phosphoadenylyl sulfate + estradiol
adenosine 3',5'-bisphosphate + estradiol sulfate
show the reaction diagram
-
the enzyme also performs the reaction of EC 2.8.2.4, estrone sulfotransferase, with low activity
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9QWG7
-
-
-
?
3'-phosphoadenylyl sulfate + L-triiodothyronine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + minoxidil
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + N-hydroxy-4-aminobiphenyl
adenosine 3',5'-bisphosphate + N-(sulfooxy)biphenyl 4-amine
show the reaction diagram
O00338, P50226, Q9BR01
-
-
-
?
3'-phosphoadenylyl sulfate + phenol
adenosine 3',5'-bisphosphate + phenyl sulfate
show the reaction diagram
O00338, P50226, Q9BR01
-
-
-
?
3'-phosphoadenylyl sulfate + serotonin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylyl sulfate + silybin B
adenosine 3',5'-bisphosphate + silybin B 20-O-sulfate
show the reaction diagram
P17988
-
-
-
?
3'-phosphoadenylyl sulfate + vanillin
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
vanillin is the best substrate for isoforms ST1 and ST3
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
Q9QWG7
-
-
-
?
3'-phosphoadenylyl sulfate + xanthurenic acid
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + 3-hydroxyindole
adenosine 3',5'-bisphosphate + 3-indoxyl sulfate
show the reaction diagram
-
in vivo function may include the production of the normal tryptophan metabolite indican
-
-
?
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-, O00338, O43704, O75897
-
-
-
?
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
P50237, P52847, Q9WUW8, Q9WUW9, -
-
-
-
?
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
-
-
?
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
phase II drug metabolizing or detoxifying enzyme, sulfate conjugation of phenolic biogenic amines, important in the biotransformation of many neurotransmitters, hormones, drugs, and xenobiotic compounds
-
-
-
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
sulfate conjugation of phenolic biogenic amines, important in the biotransformation of many neurotransmitters, hormones, drugs, and xenobiotic compounds
-
-
?
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
sulfation of environmental estrogens, overview
-
-
?
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
enzyme may be considered as detoxification enzyme which catalyzes the conjugation of xenobiotics containing a phenol group or of phenolic compounds generated by endogenous oxidation
-
-
?
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
enzyme may be considered as detoxification enzyme which catalyzes the conjugation of xenobiotics containing a phenol group or of phenolic compounds generated by endogenous oxidation
-
-
?
3'-phosphoadenylylsulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
SULTs, especially SULT1A1, are important in xenobiotic and drug metabolism because of their broad substrate specificity and extensive tissue distribution
-
-
?
3'-phosphoadenylylsulfate + dopamine
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
accounts for approximately 10% of the enzymic activity directed towards catabolism of dopamine
-
-
?
3'-phosphoadenylylsulfate + minoxidil
adenosine 3',5'-bisphosphate + minoxidil sulfate
show the reaction diagram
-
TL- and TS-PST, activation of the substrate
-
?
adenosine 3',5'-bisphosphate + dopamine sulfate
3'-phosphoadenylyl sulfate + dopamine
show the reaction diagram
-
-
-
-
r
additional information
?
-
-
culture of HT-29 cells with TNF-alpha increases activity of SULT1A1, TGF-beta increases activity to a lesser extent, insulin also increases activity of SULT1A1. TNF-alpha, TNF-beta and insulin have little effect on activity of enzyme in neuronal cell line SK-N-SH
-
-
-
additional information
?
-
-
phenolsulfotransferase is a key enzyme in drug metabolism, bile acid detoxification, and the regulation of intratissue active hormone levels. The increased gene expression of phenolsulfotransferase promotes the efficiency of detoxification. Certain antioxidant phenolic acids could induce PST-P activity in HepG2 cells, by promoting PST-P mRNA and protein expression, suggesting a novel mechanism by which phenolic acids may be implicated in phase II sulfate conjugation. Gallic acid, gentisic acid, p-hydroxybenzoic acid, and p-coumaric acid increase PST-P activity, in a dose-dependent manner. A maximum of 4fold and 5fold induction of PST-P activity is observed for both gallic acid and gentisic acid, adverse effect on cell growth at higher concentrations. A 2fold or 2.5fold increase of PST-P activity is found with either p-coumaric or p-hydroxybenzoic acid treatment, no significant effect is found for ferulic acid treatment
-
-
-
additional information
?
-
-
SULT1A1, occurring in liver plays the most important role among the human sulfotransferases in the hepatic cytosolic 7-preferential sulfation of phytoestrogens
-
-
-
additional information
?
-
P17988
estradiol exhibits neuroprotective action in the brain e.g. by activity of SULT1A1 and other phase II antioxidant enzymes, regulation mechanisms, overview
-
-
-
additional information
?
-
-
regulation of human SULT1A genes by glucocorticoids, overview
-
-
-
additional information
?
-
-
SULT is involved in drug metabolism, detoxification and hormone regulation
-
-
-
additional information
?
-
-
SULT1A1 catalyzes the sulfation of small planar phenols such as neurotransmitters, steroid hormones, acetaminophen, and 4-nitrophenol
-
-
-
additional information
?
-
P50225
SULT1A1 is a phase II metabolism enzyme responsible for xenobiotic sulfonation, substrate specificity and catalytic function, including its role in the sulfonation of endogenous substrates such as oestrogens from crystal structure, overview, SULT1A1 can also bioactivate compounds, e.g. sulfonate pro-carcinogens such as hydroxymethyl polycyclic aromatic hydrocarbons leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis, roles of allelic variants, regulation of expression and activities, overview
-
-
-
additional information
?
-
O00338, P50226, Q9BR01
SULT1A1 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview
-
-
-
additional information
?
-
P50224, P50225
SULT1A1 plays important roles in the presystemic inactivation of b2 agonists in the liver
-
-
-
additional information
?
-
-
SULT1A1 sulfates a wide variety of phenolic xenobiotics, as well as iodothyronines, and also certain N-hydroxy heterocyclic and aromatic amines, SULT1A1 is a detoxifying enzyme, overview
-
-
-
additional information
?
-
O00338, P50226, Q9BR01
SULT1A2 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview
-
-
-
additional information
?
-
O00338, P50226, Q9BR01
SULT1A3 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview
-
-
-
additional information
?
-
P50224, P50225
SULT1A3 plays important roles in the presystemic inactivation of b2 agonists in the intestine
-
-
-
additional information
?
-
O00338, P50226, Q9BR01
SULT1C*2 is involved in sulfation of toxicants in cigarette smoke extracts. By serving as substrates for SULTs, cigarette smoke toxicants may interfere with the metabolism of 17beta-estradiol and other endogenous compounds, overview
-
-
-
additional information
?
-
-
SULTs play a role in the metabolism of regulatory hormones, drugs, and carcinogens, they catalyze the sulfonation of simple phenols, estradiol, and thyroid hormones, as well as environmental xenobiotics and drugs, overview
-
-
-
additional information
?
-
-
the enzyme plays an important role in the regulation and homeostasis of monoamine neurotransmitters, by serving as substrates for SULT1A3, 7-hydroxyserotonin or 6-hydroxydopamine may interfere with the homeostasis of endogenous serotonin and dopamine
-
-
-
additional information
?
-
-
isoform ST4 shows low but not negligible activity toward 20-hydroxyecdysone, no activity toward tyramine and serotonin
-
-
-
additional information
?
