Information on EC 2.7.11.21 - polo kinase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY
2.7.11.21
-
RECOMMENDED NAME
GeneOntology No.
polo kinase
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (spindle-pole-dependent)
The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein [2].
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
cell cycle protein kinase CDC5/MSD2
P32562
-
cytokine-inducible serine/threonine-protein kinase
Q9H4B4
-
cytokine-inducible serine/threonine-protein kinase
Q60806
-
FGF-inducible kinase
-
-
-
-
Fnk
Q60806
-
hPlk1
-
-
hPlk5
-
-
mPlk5
Q4FZD7
-
PLK
Q9H4B4
-
PLK
-
-
Plk1
-
-
Plk1
Q4KMI8
-
Plk1
Q6DRK7
-
Plk1
Q62673
-
Plk1
Q5UES2
-
Plk1
-
-
Plk2
P53351
-
PLK4
O00444
-
PLK4
Q00444
-
Plk5
-
-
Plk5
Q4FZD7
-
Plo1
Saccharomyces pombe
-
-
Plx1
-
-
Polo kinase
-
-
Polo kinase
P52304
-
Polo kinase
-
-
polo related kinase
Q07832
-
polo-like kinase
-
-
polo-like kinase
Q9H4B4
-
polo-like kinase
-
-
polo-like kinase
Saccharomyces pombe
-
-
polo-like kinase
-
-
polo-like kinase
-
-
polo-like kinase
-
-
Polo-like kinase 1
-
-
Polo-like kinase 1
Q4KMI8
-
Polo-like kinase 1
Q6DRK7
-
Polo-like kinase 1
-
-
Polo-like kinase 1
Q5UES2
-
Polo-like kinase 1
-
-
Polo-like kinase 1
-
-
polo-like kinase 2
Q9NYY3
-
polo-like kinase 2
P53351
-
polo-like kinase 3
-
-
polo-like kinase 3
Q9H4B4
-
polo-like kinase 4
Q00444
-
polo-like kinase 5
-
-
polo-like kinase 5
Q4FZD7
-
polo-like kinase PLK-1
P34331
-
polo-like kinase-1
-
-
polo-like kinase-1
Q62673
-
polo-like kinase-2
-
-
polo-like-kinase 1
P53350
-
Prk
Q9H4B4
-
Proliferation-related kinase
-
-
-
-
protein kinase polo
P52304
-
Sak
Q64702
-
serine/threonine-protein kinase PLK
P53350
-
serine/threonine-protein kinase PLK
Q07832
-
serine/threonine-protein kinase plk-1
P34331
-
serine/threonine-protein kinase plk-2
Q9N2L7
-
serine/threonine-protein kinase plk-3
Q20845
-
serine/threonine-protein kinase plo1
P50528
-
serine/threonine-protein kinase SNK
P53351
-
serine/threonine-protein kinase SNK
Q9R012
-
SMK/PLK-AKIN kinase
Q64702
-
SmPlk1
Q5UES2
-
zPlk1
-
-
zPlk1
Q4KMI8
-
zPlk1
Q6DRK7
-
HsPlk1
-
-
additional information
-
the enzyme belongs to the family of polo-like kinases
CAS REGISTRY NUMBER
COMMENTARY
149433-93-2
Polo kinase
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
diverse strains
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
Plk3
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
female Wistar rats
SwissProt
Manually annotated by BRENDA team
diverse strains derived from strain W303
-
-
Manually annotated by BRENDA team
strains isogenic to BY4741
-
-
Manually annotated by BRENDA team
Saccharomyces pombe
-
-
-
Manually annotated by BRENDA team
gene plo1, diverse strains and genotypes
-
-
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
GENERAL STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
association with Hsp90 at the centrosome stabilizes the enzyme
-