Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | cell methionine and S-adenosylmethionine contents increase in response to hyperoxia in SAE and A549 cells, enzyme activity increases by 2fold within 5 days, S-adenosylmethionine content by 5fold, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
cloning and sequencing of the MAT 2A cDNA from lung epithelial cells reveals one silent nucleotide substitution compared to that expressed in Jurkat cells | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | - |
Homo sapiens | |
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-methionine + H2O | Homo sapiens | rate-limiting enzyme of the S-adenosyl-L-methionine synthesis pathway, cell methionine and S-adenosylmethionine contents increase in response to hyperoxia in SAE and A549 cells, overview | phosphate + diphosphate + S-adenosyl-L-methionine | - |
? | |
additional information | Homo sapiens | transmethylation and transsulfuration pathways, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P31153 | lung epithelial isoform and Jurkat cell isozyme of MAT 2A | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
epithelial cell | lung epithelial isoform of MAT 2A | Homo sapiens | - |
JURKAT cell | Jurkat cell isoform of MAT 2A | Homo sapiens | - |
lung | lung epithelial isoform of MAT 2A, epithelial-like and primary small airway epithelial, SAE, cells | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-methionine + H2O | - |
Homo sapiens | phosphate + diphosphate + S-adenosyl-L-methionine | - |
? | |
ATP + L-methionine + H2O | rate-limiting enzyme of the S-adenosyl-L-methionine synthesis pathway, cell methionine and S-adenosylmethionine contents increase in response to hyperoxia in SAE and A549 cells, overview | Homo sapiens | phosphate + diphosphate + S-adenosyl-L-methionine | - |
? | |
additional information | transmethylation and transsulfuration pathways, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAT | - |
Homo sapiens |
methionine adenosyl transferase 2A | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |