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Literature summary for 2.1.1.100 extracted from
- Isoprenylcysteine carboxylmethyltransferase function is essential for RAB4A-mediated integrin beta3 recycling, cell migration and cancer metastasis (2017), Oncogene, 36, 5757-5767 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | inhibition of ICMT significantly reduces cell migration in vitro and cancer invasion and metastasis in vivo. The role of ICMT is mediated by regulator RAB4A. ICMT catalyzed carboxylmethylation is critical for RAB4A activation and interaction with effectors, its localization to endosomes and recycling vesicles, and hence important for RAB4A-dependent integrin beta3 recycling to plasma membrane | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cysmethynil | - |
Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O60725 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MCF-7 cell | - |
Homo sapiens | - |
| MDA-MB-231 cell | - |
Homo sapiens | - |
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Release 2023.1 (January 2023)
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