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Literature summary for 2.7.11.25 extracted from

  • Channavajhala, P.L.; Rao, V.R.; Spaulding, V.; Lin, L.L.; Zhang, Y.G.
    hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation (2005), Biochem. Biophys. Res. Commun., 334, 1214-1218.
    View publication on PubMed
Search for more literature for 2.7.11.25

Cloned(Commentary)

Cloned (Comment) Organism
expression of FLAG-tagged MEKK3 in HEK293T and HeLa cells, co-expression of NF-kappaB Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
hKSR-2 i.e. human kinase suppressor of ras 2, selectively inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation, selectively inhibits Cot, no inhibition of MEKK4, TAK1, and Ras-Raf Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + MEK1 Homo sapiens activation by MEKK3 of MAPK signaling pathways ADP + phosphorylated MEK1
-
 ?
ATP + MEK2 Homo sapiens activation by MEKK3 of MAPK signaling pathways ADP + phosphorylated MEK2
-
 ?
ATP + MKK6 Homo sapiens activation by MEKK3 of MAPK signaling pathways ADP + phosphorylated MKK6
-
 ?
ATP + MKK7 Homo sapiens activation by MEKK3 of MAPK signaling pathways ADP + phosphorylated MKK7
-
 ?
additional information Homo sapiens Cot plays an important role in inflammation and oncogenesis, MEKK3 mediates the activation of JNK and ERK in the MAP kinase pathway and of the NF-kappaB pathway and mediates the interleukin-8 production, MEKK3 and Cot are negatively regulated by hKSR-2 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6VAB6 MEKK3 isozyme 1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + MEK1 activation by MEKK3 of MAPK signaling pathways Homo sapiens ADP + phosphorylated MEK1
-
 ?
ATP + MEK1 substrate is a MAPKK Homo sapiens ADP + phosphorylated MEK1
-
 ?
ATP + MEK2 activation by MEKK3 of MAPK signaling pathways Homo sapiens ADP + phosphorylated MEK2
-
 ?
ATP + MEK2 substrate is a MAPKK Homo sapiens ADP + phosphorylated MEK2
-
 ?
ATP + MKK6 activation by MEKK3 of MAPK signaling pathways Homo sapiens ADP + phosphorylated MKK6
-
 ?
ATP + MKK6 substrate is a MAPKK Homo sapiens ADP + phosphorylated MKK6
-
 ?
ATP + MKK7 activation by MEKK3 of MAPK signaling pathways Homo sapiens ADP + phosphorylated MKK7
-
 ?
ATP + MKK7 substrate is a MAPKK Homo sapiens ADP + phosphorylated MKK7
-
 ?
additional information Cot plays an important role in inflammation and oncogenesis, MEKK3 mediates the activation of JNK and ERK in the MAP kinase pathway and of the NF-kappaB pathway and mediates the interleukin-8 production, MEKK3 and Cot are negatively regulated by hKSR-2 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
COT
-
 Homo sapiens
MAP kinase kinase kinase 3
-
 Homo sapiens
MAP3K
-
 Homo sapiens
MAPKKK
-
 Homo sapiens
MEKK3
-
 Homo sapiens
MEKK4
-
 Homo sapiens
TAK1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens