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Literature summary for 2.7.11.18 extracted from

  • Shin, D.H.; Chun, Y.S.; Lee, K.H.; Shin, H.W.; Park, J.W.
    Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase (2009), PLoS ONE, 4, e7451.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.18

Inhibitors

Inhibitors Comment Organism Structure
human arrest defective-1 human arrest defective-1 is a bona fide regulator of MLCK, human arrest defective-1 associates with an IgG motif of MLCK and acetylates the Lys-608 residue in this motif and by so doing deactivates MLCK Homo sapiens
ML-7
-
 Homo sapiens
ML-9
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
HT-1080 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + myosin light chain
-
 Homo sapiens ADP + myosin light chain phosphate
-
 ?

Synonyms

Synonyms Comment Organism
MLCK
-
 Homo sapiens
myosin light chain kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
Calmodulin
-
 Homo sapiens