Application | Comment | Organism |
---|---|---|
medicine | - |
Homo sapiens |
medicine | inhibitor 5,10-dideazatetrahydrofolate is antiproliferate and cytotoxic against mammalian tumor cells in culture and have broad spectrum activity against transplantable mouse tumors and human tumor xenografts | Mus musculus |
Cloned (Comment) | Organism |
---|---|
cloned and expressed in Escherichia coli BL21(DE3)pLysS | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(6R)-5,10-dideazatetrahydrofolate | lometrexol | Homo sapiens | |
(6R)-dideazatetrahydrofolate diglutamate | LY235340 | Homo sapiens | |
(6R)-dideazatetrahydrofolate diglutamate | LY235340 | Mus musculus | |
(6R)-dideazatetrahydrofolate pentaglutamate | LY235542 | Homo sapiens | |
(6R)-dideazatetrahydrofolate pentaglutamate | LY235542 | Mus musculus | |
(6R)-dideazatetrahydrofolate tetraglutamate | LY266978 | Homo sapiens | |
(6R)-dideazatetrahydrofolate tetraglutamate | LY266978 | Mus musculus | |
(6R)-dideazatetrahydrofolate triglutamate | LY235337 | Homo sapiens | |
(6R)-dideazatetrahydrofolate triglutamate | LY235337 | Mus musculus | |
(6S)-dideazatetrahydrofolate | LY243246 | Homo sapiens | |
(6S)-dideazatetrahydrofolate | LY243246 | Mus musculus | |
2',5'-furan-dideazatetrahydrofolate | LY222306 | Homo sapiens | |
2',5'-furan-dideazatetrahydrofolate | LY222306 | Mus musculus | |
2',5'-thiophene dideazatetrahydrofolate | LY309886, diastereomer A; LY309887, diastereomer B | Homo sapiens | |
2',5'-thiophene dideazatetrahydrofolate | LY309886, diastereomer A; LY309887, diastereomer B | Mus musculus | |
5,10-dideazatetrahydrofolate | - |
Homo sapiens | |
5,10-dideazatetrahydrofolate | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Mus musculus | - |
tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Homo sapiens | - |
tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Mus musculus | - |
mouse | - |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colonic cancer cell | xenograft HXGC3, HC1 and VRC5 | Homo sapiens | - |
lymphosarcoma cell | 6C3HED | Mus musculus | - |
mammary carcinoma cell | 3CH | Mus musculus | - |
PANC-1 cell | xenograft, pancreatic carcinoma | Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Mus musculus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Homo sapiens | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? |