Inhibitors | Comment | Organism | Structure |
---|---|---|---|
adenosine dialdehyde | - |
Rattus norvegicus | |
S-adenosylhomocysteine | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein L-isoaspartate | Rattus norvegicus | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PC-12 cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein L-isoaspartate | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PIMT | - |
Rattus norvegicus |
protein L-isoaspartyl methyltransferase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition suppresses basic fibroblast growth factor-mediated neuronal differentiation of PC-12 cells. Enzyme deficiency inhibits neuronal differentiation of PC-12 cells by suppressing phosphorylation of MEK1/2 and ERK1/2 in the MAPK signaling pathway and Akt and mTOR in the PI3K/Akt signaling pathway | Rattus norvegicus |
physiological function | the enzyme is critical for basic fibroblast growth factor-mediated neuronal differentiation of PC-12 cells and regulates the MAPK and Akt signaling pathways | Rattus norvegicus |