Information on EC 2.7.11.24 - mitogen-activated protein kinase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.7.11.24
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RECOMMENDED NAME
GeneOntology No.
mitogen-activated protein kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a protein = ADP + a phosphoprotein
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (MAPKK-activated)
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline [6]. A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
CAS REGISTRY NUMBER
COMMENTARY hide
142243-02-5
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
animal
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1047600 A+, 1067752 A+, 1087230 A+, 1133962 A+, 1134047 A+, 1134089 A+, 1134241 A+, 1134433 A+, 1134654 A+, 1134798 A+, 1134890 A+, 1135022 A+, 1135059 A+, 1135159 A+, 1135294 A+, 1135400 A+, 1135952 A+, 1135981 A+, 1136354 A+, 1136577 A+, 1136670 A+, 1136692 A+, 1136695 A+, 1136742 A+, 1137060 A+, 1137097 A+, 1137112 A+, 1137145 A+, 1137364 A+, 1137399 A+, 1137507 A+, 1137730 A+, 1138227 A+, 1138376 A+, 1138406 A+, 1138692 A+, 1138696 A+, 1139296 A+, 1139517 A+, 1139742 A+, 1139790 A+, 1139842 A+, 1140021 A+, 1140527 A+, 1225810 A+, 1256331 A+, 1263894 A+, 1280586 A+, 1346774 A+, 1799923 A+, 1800862 A+, 1866444 A+, 1912817 A+, 1930924 A+, 1933797 A+, 1936823 A+, 1937006 A+, 1937111 A+, 1937255 A+, 1937452 A+, 1937781 A+, 1937899 A+, 1938037 A+, 1938038 A+, 1938153 A+, 1938605 A+, 1939413 A+, 1939687 A+, 1939865 A+, 1940947 A+, 1941443 A+, 1941449 A+, 1942189 A+, 1942661 A+, 1942727 A+, 1942809 A+, 1943181 A+, 1943243 A+, 1943506 A+, 1943633 A+, 1944554 A+, 1944797 A+, 1944923 A+, 1945327 A+, 1945724 A+, 1946115 A+, 2117866 A+, 2128261 A+, 2183223 A+, 2289129 A+, 2309464 A+, 2324654 A+, 2325546 A+, 2326494 A+, 2326605 A+, 2326633 A+, 2326754 A+, 2326826 A+, 2326856 A+, 2327050 A+, 2327156 A+, 2327298 A+, 2327322 A+, 2327351 A+, 2327552 A+, 2327878 A+, 2328010 A+, 2328058 A+, 2328199 A+, 2328241 A+, 2328247 A+, 2328260 A+, 2328310 A+, 2328471 A+, 2328631 A+, 2328646 A+, 2328779 A+, 2328801 A+, 2328939 A+, 2328941 A+, 2329130 A+, 2329289 A+, 2329340 A+, 2329382 A+, 2329405 A+, 2329430 A+, 2329551 A+, 2329782 A+, 2329821 A+, 2330092 A+, 2330117 A+, 2330129 A+, 2330444 A+, 2331084 A+, 2331094 A+, 2331260 A+, 2331475 A+, 2331594 A+, 2331631 A+, 2331700 A+, 2332012 A+, 2332173 A+, 2332508 A+, 2332585 A+, 2332619 A+, 2332666 A+, 2332672 A+, 2332705 A+, 2332709 A+, 2332811 A+, 2341192 A+, 2380577 A+, 2389873 A+, 2416900 A+, 2497865 A+, 2517912 A+, 2517921 A+, 2532863 A+, 2576641 A+, 2685207 A+, 2742579 A+, 2750385 A+, 2872706 A+, 2931747 A+, 2934369 A+, 2957355 A+, 2962976 A+, 2963184 A+, 2968202 A+, 2968366 A+, 2968604 A+, 2969203 A+, 2969537 A+, 2969710 A+, 2969850 A+, 2969942 A+, 2970120 A+, 2970408 A+, 2970427 A+, 2970507 A+, 2970763 A+, 2970845 A+, 2971002 A+, 2971220 A+, 2971381 A+, 2971446 A+, 2971454 A+, 2971588 A+, 2971902 A+, 2972243 A+, 2972346 A+, 2972594 A+, 2973001 A+, 2973221 A+, 2973912 A+, 2974557 A+, 2974615 A+, 2975212 A+, 2975819 A+, 2976407 A+, 2976467 A+, 2977303 A+, 2977333 A+, 491783 A+, 491796 A+, 647394 A+, 690853 A+, 691922 A+, 859780 A+, 860023 A+, 860491 A+, 860598 A+, 916314 A+, 1070873 A++, 1139746 A++, 1139787 A++, 1140072 A++, 1140075 A++, 1140225 A++, 1140356 A++, 1564563 A++, 1572667 A++, 1822457 A++, 1843247 A++, 1900232 A++, 1927492 A++, 1934115 A++, 1941154 A++, 1941343 A++, 1941475 A++, 1941902 A++, 1943828 A++, 1944139 A++, 1944243 A++, 1944400 A++, 1944824 A++, 1945278 A++, 1945385 A++, 2139176 A++, 2171992 A++, 2266664 A++, 2314405 A++, 2330188 A++, 2330240 A++, 2330267 A++, 2330349 A++, 2330501 A++, 2330655 A++, 2330804 A++, 2330807 A++, 2331321 A++, 2331367 A++, 2331514 A++, 2331749 A++, 2331888 A++, 2332106 A++, 2332119 A++, 2332185 A++, 2332187 A++, 2332288 A++, 2332291 A++, 2381516 A++, 2389952 A++, 2397339 A++, 2468647 A++, 2536103 A++, 2576433 A++, 2631653 A++, 2719602 A++, 2742006 A++, 2864439 A++, 2893427 A++, 2956416 A++, 2965646 A++, 2971879 A++, 2971961 A++, 2971996 A++, 2972251 A++, 2972319 A++, 2972340 A++, 2972363 A++, 2972409 A++, 2972887 A++, 2973711 A++, 2974417 A++, 2974887 A++, 2975262 A++, 2975467 A++, 2975750 A++, 2976005 A++, 734405 A++, 771090 A++, 771691 A++, 907291 A++, 1137892 A++, 1137901 A++, 1138031 A++, 2330566 A++, 2331142 A++, 2332240 A++, 2963884 A++, 2976566 A++, 788421 A++, 861113 A++, 1134005 A+++, 1135751 A+++
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Automatic Mining of ENzyme DAta
antarctic bacterium
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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1084484 A+, 1113162 A+, 1134042 A+, 1134447 A+, 1134721 A+, 1135132 A+, 1135174 A+, 1135238 A+, 1135710 A+, 1135939 A+, 1136038 A+, 1136276 A+, 1136383 A+, 1136532 A+, 1136632 A+, 1136674 A+, 1136757 A+, 1136950 A+, 1136972 A+, 1136981 A+, 1137049 A+, 1137261 A+, 1137335 A+, 1137390 A+, 1137675 A+, 1137799 A+, 1137800 A+, 1137878 A+, 1137968 A+, 1137976 A+, 1138062 A+, 1138093 A+, 1138183 A+, 1138254 A+, 1138278 A+, 1138383 A+, 1138604 A+, 1138641 A+, 1138823 A+, 1138858 A+, 1138885 A+, 1138976 A+, 1139011 A+, 1139075 A+, 1139234 A+, 1139285 A+, 1139430 A+, 1139433 A+, 1139468 A+, 1139674 A+, 1139694 A+, 1139729 A+, 1139750 A+, 1139798 A+, 1140031 A+, 1140116 A+, 1140175 A+, 1140234 A+, 1140293 A+, 1140397 A+, 1140602 A+, 1140657 A+, 1140701 A+, 1225390 A+, 1225673 A+, 1225714 