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Literature summary for 2.7.10.1 extracted from

  • Mphahlele, M.; Paumo, H.; Choong, Y.
    Synthesis and in vitro cytotoxicity of the 4-(halogenoanilino)-6-bromoquinazolines and their 6-(4-fluorophenyl) substituted derivatives as potential inhibitors of epidermal growth factor receptor tyrosine kinase (2017), Pharmaceuticals, 10, 87 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.10.1

Inhibitors

Inhibitors Comment Organism Structure
6-bromo-2-(4-chlorophenyl)-N-(2,4-difluorophenyl)quinazolin-4-amine
-
 Homo sapiens
6-bromo-2-(4-chlorophenyl)-N-(2-fluorophenyl)quinazolin-4-amine
-
 Homo sapiens
erlotinib
-
 Homo sapiens
gefitinib
-
 Homo sapiens
[2-(4-chlorophenyl)-6-(4-fluorophenyl)quinazolin-4-yl]-2,4-difluorophenylamine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P00533
-
-

Synonyms

Synonyms Comment Organism
EGFR-TK
-
 Homo sapiens
epidermal growth factor receptor tyrosine kinase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000013
-
 gefitinib pH and temperature not specified in the publication Homo sapiens
0.000022
-
 [2-(4-chlorophenyl)-6-(4-fluorophenyl)quinazolin-4-yl]-2,4-difluorophenylamine pH and temperature not specified in the publication Homo sapiens
0.0002
-
 6-bromo-2-(4-chlorophenyl)-N-(2-fluorophenyl)quinazolin-4-amine pH and temperature not specified in the publication Homo sapiens
0.000337
-
 6-bromo-2-(4-chlorophenyl)-N-(2,4-difluorophenyl)quinazolin-4-amine pH and temperature not specified in the publication Homo sapiens
0.000414
-
 erlotinib pH and temperature not specified in the publication Homo sapiens