Information on EC 2.1.1.100 - protein-S-isoprenylcysteine O-methyltransferase

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The expected taxonomic range for this enzyme is: Eukaryota, Archaea

EC NUMBER
COMMENTARY hide
2.1.1.100
-
RECOMMENDED NAME
GeneOntology No.
protein-S-isoprenylcysteine O-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
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-
Terpenoid backbone biosynthesis
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-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase
C-terminal S-geranylgeranylcysteine and S-geranylcysteine residues are also methylated, but more slowly.
CAS REGISTRY NUMBER
COMMENTARY hide
130731-20-3
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
Pseudoceratina sp.
strain 1247
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-
Manually annotated by BRENDA team
Pseudoceratina sp. 1247
strain 1247
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + (RhoAA) C-terminal S-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + (RhoA) C-terminal S-farnesyl-L-cysteine methyl ester
show the reaction diagram
S-adenosyl-L-methionine + 4-benzoyl-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-L-phenylalanyl-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + biotin-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + biotin-farnesyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + biotin-Peg4-K(5-Fam)YIIKGVFWDPAC(C10-Dia-zirine)-OH
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + biotin-Peg4-K(5-Fam)YIIKGVFWDPAC(C5-m-BP)-OH
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + biotin-Peg4-YIIKGVFWDPAC(C10-meta-Bp)
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + biotin-Peg4-YIIKGVFWDPAC(C10-para-Bp)
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + biotin-Peg4-YIIKGVFWDPAC(C5-meta-Bp)
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + biotin-Peg4-YIIKGVFWDPAC(C5-para-Bp)
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + biotin-Peg4-YIIKGVFWDPAC(Fr)-OH
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + biotin-S-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + biotin-S-farnesyl-L-cysteine methyl ester
show the reaction diagram
S-adenosyl-L-methionine + farnesylated and Rce1-proteolyzed K-Ras protein
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + N-acetyl-S-(3-(3-methylbut-2-enyl)-7,11-dimethyldodeca-2Z,6E,10-trien-1-yl)-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-(3-(3-methylbut-2-enyl)-7,11-dimethyldodeca-2Z,6E,10-trien-1-yl)-L-cysteine methyl ester
show the reaction diagram
-
relatively good substrate for the human Icmt enzyme
-
-
?
S-adenosyl-L-methionine + N-acetyl-S-(E)-geranyl-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-(E)-geranyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + N-acetyl-S-all trans-geranylgeranyl-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-all trans-geranylgeranyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
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S-adenosyl-L-methionine + N-acetyl-S-farnesyl-L-cysteine
?
show the reaction diagram
S-adenosyl-L-methionine + N-acetyl-S-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-farnesyl-L-cysteine methyl ester
show the reaction diagram
S-adenosyl-L-methionine + N-acetyl-S-geranylgeranyl-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-geranylgeranyl-L-cysteine methyl ester
show the reaction diagram
S-adenosyl-L-methionine + N-acetyl-S-geranylgeranyl-L-cysteine methyl ester
S-adenosyl-L-homocysteine + N-acetyl-S-geranylgeranyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine methyl ester
show the reaction diagram
-
no activity with + N-acetyl-S-geranylgeranyl-L-cysteinyl-S-geranylgeranyl-L-cysteine
-
?
S-adenosyl-L-methionine + N-acetyl-S-trans,trans-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-trans,trans-farnesyl-L-cysteine methyl ester
show the reaction diagram
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-
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S-adenosyl-L-methionine + N-acetyl-S-[(2E,6E)-farnesyl]-L-cysteine
S-adenosyl-L-homocysteine + N-acetyl-S-[(2E,6E)-farnesyl]-L-cysteine methyl ester
show the reaction diagram
S-adenosyl-L-methionine + N-biotinyl-S-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + N-biotinyl-S-farnesyl-L-cysteine methyl ester
show the reaction diagram
S-adenosyl-L-methionine + N-biotinyl-S-farnesyl-L-cysteine peptide
S-adenosyl-L-homocysteine + biotin S-farnesyl-L-cysteine peptide methyl ester
show the reaction diagram
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-
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S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
show the reaction diagram
S-adenosyl-L-methionine + Ras protein C-terminal S-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + Ras protein C-terminal S-farnesyl-L-cysteine methyl ester
show the reaction diagram
S-adenosyl-L-methionine + Ras2p
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + S-[(2E,6E)-farnesyl]-3-sulfanylpropanoic acid
S-adenosyl-L-homocysteine + methyl S-[(2E,6E)-farnesyl]-3-sulfanylpropanoate
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + S-[(2E,6E)-farnesyl]-sulfanylacetic acid
S-adenosyl-L-homocysteine + methyl S-[(2E,6E)-farnesyl]-sulfanylacetate
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
-
?
S-adenosylmethionine + N-((benzoylglycyl)glycyl)-S-farnesyl-L-cysteine
S-adenosylhomocysteine + N-((benzoylglycyl)glycyl)-S-farnesyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + N-(benzoylglycyl)-S-farnesyl-L-cysteine
S-adenosylhomocysteine + N-(benzoylglycyl)-S-farnesyl-L-cysteine methyl ester
show the reaction diagram
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-
-
?
S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-D-cysteine
S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-D-cysteine methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-L-cysteine
S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester
show the reaction diagram
S-adenosylmethionine + N-acetyl-S-3,3-dimethylallyl-L-cysteine
S-adenosylhomocysteine + N-acetyl-S-3,3-dimethylallyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + N-isobutyryl-S-farnesyl-L-cysteine
S-adenosylhomocysteine + N-isobutyryl-S-farnesyl-L-cysteine methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + N-isovaleryl-S-farnesyl-L-cysteine
S-adenosylhomocysteine + N-isovaleryl-S-farnesyl-L-cysteine methyl ester
show the reaction diagram
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-
-
?
S-adenosylmethionine + S-decyl-Leu-Ala-Arg-Tyr-Lys-Cys
S-adenosylhomocysteine + S-decyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + S-farnesyl-Leu-Ala-Arg-Tyr-Lys-Cys
S-adenosylhomocysteine + S-farnesyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
show the reaction diagram
S-adenosylmethionine + S-geranyl-Leu-Ala-Arg-Tyr-Lys-Cys
S-adenosylhomocysteine + S-geranyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + S-geranylgeranyl-Leu-Ala-Arg-Tyr-Lys-Cys
S-adenosylhomocysteine + S-geranylgeranyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + S-octyl-Leu-Ala-Arg-Tyr-Lys-Cys
S-adenosylhomocysteine + S-octyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
show the reaction diagram
-
-
-
?
S-adenosylmethionine + S-pentadecyl-Leu-Ala-Arg-Tyr-Lys-Cys
S-adenosylhomocysteine + S-pentadecyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
show the reaction diagram
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-
-
?
S-adenosylmethionine + S-tridecyl-Leu-Ala-Arg-Tyr-Lys-Cys
S-adenosylhomocysteine + S-tridecyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
show the reaction diagram
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-
-
?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + (RhoAA) C-terminal S-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + (RhoA) C-terminal S-farnesyl-L-cysteine methyl ester
show the reaction diagram
-
the enzyme modulates endothelial monolayer per meability by altering RhoA carboxyl methylation and activation, thus changing the organization of intercellular junctions. Carboxy methylation of RhoA may modulate endothelial barrier function
-
-
?
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
show the reaction diagram
S-adenosyl-L-methionine + Ras protein C-terminal S-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + Ras protein C-terminal S-farnesyl-L-cysteine methyl ester
show the reaction diagram
S-adenosyl-L-methionine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine
S-adenosyl-L-homocysteine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine methyl ester
show the reaction diagram
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-
-
-
?
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
S-adenosyl-L-methionine
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Li+
-
slight stimulation
additional information
-
metal ions are required
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1-octyl-5-m-tolyl-1H-indol-3-yl)methanamine
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-
(2R)-2-(acetylamino)-3-[[(2Z)-3,4-diphenylbut-2-en-1-yl]sulfanyl]propanoic acid
-
15.7% inhibition at 0.01 mM
(2R)-2-(acetylamino)-3-[[(2Z)-4-(2-fluorophenyl)-3-phenylbut-2-en-1-yl]sulfanyl]propanoic acid
-
25.3% inhibition at 0.01 mM
(3,5-difluoro-4-methoxyphenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine
-
-
(3-chloro-4-fluorophenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine
-
-
(3-chlorophenyl)-[2-(2,2-dimethyl-4-thiophen-2-yltetrahydropyran-4-yl)ethyl]amine
-
-
(4-chloro-3-fluorophenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine
-
-
(5-chloro-2-fluorophenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine
-
-
(R)-2-(2-((benzyloxy)methyl)benzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)-thio)propanoic acid
-
-
(R)-2-(2-(phenoxymethyl)benzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid
-
-
(R)-2-(2-(phenylthio)benzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid
-
-
(R)-2-(2-benzylbenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid
-
-
(R)-2-(2-phenoxybenzamido)-3-(((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl)thio)propanoic acid
-
-
(R)-2-(2-phenoxybenzamido)-3-(undecylthio)propanoic acid
-
-
(R)-2-(3-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid
-
-
(R)-2-(4-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid
-
-
(R)-2-(dibenzo[b,d]furan-4-carboxamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)-propanoic acid
-
-
(R)-2-(N-methyl-2-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid
-
-
(R,E)-3-((3,7-dimethylocta-2,6-dien-1-yl)thio)-2-(2-phenoxybenzamido)propanoic acid
-
-
(S)-2-(2-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid
-
-
(S)-glabrol
-
structure determination, overview
1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-(3-fluorophenyl)thiourea
-
-
1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-(3-methoxphenyl)urea
-
-
1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-(3-methoxyphenyl)thiourea
-
-
1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-phenylthiourea
-
-
1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-3-(morpholin-4-ylmethyl)-1H-indole
-
-
1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-3-(piperidin-1-ylmethyl)-1H-indole
-
-
1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-3-[(morpholin-4-yl)methyl]-1H-indole
-
-
-
1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-3-[(piperidin-1-yl)methyl]-1H-indole
-
-
-
1-(3-chlorophenyl)-3-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)thiourea
-
-
1-(3-chlorophenyl)-3-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)urea
-
-
1-(3-methylbut-2-enyl)-5-m-tolyl-1H-indole
-
-
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
-
22% inhibition
1-octyl-5-(3-methylphenyl)-1H-indole
-
a cysmethynil analogue
1-octyl-5-m-tolyl-1H-indole
-
-
1-octyl-5-m-tolyl-1H-indole-3-carboxamide
-
-
1-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methanamine
-
-
-
2'-methoxy-3',3''-diprenyl-licodione
-
isolated from Hovea parvicalyx, collected in Australia, structure determination, overview
2'-methoxy-3'-prenyllicodione
-
isolated from Hovea parvicalyx, collected in Australia, structure determination, overview
2-(1-octyl-1H-indol-3-yl)acetamide
-
-
2-(1-octyl-5-phenyl-1H-indol-3-yl)acetamide
-
-
2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-N-(3-methoxyphenyl)acetamide
-
-
2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-N-phenylacetamide
-
-
2-(5-(3-ethoxyphenyl)-1-octyl-1H-indol-3-yl)-N,N-diethylacetamide
-
-
2-(5-fluoro-1-(3-methylbut-2-enyl)-1H-indol-3-yl)acetamide
-
-
2-(5-fluoro-1-octyl-1H-indol-3-yl)acetamide
-
-
2-Carboxy-2'-hydroxy-5'-sulfoformazylbenzene
-
IC50: 1.1 mM
2-phenoxy-phenylfarnesylcysteine
-
low micromolar inhibitor
2-[1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-1H-indol-3-yl]acetamide
-
-
-
2-[1-[(2E,6E)-2,6-dimethylocta-2,6-dien-1-yl]-5-(3-methylphenyl)-1H-indol-3-yl]acetamide
-
-
-
2-[5-(2-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
-
-
2-[5-(3-ethoxyphenyl)-1-octyl-1H-indol-3-yl]-N,N-diethylacetamide
-
-
-
2-[5-(3-ethoxyphenyl)-1-octyl-1H-indol-3-yl]acetamide
-
-
2-[5-(3-ethylphenyl)-1-octyl-1H-indol-3-yl]acetamide
-
-
-
2-[5-(3-fluorophenyl)-1-(2-methylidenebut-3-en-1-yl)-1H-indol-3-yl]acetamide
-
-
-
2-[5-(3-fluorophenyl)-1-octyl-1H-indol-3-yl]acetamide
-
-
-
2-[5-(3-methoxyphenyl)-1-octyl-1H-indol-3-yl]acetamide
-
-
2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(4-methylpiperazin-1-yl)ethan-1-one
-
-
-
2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(4-methylpiperazin-1-yl)ethanone
-
-
2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(piperidin-1-yl)ethan-1-one
-
-
-
2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(piperidin-1-yl)ethanone
-
-
2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(pyrrolidin-1-yl)ethan-1-one
-
-
-
2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(pyrrolidin-1-yl)ethanone
-
-
2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
-
-
-
2-[5-(3-methylphenyl)-1-[3-(trifluoromethyl)benzyl]-1H-indol-3-yl]acetamide
-
-
2-[5-(3-methylphenyl)-1-[[3-(trifluoromethyl)phenyl]methyl]-1H-indol-3-yl]acetamide
-
-
-
2-[5-(3-methylphenyl)-1H-indol-3-yl]acetamide
-
-
2-[5-(4-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
-
-
2-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl]ethanol
-
-
-
2-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl](phenyl)amino]-1-(furan-2-yl)ethanone
-
-
2584 Da liver peptide
-
0.000071 mM, 50% inhibition
-
3,4-dichloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2Hpyran-4-yl)ethyl]aniline
-
-
3,5-dichloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline
-
-
3-(1-octyl-5-m-tolyl-1H-indol-3-yl)propanamide
-
-
3-(2,2-dimethyloxan-4-yl)-N-[(4-methoxyphenyl)methyl]-3-phenylpropan-1-amine
-
-
-
3-([(2E)-3-methyl-5-[4-(2-phenylethyl)-1H-1,2,3-triazol-1-yl]pent-2-en-1-yl]sulfanyl)propanoic acid
-
75% residual activity at 0.01 mM
3-([(2E)-3-methyl-5-[4-(3-methylbutyl)-1H-1,2,3-triazol-1-yl]pent-2-en-1-yl]sulfanyl)propanoic acid
-
modest inhibitor, 72% residual activity at 0.01 mM
3-([(2E)-3-methyl-5-[4-(naphthalen-1-yl)-1H-1,2,3-triazol-1-yl]pent-2-en-1-yl]sulfanyl)propanoic acid
-
poor inhibitor, 77% residual activity at 0.01 mM
3-([(2E)-3-methyl-5-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl]pent-2-en-1-yl]sulfanyl)propanoic acid
-
89% residual activity at 0.01 mM
3-([(2E)-3-methyl-5-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]pent-2-en-1-yl]sulfanyl)propanoic acid
-
poor inhibitor, 80% residual activity at 0.01 mM
3-([(2E)-5-[4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl)propanoic acid
-
poor inhibitor, 87% residual activity at 0.01 mM
3-([(2E)-5-[4-(4-tert-butylphenyl)-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl)propanoic acid
-
poor inhibitor, 88% residual activity at 0.01 mM
3-chloro-4-methyl-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)ethyl]aniline
-
-
3-chloro-4-methyl-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]aniline
-
-
3-chloro-N-(3-chlorophenyl)-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydropyran-4-yl)ethyl]aniline
-
-
3-chloro-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)-ethyl]aniline
-
-
3-chloro-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydrothiopyran-4-yl)ethyl]aniline
-
-
3-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-4-methylaniline
-
-
3-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline
-
-
3-chloro-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline
-
-
3-fluoro-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)-ethyl]aniline
-
-
3-fluoro-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline
-
-
3-methoxy-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)-ethyl]aniline
-
-
3-methoxy-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydropyran-4-yl)ethyl]aniline
-
-
3-methoxy-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydrothiopyran-4-yl)ethyl]aniline
-
-
3-methoxy-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline
-
-
3-methoxy-N-[2-[4-(4-methoxyphenyl)-2,2-dimethyltetrahydro-2H-pyran-4-yl]ethyl]aniline
-
-
3-methyl-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline
-
-
3-tert-butyl-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline
