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Literature summary for 2.7.11.24 extracted from
- Inhibition of c-Jun N-terminal kinase enhances temozolomide-induced cytotoxicity in human glioma cells (2009), J. Neurooncol., 95, 307-316.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| temozolomide | - |
Homo sapiens |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| SP600125 | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| U-87MG cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
| ATP + ATF-2 | - |
Homo sapiens | ADP + phosphorylated ATF-2 | - |
? | |
| ATP + c-Jun | - |
Homo sapiens | ADP + phosphorylated c-Jun | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| c-Jun N-terminal kinase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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