Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,7-dihydroxy-2,4,6-cyclo-heptatrien-1-one | beta-thujaplicinol analogue. Compound has no effect on polymerase-dependent RNase H cleavages but significantly affects the rates of polymerase-independent RNase H cleavages. In a model, the compoouind binds to the RNase H active site after the primary polymerase-dependent RNase H cleavage has occurred and stabilizes the 3'-end of the DNA primer in the polymerase active site thus blocking the enzyme's ability to carry out the polymerase-independent cleavages | Human immunodeficiency virus 1 | |
efavirenz | Compound has no effect on polymerase-dependent RNase H cleavages but significantly affects the rates of polymerase-independent RNase H cleavages. Efavirenz destabilizes the 3'-end of the DNA primer in the DNA polymerase active site and promotes RT-mediated polymerase-independent cleavages | Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
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Human immunodeficiency virus 1 | - |
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