Activating Compound | Comment | Organism | Structure |
---|---|---|---|
CP-681301 | CP-681301 treatment reverses the inhibition of GSK3beta activity | Mus musculus | |
additional information | dephosphorylation at the inhibitory GSK3beta-Ser9 site activates the enzyme, GSK3beta activity increases with aging | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | cdk5 can negatively regulate GSK3beta activity through neuregulin/ErbB signaling, phosphorylation at the inhibitory GSK3beta-Ser9 site activates GSK3beta | Mus musculus | |
p25 | p25 overexpressing mice have reduced GSK3beta activity | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein tau | - |
Mus musculus | ADP + protein tau phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase 3beta | - |
Mus musculus |
GSK3beta | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |