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Literature summary for 2.5.1.54 extracted from

  • Walker, S.R.; Jiao, W.; Parker, E.J.
    Synthesis and evaluation of dual site inhibitors of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (2011), Bioorg. Med. Chem. Lett., 21, 5092-5097.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
[(1E)-7-bromo-2-carboxyhept-1-en-1-yl]phosphonate inhibitor based on vinyl phosphonate, designed to fit into the binding sites of both phosphoenolpyruvate and D-erythrose 4-phosphate substrates simultaneously. Competitive with respect to phosphoenolpyruvate Escherichia coli
[2-carboxy-7-(phosphonatooxy)hept-1-en-1-yl]phosphonate inhibitor based on vinyl phosphonate ratio Z:E enantiomer 1:1. Inhibitor is designed to fit into the binding sites of both phosphoenolpyruvate and D-erythrose 4-phosphate substrates simultaneously. Competitive with respect to phosphoenolpyruvate Escherichia coli
[2-carboxy-7-(phosphonatooxy)hept-2-en-1-yl]phosphonate inhibitor based on allyl phosphonate, ratio Z:E enantiomer 7:3. Inhibitor is designed to fit into the binding sites of both phosphoenolpyruvate and D-erythrose 4-phosphate substrates simultaneously. Competitive with respect to phosphoenolpyruvate Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0036
-
pH not specified in the publication, temperature not specified in the publication Escherichia coli [(1E)-7-bromo-2-carboxyhept-1-en-1-yl]phosphonate
0.0053
-
pH not specified in the publication, temperature not specified in the publication Escherichia coli [2-carboxy-7-(phosphonatooxy)hept-1-en-1-yl]phosphonate
0.154
-
pH not specified in the publication, temperature not specified in the publication Escherichia coli [2-carboxy-7-(phosphonatooxy)hept-2-en-1-yl]phosphonate