Application | Comment | Organism |
---|---|---|
additional information | Plk1 controls both spindle elongation and cytokinesis, coordinates chromosome segregation with cytokinesis through its dual control of anaphase B and contractile ring assembly | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BI-2536 | blocks contractile ring assembly by preventing the localization of Rho and Rho-GEF without affecting the assembly of the central spindle | Homo sapiens | |
BTO-1 | blocks contractile ring assembly by preventing the localization of Rho and Rho-GEF without affecting the assembly of the central spindle | Homo sapiens | |
cyclapolin 1 | - |
Homo sapiens | |
DAP81 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
chromosome | - |
Homo sapiens | 5694 | - |
kinetochore | - |
Homo sapiens | 776 | - |
spindle | - |
Homo sapiens | 5819 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein | Homo sapiens | - |
ADP + phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P53350 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein | - |
Homo sapiens | ADP + phosphoprotein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Plk1 | - |
Homo sapiens |
Polo-like kinase 1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0008 | - |
- |
Homo sapiens | BI-2536 | |
0.008 | - |
- |
Homo sapiens | BTO-1 |