Application | Comment | Organism |
---|---|---|
medicine | EGFR protein is overexpressed in 65% of cases recurrent glioblastoma multiformes. EGFR protein overexpression is associated with EGFR gene amplification in 35% of cases, and with high polysomy in 15% of cases. Mutations in the kinase domain are absent in recurrent glioblastoma multiforme, and this may be a preponderant factor in the lack of major clinical responses of tyrosine kinase inhibitors in glioblastoma multiforme. Responsiveness to EGFR kinase inhibitors is strongly associated with coexpression of EGFRvIII and PTEN | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
EGFR kinase | - |
Homo sapiens |
EGFR tyrosine kinase | - |
Homo sapiens |