Application | Comment | Organism |
---|---|---|
medicine | deficiency for diacylglycerol kinase zeta results in impaired interleukin 12 and tumor necrosis factor alpha production following toll-like receptor stimulation in vitro and in vivo, increased resistance to endotoxin shock, and enhanced susceptibility to Toxoplasma gondii infection | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | deficiency for diacylglycerol kinase zeta results in impaired interleukin 12 and tumor necrosis factor alpha production following toll-like receptor stimulation in vitro and in vivo, increased resistance to endotoxin shock, and enhanced susceptibility to Toxoplasma gondii infection. Deficiency results in increased activation of the phosphatidylinositol 3-kinase-Akt pathway. Inhibition of phosphatidylinositol 3-kinase activity or treatment with phosphatidic acid can restore lipopolysaccharide-induced interleukin 12 production by diacylglycerol kinase zeta-deficient mice | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus | Q80UP3 | diacylglycerol kinase zeta | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
dendritic cell | - |
Mus musculus | - |
macrophage | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DGKzeta | - |
Mus musculus |