Literature summary for 2.7.11.8 extracted from

Izquierdo, J.M.; Valcarcel, J.
Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing (2007), J. Biol. Chem., 282, 1539-1543.

Cloned(Commentary)

Cloned (Comment)	Organism
HA-tagged FAST K overexpression in HeLa cells enhances exon 6 inclusion of Fas reporters transfected in the cells, effects of FAST K are mediated by changes in the function of TIA-1/TIAR, i.e. T-cell intracellular antigen 1, and TIA-related proteins, the effects of FAST K overexpression are largely suppressed by depletion of TIA-1 and TIAR and are significantly compromised by mutation of a TIA-1/TIAR-responsive enhancer present downstream of exon 6 5' splice site, expression of GST-tagged TIA in HeLa cells	Homo sapiens

Cloned (Comment)

Organism

HA-tagged FAST K overexpression in HeLa cells enhances exon 6 inclusion of Fas reporters transfected in the cells, effects of FAST K are mediated by changes in the function of TIA-1/TIAR, i.e. T-cell intracellular antigen 1, and TIA-related proteins, the effects of FAST K overexpression are largely suppressed by depletion of TIA-1 and TIAR and are significantly compromised by mutation of a TIA-1/TIAR-responsive enhancer present downstream of exon 6 5' splice site, expression of GST-tagged TIA in HeLa cells

Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
ATP + [Fas-activated serine/threonine protein]	Homo sapiens	-	ADP + [Fas-activated serine/threonine phosphoprotein]	-	?
ATP + [T-cell intracellular antigen 1]	Homo sapiens	FAST K is known to interact with and phosphorylate TIA-1, effects of FAST K on other splicing factors and associated splicing regulatory motifs are mediated by changes in the function of TIA-1/TIAR, i.e. T-cell intracellular antigen 1 and TIA-related proteins, interaction analysis of FAST K with TIA, overview	ADP + [T-cell intracellular antigen 1 phosphoprotein]	-	?
additional information	Homo sapiens	Fas signaling is connected with the activity of splicing factors that modulate Fas alternative splicing, suggesting the existence of an autoregulatory loop that could serve to amplify Fas responses, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
ATP + Fas-activated serine/threonine protein	-	Homo sapiens	ADP + Fas-activated serine/threonine phosphoprotein	-	?
ATP + [Fas-activated serine/threonine protein]	-	Homo sapiens	ADP + [Fas-activated serine/threonine phosphoprotein]	-	?
ATP + [T-cell intracellular antigen 1]	FAST K is known to interact with and phosphorylate TIA-1, effects of FAST K on other splicing factors and associated splicing regulatory motifs are mediated by changes in the function of TIA-1/TIAR, i.e. T-cell intracellular antigen 1 and TIA-related proteins, interaction analysis of FAST K with TIA, overview	Homo sapiens	ADP + [T-cell intracellular antigen 1 phosphoprotein]	-	?
ATP + [T-cell intracellular antigen 1]	in vitro phosphorylation of TIA-1 by FAST K results in enhanced U1 snRNP recruitment, overview	Homo sapiens	ADP + [T-cell intracellular antigen 1 phosphoprotein]	-	?
additional information	Fas signaling is connected with the activity of splicing factors that modulate Fas alternative splicing, suggesting the existence of an autoregulatory loop that could serve to amplify Fas responses, overview	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
Fas-activated serine/threonine kinase	-	Homo sapiens
FAST K	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens