Literature summary for 2.4.1.198 extracted from

Sobering, A.K.; Watanabe, R.; Romeo, M.J.; Yan, B.C.; Specht, C.A.; Orlean, P.; Riezman, H.; Levin, D.E.
Yeast Ras regulates the complex that catalyzes the first step in GPI-anchor biosynthesis at the ER (2004), Cell, 117, 637-648.

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Protein Variants

Protein Variants	Comment	Organism
additional information	subunit eri1 deletion mutant, displays growth arrest at 37°C and cell wall defect at permissive temperature, defect is suppressed by increased UDP-GlcNAc levels. Mutant also accumulates chitin and is deficient in maturation of glucosamine phosphatidyl-inositol anchor proteins in the ER	Saccharomyces cerevisiae

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	GTP-bound Ras2 protein associates in vivo with enzyme complex and inhibits its activity. Ras2 associates with enzyme complex subunit Eri1	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Subunits

Subunits	Comment	Organism
More	GTP-bound Ras2 protein associates in vivo with enzyme complex and inhibits its activity	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)