-
-
the enzyme is active in conjugating the polychlorobiphenyl alcohols, e.g. 3'-OH-trichlorobiphenyl, 4'-OH-trichlorobiphenyl and 4'-OH-(chlorobiphenyl)112, SULT2A1 is active with 4-OH-(chlorobiphenyl)34 and 4'-OH-(chlorobiphenyl)68, but not with 4'-OH-nonachlorobiphenyl
-
-
-
COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
3'-phosphoadenylyl sulfate
-
the overall physiological reaction is a transfer of the sulfate group between 2-naphthol and 4-nitrophenol with the intermediate formation of 3'-phosphoadenylyl sulfate from adenosine 3',5'-bisphosphate
3'-phosphoadenylyl sulfate
-
binds tightly to the enzyme
adenosine 3',5'-bisphosphate
-
1 mol of, tightly bound to the alpha-enzyme form, but not to the beta-enzyme form
adenosine 3',5'-bisphosphate
-
the overall physiological reaction is a transfer of the sulfate group between 2-naphthol and 4-nitrophenol with the intermediate formation of 3'-phosphoadenylyl sulfate from adenosine 3',5'-bisphosphate
adenosine 3',5'-bisphosphate
-
binds tightly to the enzyme
adenosine 3',5'-bisphosphate
-
-
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Cd2+
Q6XZC1
-
Co2+
Q6XZC1
-
Cu2+
Q6XZC1
-
Fe2+
Q6XZC1
-
Hg2+
Q6XZC1
-
KCl
-
50 mM, 60% inhibition of isoenzyme A, slight activation of isoenzyme B, aryl sulfotransferase I and II are activated appreciably in the presence of 0.5 M KCl or NaCl
Mg2+
-
activates; activates
Mg2+
-
MgCl2 (10 mM) enhances isoform ST3 activity by 50%, whereas no effects of these cations are observed for isoforms ST1 and ST4
Mn2+
O43704
stimulates M-PST about 3.5fold, with substrate D-tyrosine
Mn2+
-
complex formation with the substrate enhances the stimulating effect; stimulates, higher effect with D-isomers of 3,4-dihydroxyphenylalanine and tyrosine than with the L-isomer as substrates, highly stereospecific, kinetics
Mn2+
-
P-PST, slightly stimulating with acetaminophen as substrate
Mn2+
-
stimulates. Asp86 appears to be critical for the Mn2+-stimulation of the Dopa/tyrosine-sulfating activity of SULT1A3
NaCl
-
aryl sulfotransferase I and II are activated appreciably in the presence of 0.5 M NaCl or KCl
NaCl
-
activates; activates
Zn2+
Q6XZC1
-
Mn2+
-
significant stimulation of enzyme form SULT1 ST5
additional information
-
-
additional information
-
no effect: Mg2+
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
(+)-(R)-2-Methyl-1-phenyl-1-propanol
-
competitive to 1-naphthalene methanol
(+)-(S)-1,2,3,4-Tetrahydro-1-naphthol
-
competitive to 1-naphthalene methanol
(+)-catechin
P50224, P50225
;
(-)-epicatechin
P50224, P50225
; complete inhibition of SULT1A1
(-)-epicatechin gallate
P50224, P50225
almost complete inhibition of SULT1A1; almost complete inhibition of SULT1A3
(-)-epigallocatechin
P50224, P50225
; complete inhibition of SULT1A1
(-)-epigallocatechin gallate
P50224, P50225
almost complete inhibition of SULT1A1; almost complete inhibition of SULT1A3
1-hydroxy-4-ethylbenzene
-
-
1-Naphthol
Q29476
SULT1A1, substrate inhibition at 0.0005 mM
17alpha-ethinylestradiol
-
potent inhibitor, 17alpha-ethinylestradiol binds and inhibits isoform SULT1A1 activity toward 4-nitrophenol and 2-naphthol at low nanomolar concentrations, whereas the compound is not sulfated until significantly higher concentrations are reached
2,3',4,6-tetrachlorobiphenyl-4'-ol
O43704
i.e. 4'-OH-CB69; i.e. 4'-OH-CB69
2,3,3',5,5',6-hexachlorobiphenyl-4'-ol
O43704
i.e. 4'-OH-CB165, a mixed, noncompetitive-uncompetitive inhibitor; i.e. 4'-OH-CB165, a mixed, noncompetitive-uncompetitive inhibitor
2,3,3',5,6-pentachlorobiphenyl-4'-ol
O43704
i.e. 4'-OH-CB112; i.e. 4'-OH-CB112
2,3-Butanedione
P50225
Arg-specific modification reagent; SULT1A1, inactivation
2,6-Dichloro-4-nitrophenol
-
competitive to 4-nitrophenol, 0.01 mM: 15% inhibition with substrate 4-nitrophenol, 78% inhibition with substrate dopamine
2,6-Dichloro-4-nitrophenol
-
-
2,6-Dichloro-4-nitrophenol
-
2 forms, TL: relatively resistant to inhibition by 2,6-dichloro-4-nitrophenol, TS: relatively sensitive to 2,6-dichloro-4-nitrophenol
2,6-Dichloro-4-nitrophenol
-
PI-PST and PII-PST
2,6-Dichloro-4-nitrophenol
-
-
2,6-Dichloro-4-nitrophenol
-
SULT1A1 is more sensitive than SULT1A3
2,6-Dichloro-4-nitrophenol
-
-
2,6-Dichloro-4-nitrophenol
-, O00338, O75897
strong
2,6-Dichloro-4-nitrophenol
P50237, P52847, Q9WUW8, Q9WUW9, -
strong
2,6-Dichloro-4-nitrophenol
-
IC50: 0.0019 mM, enzyme form SULT1A1; IC50: 0.52 mM, enzyme form SULT1A3
2,6-Dichloro-4-nitrophenol
-
; non-specific SULT inhibitor
2,6-Dichloro-4-nitrophenol
Q9QWG7
non-specific SULT inhibitor; non-specific SULT inhibitor
2,6-dichloro-4-nitrophenyl phosphate
-
i.e. DCNP; i.e. DCNP
-
2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
O00338, P50226, Q9BR01
mixed competitive-noncompetitive type inhibition of SULT1A1 versus 17beta-estradiol
2-Aminophenol
O43704
substrate inhibition of SULT1A1
2-Ethylphenol
-
inhibits SULT1A1/2 and SULT1A3
2-n-propylphenol
-
inhibits SULT1A1/2, but not SULT1A3
2-sec-Butylphenol
-
inhibits SULT1A1/2, but not SULT1A3
2-sec-propylphenol
-
inhibits SULT1A1/2 and SULT1A3
-
2-tert-butylphenol
-
inhibits SULT1A1/2, but not SULT1A3
3',4,5'-trichlorobiphenyl-4'-ol
O43704
i.e. 4'-OH-CB39; i.e. 4'-OH-CB39
3'-phosphoadenylylsulfate
-
substrate inhibition
3,3',4-trichlorobiphenyl-6'-ol
O43704
i.e. 6'-OH-CB35; i.e. 6'-OH-CB35
3,3',5',6-tetrachlorobiphenyl-4'-ol
O43704
i.e. 4'-OH-CB72; i.e. 4'-OH-CB72
3,3',5-triiodo-L-thyronine
P52847
substrate inhibition at 0.25 mM
3,4-dihydroxymandelic acid
-
-
3,4-dihydroxyphenylacetic acid
-
-
3,4-dihydroxyphenylethyleneglycol
-
-
3,5-dibromo-4-hydroxy-benzoic acid (6-chloro-4-oxo-4H-chromen-3-ylmethylene)-hydrazide
-
DBHM
3,5-dibromo-4-hydroxybenzoic acid (6,8-dichloro-4-oxo-4H-chromen-3-ylmethylene) hydrazide
-
DBHD
3-Methoxy-4-hydroxyphenethanol
-
-
3-methoxy-4-hydroxyphenylacetic acid
-
-
3-methoxy-4-hydroxyphenylethyleneglycol
-
-
4-aminobiphenyl
O00338, P50226, Q9BR01
i.e. 4-ABP, mixed competitive-noncompetitive type inhibition of SULT1A1 versus 17beta-estradiol
4-chlorobiphenyl-3'-ol
O43704
i.e. 3'-OH-CB3, inhibitory effects on different SULT1A1 genotypes, overview; i.e. 3'-OH-CB3, inhibitory effects on different SULT1A1 genotypes, overview
4-chlorobiphenyl-4'-ol
O43704
i.e. 4'-OH-CB3; i.e. 4'-OH-CB3
4-n-amylphenol
-
inhibits SULT1A1/2, but not SULT1A3
4-n-Heptylphenol
-
inhibits SULT1A1/2, but not SULT1A3
4-n-nonylphenol
-
inhibits SULT1A1/2, but not SULT1A3
4-n-octylphenol
-
inhibits SULT1A1/2, but not SULT1A3
4-nitrophenol
-
sulfation of 2,6-dichloro-4-nitrophenol or dopamine, competitive
4-nitrophenol
-
at high concentration
4-nitrophenol
-
SULT1A1/2
4-nitrophenol
Q29476
SULT1A1, substrate inhibition at 0.001 mM
4-nitrophenol
-
substrate inhibition, enzyme form SULT1D1
4-nitrophenol
P50225
substrate inhibition at high concentrations, enzyme form SULT1A1
4-nitrophenol
-
strong substrate inhibition above 0.0025 mM, enzyme form SULT1A1
4-nitrophenol
O43704
substrate inhibition of SULT1A1
4-nonyl phenol
-
a common estrogenic marine pollutant
5,7-dichlorokynurenic acid
-
;
5,7-dichlorokynurenic acid
Q9QWG7
;
5-chloro-7-iodo-8-quinolinol
-
inhibits isoform SULT1A3-mediated sulfation of dopamine in a dose-dependent manner
-
6',7'-dihydroxybergamottin
P50224, P50225
; inhibition of SULT1A1; significantly inhibits the activity of SULT1A1
6-Hydroxydopamine
-
competiitve versus dopamine, complete inhibition at about 1 mM
7-hydroxyserotonin
-
competitive versus serotonin, complete inhibition at about 1 mM
Acetylsalicylate
-
binds near enough to the substrate site to prevent catalysis but does not affect dissociation of the substrate-enzyme complex
acyl-CoA
P50227
weak inhibition
adenosine 3',5'-bisphosphate
-
competitive
adenosine 3',5'-bisphosphate
-
-
adenosine 3',5'-bisphosphate
-
-
adenosine 3',5'-bisphosphate
-
strong inhibitor, enzyme form SULT1A1
adenosine 5'-(beta,gamma-imido) triphosphate
-
i.e. AMP-PNP, a non-hydrolysable ATP analogue
ADP
-
isoenzyme I
apigenin
-
antagonizes aminoflavone by inhibiting SULT1A1
ATP
-
isoenzyme I
bergamottin
P50224, P50225
; inhibition of SULT1A1; inhibition of SULT1A3; significantly inhibits the activity of SULT1A1
caffeic acid
-
inhibition of P-PST and M-PST
Cd2+
-
recombinant enzyme form SULT1 ST5
chlorogenic acid
-
inhibition of P-PST and M-PST
Chlorpromazine
-
-
Cibacron blue
-
isozyme I
Co2+
-
P-PST, not M-PST; P-PST, slightly inhibiting with minoxidil as substrate
Co2+
-
recombinant enzyme form SULT1 ST5
CoA
P50227
reversible covalent inhibition, the inactivation of the dimeric enzyme is stoichiometric, binding structure and mechanism, overview
coenzyme A
P50227
-
Cu2+
-
M-PST and P-PST, strong inhibition
Cu2+
-
recombinant enzyme form SULT1 ST5
daidzein
-
0.01 mM, 29% inhibition, enzyme form SULT1A3; 0.01 mM, 69% inhibition, enzyme form SULT1A1
daidzein
-
antagonizes aminoflavone by inhibiting SULT1A1
diethyldicarbonate
-
His108 is critical for activity
dopamine
-
substrate inhibition, enzyme form SULT1D1
dopamine
P50225
substrate inhibition at high concentrations, SULT1A3; wild-type enzyme SULT1A1 shows no substrate inhibition, mutant enzyme F247L shows substrate inhibition
dopamine
-
substrate inhibition at concentrations higher than 0.03 mM
dopamine 3-O-sulfate
-
35-85% product inhibition of SULT1A3
dopamine 4-O-sulfate
-
40-80% product inhibition of SULT1A3
Fe2+
-
M-PST, not P-PST
-
Fe2+
-
recombinant enzyme form SULT1 ST5
-
gavestinel
-
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt; i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
gavestinel
Q9QWG7
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt; i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
genistein
-
0.01 mM, 19% inhibition, enzyme form SULT1A3; 0.01 mM, 80% inhibition, enzyme form SULT1A1
genistein
-
antagonizes aminoflavone by inhibiting SULT1A1
Hg2+
-
M-PST and P-PST, strong inhibition
Hg2+
-
recombinant enzyme form SULT1 ST5
hydroxybenzo[a]pyrenes
-
substrate inhibition above 0.0005 mM
Ibuprofen
-
-
Indomethacin
-
-
KCl
-
50 mM, 60% inhibition of isoenzyme A, slight activation of isoenzyme B
Kynurenic acid
-
;
Kynurenic acid
Q9QWG7
; exhibits selective inhibitory effects on Sult1b1-mediated sulfation of various compounds with IC50 values in the low micromolar range,
L-tyrosine O4-sulfate
-
noncompetitive
L689,560
-
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline; i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
L689,560
Q9QWG7
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline; i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
L701,324
-
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone; i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
L701,324
Q9QWG7
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone; i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
meclofenamate
-
binds near enough to the substrate site to prevent catalysis but does not affect dissociation of the substrate-enzyme complex
Mefenamic acid
-
-
Mefenamic acid
-
;
Mefenamic acid
Q9QWG7
;
N-Hydroxy-4-aminobiphenyl
O00338, P50226, Q9BR01
i.e. N-OH-4-ABP, mixed competitive-noncompetitive type inhibition of SULT1A1 versus 17beta-estradiol
NaCl
-
PI-PST: 50% inhibition at 100 mM, PII-PST: 20% inhibition at 0.3 M
NaCl
-
50% inhibition at: 325 mM; M-PST
NaCl
-
TL-PST is more resistant to inhibition as TS-PST
NaCl
-
SULT1A1 is more sensitive than SULT1A3
NaCl
-
IC50: 178.7 mM, enzyme form SULT1A3; IC50: 62.5 mM, enzyme form SULT1A1
Naringenin
P50224, P50225
; inhibition of SULT1A1; partial inhibition of SULT1A3; significantly inhibits the activity of SULT1A1
naringin
P50224, P50225
inhibition of SULT1A3
nimesulide
-
binds near enough to the substrate site to prevent catalysis but not affect dissociation of the substrate-enzyme complex
nobiletin
P50224, P50225
belongs to the most potent inhibitors; belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1; partial inhibition of SULT1A3
palmitoyl-CoA
P50227
-
Pb2+
-
recombinant enzyme form SULT1 ST5
Pentachlorophenol
-
-
Pentachlorophenol
-, O00338, O75897
strong
Pentachlorophenol
P50237, P52847, Q9WUW8, Q9WUW9, -
strong
Pentachlorophenol
P50225
inhibits SULT1A1
Phenylglyoxal
-
-
piroxicam
-
-
protocatechuic acid
-
inhibition of P-PST and M-PST
punicalagin
-
-
pyridoxal 5'-phosphate
-
50% inhibition at 0.001 mM, excess of 2-naphthol protects
pyridoxal 5'-phosphate
-
a competitive inhibitor for sulfotransferases
quercetin
P50224, P50225
belongs to the most potent inhibitors; belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1; partial inhibition of SULT1A3
quercetin
-
a potent inhibitor of SULT1A1
quercetin
-
found in many fruits, vegetables and wine, is a potent inhibitor of the sulfation of 4-nitrophenol, estradiol, and several drug substrates in human liver cytosol and with recombinantly expressed human SULT1A1
resveratrol
-
substrate inhibition
salicylate
-
-
Sinapic acid
-
inhibition of P-PST and M-PST
syringic acid
-
inhibition of P-PST and M-PST
tangeretin
P50224, P50225
belongs to the most potent inhibitors; belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1; partial inhibition of SULT1A3
theaflavin
P50224, P50225
complete inhibition of SULT1A1; strong inhibition of SULT1A3
thearubigin
P50224, P50225
complete inhibition of SULT1A1; strong inhibition of SULT1A3
tributyltin
-
a common androgenic marine pollutant
Triphenyltin
-
a common androgenic marine pollutant
Vanillic acid
-
inhibition of P-PST and M-PST
Zn2+
-
P-PST and M-PST
Zn2+
-
recombinant enzyme form SULT1 ST5
additional information
-
no inhibition by adrenaline
-
additional information
-
no inhibition by normetanephrine, metanephrine, dopamine, the presence of an amino group on the side chain which is positively charged at pH 7.4 drastically decreases inhibitory power, substrate inhibition for most compounds at concentrations exceeding approximately 5times the Km
-
additional information
-
influence of divalent metal ions, overview
-
additional information
-, O00338, O75897
structural basis for inhibition, mechanism
-
additional information
P50237, P52847, Q9WUW8, Q9WUW9, -
-
-
additional information
P50225
SULT1A3 shows no substrate inhibition by 4-nitrophenol
-
additional information
-
enzyme form SULT1A1 is significantly inhibited by all beverages examined (grapefruit juice, orange juice, green tea and black tea) at a concentration of 10%. Green tea and black tea exhibit potent inhibition, even at a concentration of 5%, they both inhibit SULT1A1 by 100%; enzyme form SULT1A3 is significantly inhibited by all beverages examined (grapefruit juice, orange juice, green tea and black tea) at a concentration of 10%. Green tea and black tea exhibit potent inhibition, even at a concentration of 5%, they both inhibit SULT1A3 by more than 95%
-
additional information
-
no inhibition by tributyltin
-
additional information
P50224, P50225
grapefruit juice and orange juice show a weak inhibition of SULT1A3, green tea, black tea and oolong tea show a good inhibition of SULT1A3; naringin and bergamottin do not inhibit SULT1A1, inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3, inhibitory action of green tea on SULT1A3 is competitive, while that of black tea and oolong tea is mixed competitive/non-competitive, no mechanism-based inhibition, the mode of inhibition is competitive, overview; naringin does not inhibit SULT1A1, grapefruit juice and orange juice show a good inhibition of SULT1A1, green tea, black tea and oolong tea are also inhibitors of SULT1A1; no inhibition of SULT1A3 by 60,70-dihydroxybergamottin, inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3, inhibitory action of green tea on SULT1A3 is competitive, while that of black tea and oolong tea is mixed competitive/non-competitive, no mechanism-based inhibition, the mode of inhibition is competitive, overview
-
additional information
O43704
inhibitory potency of diverse derivatives of hydroxylated polychlorobiphenyls, no inhibition by 3,3',4,5,6-pentachlorobiphenyl-4'-ol, 3,3',4,5'-tetrachlorobiphenyl-4'-ol, 3,3',5-trichlorobiphenyl-4'-ol, 3,3',4-trichlorobiphenyl-4'-ol, 2,3',5'-trichlorobiphenyl-4'-ol, 3',5'-dichlorobiphenyl-4'-ol, 4-chlorobiphenyl-2'-ol, overview; inhibitory potency of diverse derivatives of hydroxylated polychlorobiphenyls, no inhibition by 3,3',4,5,6-pentachlorobiphenyl-4'-ol, 3,3',4,5'-tetrachlorobiphenyl-4'-ol, 3,3',5-trichlorobiphenyl-4'-ol, 3,3',4-trichlorobiphenyl-4'-ol, 2,3',5'-trichlorobiphenyl-4'-ol, 3',5'-dichlorobiphenyl-4'-ol, 4-chlorobiphenyl-2'-ol, overview
-
additional information
-
oxidation of phenolic substrates to carboxylates inhibits the enzyme in a competitive, reversible manner
-
additional information
-
no effect by dexamethasone in Hep-G2 cells on SULT1A3 activity on 4-nitrophennol
-
additional information
-
substrate inhibition of allozymes SULT1A1*1, *2 and *3 is observed for most substrates
-
additional information
-
isoprenaline is poor inhibitor of SULT1B1
-
additional information
-
SULT1A1 and SULT1A3 are potently inhibited by natural products present in juices, apple, grape, grapefruit, green and black teas, and coffee
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
adenosine 3',5'-bisphosphate
-
the beta-enzyme form shows a hyperbolic dependence on adenosine 3',5'-bisphosphate concentration, whereas the alpha-enzyme form is not stimulated
adenosine 3',5'-bisphosphate
P17988
-
Diamide
-
i.e. 1,1'-azobis(N,N-dimethylformamide), diamide significantly increases the sulfation of 7-hydroxycoumarin at an optimal concentration of 0.005 mM
EDTA
-
10 mM, stimulates isozymes A and B
ferulic acid
-
activation of M-PST
Gallic acid
-
activation of P-PST and M-PST
gentisic acid
-
activation of P-PST and M-PST
GSH
-
increases activity
morpholinosydnonimine
-
i.e. SIN-1, a peroxynitrite generator, activates SULT1A3 in vivo in Hep-G2 cells
o-coumaric acid
-
activation of P-PST
p-coumaric acid
-
activation of P-PST
p-hydroxybenzoic acid
-
activation of P-PST and M-PST
tert-butyl hydroperoxide
-
tert-butyl hydroperoxide significantly increases the sulfation of 7-hydroxycoumarin at an optimal concentration of 0.01 mM
m-coumaric acid
-
activation of P-PST
additional information
-
aryl sulfotransferase IV, oxidation causes an increase in sulfation of 4-nitrophenol and a shift of pH-optimum at physiological pH
-
additional information
-, O00338, O75897
structural basis for activation, mechanism
-
additional information
P50237, P52847, Q9WUW8, Q9WUW9, -
-
-
additional information
-
when p-hydroxybenzoic acid is combined with each of the other phenolic acids, a synergistic effect with respect to the promotion of PST-P activity is obtained. A potential synergistic effect for the PST-P activity is found in the following combination: p-hydroxybenzoic acid + gallic acid + gentisic acid, p-hydroxybenzoic acid + gallic acid + m-coumaric acid, p-hydroxybenzoic acid + o-coumaric acid + p-coumaric acid, p-hydroxybenzoic acid + o-coumaric acid + m-coumaric acid, gallic acid + gentisic acid + p-coumaric acid, and gallic acid + o-coumaric acid + m-coumaric acid
-
additional information
P17988
estradiol, in constant application, leads to increased SULT1A1 levels in the striatum of rats, correlation of estradiol and SULT1A1 levels, other brain regions like cortex, cerebellum, and hippocampus, are less sensitive
-
additional information
-
5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one induces the expression of SULT1A1 via the aryl hydrocarbon receptor, AhR, signaling pathway, mechanism, overview
-
additional information
-
glucocorticoids and prednisolone induce SULT1A3 activity on dopamine 1.2-1.8fold, but not SULT1A1, no effect by dexamethasone in Hep-G2 cells on SULT1A3 activity on 4-nitrophenol
-
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.00099
-
1-Naphthol
-
isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.0024
-
17beta-estradiol
-
pH not specified in the publication, at 37C
0.009
-
2-Aminophenol
O43704
SULT1A1, pH 7.4, 37C
0.114
-
2-Aminophenol
O43704
SULT1B1, pH 7.4, 37C
0.223
-
2-Aminophenol
O43704
SULT1A3, pH 7.4, 37C
0.15
-
2-chlorophenol
-
isoenzyme I, pH 6.5, 37C
0.5
-
2-chlorophenol
-
pH 7.0, 37C
0.06
-
2-Naphthol
-
isoenzyme I, pH 6.5, 37C
0.09
-
2-Naphthol
-
isoenzyme II, pH 6.5, 37C
0.0012
-
3'-phosphoadenylyl sulfate
-
isoform ST4, in 50 mM sodium phosphate, pH 6.8, at 37C
0.0021
-
3'-phosphoadenylyl sulfate
-
isoform ST1, in 50 mM sodium phosphate, pH 6.8, at 37C
0.024
-
3'-phosphoadenylyl sulfate
-
isoform ST3, in 50 mM sodium phosphate, pH 6.8, at 37C
0.00035
-
3'-phosphoadenylylsulfate
-
pH 8.5
0.00035
-
3'-phosphoadenylylsulfate
-
M-PST, pH 7.0, 37C
0.0017
-
3'-phosphoadenylylsulfate
-
with dopamine, isoenzyme A, pH 6.0, 37C
0.002
-
3'-phosphoadenylylsulfate
-
SULT1A3 mutant H143Y, pH 7.4, 37C
0.003
-
3'-phosphoadenylylsulfate
-
SULT1A3 mutant E146A, pH 7.4, 37C
0.0043
-
3'-phosphoadenylylsulfate
-
wild-type SULT1A1, pH 7.4, 37C
0.0046
-
3'-phosphoadenylylsulfate
-
wild-type SULT1A3, pH 7.4, 37C
0.0048
-
3'-phosphoadenylylsulfate
-
SULT1A3 double mutant H143Y/E146A, pH 7.4, 37C
0.0065
-
3'-phosphoadenylylsulfate
-
with 2-naphthol, isoenzyme I, pH 6.5, 37C
0.012
-
3'-phosphoadenylylsulfate
-
with 2-naphthol, isoenzyme II, pH 6.5, 37C
0.021
-
3'-phosphoadenylylsulfate
-
with dopamine
0.023
-
3'-phosphoadenylylsulfate
-
with minoxidil
0.026
-
3'-phosphoadenylylsulfate
-
with dopamine, isoenzyme B, pH 9.5, 37C
0.047
-
3'-phosphoadenylylsulfate
-
SULT1A1, pH 7.2, 37C
0.07
-
3'-phosphoadenylylsulfate
-
SULT1A3, pH 6.5, 37C
0.17
-
3'-phosphoadenylylsulfate
-
enzyme form SULT1A3
0.51
-
3'-phosphoadenylylsulfate
-
enzyme form SULT1A1
0.036
-
3,3',5'-triiodo-L-thyronine
P50225
SULT1A1 allozyme 1, pH 7.0, 37C
0.05
-
3,3',5'-triiodo-L-thyronine
P50225
SULT1A1 allozyme 2, pH 7.0, 37C
0.0277
-
3,3',5-triiodo-D-thyronine
-
pH 8.0, 28C, enzyme form SULT1 ST5
0.0387
-
3,3',5-triiodo-L-thyronine
-
pH 8.0, 28C, enzyme form SULT1 ST5
0.084
-
3,3',5-triiodo-L-thyronine
P50225
SULT1A1 allozyme 1, pH 7.0, 37C
0.126
-
3,3',5-triiodo-L-thyronine
P50225
SULT1A1 allozyme 2, pH 7.0, 37C
0.00051
-
3,3'-diiodo-L-thyronine
P50225
SULT1A1 allozyme 2, pH 7.0, 37C
0.00063
-
3,3'-diiodo-L-thyronine
P50225
SULT1A1 allozyme 1, pH 7.0, 37C
0.017
-
3,4-dihydroxyphenylglycol
-
pH 6.0, 37C
0.12
-
3-chlorophenol
-
isoenzyme I, pH 6.5, 37C
0.16
-
3-chlorophenol
-
isoenzyme II, pH 6.5, 37C
0.02
-
3-cyano-7-hydroxycoumarin
-
wild type enzyme, in 50 mM HEPES, pH 7.5, 7 mM MgCl2, and 1.5 mM dithiothreitol, at 22C
-
5.3e-05
-
3-Hydroxybenzo[a]pyrene
-
liver enzyme, pH 7.0, 35C
6.9e-05
-
3-Hydroxybenzo[a]pyrene
-
intestinal enzyme, pH 7.0, 35C
0.07
-
3-hydroxyindole
-
isoenzyme II, pH 6.5, 37C
0.08
-
3-hydroxyindole
-
isoenzyme I, pH 6.5, 37C
0.018
-
3-methoxy-4-hydroxyphenylglycol
-
pH 6.4, 37C
1.4
-
3-methylphenol
-
isoenzyme II, pH 6.5, 37C
0.1305
-
3-nitro-L-tyrosine
-
SULT1A3, pH 7.0, 37C
0.1444
-
3-nitro-L-tyrosine
-
SULT1A3, pH 5.5, 37C
0.1641
-
3-nitro-L-tyrosine
-
SULT1A3, pH 9.0, 37C
0.42
-
3-Nitrophenol
-
pH 7.0, 37C
0.44
-
3-Nitrophenol
-
isoenzyme II, pH 6.5, 37C
1
-
3-Nitrophenol
-
isoenzyme I, pH 6.5, 37C
0.00018
-
3alpha-tibolone
-
pH 7.5, 37C, postmenopausal liver enzyme; pH 7.5, 37C, postmenopausal liver enzyme
0.00042
-
3beta-tibolone
-
pH 7.5, 37C, postmenopausal liver enzyme; pH 7.5, 37C, postmenopausal liver enzyme
1.6
-
4-acetamidophenol
-
isoenzyme II, pH 6.5, 37C
2.1
-
4-acetamidophenol
-
isoenzyme I, pH 6.5, 37C
0.55
-
4-Chlorophenol
-
pH 7.0, 37C
1.2
-
4-Chlorophenol
-
isoenzyme II, pH 6.5, 37C
1.5
-
4-Chlorophenol
-
isoenzyme I, pH 6.5, 37C
0.18
-
4-Hydroxybiphenyl
-
isoenzyme I, pH 6.5, 37C
0.25
-
4-Hydroxybiphenyl
-
isoenzyme II, pH 6.5, 37C
4.2
-
4-methoxyphenol
-
isoenzyme I, pH 6.5, 37C
6.5
-
4-methoxyphenol
-
isoenzyme II, pH 6.5, 37C
2.2
-
4-Methylphenol
-
isoenzyme II, pH 6.5, 37C
2.9
-
4-Methylphenol
-
isoenzyme I, pH 6.5, 37C
6.9e-05
-
4-nitrophenol
Q29476
SULT1A1, pH 7.3-7.4
0.00015
-
4-nitrophenol
Q29476
SULT1A1, pH 7.0
0.00036
-
4-nitrophenol
O43704
recombinant wild-type P-PST, pH 7.0, 37C
0.00041
-
4-nitrophenol
-
isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.00053
-
4-nitrophenol
-
SULT1A1, pH 7.2, 37C
0.0006
-
4-nitrophenol
-
recombinant isozyme P-PST, i.e. HAST1
0.00084
-
4-nitrophenol
-
enzyme form SULT1A1
0.00119
-
4-nitrophenol
O43704
pH 7.0, 37C, SULT1A1
0.0015
-
4-nitrophenol
-
mutant enzyme D247L, enzyme form SULT1D1
0.003
-
4-nitrophenol
-
H-PST, pH 6.8, 37C
0.003
-
4-nitrophenol
-
ST1A3, pH 7.4, 37C
0.0032
-
4-nitrophenol
-
ST1a4, pH 7.4, 37C
0.0033
-
4-nitrophenol
Q9XT99
ST1A8, pH 7.4, 37C
0.0038
-
4-nitrophenol
-
pH 7.4, 37C; wild-type SULT1A1
0.0038
-
4-nitrophenol
-
pH 7.4, 37C
0.0038
-
4-nitrophenol
-
pH 7.4, 37C; ST1A1
0.004
-
4-nitrophenol
O43704
SULT1A1, pH 7.4, 37C
0.0061
-
4-nitrophenol
-
SULT1A3 mutant E146A, pH 7.4, 37C
0.0094
-
4-nitrophenol
-
SULT1A3 double mutant H143Y/E146A, pH 7.4, 37C
0.037
-
4-nitrophenol
-
isoform ST4, in 50 mM sodium phosphate, pH 6.8, at 37C
0.065
-
4-nitrophenol
O43704
SULT1B1, pH 7.4, 37C
0.167
-
4-nitrophenol
O43704
recombinant wild-type M-PST, pH 7.0, 37C
0.18
-
4-nitrophenol
-
wild-type enzyme, enzyme form SULT1D1
0.24
-
4-nitrophenol
-
isoform ST1, in 50 mM sodium phosphate, pH 6.8, at 37C
0.345
-
4-nitrophenol
-
recombinant isozyme M-PST, i.e. HAST3
0.5
-
4-nitrophenol
-
above, ST1A5, pH 7.4, 37C
0.58
-
4-nitrophenol
-
enzyme form SULT1A1
0.66
-
4-nitrophenol
O43704
SULT1A3, pH 7.4, 37C
1.25
-
4-nitrophenol
-
pH 7.0, 37C
1.3
-
4-nitrophenol
-
isoform ST3, in 50 mM sodium phosphate, pH 6.8, at 37C
1.38
-
4-nitrophenol
-
wild-type SULT1A3, pH 7.4, 37C
1.47
-
4-nitrophenol
-
SULT1A3 mutant H143Y, pH 7.4, 37C
1.6
-
4-nitrophenol
-
isoenzyme I, pH 6.5, 37C
1.6
-
4-nitrophenol
-
mutant enzyme O86D, enzyme form SULT1D1
2.5
-
4-nitrophenol
-
isoenzyme II, pH 6.5, 37C
30.9
-
4-nitrophenol
P52847
pH 9.3, 37C
0.29
-
5-hydroxyindole
-
isoenzyme I, pH 6.5, 37C
0.3
-
5-hydroxyindole
-
isoenzyme II, pH 6.5, 37C
0.53
-
5-hydroxytryptamine
-
isoenzyme II, pH 6.5, 37C
1.6
-
5-hydroxytryptamine
-
isoenzyme I, pH 6.5, 37C
0.019
-
6-Hydroxydopamine
-
pH 7.0, 37C, SULT1A3
0.018
-
6-hydroxymelatonin
-
ST1A3, pH 7.4, 37C
0.03
-
6-hydroxymelatonin
Q9XT99
pH 7.4, 37C; ST1A8
0.03
-
6-hydroxymelatonin
-
pH 7.4, 37C; ST1A1
0.04
-
6-hydroxymelatonin
-
ST1a4, pH 7.4, 37C
0.065
-
6-hydroxymelatonin
-
ST1A5, pH 7.4, 37C
0.000125
-
7-hydroxybenzo[a]pyrene
-
intestinal enzyme, pH 7.0, 35C
0.000126
-
7-hydroxybenzo[a]pyrene
-
liver enzyme, pH 7.0, 35C
0.04
-
7-hydroxyserotonin
-
pH 7.0, 37C, SULT1A3
3.6e-05
-
9-hydroxybenzo[a]pyrene
-
liver enzyme, pH 7.0, 35C
4.1e-05
-
9-hydroxybenzo[a]pyrene
-
intestinal enzyme, pH 7.0, 35C
0.43
-
acetaminophen
-
M-PST, pH 7.0, 37C
0.0023
-
adenosine 2',3'-cyclic phosphate 5'-phosphate
-
pH 7.0, 25C
0.067
-
adenosine 2',5'-bisphosphate
-
pH 7.0, 25C
0.0004
-
adenosine 3',5'-bisphosphate
-
pH 7.0, 25C
4.3
-
adenosine 5'-monophosphate
-
pH 7.0, 25C
0.00172
-
apigenin
-
pH 6.5, 37C, allozyme SULT1A1*1
0.00257
-
apigenin
-
pH 6.5, 37C, allozyme SULT1A1*3
0.00264
-
apigenin
-
pH 6.5, 37C, allozyme SULT1A1*2
0.0026
-
beta-estradiol
-
isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.014
-
beta-estradiol
Q29476
SULT1A1, pH 7.3-7.4
0.0977
-
beta-Naphthol
-
pH 8.0, 28C, enzyme form SULT1 ST5
0.0025
-
chrysin
-
pH 6.5, 37C, allozyme SULT1A1*1
3.44
-
D-3,4-dihydroxyphenylalanine
P52847
pH 9.3, 37C
0.00047
-
daidzein
-
enzyme form SULT1A1, 7-sulfate formation
0.00054
-
daidzein
-
enzyme form SULT1A1, 4'-sulfate formation
0.00257
-
daidzein
-
enzyme form SULT1E1, 7-sulfate formation
0.00324
-
daidzein
-
enzyme form SULT1E1, 4'-sulfate formation
0.0044
-
daidzein
A0FIP8, -
pH 7.0, 20C, recombinant SULT1,3
0.0456
-
daidzein
-
enzyme form SULT2A1, 7-sulfate formation
0.0511
-
daidzein
-
enzyme form SULT2A1, 4'-sulfate formation
0.407
-
daidzein
-
enzyme form SULT1A3, 4'-sulfate formation
0.0443
-
daidzein 4'-sulfate
-
enzyme form SULT1A1
0.0516
-
daidzein 4'-sulfate
-
enzyme form SULT1E1
0.0435
-
daidzein 7-sulfate
-
enzyme form SULT1E1
0.0699
-
daidzein 7-sulfate
-
enzyme form SULT1A1
0.01
-
dihydroxyphenylacetic acid
-
pH 5.8, 37C
0.015
-
dobutamine
-
M-PST, pH 7.0, 37C
0.00065
-
dopamine
-
wild-type SULT1A3: purified recombinant enzyme from Escherichia coli, pH 7.4, 37C
0.00094
-
dopamine
-
wild-type SULT1A3: recombinant from V79 cells, pH 7.4, 37C
0.001
-
dopamine
-
wild-type SULT1A3: native enzyme, and recombinant from COS-7 cells, Escherichia coli, Saccharomyces cerevisiae, pH 7.4, 37C
0.0014
-
dopamine
O43704
recombinant wild-type M-PST, pH 7.0, 37C
0.0022
-
dopamine
-
wild-type SULT1A3, pH 7.4, 37C
0.0022
-
dopamine
-
dopamine 4-O-sulfate formation, recombinant SULT1A3
0.0026
-
dopamine
-
dopamine 3-O-sulfate formation, recombinant SULT1A3
0.0029
-
dopamine
-
M-PST, pH 7.0, 37C
0.0036
-
dopamine
-
wild-type enzyme, enzyme form SULT1D1
0.0053
-
dopamine
-
isoform SULT1A3, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.0056
-
dopamine
-
SULT1A3 mutant H143Y, pH 7.4, 37C
0.0062
-
dopamine
-
isoenzyme B, pH 9.5, 37C
0.0065
-
dopamine
-
SULT1A3, pH 7.0, 37C
0.0068
-
dopamine
-
at pH 7.0 and 37C
0.007
-
dopamine
-
pH 7.0, 37C, SULT1A3
0.0071
-
dopamine
-
SULT1A3, pH 6.5, 37C
0.0097
-
dopamine
-
recombinant isozyme M-PST, i.e. HAST3
0.011
-
dopamine
-
-
0.014
-
dopamine
-
ST1A5, pH 7.4, 37C
0.0177
-
dopamine
-
isoenzyme A, pH 6.0, 37C
0.02
-
dopamine
-
pH 9.0, 37C
0.031
-
dopamine
-
mutant enzyme D247L, enzyme form SULT1D1
0.0316
-
dopamine
-
SULT1A3, pH 11.0, 37C
0.037
-
dopamine
-
mutant enzyme O86D, enzyme form SULT1D1
0.0381
-
dopamine
-
SULT1A3, pH 9.0, 37C
0.087
-
dopamine
-
SULT1A3 double mutant H143Y/E146A, pH 7.4, 37C
0.0875
-
dopamine
O43704
recombinant wild-type P-PST, pH 7.0, 37C
0.098
-
dopamine
-
ST1a4, pH 7.4, 37C
0.109
-
dopamine
-
wild-type SULT1A1, pH 7.4, 37C
0.127
-
dopamine
-
SULT1A3 mutant E146A, pH 7.4, 37C
0.13
-
dopamine
-
pH 7.4, 37C; ST1A3
0.13
-
dopamine
-
pH 7.4, 37C; ST1A1
0.175
-
dopamine
Q29476
SULT1A1, pH 7.0
0.18
-
dopamine
Q29476
SULT1A1, pH 7.3-7.4
0.24
-
dopamine
P52847
pH 9.3, 37C
0.5
-
dopamine
Q9XT99
ST1A8, pH 7.4, 37C
2.2
-
dopamine
-
recombinant isozyme P-PST, i.e. HAST1
11.3
-
dopamine
-
enzyme form SULT1A3
0.065
-
epicatechin
-
pH 6.5, 37C, allozyme SULT1A1*3
0.242
-
epicatechin
-
pH 6.5, 37C, allozyme SULT1A1*1
0.419
-
epicatechin
-
pH 6.5, 37C, allozyme SULT1A1*2
0.00051
-
genistein
-
enzyme form SULT1A1, 7-sulfate formation
0.00052
-
genistein
-
enzyme form SULT1A1, 4'-sulfate formation
0.0017
-
genistein
A0FIP8, -
pH 7.0, 20C, recombinant SULT1,3
0.00279
-
genistein
-
enzyme form SULT1E1, 7-sulfate formation
0.00294
-
genistein
-
enzyme form SULT1E1, 4'-sulfate formation
0.025
-
genistein
-
enzyme form SULT2A1, 7-sulfate formation
0.0559
-
genistein
-
enzyme form SULT2A1, 4'-sulfate formation
0.371
-
genistein
-
enzyme form SULT1A3, 4'-sulfate formation
0.0114
-
genistein 4'-sulfate
-
enzyme form SULT1A1
0.0266
-
genistein 4'-sulfate
-
enzyme form SULT1E1
0.03
-
genistein 7-sulfate
-
enzyme form SULT1E1
0.0316
-
genistein 7-sulfate
-
enzyme form SULT1A1
0.014
-
homovanillic acid
-
pH 5.8, 37C
0.6
-
hydroquinone
-
isoenzyme II, pH 6.5, 37C
1.8
-
hydroquinone
-
isoenzyme I, pH 6.5, 37C
0.76
-
L-3,4-dihydroxyphenylalanine
P52847
pH 9.3, 37C
0.714
-
L-4-hydroxyphenylglycine
-
pH 7.0, 37C
0.0445
-
L-thyroxine
-
pH 8.0, 28C, enzyme form SULT1 ST5
0.101
-
L-thyroxine
P50225
SULT1A1 allozyme 1, pH 7.0, 37C
0.208
-
L-thyroxine
P50225
SULT1A1 allozyme 2, pH 7.0, 37C
0.0939
-
L-triiodothyronine
Q9QWG7
isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.033
-
L-tyrosine
-
pH 7.0, 37C
0.2
-
minoxidil
-
P-PST, pH 7.0, 37C
0.1
-
norepinephrine
-
pH 9.0, 37C
0.00035
-
p-nitrophenol
Q9QWG7
isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.0529
-
p-nitrophenol
Q9QWG7
isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.04
-
Phenol
-
pH 5.8, 37C
1.8
-
Phenol
-
isoenzyme I, pH 6.5, 37C
2.6
-
Phenol
-
isoenzyme II, pH 6.5, 37C
0.0351
-
quercetin
-
pH 6.5, 37C, allozyme SULT1A1*1
0.0005
-
resveratrol
-
pH 6.5, 37C, allozyme SULT1A1*2
0.0011
-
resveratrol
-
pH 6.5, 37C, allozyme SULT1A1*3
0.0023
-
resveratrol
-
pH 6.5, 37C, allozyme SULT1A1*1
0.438
-
ritodrine
-
enzyme form SULT1A3
3.08
-
ritodrine
-
enzyme form SULT1A1
0.133
-
serotonin
-
pH 7.0, 37C, SULT1A3
0.0066
-
trans-resveratrol-3-O sulfate
-
ZR-75-1 cell
0.0161
-
trans-resveratrol-3-O sulfate
-
SULT1A1-transfected MDA-MB-231 cell
0.833
-
tyrosylglycine
-
pH 8.5
0.1
-
vanillylmandelic acid
-
pH 6.2, 37C
0.00053
-
xanthurenic acid
Q9QWG7
isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.0433
-
xanthurenic acid
-
isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.0509
-
xanthurenic acid
Q9QWG7
isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.55
-
minoxidil
Q29476
SULT1A1, pH 7.3-7.4
additional information
-
additional information
-
-
-
additional information
-
additional information
-
-
-
additional information
-
additional information