-
-
3-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethylamino]benzoic acid
-
-
3-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethylamino]phenol
-
-
3-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]phenol
-
-
-
3-[4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1H-1,2,3-triazol-1-yl]propanoic acid
-
modest inhibitor, 53% residual activity at 0.01 mM
3-[4-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-1H-1,2,3-triazol-1-yl]propanoic acid
-
modest inhibitor, 75% residual activity at 0.01 mM
3-[4-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-1H-1,2,3-triazol-1-yl]propanoic acid
-
modest inhibitor, 69% residual activity at 0.01 mM
3-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]propanamide
-
-
-
3-[[(2E)-3-methyl-5-(4-pentyl-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl]sulfanyl]propanoic acid
-
modest inhibitor, 77% residual activity at 0.01 mM
3-[[(2E)-3-methyl-5-(4-phenyl-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl]sulfanyl]propanoic acid
-
poor inhibitor, 88% residual activity at 0.01 mM
3-[[(2E)-3-methyl-5-(4-[2-[4-(thiophen-2-yl)phenyl]ethyl]-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl]sulfanyl]propanoic acid
-
63% residual activity at 0.01 mM
3-[[(2E)-3-methyl-5-[4-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1H-1,2,3-triazol-1-yl]pent-2-en-1-yl]sulfanyl]propanoic acid
-
90% residual activity at 0.01 mM
3-[[(2E)-5-(4-benzyl-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl]sulfanyl]propanoic acid
-
82% residual activity at 0.01 mM
3-[[(2E)-5-[4-[(biphenyl-4-yloxy)methyl]-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl]propanoic acid
-
75% residual activity at 0.01 mM
3-[[(2E)-5-[4-[2-(3'-cyanobiphenyl-4-yl)ethyl]-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl]propanoic acid
-
74% residual activity at 0.01 mM
3-[[(2E)-5-[4-[2-(4'-fluorobiphenyl-4-yl)ethyl]-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl]propanoic acid
-
42% residual activity at 0.01 mM
3-[[(2E)-5-[4-[2-(biphenyl-3-yl)ethyl]-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl]propanoic acid
-
74% residual activity at 0.01 mM
3-[[(2E)-5-[4-[2-(biphenyl-4-yl)ethyl]-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl]propanoic acid
-
43% residual activity at 0.01 mM
3-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]-N,N-dimethylbenzenesulfonamide
-
-
3-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]benzonitrile
-
-
4-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-3-methylaniline
-
-
4-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline
-
-
4-hydroxyphenylglyoxal
-
48% inhibition
4-tert-butyl-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline
-
-
4-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]-N-methylbenzene-1-sulfonamide
-
-
-
4-[4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1H-1,2,3-triazol-1-yl]butanoic acid
-
modest inhibitor, 83% residual activity at 0.01 mM
4-[4-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-1H-1,2,3-triazol-1-yl]butanoic acid
-
modest inhibitor, 90% residual activity at 0.01 mM
4-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]benzenesulfonamide
-
-
4-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]benzonitrile
-
-
5'-deoxymethylthioadenosine
-
-
5-(3-methylphenyl)-1-octyl-1H-indole-3-carboxamide
-
-
-
5-(3-methylphenyl)-1-octyl-3-(piperidin-1-ylmethyl)-1H-indole
-
-
5-(3-methylphenyl)-1-octyl-3-(pyrrolidin-1-ylmethyl)-1H-indole
-
-
5-(3-methylphenyl)-1-octyl-3-[(piperidin-1-yl)methyl]-1H-indole
-
-
-
5-(3-methylphenyl)-1-octyl-3-[(pyrrolidin-1-yl)methyl]-1H-indole
-
-
-
5-(3-methylphenyl)-3-(morpholin-4-ylmethyl)-1-octyl-1H-indole
-
-
5-(3-methylphenyl)-3-[(4-methylpiperazin-1-yl)methyl]-1-octyl-1H-indole
-
-
5-(3-methylphenyl)-3-[(morpholin-4-yl)methyl]-1-octyl-1H-indole
-
-
-
5-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]-N,N-dimethylpyridin-2-amine
-
-
-
5-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]pyrimidin-2-amine
-
-
-
5-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]pyrimidine-2-carbonitrile
-
-
-
5-[4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1H-1,2,3-triazol-1-yl]pentanoic acid
-
modest inhibitor, 73% residual activity at 0.01 mM
adenosine
-
plus homocysteine
aplysamine 6
biotin-Peg4-YIIKGVFWDPAC(C10-meta-Bp)
-
-
-
biotin-Peg4-YIIKGVFWDPAC(C10-para-Bp)
-
-
-
biotin-Peg4-YIIKGVFWDPAC(C5-meta-Bp)
-
-
-
biotin-Peg4-YIIKGVFWDPAC(C5-para-Bp)
-
-
-
Ca2+
-
moderate inhibition
CTAB
-
0.1%, more than 90% inhibition
Cu2+
-
complete inhibition
cysmethynil
deoxycholate
-
0.1%, 51% inhibition
Diethylpyrocarbonate
-
96% inhibition
dimethylsulfoxid
-
more than 4% cause inhibition
ethyl 4-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]amino]benzoate
-
-
ethyl [5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetate
-
-
FTI-2628
-
-
Hg2+
-
complete inhibition
iodoacetic acid
-
16% inhibition
methyl 3-([(2E)-3-methyl-5-[4-(2-phenylethyl)-1H-1,2,3-triazol-1-yl]pent-2-en-1-yl]sulfanyl)propanoate
-
69% residual activity at 0.01 mM
methyl 3-([(2E)-3-methyl-5-[4-(3-methylbutyl)-1H-1,2,3-triazol-1-yl]pent-2-en-1-yl]sulfanyl)propanoate
-
modest inhibitor, 77% residual activity at 0.01 mM
methyl 3-([(2E)-3-methyl-5-[4-(naphthalen-1-yl)-1H-1,2,3-triazol-1-yl]pent-2-en-1-yl]sulfanyl)propanoate
-
poor inhibitor, 82% residual activity at 0.01 mM
methyl 3-([(2E)-3-methyl-5-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl]pent-2-en-1-yl]sulfanyl)propanoate
-
89% residual activity at 0.01 mM
methyl 3-([(2E)-3-methyl-5-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]pent-2-en-1-yl]sulfanyl)propanoate
-
poor inhibitor, 82% residual activity at 0.01 mM
methyl 3-([(2E)-5-[4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl)propanoate
-
poor inhibitor, 91% residual activity at 0.01 mM
methyl 3-([(2E)-5-[4-(4-tert-butylphenyl)-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl)propanoate
-
poor inhibitor, 84% residual activity at 0.01 mM
methyl 3-[[(2E)-3-methyl-5-(4-nonyl-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl]sulfanyl]propanoate
-
modest inhibitor, 67% residual activity at 0.01 mM
methyl 3-[[(2E)-3-methyl-5-(4-pentyl-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl]sulfanyl]propanoate
-
modest inhibitor, 76% residual activity at 0.01 mM
methyl 3-[[(2E)-3-methyl-5-(4-phenyl-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl]sulfanyl]propanoate
-
poor inhibitor, 89% residual activity at 0.01 mM
methyl 3-[[(2E)-3-methyl-5-(4-[2-[4-(thiophen-2-yl)phenyl]ethyl]-1H-1,2,3-triazol-1-yl)pent-2-en-1-yl]sulfanyl]propanoate
-
57% residual activity at 0.01 mM
methyl 3-[[(2E)-3-methyl-5-[4-[2-(1,1':4',1''-terphenyl-4-yl)ethyl]-1H-1,2,3-triazol-1-yl]pent-2-en-1-yl]sulfanyl]propanoate
-
79% residual activity at 0.01 mM
methyl 3-[[(2E)-3-methyl-5-[4-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1H-1,2,3-triazol-1-yl]pent-2-en-1-yl]sulfanyl]propanoate
-
80% residual activity at 0.01 mM
methyl 3-[[(2E)-5-(4-benzyl-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl]sulfanyl]propanoate
-
80% residual activity at 0.01 mM
methyl 3-[[(2E)-5-[4-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl]propanoate
-
modest inhibitor, 59% residual activity at 0.01 mM
methyl 3-[[(2E)-5-[4-[(biphenyl-4-yloxy)methyl]-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl]propanoate
-
67% residual activity at 0.01 mM
methyl 3-[[(2E)-5-[4-[2-(3'-cyanobiphenyl-4-yl)ethyl]-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl]propanoate
-
30% residual activity at 0.01 mM
methyl 3-[[(2E)-5-[4-[2-(4'-fluorobiphenyl-4-yl)ethyl]-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl]propanoate
-
28% residual activity at 0.01 mM
methyl 3-[[(2E)-5-[4-[2-(biphenyl-2-yl)ethyl]-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl]propanoate
-
74% residual activity at 0.01 mM
methyl 3-[[(2E)-5-[4-[2-(biphenyl-3-yl)ethyl]-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl]propanoate
-
65% residual activity at 0.01 mM
methyl 3-[[(2E)-5-[4-[2-(biphenyl-4-yl)ethyl]-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl]propanoate
-
potent competitive inhibitor, 14% residual activity at 0.01 mM
methyl 3-[[(2E)-5-[4-[2-([1,1'-biphenyl]-4-yl)ethyl]-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl]propanoate
-
-
-
methyl ester of N-acetyl-S-farnesyl-L-cysteine
-
-
methyl [5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetate
-
-
methylthioadenosine
-
0.9 mM, 50% inhibition
Mn2+
-
moderate inhibition
mono iodoacetate
-
moderate inhibition
N'-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N,N-dimethylbenzene-1,3-diamine
-
-
N,N'-dicyclohexylcarbodiimide
-
76% inhibition
N,N-diethyl-2-(5-(3-methoxyphenyl)-1-octyl-1H-indol-3-yl)acetamide
-
-
N,N-diethyl-2-[5-(3-methoxyphenyl)-1-octyl-1H-indol-3-yl]acetamide
-
-
-
N,N-diethyl-2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
-
-
N,N-dimethyl-1-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methanamine
-
-
N,N-dimethyl-2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
-
-
N-((1-octyl-5-m-tolyl-1H-indol-3-yl)methyl)methanesulfonamide
-
-
N-(2-methylidenebut-3-en-1-yl)-2-[5-(3-methylphenyl)-1-[3-(trifluoromethyl)benzyl]-1H-indol-3-yl]acetamide
-
-
N-(2-phenoxybenzoyl)-3-[4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1H-1,2,3-triazol-1-yl]-L-alanine
-
35.9% inhibition at 0.01 mM
N-(2-phenoxybenzoyl)-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine
-
-
-
N-(3-chlorophenyl)-2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)acetamide
-
-
N-(3-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]phenyl)acetamide
-
-
N-(5-methoxy-2-nitrobenzoyl)-3-[4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1H-1,2,3-triazol-1-yl]-L-alanine
-
10.1% inhibition at 0.01 mM
N-(biphenyl-2-ylcarbonyl)-3-[4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1H-1,2,3-triazol-1-yl]-L-alanine
-
17% inhibition at 0.01 mM
N-acetyl-3-[4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1H-1,2,3-triazol-1-yl]-L-alanine
-
19.5% inhibition at 0.01 mM
N-Acetyl-S-(3-(3-methylbut-2-enyl)-5-(4-phenyl)phenylpent-2Z-en-1-yl)-L-cysteine
N-acetyl-S-(3-(3-methylbut-2-enyl)-7,11-dimethyldodeca-2Z,6E,10-trien-1-yl)-L-cysteine
-
competitive inhibitor of overexpressed yeast Icmt
N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
-
N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester
-
mixed-type vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine
N-acetyl-S-(E,E)-geranylgeranyl-L-cysteine
-
-
N-acetyl-S-farnesyl-L-cysteine
N-acetyl-S-farnesyl-L-cysteine methyl ester
-
-
N-acetyl-S-farnesyl-L-cysteine methylester
-
noncompetitive inhibition with respect to biotin-S-farnesyl-L-cysteine, mixed type inhibition with respect to S-adenosyl-L-methionine
N-acetyl-S-geranylgeranyl-L-cysteine
N-acetyl-S-[(2E)-3-methyl-4-(4-phenoxyphenoxy)but-2-en-1-yl]-L-cysteine
-
15.5% inhibition at 0.01 mM
N-acetyl-S-[(2E)-3-methyl-4-[(naphthalen-2-ylamino)oxy]but-2-en-1-yl]-L-cysteine
-
14.5% inhibition at 0.01 mM
N-acetyl-S-[(2E)-3-methyl-5-(4-octylphenyl)pent-2-en-1-yl]-L-cysteine
-
31.1% inhibition at 0.01 mM
N-acetyl-S-[(2E)-3-methyl-5-(4-pentylphenyl)pent-2-en-1-yl]-L-cysteine
-
23.1% inhibition at 0.01 mM
N-acetyl-S-[(2E)-3-methyl-5-(4-propylphenyl)pent-2-en-1-yl]-L-cysteine
-
20.7% inhibition at 0.01 mM
N-acetyl-S-[(2E)-3-methyl-7-(4-phenoxyphenoxy)hept-2-en-1-yl]-L-cysteine
-
19.4% inhibition at 0.01 mM
N-acetyl-S-[(2E)-3-methyl-7-[(naphthalen-2-ylamino)oxy]hept-2-en-1-yl]-L-cysteine
-
22.4% inhibition at 0.01 mM
N-acetyl-S-[(2E)-4-(4-benzylphenoxy)-3-methylbut-2-en-1-yl]-L-cysteine
-
9.8% inhibition at 0.01 mM
N-acetyl-S-[(2E)-5-(4-hexylphenyl)-3-methylpent-2-en-1-yl]-L-cysteine
-
18.8% inhibition at 0.01 mM
N-acetyl-S-[(2Z)-4-(biphenyl-4-yl)-3-phenylbut-2-en-1-yl]-L-cysteine
-
26.6% inhibition at 0.01 mM
N-benzyl-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]furan-2-carboxamide
-
-
N-bromosuccinimide
-
56% inhibition in the presence of S-adenosyl-L-homocysteine, 87% inhibition in the absence of S-adenosyl-L-homocysteine
N-ethyl-N-((1-(3-methylbut-2-enyl)-1H-indol-3-yl)methyl) ethanamine
-
-
N-ethyl-N-((5-fluoro-1-(3-methylbut-2-enyl)-1H-indol-3-yl)methyl)ethanamine
-
-
N-ethyl-N-([1-octyl-5-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl)ethanamine
-
-
-
N-ethyl-N-([5-[4-(methanesulfonyl)phenyl]-1-octyl-1H-indol-3-yl]methyl)ethanamine
-
-
-
N-ethyl-N-[(4-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine
-
-
-
N-ethyl-N-[(5-fluoro-1-octyl-1H-indol-3-yl)methyl]-ethanamine
-
-
N-ethyl-N-[(5-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine
-
-
-
N-ethyl-N-[(6-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine
-
-
-
N-ethyl-N-[(7-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine
-
-
-
N-ethyl-N-[[1-(2-methylidenebut-3-en-1-yl)-1H-indol-3-yl]methyl]ethanamine
-
-
-
N-ethyl-N-[[1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-1H-indol-3-yl]methyl]ethanamine
-
-
N-ethyl-N-[[1-octyl-5-(pyridin-3-yl)-1H-indol-3-yl]methyl]ethanamine
-
-
-
N-ethyl-N-[[1-octyl-5-(pyrimidin-5-yl)-1H-indol-3-yl]methyl]ethanamine
-
-
-
N-ethyl-N-[[5-(2-fluorophenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
-
-
-
N-ethyl-N-[[5-(2-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
-
-
N-ethyl-N-[[5-(3-fluorophenyl)-1-(2-methylidenebut-3-en-1-yl)-1H-indol-3-yl]methyl]ethanamine
-
-
-
N-ethyl-N-[[5-(3-fluorophenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
-
-
-
N-ethyl-N-[[5-(3-fluoropyridin-4-yl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
-
-
-
N-ethyl-N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
-
-
N-ethyl-N-[[5-(4-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
-
-
N-ethylmaleimide
N-methyl-N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]propan-2-amine
-
-
n-octyl beta-glucoside
-
0.2%, 55-75% inhibition
N-[(1-octyl-5-m-tolyl-1H-indol-3-yl)methyl]acetamide
-
-
N-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2-[5-(3-methylphenyl)-1-[3-(trifluoromethyl)benzyl]-1H-indol-3-yl]acetamide
-
-
N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydropyran-4-yl)-ethyl]aniline
-
-
N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydrothiopyran-4-yl)ethyl]aniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-2-methylaniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3,4-dimethoxyaniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3,5-dimethylaniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-(trifluoromethoxy)aniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-(trifluoromethyl)aniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-ethylaniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-fluoroaniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-isopropylaniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-methoxy-4-methylaniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-methoxyaniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-methylaniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-(trifluoromethoxy)aniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-fluoroaniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-isopropylaniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-methoxyaniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-methylaniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N,3-dimethylaniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N-methylaniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N-phenylacetamide
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]aniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-3,4-dimethylaniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-3-nitroaniline
-
-
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-4-nitroaniline
-
-
N-[2-(benzyloxy)benzoyl]-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine
-
-
N-[3-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-3-(2-methoxyphenyl)propyl]-N-(4-methoxybenzyl)furan-2-carboxamide
-
the inhibitor is competitive with respect to a prenylated methyl acceptor substrate but noncompetitive toward the S-adenosyl-L-methionine
N-[3-(phenylsulfonyl)propanoyl]-3-[4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1H-1,2,3-triazol-1-yl]-L-alanine
-
22.7% inhibition at 0.01 mM
N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]-N-(propan-2-yl)propan-2-amine
-
-
N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]-N-propylpropan-1-amine
-
-
N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]acetamide
-
-
-
N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]methanesulfonamide
-
-
-
Nonidet P40
-
0.1%, 73% inhibition
Phenylglyoxal
-
74% inhibition, inhibition increases with the alkanity of the preincubation medium, S-adenosyl-L-methionine protects against inhibition
retinoic acid
-
20% decrease of N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation in cells treated with 0.01 mM retinoic acid
S-(Geranylgeranyl-2-thio)acetic acid
-
-
S-adenosyl-L-homocysteine
S-adenosylethionine
-
-
S-farnesyl thiosalicylic acid
S-farnesyl-4-chlorothiosalicylic acid
-
-
S-farnesyl-4-fluorothiosalicylic acid
-
-
S-farnesyl-5-chlorothiosalicylic acid
-
-
S-farnesyl-5-fluorothiosalicylic acid
-
-
S-Farnesylthioacetic acid
S-[(2E)-3-[2-([1,1'-biphenyl]-4-yl)ethyl]-6-methylhepta-2,5-dien-1-yl]-N-(2-phenoxybenzoyl)-L-cysteine
-
-
-
S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine
-
-
-
S-{(2E)-3-[2-(biphenyl-4-yl)ethyl]-6-methylhepta-2,5-dien-1-yl}-N-(2-phenoxybenzoyl)-L-homocysteine
-
low micromolar inhibitor
sinefungin
spermatinamine
-
-
Triton X-100
-
0.1%, 63% inhibition
Tween 80
-
0.1%, 33% inhibition
Zn2+
-
complete inhibition
[2-(2,2-dimethyl-4-p-tolyltetrahydropyran-4-yl)ethyl]-(3-methoxyphenyl)amine
-
-
[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-(2-fluorophenyl)amine
-
-
[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]-(2-fluoro-4-methylphenyl)amine
-
-
[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]-(3-fluoro-4-methoxyphenyl)amine
-
-
[2-(2,2-dimethyl-4-thiophen-2-yltetrahydropyran-4-yl)-ethyl]-(3-methoxyphenyl)amine
-
-
[2-(2,2-dimethyl-4-thiophen-2-yltetrahydropyran-4-yl)-ethyl]phenylamine
-
-
[2-[4-(3-chlorophenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine
-
-
[2-[4-(3-fluoro-phenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine
-
-
[2-[4-(4-chlorophenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine
-
-
[2-[4-(4-fluorophenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine
-
-
[4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1H-1,2,3-triazol-1-yl]acetic acid
-
modest inhibitor, 65% residual activity at 0.01 mM
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
formyl-methionine-leucine-phenylalanine
-
stimulation of carboxyl methylation of GTP-binding proteins through a substrate-dependent mechanism
-
guanosine 5'-[gamma-thio]-triphosphate
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0059 - 0.0179
4-benzoyl-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-L-phenylalanyl-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine
0.0066
biotin-Peg4-K(5-Fam)YIIKGVFWDPAC(C10-Dia-zirine)-OH
-
apparent value, at pH 7.5 and 30C
-
0.0278
biotin-Peg4-K(5-Fam)YIIKGVFWDPAC(C5-m-BP)-OH
-
apparent value, at pH 7.5 and 30C
-
0.015
biotin-Peg4-YIIKGVFWDPAC(C10-meta-Bp)
-
at pH 7.5 and 25C
-
0.0051
biotin-Peg4-YIIKGVFWDPAC(C10-para-Bp)
-
at pH 7.5 and 25C
-
0.0146
biotin-Peg4-YIIKGVFWDPAC(C5-meta-Bp)
-
IC50 above 0.1 mM, at pH 7.5 and 25C
-
0.0061
biotin-Peg4-YIIKGVFWDPAC(C5-para-Bp)
-
IC50 above 0.1 mM, at pH 7.5 and 25C
-
0.0122
biotin-Peg4-YIIKGVFWDPAC(Fr)-OH
-
apparent value, at pH 7.5 and 30C
-
0.0021
biotin-S-farnesyl-L-cysteine
-
-
0.0029
farnesylated and Rce1-proteolyzed K-Ras protein
-
-
-
0.0105
N-((benzoylglycyl)glycyl)-S-farnesyl-L-cysteine
-
-
0.00255
N-(benzoylglycyl)-S-farnesyl-L-cysteine
-
-
1
N-acetyl-S-(E)-geranyl-L-cysteine
-
-
0.04
N-acetyl-S-(E,E)-farnesyl-D-cysteine
-
-
0.00017 - 11.1
N-acetyl-S-(E,E)-farnesyl-L-cysteine
5
N-acetyl-S-3,3-dimethylalkyl-L-cysteine
-
-
0.003 - 0.0223
N-acetyl-S-farnesyl-L-cysteine
0.0014 - 0.166
N-acetyl-S-geranylgeranyl-L-cysteine
0.0032
N-acetyl-S-geranylgeranyl-L-cysteine methyl ester
-
-
0.594
N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine
-
-
0.00295
N-isobutyryl-S-farnesyl-L-cysteine
-
-
0.00255
N-isovaleryl-S-farnesyl-L-cysteine
-
-
0.00013 - 3.8
S-adenosyl-L-methionine
0.48
S-decyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
-
0.0022
S-farnesyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
-
0.389
S-geranyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
-
0.0109
S-geranylgeranyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
-
1.76
S-octyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
-
1.12
S-pentadecyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
-
0.64
S-tridecyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
-
0.0034 - 0.0183
S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.93
biotin-S-farnesyl-L-cysteine
Anopheles gambiae
Q7PXA7
wild type enzyme, at pH 7.4 and 25C
0.5 - 1.25
S-adenosyl-L-methionine
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3.95
5'-deoxymethylthioadenosine
-
-
0.0022 - 0.00239
cysmethynil
0.0004
methyl 3-[[(2E)-5-[4-[2-(biphenyl-4-yl)ethyl]-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl]propanoate
-
pH and temperature not specified in the publication
0.0354 - 0.6144
N-Acetyl-S-(3-(3-methylbut-2-enyl)-5-(4-phenyl)phenylpent-2Z-en-1-yl)-L-cysteine
0.0171
N-acetyl-S-(3-(3-methylbut-2-enyl)-7,11-dimethyldodeca-2Z,6E,10-trien-1-yl)-L-cysteine
-
-
0.0026
N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
competitive vs. N-acetyl-S-(E,E)-geranylgeranyl-L-cysteine
0.041
N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester
-
-
0.0023
N-acetyl-S-(E,E)-geranylgeranyl-L-cysteine
-
competitive vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine
0.00207 - 0.005
N-acetyl-S-farnesyl-L-cysteine methyl ester
0.0039
S-(Geranylgeranyl-2-thio)acetic acid
-
competitive vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine
0.00157 - 1.8
S-adenosyl-L-homocysteine
0.00645 - 0.0218
S-adenosylethionine
0.0028
S-farnesyl thiosalicylic acid
-
-
0.028
S-farnesyl-4-chlorothiosalicylic acid
-
-
0.023
S-farnesyl-4-fluorothiosalicylic acid
-
-
0.0085
S-farnesyl-5-chlorothiosalicylic acid
-
-
0.0063
S-farnesyl-5-fluorothiosalicylic acid
-
-
0.00117 - 0.0137
S-Farnesylthioacetic acid
0.00007 - 0.000318
sinefungin
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0007
(1-octyl-5-m-tolyl-1H-indol-3-yl)methanamine
Homo sapiens
-
in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
0.000031
(3,5-difluoro-4-methoxyphenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000025
(3-chloro-4-fluorophenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.0000038
(3-chlorophenyl)-[2-(2,2-dimethyl-4-thiophen-2-yltetrahydropyran-4-yl)ethyl]amine
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00047
(4-chloro-3-fluorophenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000032
(5-chloro-2-fluorophenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.049
(R)-2-(2-((benzyloxy)methyl)benzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)-thio)propanoic acid
Homo sapiens
-
in 100 mM Tris-HCl, pH 7.5, at 30C
0.075
(R)-2-(2-(phenoxymethyl)benzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid
Homo sapiens
-
in 100 mM Tris-HCl, pH 7.5, at 30C
0.0147
(R)-2-(2-(phenylthio)benzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid
Homo sapiens
-
in 100 mM Tris-HCl, pH 7.5, at 30C
0.038
(R)-2-(2-benzylbenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid
0.21
(R)-2-(2-phenoxybenzamido)-3-(undecylthio)propanoic acid
Homo sapiens
-
in 100 mM Tris-HCl, pH 7.5, at 30C
0.0226
(R)-2-(3-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid
Homo sapiens
-
in 100 mM Tris-HCl, pH 7.5, at 30C
0.063
(R)-2-(4-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid
Homo sapiens
-
in 100 mM Tris-HCl, pH 7.5, at 30C
0.058
(R)-2-(dibenzo[b,d]furan-4-carboxamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)-propanoic acid
Homo sapiens
-
in 100 mM Tris-HCl, pH 7.5, at 30C
0.0067
(R)-2-(N-methyl-2-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid
Homo sapiens
-
in 100 mM Tris-HCl, pH 7.5, at 30C
0.149
(R,E)-3-((3,7-dimethylocta-2,6-dien-1-yl)thio)-2-(2-phenoxybenzamido)propanoic acid
Homo sapiens
-
in 100 mM Tris-HCl, pH 7.5, at 30C
0.0078
(S)-2-(2-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid
Homo sapiens
-
in 100 mM Tris-HCl, pH 7.5, at 30C
0.025
(S)-glabrol
Homo sapiens
-
-
0.001
1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-(3-fluorophenyl)thiourea
1
1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-(3-methoxyphenyl)thiourea
Homo sapiens
-
IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.001
1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-phenylthiourea
Homo sapiens
-
IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.002
1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-3-(morpholin-4-ylmethyl)-1H-indole
Homo sapiens
-
in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
0.0021
1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-3-(piperidin-1-ylmethyl)-1H-indole
Homo sapiens
-
in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
0.002
1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-3-[(morpholin-4-yl)methyl]-1H-indole
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0021
1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-3-[(piperidin-1-yl)methyl]-1H-indole
Homo sapiens
-
pH and temperature not specified in the publication
-
1
1-(3-chlorophenyl)-3-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)thiourea
0.1
1-(3-methylbut-2-enyl)-5-m-tolyl-1H-indole
0.03
1-octyl-5-m-tolyl-1H-indole-3-carboxamide
Homo sapiens
-
in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
0.0007
1-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methanamine
Homo sapiens
-
pH and temperature not specified in the publication
-
0.017
2'-methoxy-3',3''-diprenyl-licodione
Homo sapiens
-
-
0.03
2'-methoxy-3'-prenyllicodione
Homo sapiens
-
-
0.0065
2-(1-octyl-1H-indol-3-yl)acetamide
0.0018
2-(1-octyl-5-phenyl-1H-indol-3-yl)acetamide
0.005
2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-N-(3-methoxyphenyl)acetamide
0.001
2-(5-(3-ethoxyphenyl)-1-octyl-1H-indol-3-yl)-N,N-diethylacetamide
Homo sapiens
-
in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
0.069
2-(5-fluoro-1-(3-methylbut-2-enyl)-1H-indol-3-yl)acetamide
Homo sapiens
-
in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
0.007
2-(5-fluoro-1-octyl-1H-indol-3-yl)acetamide
Homo sapiens
-
in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
1.1
2-Carboxy-2'-hydroxy-5'-sulfoformazylbenzene
Saccharomyces cerevisiae
-
IC50: 1.1 mM
0.0062
2-phenoxy-phenylfarnesylcysteine
Homo sapiens
-
in 100 mM Tris-HCl, pH 7.5, at 30C
0.0077
2-[1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-1H-indol-3-yl]acetamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0011
2-[1-[(2E,6E)-2,6-dimethylocta-2,6-dien-1-yl]-5-(3-methylphenyl)-1H-indol-3-yl]acetamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.001
2-[5-(2-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
0.0013
2-[5-(3-ethoxyphenyl)-1-octyl-1H-indol-3-yl]acetamide
0.069
2-[5-(3-fluorophenyl)-1-(2-methylidenebut-3-en-1-yl)-1H-indol-3-yl]acetamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.007
2-[5-(3-fluorophenyl)-1-octyl-1H-indol-3-yl]acetamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0019
2-[5-(3-methoxyphenyl)-1-octyl-1H-indol-3-yl]acetamide
0.0017
2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(4-methylpiperazin-1-yl)ethan-1-one
0.0018
2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(piperidin-1-yl)ethan-1-one
0.0012
2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(pyrrolidin-1-yl)ethan-1-one
0.0015
2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0025
2-[5-(3-methylphenyl)-1-[3-(trifluoromethyl)benzyl]-1H-indol-3-yl]acetamide
0.033
2-[5-(3-methylphenyl)-1H-indol-3-yl]acetamide
0.001
2-[5-(4-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
0.00031
2-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl](phenyl)amino]-1-(furan-2-yl)ethanone
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000181
3,4-dichloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2Hpyran-4-yl)ethyl]aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00017
3,5-dichloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.0012
3-(1-octyl-5-m-tolyl-1H-indol-3-yl)propanamide
Homo sapiens
-
in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
0.001
3-chloro-4-methyl-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)ethyl]aniline
Homo sapiens
-
IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00046
3-chloro-4-methyl-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.005
3-chloro-N-(3-chlorophenyl)-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydropyran-4-yl)ethyl]aniline
Homo sapiens
-
IC50 above 0.005 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.001
3-chloro-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)-ethyl]aniline
Homo sapiens
-
IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00249
3-chloro-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydrothiopyran-4-yl)ethyl]aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000049
3-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-4-methylaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000025
3-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00383
3-chloro-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.001
3-fluoro-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)-ethyl]aniline
Homo sapiens
-
IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00325
3-fluoro-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.001
3-methoxy-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)-ethyl]aniline
Homo sapiens
-
IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.0000013
3-methoxy-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydropyran-4-yl)ethyl]aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00042
3-methoxy-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydrothiopyran-4-yl)ethyl]aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000777
3-methoxy-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.0125
3-methoxy-N-[2-[4-(4-methoxyphenyl)-2,2-dimethyltetrahydro-2H-pyran-4-yl]ethyl]aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00325
3-methyl-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000556
3-tert-butyl-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.005
3-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethylamino]benzoic acid
0.00245
3-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]phenol
Homo sapiens
-
at pH 7.4 and 37C
-
0.0012
3-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]propanamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.00383
3-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]-N,N-dimethylbenzenesulfonamide
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000066
3-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]benzonitrile
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000308
4-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-3-methylaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00036
4-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00076
4-tert-butyl-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00171
4-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]-N-methylbenzene-1-sulfonamide
Homo sapiens
-
at pH 7.4 and 37C
-
0.0131
4-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]benzenesulfonamide
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000123
4-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]benzonitrile
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.03
5-(3-methylphenyl)-1-octyl-1H-indole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0007
5-(3-methylphenyl)-1-octyl-3-(piperidin-1-ylmethyl)-1H-indole
Homo sapiens
-
in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
0.0005
5-(3-methylphenyl)-1-octyl-3-(pyrrolidin-1-ylmethyl)-1H-indole
Homo sapiens
-
in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
0.0007
5-(3-methylphenyl)-1-octyl-3-[(piperidin-1-yl)methyl]-1H-indole
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0005
5-(3-methylphenyl)-1-octyl-3-[(pyrrolidin-1-yl)methyl]-1H-indole
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0027
5-(3-methylphenyl)-3-(morpholin-4-ylmethyl)-1-octyl-1H-indole
Homo sapiens
-
in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
0.0009
5-(3-methylphenyl)-3-[(4-methylpiperazin-1-yl)methyl]-1-octyl-1H-indole
0.0027
5-(3-methylphenyl)-3-[(morpholin-4-yl)methyl]-1-octyl-1H-indole
Homo sapiens
-
pH and temperature not specified in the publication
-
0.00163
5-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]-N,N-dimethylpyridin-2-amine
Homo sapiens
-
at pH 7.4 and 37C
-
0.00086
5-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]pyrimidin-2-amine
Homo sapiens
-
at pH 7.4 and 37C
-
0.00226
5-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]pyrimidine-2-carbonitrile
Homo sapiens
-
at pH 7.4 and 37C
-
0.0257
biotin-Peg4-YIIKGVFWDPAC(C10-meta-Bp)
Saccharomyces cerevisiae
-
at pH 7.5 and 25C
-
0.0137
biotin-Peg4-YIIKGVFWDPAC(C10-para-Bp)
Saccharomyces cerevisiae
-
at pH 7.5 and 25C
-
0.1
biotin-Peg4-YIIKGVFWDPAC(C5-meta-Bp), biotin-Peg4-YIIKGVFWDPAC(C5-para-Bp)
Saccharomyces cerevisiae
-
IC50 above 0.1 mM, at pH 7.5 and 25C
-
0.0015 - 0.0019
cysmethynil
0.00288
ethyl 4-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]amino]benzoate
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.1
ethyl [5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetate
Homo sapiens
-
IC50 above 0.1 mM, in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
0.076
methyl [5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetate
0.000131
N'-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N,N-dimethylbenzene-1,3-diamine
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.0008
N,N-diethyl-2-(5-(3-methoxyphenyl)-1-octyl-1H-indol-3-yl)acetamide
0.0014
N,N-diethyl-2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
0.0013
N,N-dimethyl-1-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methanamine
0.0015
N,N-dimethyl-2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
0.0012
N-((1-octyl-5-m-tolyl-1H-indol-3-yl)methyl)methanesulfonamide
Homo sapiens
-
in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
0.0077
N-(2-methylidenebut-3-en-1-yl)-2-[5-(3-methylphenyl)-1-[3-(trifluoromethyl)benzyl]-1H-indol-3-yl]acetamide
Homo sapiens
-
in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
0.0194
N-(2-phenoxybenzoyl)-3-[4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1H-1,2,3-triazol-1-yl]-L-alanine
Homo sapiens
-
pH and temperature not specified in the publication
0.005
N-(3-chlorophenyl)-2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)acetamide
Homo sapiens
-
IC50 above 0.005 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00135
N-(3-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]phenyl)acetamide
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.0346
N-acetyl-S-[(2E)-3-methyl-5-(4-octylphenyl)pent-2-en-1-yl]-L-cysteine
Homo sapiens
-
pH and temperature not specified in the publication
0.00012
N-benzyl-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]furan-2-carboxamide
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.067
N-ethyl-N-((1-(3-methylbut-2-enyl)-1H-indol-3-yl)methyl) ethanamine
Homo sapiens
-
in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
0.035
N-ethyl-N-((5-fluoro-1-(3-methylbut-2-enyl)-1H-indol-3-yl)methyl)ethanamine
Homo sapiens
-
in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
0.00261
N-ethyl-N-([1-octyl-5-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl)ethanamine
Homo sapiens
-
at pH 7.4 and 37C
-
0.00172
N-ethyl-N-([5-[4-(methanesulfonyl)phenyl]-1-octyl-1H-indol-3-yl]methyl)ethanamine
Homo sapiens
-
at pH 7.4 and 37C
-
0.00442
N-ethyl-N-[(4-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine
Homo sapiens
-
at pH 7.4 and 37C
-
0.0041
N-ethyl-N-[(5-fluoro-1-octyl-1H-indol-3-yl)methyl]-ethanamine
Homo sapiens
-
in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
0.00483
N-ethyl-N-[(5-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine
Homo sapiens
-
at pH 7.4 and 37C
-
0.00222
N-ethyl-N-[(6-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine
Homo sapiens
-
at pH 7.4 and 37C
-
0.00227
N-ethyl-N-[(7-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine
Homo sapiens
-
at pH 7.4 and 37C
-
0.067
N-ethyl-N-[[1-(2-methylidenebut-3-en-1-yl)-1H-indol-3-yl]methyl]ethanamine
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0024
N-ethyl-N-[[1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-1H-indol-3-yl]methyl]ethanamine
0.00175
N-ethyl-N-[[1-octyl-5-(pyridin-3-yl)-1H-indol-3-yl]methyl]ethanamine
Homo sapiens
-
at pH 7.4 and 37C
-
0.00158
N-ethyl-N-[[1-octyl-5-(pyrimidin-5-yl)-1H-indol-3-yl]methyl]ethanamine
Homo sapiens
-
at pH 7.4 and 37C
-
0.00256
N-ethyl-N-[[5-(2-fluorophenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
Homo sapiens
-
at pH 7.4 and 37C
-
0.0006
N-ethyl-N-[[5-(2-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
0.035
N-ethyl-N-[[5-(3-fluorophenyl)-1-(2-methylidenebut-3-en-1-yl)-1H-indol-3-yl]methyl]ethanamine
Homo sapiens
-
pH and temperature not specified in the publication
-
0.00161 - 0.0041
N-ethyl-N-[[5-(3-fluorophenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
0.00096
N-ethyl-N-[[5-(3-fluoropyridin-4-yl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
Homo sapiens
-
at pH 7.4 and 37C
-
0.0007 - 0.00218
N-ethyl-N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
0.0006
N-ethyl-N-[[5-(4-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
0.0009
N-methyl-N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]propan-2-amine
0.0018
N-[(1-octyl-5-m-tolyl-1H-indol-3-yl)methyl]acetamide
Homo sapiens
-
in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
0.0011
N-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2-[5-(3-methylphenyl)-1-[3-(trifluoromethyl)benzyl]-1H-indol-3-yl]acetamide
Homo sapiens
-
in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37C
0.000015
N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydropyran-4-yl)-ethyl]aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.001
N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydrothiopyran-4-yl)ethyl]aniline
Homo sapiens
-
IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.0036
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-2-methylaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000652
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3,4-dimethoxyaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000054
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3,5-dimethylaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00009
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-(trifluoromethoxy)aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00038
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-(trifluoromethyl)aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00004
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-ethylaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000052
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-fluoroaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000167
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-isopropylaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00009
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-methoxy-4-methylaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000015
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-methoxyaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000031
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-methylaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000184
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-(trifluoromethoxy)aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000168
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-fluoroaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000132
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-isopropylaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00027
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-methoxyaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000031
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-methylaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00985
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N,3-dimethylaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.01
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N-methylaniline
Homo sapiens
-
IC50 above 0.01 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00234
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N-phenylacetamide
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.0027
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]aniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000069
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-3,4-dimethylaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000026
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-3-nitroaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000682
N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-4-nitroaniline
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.0134
N-[2-(benzyloxy)benzoyl]-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine
Homo sapiens
-
in 100 mM Tris-HCl, pH 7.5, at 30C
0.0035
N-[3-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-3-(2-methoxyphenyl)propyl]-N-(4-methoxybenzyl)furan-2-carboxamide
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.0017
N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]-N-(propan-2-yl)propan-2-amine
0.0008
N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]-N-propylpropan-1-amine
0.0018
N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]acetamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.0012
N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]methanesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
-
0.00543
S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine
Homo sapiens
-
at pH 7.4 and 37C
-
0.0025
S-{(2E)-3-[2-(biphenyl-4-yl)ethyl]-6-methylhepta-2,5-dien-1-yl}-N-(2-phenoxybenzoyl)-L-homocysteine
Homo sapiens
-
in 100 mM Tris-HCl, pH 7.5, at 30C
0.00419
[2-(2,2-dimethyl-4-p-tolyltetrahydropyran-4-yl)ethyl]-(3-methoxyphenyl)amine
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00055
[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-(2-fluorophenyl)amine
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.0003
[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]-(2-fluoro-4-methylphenyl)amine
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00016
[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]-(3-fluoro-4-methoxyphenyl)amine
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000019
[2-(2,2-dimethyl-4-thiophen-2-yltetrahydropyran-4-yl)-ethyl]-(3-methoxyphenyl)amine
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00027
[2-(2,2-dimethyl-4-thiophen-2-yltetrahydropyran-4-yl)-ethyl]phenylamine
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00019
[2-[4-(3-chlorophenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.000008
[2-[4-(3-fluoro-phenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.00063
[2-[4-(4-chlorophenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
0.0001
[2-[4-(4-fluorophenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine
Homo sapiens
-
in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000143
-
-
0.755
-
wild type enzyme, at pH and C
additional information
-
activities of wild-type and mutant enzymes expressed in HEK-293 cells
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
-
assay at
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.6 - 8.6
-
-
7.4 - 8
-
-
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
22
-
assay at room temperature
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10 - 44
-
for the Escherichia coli polar lipid (control), Ste14p activity remains essentially constant when the assay temperature is maintained at 10, 16, 32, or 44C, activity in DMPC is unchanged below (16 C) and above (32 C) its phase transition temperature, yielding activity levels that are the same as the Escherichia coli polar lipid values within experimental error, for C20-BAS activity is only 5% of that observed for the Escherichia coli polar lipid above (32 C) and below (10 C) the phase transition temperature of C20BAS
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
adrenal chromaffin cells
Manually annotated by BRENDA team
-
insulin-secreting
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
light membrane fraction
Manually annotated by BRENDA team
-
stably overexpressing isoprenylcysteine carboxyl methyltransferase/GFP cDNA
Manually annotated by BRENDA team
-
outer segment
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
Ste14p activity is lost in vesicles composed of 75-100 mol% C20BAS and 0-100 mol% C32BAS but retained in vesicles with 0-50 mol% C20BAS and 0-100 mol% C32phytBAS
Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
24000
-
radiation inactivation
30000
-
gel filtration, photoaffinity labelling
98000
-
radiation inactivation
180000
-
gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homodimer
-
2 * 23000, untagged enzyme, SDS-PAGE; 2 * 35000, His-tagged enzyme, SDS-PAGE
monomer
-
1 * 24000, deduced from nucleotide sequence
additional information
-
enzyme may be a homotetramer
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.5 - 9.5
-
stable
485037
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
complete loss of activity after exposure to detergent e.g. CHAPS, octyl-beta-glucoside and sodium deoxycholate, activity can be reconstituted by removal of the detergent in the presence of phospholipid
-
the membrane-associated activity is highly stable even upon repeated freeze-thaw cycles
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-70C, 6 months
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
acid treatment, DEAE-cellulose, Superose 6, Superdex 75, partially purified
-
by Talon metal affinity chromatography
-
Ni-NTA column chromatography, ion exchange column chromatography, and gel filtration
-
Q-Sepharose, partially purified
-
Talon metal affinity bead chromatography
-
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli C41(DE3) cells
-
expressed in Saccharomyces cerevisiae strain SM1188
-
expressed in Sf9 insect cells
-
expressed in Spodoptera frugiperda ovarian membranes
-
expression in Sf9 cells
-
expression of TrpE-STE14 methyl transferase fusion protein in Escherichia coli
-
His-Ste14p, which encodes Ste14p with a 10 x histidine tag followed by a triply iterated myc epitope repeat at the N terminus under the constitutive control of the phosphoglycerate kinase promoter, overexpressed in Saccharomyces cerevisiae
-
His10myc3-tagged Ste14p expressed in Saccharomyces cereVisiae
-
Icmt, expression in HEK-293 cells and Cos-1 cells
-
into the pCHH10m3N vector, overexpressed in Saccharomyces cerevisiae
-
overepression in tissue culture cells
-
the ICMT isozyme is encoded by the STE14A ICMT gene; the ICMT isozyme is encoded by the STE14B ICMT gene
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
abscisic acid promotes abscisic acid responsiveness of plant cells via induction of ICME expression; abscisic acid promotes abscisic acid responsiveness of plant cells via induction of ICME expression
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E141A
biochemically inactive mutant
F216A
the mutant shows reduced activity compared to the wild type enzyme
F216R
the mutant shows reduced activity compared to the wild type enzyme
F216Y
the mutant shows wild type activity
W240A
the mutant shows reduced activity compared to the wild type enzyme
Y107A
the mutant shows reduced activity compared to the wild type enzyme
D122A
-
site-directed mutagenesis, the mutant shows decreased activity compared to the wild-type enzyme, comparison of membrane topology
E107A
-
site-directed mutagenesis, the mutant shows decreased activity compared to the wild-type enzyme, comparison of membrane topology
E142A
-
site-directed mutagenesis, the mutant shows decreased activity compared to the wild-type enzyme, comparison of membrane topology
E146A
-
site-directed mutagenesis, the mutant shows decreased activity compared to the wild-type enzyme, comparison of membrane topology
E251A
-
site-directed mutagenesis, the mutant shows decreased activity compared to the wild-type enzyme, comparison of membrane topology
E252A
-
site-directed mutagenesis, the mutant shows decreased activity compared to the wild-type enzyme, comparison of membrane topology
F124A
-
site-directed mutagenesis, the mutant shows decreased activity compared to the wild-type enzyme, comparison of membrane topology
F124R
-
site-directed mutagenesis, the mutant shows decreased activity compared to the wild-type enzyme, comparison of membrane topology
F258A
-
site-directed mutagenesis, the mutant shows decreased activity compared to the wild-type enzyme, comparison of membrane topology
F72A
-
site-directed mutagenesis, the mutant shows decreased activity compared to the wild-type enzyme, comparison of membrane topology
P275A
-
site-directed mutagenesis, the mutant shows decreased activity compared to the wild-type enzyme, comparison of membrane topology
R209A
-
site-directed mutagenesis, the mutant shows activity similar to the wild-type enzyme, comparison of membrane topology
R63A
-
site-directed mutagenesis, the mutant shows decreased activity compared to the wild-type enzyme, comparison of membrane topology
RH209/210A
-
site-directed mutagenesis, the mutant shows decreased activity compared to the wild-type enzyme, comparison of membrane topology
S123A
-
site-directed mutagenesis, the mutant shows decreased activity compared to the wild-type enzyme, comparison of membrane topology
W241A
-
site-directed mutagenesis, the mutant shows decreased activity compared to the wild-type enzyme, comparison of membrane topology
Y266A
-
site-directed mutagenesis, the mutant shows increased activity comapred to the wild-type enzyme, comparison of membrane topology
E167A
-
the mutation leads to strongly reduced activity compared to the wild type enzyme
H113A
-
the mutation leads to strongly reduced activity compared to the wild type enzyme
H126A
-
the mutation leads to strongly reduced activity compared to the wild type enzyme
R163A
-
the mutation leads to strongly reduced activity compared to the wild type enzyme
E213Q
-
the mutant is enzymatically almost inactive (5% activity compared to the wild type)
L81F
-
the mutant shows little to no in vitro methyltransferase activity
additional information
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
biotechnology
the enzyme is a target for metabolic engineering of crop species for drought tolerance by targeted alterations in isoprenylcysteine methylation; the enzyme is a target for metabolic engineering of crop species for drought tolerance by targeted alterations in isoprenylcysteine methylation
drug development
-
the enzyme is a target for anticancer drug design
medicine
pharmacology
-
the enzyme is a target in anticancer therapy
Show AA Sequence (1724 entries)
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