A+, 1225724 A+, 1225742 A+, 1280364 A+, 1567682 A+, 1572471 A+, 1586086 A+, 1644727 A+, 1856299 A+, 1937316 A+, 1937486 A+, 1938037 A+, 1938326 A+, 1938346 A+, 1938429 A+, 1939474 A+, 1939501 A+, 1939645 A+, 1940027 A+, 1940190 A+, 1940439 A+, 1940640 A+, 1941449 A+, 1941876 A+, 1942113 A+, 1942423 A+, 1942526 A+, 1942756 A+, 1943418 A+, 1943946 A+, 1944085 A+, 1944515 A+, 1944529 A+, 1944547 A+, 1945283 A+, 1945561 A+, 1945573 A+, 2192511 A+, 2324654 A+, 2327590 A+, 2327694 A+, 2327757 A+, 2327785 A+, 2328140 A+, 2330290 A+, 2330491 A+, 2330523 A+, 2331780 A+, 2331926 A+, 2332038 A+, 2332534 A+, 2663453 A+, 2969544 A+, 2970346 A+, 2971834 A+, 2972267 A+, 2972917 A+, 2973394 A+, 2975695 A+, 491796 A+, 491801 A+, 664751 A+, 680719 A+, 689546 A+, 694408 A+, 706186 A+, 764721 A+, 810820 A+, 859944 A+, 860269 A+, 860981 A+, 861058 A+, 907260 A+, 972982 A+, 1137834 A++, 1138993 A++, 1139771 A++, 1140144 A++, 1140146 A++, 1942306 A++, 1944076 A++, 1944973 A++, 1225793 A++, 1225809 A++, 1943882 A++, 1944107 A++, 2172421 A++, 2331905 A++, 2332126 A++, 2971891 A++, 2973610 A++, 861248 A++, 1134478 A+++, 1134640 A+++, 1134745 A+++, 1134937 A+++, 1135126 A+++, 1135152 A+++, 1135850 A+++, 1136458 A+++, 1136885 A+++, 1136975 A+++, 1137034 A+++, 1137364 A+++, 1137402 A+++, 1137469 A+++, 1137574 A+++, 1137628 A+++, 1137807 A+++, 1137957 A+++, 1138106 A+++, 1138352 A+++, 1138904 A+++, 1139136 A+++, 1139531 A+++, 1139692 A+++, 1140290 A+++, 689628 A+++, 1137926 A++++
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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1032602 A+, 1119090 A+, 1119708 A+, 1119811 A+, 1134129 A+, 1134170 A+, 1134413 A+, 1134495 A+, 1134514 A+, 1134639 A+, 1134730 A+, 1134931 A+, 1135046 A+, 1135345 A+, 1135555 A+, 1135581 A+, 1136352 A+, 1136366 A+, 1136813 A+, 1136983 A+, 1139575 A+, 1225667 A+, 1255480 A+, 1387104 A+, 1714061 A+, 1911837 A+, 1913415 A+, 1937267 A+, 1937302 A+, 1940100 A+, 1940895 A+, 1941152 A+, 1941285 A+, 2157257 A+, 2170165 A+, 2224328 A+, 2259868 A+, 2305143 A+, 2305891 A+, 2307170 A+, 2308640 A+, 2308982 A+, 2311763 A+, 2313116 A+, 2317028 A+, 2322127 A+, 2326430 A+, 2326443 A+, 2326452 A+, 2326488 A+, 2326618 A+, 2326630 A+, 2326797 A+, 2326843 A+, 2326865 A+, 2326896 A+, 2326963 A+, 2327009 A+, 2327162 A+, 2327216 A+, 2327323 A+, 2327570 A+, 2327708 A+, 2327727 A+, 2327742 A+, 2327962 A+, 2327997 A+, 2328011 A+, 2328761 A+, 2328797 A+, 2329010 A+, 2329120 A+, 2329132 A+, 2329484 A+, 2329514 A+, 2330361 A+, 2331359 A+, 2389711 A+, 2390395 A+, 2415028 A+, 2515313 A+, 2642003 A+, 2765500 A+, 2938104 A+, 2958724 A+, 2959866 A+, 2967024 A+, 2967197 A+, 2967400 A+, 2967654 A+, 2967678 A+, 2967751 A+, 2967997 A+, 2968166 A+, 