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Literature summary for 2.1.1.77 extracted from

  • Furuchi, T.; Sakurako, K.; Katane, M.; Sekine, M.; Homma, H.
    The role of protein L-isoaspartyl/D-aspartyl O-methyltransferase (PIMT) in intracellular signal transduction (2010), Chem. Biodivers., 7, 1337-1348.
    View publication on PubMed
Search for more literature for 2.1.1.77

Inhibitors

Inhibitors Comment Organism Structure
S-adenosyl-L-homocysteine
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.055
-
 7-nitro-2,1,3-benzoxadiazole-labeled delta sleep-inducing peptide L-isoaspartate pH not specified in the publication, at 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + protein D-aspartate Homo sapiens
-
 S-adenosyl-L-homocysteine + protein D-aspartate methyl ester
-
 ?
S-adenosyl-L-methionine + protein L-isoaspartate Homo sapiens
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate methyl ester
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 7-nitro-2,1,3-benzoxadiazole-labeled delta sleep-inducing peptide L-isoaspartate
-
 Homo sapiens S-adenosyl-L-homocysteine + 7-nitro-2,1,3-benzoxadiazole-labeled delta sleep-inducing peptide L-isoaspartate methyl ester
-
 ?
S-adenosyl-L-methionine + protein D-aspartate
-
 Homo sapiens S-adenosyl-L-homocysteine + protein D-aspartate methyl ester
-
 ?
S-adenosyl-L-methionine + protein L-isoaspartate
-
 Homo sapiens S-adenosyl-L-homocysteine + protein L-isoaspartate methyl ester
-
 ?

Synonyms

Synonyms Comment Organism
L-isoaspartyl/D-aspartyl O-methyltransferase
-
 Homo sapiens
PIMT
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme activity and expression are 50% lower in the hippocampus of epileptic patients down

General Information

General Information Comment Organism
malfunction silencing enzym expression results in the accumulation of proteins with racemized or isomerized Asp residues. Suppression of enzyme expression leads to epidermal growth factor-stimulated hyperactivation of the MAP-kinase Homo sapiens
physiological function protein L-isoaspartyl/D-aspartyl O-methyltransferase is a repair enzyme that initiates the conversion of L-isoaspartyl (or D-Asp) residues to L-aspartyl residues. Isomerization of Asn or Asp residues, and the repair of atypical residues by PIMT plays a role in the posttranslational regulation of protein activity. The repair of abnormal residues by the enzyme is essential for maintenance of the central nervous system Homo sapiens