Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | - |
Homo sapiens | diphosphate + DNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA polymerase | - |
Homo sapiens |
pol alpha | isozyme | Homo sapiens |
pol beta | isozyme | Homo sapiens |
pol delta | isozyme | Homo sapiens |
POl epsilon | isozyme | Homo sapiens |
Pol eta | isozyme | Homo sapiens |
Pol gamma | isozyme | Homo sapiens |
pol iota | isozyme | Homo sapiens |
pol kappa | isozyme | Homo sapiens |
Pol lambda | isozyme | Homo sapiens |
Pol mu | isozyme | Homo sapiens |
Pol theta | isozyme | Homo sapiens |
Pol zeta | isozyme | Homo sapiens |
Rec1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | mutations in or altered expression of Pol gamma coupled with oxidative damage to mitochondrial DNA may be involved in Parkinson disease and Alzheimer disease | Homo sapiens |
physiological function | Pol alpha catalyses initiation of chromosomal DNA replication at origins and at Okazaki fragments on the lagging strand, Pol beta participates in base-excision repair, Pol gamma catalyses mitochondrial DNA synthetic processes, Pol delta participates in lagging-strand synthesis, and Pol epsilon has a role in the synthesis of the leading strand of chromosomal DNA, Pol eta functions in bypass UV lesions,Pol iota, Pol kappa, and Pol zeta function in bypass synthesis, Pol lambda functions in base excision repair, Pol mu functions in non-homologous end joining, Pol theta functions in DNA repair, and DNA polymerase Rec1 incorporates dC opposite abasic sites. Pol beta can be classified as a tumour suppressor | Homo sapiens |