Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + DNA | Homo sapiens | DNMT3B interacts with several components of the condensin complex (hCAP-C,hCAP-E and hCAP-G) and KIF4A. Condensin mediates genome-wide chromosome condensation at the onset of mitosis and is critical for proper segregation of sister chromatids. KIF4A is proposed to be a motor protein carrying DNA as cargo. DNMT3B also interacts with histone deacetylase 1 (HDAC1), the co-repressor SIN3A and the ATP-dependent chromatin remodeling enzyme hSNF2H. DNMT3B co-localizes with condensin and KIF4A on condensed chromosomes throughout mitosis, direct link between the machineries regulating DNA methylation and mitotic chromosome condensation. DNMT3B may have a previously unrecognized function during the mitotic phase of the cell cycle | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UBC3 | - |
- |
Purification (Comment) | Organism |
---|---|
DNMT3B copurifies with several components of the condensin complex and KIF4A | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + DNA | DNMT3B interacts with several components of the condensin complex (hCAP-C,hCAP-E and hCAP-G) and KIF4A. Condensin mediates genome-wide chromosome condensation at the onset of mitosis and is critical for proper segregation of sister chromatids. KIF4A is proposed to be a motor protein carrying DNA as cargo. DNMT3B also interacts with histone deacetylase 1 (HDAC1), the co-repressor SIN3A and the ATP-dependent chromatin remodeling enzyme hSNF2H. DNMT3B co-localizes with condensin and KIF4A on condensed chromosomes throughout mitosis, direct link between the machineries regulating DNA methylation and mitotic chromosome condensation. DNMT3B may have a previously unrecognized function during the mitotic phase of the cell cycle | Homo sapiens | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA methyltransferase | - |
Homo sapiens |
DNMT3B | - |
Homo sapiens |