Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(-)-epigallocatechin-3-O-gallate | IC50: 0.05-0.07 nM for the O-methylation of 2-hydroxyestradiol, IC50: 200-500 nM for O-methylation of 4-hydroxyestradiol | Homo sapiens | |
catechin | IC50: 14-17 nM for the O-methylation of 2-hydroxyestradiol, IC50: 0.005-0.007 mM for O-methylation of 4-hydroxyestradiol | Homo sapiens | |
epicatechin | IC50: 44-65 nM for the O-methylation of 2-hydroxyestradiol, IC50: 0.01-0.018 mM for O-methylation of 4-hydroxyestradiol | Homo sapiens | |
fisetin | IC50: 0.0033-0.0045 nM for the O-methylation of 2-hydroxyestradiol, IC50: 0.0026-0.0042 nM for O-methylation of 4-hydroxyestradiol | Homo sapiens | |
quercetin | IC50: 0.0009-0.0015 mM for the O-methylation of 2-hydroxyestradiol, IC50: 0.0005-0.0012 mM for O-methylation of 4-hydroxyestradiol | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 2-hydroxyestradiol | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + 4-hydroxyestradiol | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
COMT | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00004 | 0.00007 | IC50: 0.04-0.07 microM for the O-methylation of 2-hydroxyestradiol | Homo sapiens | (-)-epigallocatechin-3-O-gallate | |
0.00037 | 0.00046 | IC50: 0.37-0.46 microM for O-methylation of 4-hydroxyestradiol | Homo sapiens | (-)-epigallocatechin-3-O-gallate | |
0.0005 | 0.0012 | IC50: 0.0009-0.0015 mM for the O-methylation of 2-hydroxyestradiol, IC50: 0.0005-0.0012 mM for O-methylation of 4-hydroxyestradiol | Homo sapiens | quercetin | |
0.0026 | 0.0042 | IC50: 0.0026-0.0042 mM for O-methylation of 4-hydroxyestradiol | Homo sapiens | fisetin | |
0.0033 | 0.0045 | IC50: 0.0033-0.0045 mM for the O-methylation of 2-hydroxyestradiol | Homo sapiens | fisetin | |
0.005 | 0.007 | IC50: 14-17 nM for the O-methylation of 2-hydroxyestradiol, IC50: 0.005-0.007 mM for O-methylation of 4-hydroxyestradiol | Homo sapiens | catechin | |
0.01 | 0.018 | IC50: 44-65 nM for the O-methylation of 2-hydroxyestradiol, IC50: 0.01-0.018 mM for O-methylation of 4-hydroxyestradiol | Homo sapiens | epicatechin |