-
-
-
additional information
-
additional information
O43704
kinetics, chimeric enzymes
-
additional information
-
additional information
-
kinetics; kinetics
-
additional information
-
additional information
-
ping-pong kinetics
-
additional information
-
additional information
-
kinetics; Km for 3'-phosphoadenylylsulfate with several substrates, liver and intestinal enzyme
-
additional information
-
additional information
-
kinetics
-
additional information
-
additional information
-
kinetics
-
additional information
-
additional information
-
kinetics of SULT1A1 allozymes 1 and 2 with 4-nitrophenol
-
additional information
-
additional information
-
kinetics
-
additional information
-
additional information
P50225
kinetics of Arg mutants
-
additional information
-
additional information
-
kinetics
-
additional information
-
additional information
Q29476
kinetics
-
additional information
-
additional information
-, O00338, O75897
kinetics; kinetics; kinetics; kinetics
-
additional information
-
additional information
P52846
kinetics
-
additional information
-
additional information
-, O35401, Q80VR3, Q9QWG7
kinetics; kinetics; kinetics; kinetics
-
additional information
-
additional information
O46503, Q9XT99
kinetics; kinetics
-
additional information
-
additional information
P50237, P52847, Q9WUW8, Q9WUW9, -
kinetics; kinetics; kinetics; kinetics; kinetics
-
additional information
-
additional information
-
SULT1A3, kinetics and pH-dependence
-
additional information
-
additional information
-
SULT1A3, kinetics
-
additional information
-
additional information
-
kinetic constants of competitive inhibitors
-
additional information
-
additional information
-
kinetics of SULT1A1 allozymes, overview
-
additional information
-
additional information
-
kinetics, SULT1A3
-
additional information
-
additional information
-
kinetics; kinetics
-
TURNOVER NUMBER [1/s]
TURNOVER NUMBER MAXIMUM[1/s]
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.733
-
2-chlorophenol
-
isoenzyme I
0.783
-
2-Naphthol
-
isoenzyme I
0.9
-
2-Naphthol
-
isoenzyme II
8.5
-
3'-phosphoadenylyl sulfate
-
isoform ST1, in 50 mM sodium phosphate, pH 6.8, at 37C
27
-
3'-phosphoadenylyl sulfate
-
isoform ST4, in 50 mM sodium phosphate, pH 6.8, at 37C
40.7
-
3'-phosphoadenylyl sulfate
-
isoform ST3, in 50 mM sodium phosphate, pH 6.8, at 37C
0.65
-
3-hydroxyindole
-
-
0.733
-
3-hydroxyindole
-
isoenzyme I
0.667
-
4-Chlorophenol
-
isoenzyme II
0.8
-
4-Chlorophenol
-
isoenzyme I
1.55
-
4-methoxyphenol
-
isoenzyme I
2
-
4-methoxyphenol
-
isoenzyme II
0.026
-
4-nitrophenol
-
mutant enzyme D247L, enzyme form SULT1D1
0.089
-
4-nitrophenol
-
mutant enzyme O86D, enzyme form SULT1D1
0.15
-
4-nitrophenol
-
wild-type enzyme, enzyme form SULT1D1
30
-
4-nitrophenol
-
isoform ST1, in 50 mM sodium phosphate, pH 6.8, at 37C
70
-
4-nitrophenol
-
isoform ST4, in 50 mM sodium phosphate, pH 6.8, at 37C
330
-
4-nitrophenol
-
isoform ST3, in 50 mM sodium phosphate, pH 6.8, at 37C
0.6
-
5-hydroxyindole
-
isoenzyme II
0.65
-
5-hydroxyindole
-
isoenzyme I
0.01
-
5-hydroxytryptamine
-
isoenzyme II
0.025
-
5-hydroxytryptamine
-
isoenzyme I
0.00033
-
daidzein
-
enzyme form SULT2A1, 4'-sulfate formation
0.0035
-
daidzein
-
enzyme form SULT2A1, 7-sulfate formation
0.005
-
daidzein
-
enzyme form SULT1A3, 4'-sulfate formation
0.0055
-
daidzein
-
enzyme form SULT1A1, 4'-sulfate formation
0.02
-
daidzein
-
enzyme form SULT1A1, 7-sulfate formation
0.095
-
daidzein
-
enzyme form SULT1E1, 7-sulfate formation
0.1065
-
daidzein
-
enzyme form SULT1E1, 4'-sulfate formation
0.00183
-
daidzein 4'-sulfate
-
enzyme form SULT1A1
0.063
-
daidzein 4'-sulfate
-
enzyme form SULT1E1
0.00016
-
daidzein 7-sulfate
-
enzyme form SULT1A1
0.076
-
daidzein 7-sulfate
-
enzyme form SULT1E1
0.028
-
dopamine
-
mutant enzyme D247L, enzyme form SULT1D1
0.09
-
dopamine
-
mutant enzyme O86D, enzyme form SULT1D1
0.18
-
dopamine
-
wild-type enzyme, enzyme form SULT1D1
0.0015
-
genistein
-
enzyme form SULT2A1, 4'-sulfate formation
0.0062
-
genistein
-
enzyme form SULT2A1, 7-sulfate formation
0.013
-
genistein
-
enzyme form SULT1A1, 4'-sulfate formation
0.024
-
genistein
-
enzyme form SULT1A3, 4'-sulfate formation
0.11
-
genistein
-
enzyme form SULT1A1, 7-sulfate formation
0.12
-
genistein
-
enzyme form SULT1E1, 7-sulfate formation
0.124
-
genistein
-
enzyme form SULT1E1, 4'-sulfate formation
0.0067
-
genistein 4'-sulfate
-
enzyme form SULT1A1
0.035
-
genistein 4'-sulfate
-
enzyme form SULT1E1
0.00116
-
genistein 7-sulfate
-
enzyme form SULT1A1
0.113
-
Phenol
-
isoenzyme I
0.122
-
Phenol
-
isoenzyme II
0.06
-
genistein 7-sulfate
-
enzyme form SULT1E1
additional information
-
additional information
-
-
-
kcat/KM VALUE [1/mMs-1]
kcat/KM VALUE [1/mMs-1] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.149
-
3-cyano-7-hydroxycoumarin
-
mutant enzyme Q56E/A101S/T117S/Q177K/M223I/V243L, in 50 mM HEPES, pH 7.5, 7 mM MgCl2, and 1.5 mM dithiothreitol, at 22C
0
0.308
-
3-cyano-7-hydroxycoumarin
-
mutant enzyme D249G, in 50 mM HEPES, pH 7.5, 7 mM MgCl2, and 1.5 mM dithiothreitol, at 22C
0
0.466
-
3-cyano-7-hydroxycoumarin
-
mutant enzyme Q56E/L67V/A101S/T117S/H213R/F222L/V243I/D249G, in 50 mM HEPES, pH 7.5, 7 mM MgCl2, and 1.5 mM dithiothreitol, at 22C
0
1.2
-
3-cyano-7-hydroxycoumarin
-
wild type enzyme, in 50 mM HEPES, pH 7.5, 7 mM MgCl2, and 1.5 mM dithiothreitol, at 22C
0
Ki VALUE [mM]
Ki VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.0123
-
1-hydroxy-4-ethylbenzene
-
SULT1A1/2, pH 7.0, 37C
8.9e-06
-
17alpha-ethinylestradiol
-
for 4-nitrophenol sulfation, pH not specified in the publication, at 37C
1.49e-05
-
17alpha-ethinylestradiol
-
for 17beta-estradiol sulfation, pH not specified in the publication, at 37C
1.9e-05
-
17alpha-ethinylestradiol
-
for 2-naphthol sulfation, pH not specified in the publication, at 37C
0.0018
-
2,3,3',5,5',6-hexachlorobiphenyl-4'-ol
O43704
pH 7.0, 37C, SULT1A1
0.108
-
2-Aminophenol
O43704
SULT1A1, pH 7.4, 37C
0.00035
-
3'-phosphoadenylylsulfate
-
P-PST, pH 8.5
0.0151
-
4-n-amylphenol
-
SULT1A1/2, pH 7.0, 37C
0.0052
-
4-nitrophenol
-
SULT1A1/2, pH 7.0, 37C
0.034
-
4-nitrophenol
O43704
SULT1A1, pH 7.4, 37C
0.063
-
4-nitrophenol
-
substrate inhibition, mutant enzyme D247L, enzyme form SULT1D1
1
-
4-nitrophenol
-
substrate inhibition, wild-type enzyme, enzyme form SULT1D1
0.0014
-
Acetylsalicylate
-
pH 7.4, 37C, versus 4-nitrophenol
0.0024
-
Acetylsalicylate
-
pH 7.4, 37C, versus 3'-phosphoadenylyl sulfate
7e-05
-
adenosine 3',5'-bisphosphate
-
M-PST, pH 7.0, 37C
0.02
-
adenosine 3',5'-bisphosphate
-
pH 7.0, 37C
0.18
-
ATP
-
M-PST, pH 7.0, 37C
0.0021
0.0028
CoA
P50227
pH 7.4, 25C, recombinant SULT1A1, method B
0.00573
-
CoA
P50227
pH 7.4, 25C, recombinant SULT1A1, method A
0.00577
-
coenzyme A
P50227
-
0.061
-
dopamine
-
substrate inhibition, wild-type enzyme, enzyme form SULT1D1
0.174
-
dopamine
-
at pH 7.0 and 37C
0.5
-
L-tyrosine O4-sulfate
-
pH 7.0, 37C
4.5e-05
-
meclofenamate
-
pH 7.4, 37C, versus 4-nitrophenol
0.00071
-
nimesulide
-
pH 7.4, 37C, versus 4-nitrophenol
0.00099
-
nimesulide
-
pH 7.4, 37C, versus 3'-phosphoadenylyl sulfate
0.023
-
pyridoxal 5'-phosphate
-
-
5.6e-05
-
meclofenamate
-
pH 7.4, 37C, versus 3'-phosphoadenylyl sulfate
additional information
-
additional information
P50227
inhibition kinetics
-
additional information
-
additional information
O43704
inhibition kinetics with hydroxylated polychlorobiphenyls; inhibition kinetics with hydroxylated polychlorobiphenyls
-
IC50 VALUE [mM]
IC50 VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.00101
-
2,3',4,6-tetrachlorobiphenyl-4'-ol
O43704
pH 7.0, 37C, SULT1A1
0.1
-
2,3',4,6-tetrachlorobiphenyl-4'-ol
O43704
above, pH 7.0, 37C, SULT1B1
0.00051
-
2,3,3',5,5',6-hexachlorobiphenyl-4'-ol
O43704
pH 7.0, 37C, SULT1A1
0.1
-
2,3,3',5,5',6-hexachlorobiphenyl-4'-ol
O43704
above, pH 7.0, 37C, SULT1B1
0.00054
-
2,3,3',5,6-pentachlorobiphenyl-4'-ol
O43704
pH 7.0, 37C, SULT1A1
0.1
-
2,3,3',5,6-pentachlorobiphenyl-4'-ol
O43704
above, pH 7.0, 37C, SULT1B1
2e-05
-
2,6-Dichloro-4-nitrophenol
Q9QWG7
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.00017
-
2,6-Dichloro-4-nitrophenol
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.00039
-
2,6-Dichloro-4-nitrophenol
-
isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.0004
-
2,6-Dichloro-4-nitrophenol
Q9QWG7
isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.0019
-
2,6-Dichloro-4-nitrophenol
-
IC50: 0.0019 mM, enzyme form SULT1A1
0.018
-
2,6-Dichloro-4-nitrophenol
Q9QWG7
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.0372
-
2,6-Dichloro-4-nitrophenol
Q9QWG7
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.52
-
2,6-Dichloro-4-nitrophenol
-
IC50: 0.52 mM, enzyme form SULT1A3
0.00196
-
3',4,5'-trichlorobiphenyl-4'-ol
O43704
pH 7.0, 37C, SULT1A1
0.1
-
3',4,5'-trichlorobiphenyl-4'-ol
O43704
above, pH 7.0, 37C, SULT1B1
0.0117
-
3,3',4-trichlorobiphenyl-6'-ol
O43704
pH 7.0, 37C, SULT1B1
0.0351
-
3,3',4-trichlorobiphenyl-6'-ol
O43704
pH 7.0, 37C, SULT1A1
0.00041
-
3,3',5',6-tetrachlorobiphenyl-4'-ol
O43704
pH 7.0, 37C, SULT1A1
0.1
-
3,3',5',6-tetrachlorobiphenyl-4'-ol
O43704
above, pH 7.0, 37C, SULT1B1
0.00026
-
4-chlorobiphenyl-3'-ol
O43704
pH 7.0, 37C, SULT1A1
0.0082
-
4-chlorobiphenyl-3'-ol
O43704
pH 7.0, 37C, SULT1B1
0.0062
-
4-chlorobiphenyl-4'-ol
O43704
pH 7.0, 37C, SULT1A1
0.1
-
4-chlorobiphenyl-4'-ol
O43704
above, pH 7.0, 37C, SULT1B1
0.0137
-
5,7-dichlorokynurenic acid
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.0208
-
5,7-dichlorokynurenic acid
-
IC50 above 1.0 mM, isoform SULT1A1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.0696
-
5,7-dichlorokynurenic acid
Q9QWG7
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.0986
-
5,7-dichlorokynurenic acid
Q9QWG7
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.0279
-
5-chloro-7-iodo-8-quinolinol
-
using dopamine as substrate, in 0.1 M potassium phosphate buffer (pH 7.4), 1 mM dithiothreitol, 5 mM MgCl2, at 37C
-
1.3
-
Acetylsalicylate
-
pH 7.4, 37C, versus 4-nitrophenol
0.00072
-
gavestinel
Q9QWG7
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.00092
-
gavestinel
Q9QWG7
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.0106
-
gavestinel
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
146
-
gavestinel
-
IC50 above 0.25 mM, isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
1.9
-
Ibuprofen
-
pH 7.4, 37C, versus 4-nitrophenol
0.003
-
Kynurenic acid
Q9QWG7
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C; isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.0049
-
Kynurenic acid
Q9QWG7
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C; isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.0188
-
Kynurenic acid
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.022
-
Kynurenic acid
-
isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.25
-
Kynurenic acid
Q9QWG7
IC50 above 0.25 mM, isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C; IC50 above 0.25 mM, isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.117
-
L689,560
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.1663
-
L689,560
Q9QWG7
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.1796
-
L689,560
Q9QWG7
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.25
-
L689,560
-
IC50 above 0.25 mM, isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.00011
-
meclofenamate
-
pH 7.4, 37C, versus 4-nitrophenol
0.005
-
Mefenamic acid
Q9QWG7
IC50 above 0.005 mM, isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C; IC50 above 0.005 mM, isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.0149
-
Mefenamic acid
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
0.0304
-
Mefenamic acid
-
isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37C
62.5
-
NaCl
-
IC50: 62.5 mM, enzyme form SULT1A1
178.7
-
NaCl
-
IC50: 178.7 mM, enzyme form SULT1A3
1.7
-
Naproxen
-
pH 7.4, 37C, versus 4-nitrophenol
0.0012
-
nimesulide
-
pH 7.4, 37C, versus 4-nitrophenol
0.38
-
piroxicam
-
pH 7.4, 37C, versus 4-nitrophenol
0.39
-
piroxicam
-
pH 7.4, 37C, versus 4-nitrophenol
0.045
-
punicalagin
-
in 10 mM phosphate buffer (pH 7.4), at 37C
0.001
-
quercetin
-
below, SULT1A1; SULT1E1
0.064
-
quercetin
-
SULT2A1
0.038
-
resveratrol
-
wild-type MDA-MB-231 cell
0.054
-
resveratrol
-
SULT1A1-transfected MDA-MB-231 cell
0.074
-
resveratrol
-
ZR-75-1 cell
0.15
-
salicylic acid
-
pH 7.4, 37C, versus 4-nitrophenol
3.8
-
sulindac
-
pH 7.4, 37C, versus 4-nitrophenol
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
9e-10
-
-
reaction of EC 2.8.2.4, estrone sulfotransferase, SULT1A2
2.3e-09
-
-
reaction of EC 2.8.2.4, estrone sulfotransferase, SULT1A1*2
7e-07
-
-
purified SULT1C1, substrate 4-nitrophenol
1e-05
-
-
SULT1A3, substrate L-DOPA
9e-05
0.00452
O00338, P50226, Q9BR01
SULT activities with 3-naphthylamine, overview; SULT activities with 3-naphthylamine, overview; SULT activities with 3-naphthylamine, overview; SULT activities with 3-naphthylamine, overview; SULT activities with 3-naphthylamine, overview
0.00014
0.00052
O00338, P50226, Q9BR01
SULT activities with N-hydroxy-4-aminobiphenyl, overview; SULT activities with N-hydroxy-4-aminobiphenyl, overview; SULT activities with N-hydroxy-4-aminobiphenyl, overview; SULT activities with N-hydroxy-4-aminobiphenyl, overview
0.00031
0.01201
O00338, P50226, Q9BR01
SULT activities with caffeic acid, overview; SULT activities with caffeic acid, overview; SULT activities with caffeic acid, overview; SULT activities with caffeic acid, overview
0.00085
-
-
SULT1A3, substrate DL-3-hydroxyphenylalanine
0.0016
-
-
purified isozyme A
0.0019
-
-
purified SULT1C2, substrate 4-octylphenol
0.002
-
-
purified P-PST, substrate 4-nonylphenol
0.00206
-
-
SULT1A3, substrate L-tyrosine
0.00211
-
-
SULT1A3, substrate 3-nitro-L-tyrosine
0.0022
-
P52847
purified enzyme
0.0024
-
-
purified P1-PST
0.0028
-
-
purified M-PST, substrate dopamine
0.0036
-
-
purified isozyme B
0.0066
0.0166
O00338, P50226, Q9BR01
SULT activities with catechol, overview; SULT activities with catechol, overview; SULT activities with catechol, overview; SULT activities with catechol, overview
0.0077
-
-
purified M-PST
0.0117
0.0125
P17988
SULT1A1, untreated male and female rat striata
0.01592
-
-
SULT1A3, substrate dopamine
0.0199
0.0239
P17988
SULT1A1, estradiol-treated male and female rat striata
0.054
-
-
purified recombinant H-PST
0.059
-
-
purified M-PST mutantD86A, substrate dopamine
0.063
-
-
purified M-PST mutantD86A, substrate dopamine + Mn2+
0.106
-
-
M-PST, substrate dobutamine
0.121
-
O43704
purified SULT1A1, substrate 2-aminophenol
0.147
-
-
P-PST, substrate (+/-)isoproterenol
0.2
-
-
purified recombinant SULT1A3
0.205
-
-
purified enzyme
0.25
-
-
arylsulfotransferase I
0.282
-
-
arylsulfotransferase II
0.34
-
-
purified PI-PST
0.5
-
-
purified M-PST wild-type enzyme, substrate dopamine
1.13
-
-
purified M-PST wild-type enzyme, substrate dopamine + Mn2+
additional information
-
-
rapid, simple sensitive radioassay
additional information
-
-
-
additional information
-
-
-
additional information
-
-
activity with diverse substrates, overview
additional information
-
Q9XT99
activity with diverse substrates, overview
additional information
-
-
activity with diverse substrates, overview
additional information
-
-
assay development with 4-nitrophenol to distinguish SULT1A1 allozymes and SULT1B1 from liver
additional information
-
-
activity of P-PST and M-PST with drug compounds as substrates, overview
additional information
-
-
a method based on electrophoretically mediated microanalysis is developed for SULT1A1 assay. In this plug-plug electrophoretically mediated microanalysis method, the electrophoresis process prior to the in-capillary contact of enzyme and substrate permits the preseparation of the inhibitor PAP from the sulfate donor PAPS
additional information
-
O43704
-
additional information
-
-
development of a HPLC-based dopamine 3-O-sulfate and dopamine 4-O-sulfate product detection method, the formation of the dopamine 3-O-sulfate is much higher with SULT1A3 than the dopamine 4-O-sulfate formation, overview
additional information
-
-
substrate specificity of the three allozymes SULT1A1*1, *2, and *3, overview
additional information
-
P50225
activities of SULT1A1*1 and SULT1A1*2 allozymes with trans-4-hydroxytamoxifen, overview
additional information
-
-
-
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5.5
-
-
with substrate 2-naphthol, aryl sulfotransferase I and II
5.5
-
-
with substrate 4-nitrophenol, isoenzyme B
5.5
-
-
with substrate 4-nitrophenol, aryl sulfotransferase IV
5.7
-
-
-
6
-
-
with substrate dopamine, isoenzyme A
6
-
-
with substrate 3,4-dihydroxyphenylglycol
6
-
-
with beta-naphthol as substrate, two optima at pH 6.0 and at pH 9.0 with 3,3',5-triiodo-L-thyronine as substrate, enzyme form SULT1 ST5
6.2
-
-
with substrate vanillylmandelic acid
6.2
-
P50225
assay at
6.4
6.8
-
isoform ST3
6.4
-
-
with substrate 3-methoxy-4-hydroxyphenylglycol
6.5
10.5
-
SULT1A3, broad optimum with substrate dopamine
6.5
-
-
with substrate 2-naphthol, aryl sulfotransferase II
6.5
-
-
isoenzyme A; with substrate 4-nitrophenol
6.5
-
-
with substrate 2-naphthol, a second optimum at pH 9.5; with substrate 4-nitrophenol
6.5
-
-
SULT1A3
6.5
-
-
assay at
6.8
-
-
assay at
6.8
-
P50224, P50225
assay at; assay at
7
-
-
assay at
7
-
-
M-PST, with substrate dopamine
7
-
O43704
assay at
7
-
-
assay at
7
-
-
assay at
7
-
-
assay at
7
-
P50225
assay at
7
-
Q29476
assay at
7
-
-
assay at
7
-
Q6XZC1
with n-propyl gallate as substrate
7
-
A0FIP8, -
assay at
7
-
-
SULT1A3, with substrate 3-nitro-L-tyrosine
7
-
O43704
assay at; assay at
7
-
-
with substrate 7-hydroxyserotonin
7.2
-
-
SULT1A1
7.4
-
-
assay at
7.4
-
-
assay at
7.4
-
Q9XT99
assay at
7.4
-
-
assay at
7.4
-
-
assay at
7.4
-
Q29476
assay at
7.4
-
P50227
assay at
7.4
-
O43704
assay at; assay at; assay at
7.4
-
-
assay at
7.5
-
-
assay at
7.5
-
-
;
7.5
-
O00338, P50226, Q9BR01
assay at; assay at; assay at; assay at; assay at; assay at
8
9
-
with substrates dopamine and 6-hydroxydopamine
8.5
-
-
-
9
-
-
with substrate dopamine or norepinephrine
9
-
-
two optima at pH 6.0 and at pH 9.0 with 3,3',5-triiodo-L-thyronine as substrate, enzyme form SULT1 ST5
9.3
-
P52847
-
9.5
-
-
with substrate dopamine, isoenzyme B
9.5
-
-
substrate 2-naphthol, second optimum at pH 6.5
11
-
-
with substrate serotonin
additional information
-
-
aryl sulfotransferase IV, oxidation causes an increase in sulfation of 4-nitrophenol and a shift of pH-optimum at physiological pH
additional information
-
-, O00338, O75897
assay conditions for several enzyme forms with different substrates
additional information
-
P50237, P52847, Q9WUW8, Q9WUW9, -
assay conditions for several enzyme forms with different substrates
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6.5
8
Q6XZC1
pH 6.5: about 65% of maximal activity, pH 8.0: about 60% of maximal activity, with n-propyl gallate as substrate
6.5
8.5
-
about 65% activity at pH 6.5 and about 50% activity at pH 8.5
additional information
-
-
-
additional information
-
-
-
additional information
-
-
-
additional information
-
-
aryl sulfotransferase IV is ineffective at physiological pH
TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
20
-
A0FIP8, -
assay at
25
-
-
assay at
25
-
P50227
assay at
30
-
-
isoform ST4
35
-
-
assay at
35
-
-
isoform ST1
37
-
-
assay at
37
-
-
assay at
37
-
-
assay at
37
-
-
assay at
37
-
-
assay at
37
-
P52847
assay at
37
-
-
assay at
37
-
O43704
assay at
37
-
-
assay at
37
-
-
-
37
-
-
assay at
37
-
P50225
assay at
37
-
-
assay at
37
-
Q9XT99
assay at
37
-
-
assay at
37
-
-
assay at
37
-
P50225
assay at
37
-
-
assay at
37
-
O43704
assay at; assay at; assay at
37
-
-
assay at
37
-
P50224, P50225
assay at; assay at
37
-
-
assay at
37
-
O43704
assay at; assay at
37
-
-
assay at
37
-
P50225
assay at
37
-
-
assay at
37
-
-
assay at; assay at
37
-
O00338, P50226, Q9BR01
assay at; assay at; assay at; assay at; assay at; assay at
37
-
-
-
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
30
45
-
about 60% activity at 30C and about 90% activity at 45C, no activity at 50C
additional information
-
-
incubation at 37C causes a selective decrease in activity towards dopamine compared with phenol
pI VALUE
pI VALUE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6.5
-
-
isoelectric focusing
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
O00338, P50226, Q9BR01
pulmonary, endothelial cell; pulmonary, endothelial cell; pulmonary, endothelial cell; pulmonary, endothelial cell; pulmonary, endothelial cell
Manually annotated by BRENDA team
-
expression of SULT1A1, activity varies with gender and season, platelet phenotypes, overview
Manually annotated by BRENDA team
A0FIP8, -
low SULT1,3 expression level
Manually annotated by BRENDA team
P17988
SULT1A1, mainly striatum, lower contents in cortex, hippocampus, and cerebellum
Manually annotated by BRENDA team
-
SULT4A1, an orphan member of the SULT family expressed primarily in the brain
Manually annotated by BRENDA team
-
recombinant SULT1A1 expressed in insect Sf9 cells
Manually annotated by BRENDA team
Q29476
; higher content in male than in female dogs; SULT1A1
Manually annotated by BRENDA team
Q6XZC1
low level of expression in the segmentation period during the embryonic development
Manually annotated by BRENDA team
-
significant level of expression at the beginning of the hatching period during embryogenesis, enzyme form SULT1 ST5
Manually annotated by BRENDA team
O00338, P50226, Q9BR01
primary pulmonary artery endothelial cells and lung microvascular endothelial cells; primary pulmonary artery endothelial cells and lung microvascular endothelial cells; primary pulmonary artery endothelial cells and lung microvascular endothelial cells; primary pulmonary artery endothelial cells and lung microvascular endothelial cells; primary pulmonary artery endothelial cells and lung microvascular endothelial cells
Manually annotated by BRENDA team
A0FIP8, -
low SULT1,3 expression level
Manually annotated by BRENDA team
A0FIP8, -
low SULT1,3 expression level
Manually annotated by BRENDA team
Q6Y0X5, -
-
Manually annotated by BRENDA team
-
hepatoma cell line
Manually annotated by BRENDA team
O00338, P50226, Q9BR01
human hepatoma cell line, ATCC HB 8065; human hepatoma cell line, ATCC HB 8065; human hepatoma cell line, ATCC HB 8065; human hepatoma cell line, ATCC HB 8065; human hepatoma cell line, ATCC HB 8065
Manually annotated by BRENDA team
-
osteosarcoma cell line; predominantly contains SULT1A3 activity
Manually annotated by BRENDA team
-
culture with TNF-alpha increases activity of SULT1A1, TGF-beta increases activity to a lesser extent, insulin also increases activity of SULT1A1; culture with TNF-alpha increases activity of SULT1A1, TGF-beta increases activity to a lesser extent, insulin does not increase activity of SULT1A3; HT-29. Culture with TNF-alpha increases activity of SULT1A1, TGF-beta increases activity to a lesser extent, insulin also increases activity of SULT1A1; HT-29. Culture with TNF-alpha increases activity of SULT1A1, TGF-beta increases activity to a lesser extent, insulin does not increase activity of SULT1A3
Manually annotated by BRENDA team
Q29476
; higher content in male than in female dogs; SULT1A1
Manually annotated by BRENDA team
-
enzyme form SULT1A1; enzyme form SULT1A3
Manually annotated by BRENDA team
-
activity is very low in comparison to activity in rat liver. In most cases the activities are present throughout the entire intestine and not restricted to a particular portion of this organ
Manually annotated by BRENDA team
P50224, P50225
SULT1A3
Manually annotated by BRENDA team
-
high expression
Manually annotated by BRENDA team
-
mucosa, TL-PST
Manually annotated by BRENDA team
Q29476
; higher content in male than in female dogs; SULT1A1
Manually annotated by BRENDA team
-
S9 fractions
Manually annotated by BRENDA team
Q29476
SULT1A1, higher content in male than in female dogs
Manually annotated by BRENDA team
Q6Y0X5, -
-
Manually annotated by BRENDA team
A0FIP8, -
high SULT1,3 expression level
Manually annotated by BRENDA team
Q6XZC1
high level expression throughout the larval stage onto maturity
Manually annotated by BRENDA team
-
gradual increase in expression to a high level of expression throughout the larval stage of maturity, enzyme form SULT1 ST5
Manually annotated by BRENDA team
-
2 forms of P-PST: PI-PST and PII-PST, differing in their thermostability
Manually annotated by BRENDA team
-
aryl sulfotransferase IV
Manually annotated by BRENDA team
-
ST1A3 and ST1A5
Manually annotated by BRENDA team
-
SULT1A1; SULT1B1
Manually annotated by BRENDA team