2968285 A+, 2968372 A+, 2969094 A+, 2971825 A+, 2971827 A+, 2972072 A+, 2972914 A+, 2974737 A+, 2975902 A+, 669269 A+, 859936 A+, 917264 A+, 1583517 A++, 2275771 A++, 2332143 A++, 2677127 A++, 2941193 A++, 2974153 A++, 2976320 A++, 2342500 A++, 1134056 A+++, 1134144 A+++, 1134159 A+++, 1134287 A+++, 1134342 A+++, 1134402 A+++, 1134831 A+++, 1134966 A+++, 1134968 A+++, 1135427 A+++, 1136296 A+++, 1137291 A+++
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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1116206 A+, 1117623 A+, 1122335 A+, 1130614 A+, 1132567 A+, 1134111 A+, 1134171 A+, 1134248 A+, 1134275 A+, 1134302 A+, 1134386 A+, 1134401 A+, 1134403 A+, 1134627 A+, 1134976 A+, 1134994 A+, 1135033 A+, 1135181 A+, 1135220 A+, 1135417 A+, 1135626 A+, 1136295 A+, 1136323 A+, 1136533 A+, 1136914 A+, 1137033 A+, 1137225 A+, 1137361 A+, 1138019 A+, 1138203 A+, 1138204 A+, 1138337 A+, 1138346 A+, 1138705 A+, 1138890 A+, 1139488 A+, 1139551 A+, 1139629 A+, 1139882 A+, 1140281 A+, 1140312 A+, 1140431 A+, 1140561 A+, 1140640 A+, 1176911 A+, 1188735 A+, 1190613 A+, 1340554 A+, 1482722 A+, 1560609 A+, 1655406 A+, 1709272 A+, 1907549 A+, 1913693 A+, 1915301 A+, 1919896 A+, 1921650 A+, 1923789 A+, 1931817 A+, 1936784 A+, 1936870 A+, 1936931 A+, 1937093 A+, 1938167 A+, 1938458 A+, 1938475 A+, 1939663 A+, 1940003 A+, 1940608 A+, 1941348 A+, 1941651 A+, 1943340 A+, 1943341 A+, 1944002 A+, 1945718 A+, 2169972 A+, 2304549 A+, 2307343 A+, 2311540 A+, 2323651 A+, 2326738 A+, 2328421 A+, 2330571 A+, 2330726 A+, 2331164 A+, 2331736 A+, 2331902 A+, 2363195 A+, 2538075 A+, 2661762 A+, 2674493 A+, 2929113 A+, 2929387 A+, 2933754 A+, 2937947 A+, 2946561 A+, 2956608 A+, 2958710 A+, 2960764 A+, 2961394 A+, 2961615 A+, 2961695 A+, 2967161 A+, 2968948 A+, 2969680 A+, 2971924 A+, 2972878 A+, 2973449 A+, 2974751 A+, 2977269 A+, 2977427 A+, 491445 A+, 491774 A+, 491775 A+, 491807 A+, 491913 A+, 491914 A+, 682529 A+, 859976 A+, 860780 A+, 1139181 A++, 1139456 A++, 1140128 A++, 1917485 A++, 2330773 A++, 2972109 A++, 2975580 A++, 705707 A++, 1917201 A++, 1919082 A++, 1919090 A++, 2313140 A++, 2314867 A++, 2324947 A++, 2330699 A++, 2664534 A++, 2971946 A++, 2976331 A++, 1060885 A+++, 1134123 A+++, 1134151 A+++, 1134481 A+++, 1134548 A+++, 1134567 A+++, 1134624 A+++, 1134812 A+++, 1135021 A+++, 1135125 A+++, 1135577 A+++, 1136057 A+++, 1136183 A+++, 1136426 A+++, 1137432 A+++, 1137504 A+++, 1137776 A+++, 1137925 A+++, 1137935 A+++, 1138035 A+++, 1139063 A+++, 1139070 A+++, 1140482 A+++, 1140676 A+++, 491722 A+++, 491723 A+++, 491724 A+++, 491757 A+++, 1138146 A++++, 1138231 A++++, 1138581 A++++, 1139775 A++++, 1139823 A++++, 1139831 A++++
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta