Information on EC 2.7.11.8 - Fas-activated serine/threonine kinase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.7.11.8
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RECOMMENDED NAME
GeneOntology No.
Fas-activated serine/threonine kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein]
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:[Fas-activated serine/threonine protein] phosphotransferase
This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.
CAS REGISTRY NUMBER
COMMENTARY hide
170347-50-9
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + Fas-activated serine/threonine protein
ADP + Fas-activated serine/threonine phosphoprotein
show the reaction diagram
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?
ATP + TIA-1
ADP + ?
show the reaction diagram
ATP + TIA-1
ADP + phosphorylated TIA-1
show the reaction diagram
ATP + [Fas-activated serine/threonine protein]
ADP + [Fas-activated serine/threonine phosphoprotein]
show the reaction diagram
ATP + [T-cell intracellular antigen 1]
ADP + [T-cell intracellular antigen 1 phosphoprotein]
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + TIA-1
ADP + ?
show the reaction diagram
Q14296
rapidly activated during Fas-mediated apoptosis. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation, suggesting a role in signaling downstream events in the apoptotic program
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ATP + TIA-1
ADP + phosphorylated TIA-1
show the reaction diagram
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FAST serves as a sensor for mitochondrial stress modulating a TIA-1 regulated posttranscriptional stress response program, FAST might prevent TIA-1 mediated silencing of mRNA encoding inhibitors of of apoptosis
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ATP + [Fas-activated serine/threonine protein]
ADP + [Fas-activated serine/threonine phosphoprotein]
show the reaction diagram
ATP + [T-cell intracellular antigen 1]
ADP + [T-cell intracellular antigen 1 phosphoprotein]
show the reaction diagram
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FAST K is known to interact with and phosphorylate TIA-1, effects of FAST K on other splicing factors and associated splicing regulatory motifs are mediated by changes in the function of TIA-1/TIAR, i.e. T-cell intracellular antigen 1 and TIA-related proteins, interaction analysis of FAST K with TIA, overview
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additional information
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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rapidly activated during Fas-mediated apoptosis
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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interaction with BCL-XL
Manually annotated by BRENDA team
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 50000, mitochondrial isoform, SDS-PAGE; x * 50000, mitochondrial isoform, SDS-PAGE; x * 60000, cytosolic isoform, SDS-PAGE; x * 60000, cytosolic isoform, SDS-PAGE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
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enzyme is phosphorylated on serine and threonine residues. In response to Fas ligation, it is rapidly dephosphorylated and concomitantly activated to phosphorylate TIA-1
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partially, subcellular fractionation
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
HA-tagged FAST K overexpression in HeLa cells enhances exon 6 inclusion of Fas reporters transfected in the cells, effects of FAST K are mediated by changes in the function of TIA-1/TIAR, i.e. T-cell intracellular antigen 1, and TIA-related proteins, the effects of FAST K overexpression are largely suppressed by depletion of TIA-1 and TIAR and are significantly compromised by mutation of a TIA-1/TIAR-responsive enhancer present downstream of exon 6 5' splice site, expression of GST-tagged TIA in HeLa cells
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overexpression of HA-tagged enzyme in HeLa cells and in COS-7 cells, expression of GFP-tagged enzyme in COS-7 cells
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overexpression of HA-tagged enzyme in HeLa cells and in COS-7 cells, recombinant FAST promotes the expression of co-transfected reporter proteins, e.g. beta-galactosidase, via its TIA-1 binding domain, and increases the expression of endogenous cIAP-1 and XIAP, but not GAPDH, in HeLa cells
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
miR-106a-5p upregulates enzyme expression via a post-transcriptional mechanism and by affecting its mRNA stability
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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the increased enzyme expression of is significantly associated with poor survival outcome in astrocytoma patients