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Literature summary for 2.7.10.1 extracted from

  • Mohammadi, M.; Dionne, C.A.; Li, W.; Li, N.; Spivak, T.; Honegger, A.M.; Jaye, M.; Schlessinger, J.
    Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis (1992), Nature, 358, 681-684.
    View publication on PubMed
Search for more literature for 2.7.10.1

Protein Variants

Protein Variants Comment Organism
Y766F the Y766F FGF receptor mutant is unable to associate with tyrosine-phosphorylate PLC gamma or to stimulate hydrolysis of phosphatidylinositol. Nevertheless, the Y766F FGF receptor mutant can be autophosphorylated, and can phosphorylate several cellular proteins and stimulate DNA synthesis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + phospholipase C gamma Homo sapiens growth factor-induced tyrosine phosphorylation of PLC gamma is essential for stimulation of phosphatidylinositol hydrolysis in vitro and in vivo ADP + phosphorylated phospholipase C gamma
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P11362
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-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of the conserved Tyr 766 of the FGF receptor is essential for phosphorylation of PLC gamma and for hydrolysis of phosphatidylinositol Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + phospholipase C gamma
-
 Homo sapiens ADP + phosphorylated phospholipase C gamma
-
 ?
ATP + phospholipase C gamma growth factor-induced tyrosine phosphorylation of PLC gamma is essential for stimulation of phosphatidylinositol hydrolysis in vitro and in vivo Homo sapiens ADP + phosphorylated phospholipase C gamma
-
 ?

Synonyms

Synonyms Comment Organism
basic fibroblast growth factor receptor 1
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 Homo sapiens