Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.54 extracted from

  • Furdui, C.; Zhou, L.; Woodard, R.W.; Anderson, K.S.
    Insights into the mechanism of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (Phe) from Escherichia coli using a transient kinetic analysis (2004), J. Biol. Chem., 279, 45618-45625.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+
-
Escherichia coli
Mn2+
-
Escherichia coli
Zn2+
-
Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
isoform AroG
-

Reaction

Reaction Comment Organism Reaction ID
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate product release is rate-limiting, rate constant for product formation is higher with Mn2+ than with Zn2+ or Cu2+. Role of metal ion is to position the amino acids with the appropriate geometry required to coordinate and activate the water molecule Escherichia coli