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Literature summary for 1.8.1.9 extracted from

  • Kameritsch, P.; Singer, M.; Nuernbergk, C.; Rios, N.; Reyes, A.M.; Schmidt, K.; Kirsch, J.; Schneider, H.; Mueller, S.; Pogoda, K.; Cui, R.; Kirchner, T.; de Wit, C.; Lange-Sperandio, B.; Pohl, U.; Conrad, M.; Radi, R.; Beck, H.
    The mitochondrial thioredoxin reductase system (TrxR2) in vascular endothelium controls peroxynitrite levels and tissue integrity (2021), Proc. Natl. Acad. Sci. USA, 118, e1921828118 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.1.9

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Mus musculus 5739
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Organism

Organism UniProt Comment Textmining
Mus musculus Q9JLT4
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-

Source Tissue

Source Tissue Comment Organism Textmining
vascular endothelium
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 Mus musculus
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Synonyms

Synonyms Comment Organism
TrxR2
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 Mus musculus

General Information

General Information Comment Organism
malfunction Trxrd2-/- cells are more susceptible to glutathione depletion. Loss of Trxrd2 results in enhanced peroxynitrite steady-state levels in both vascular endothelial cells and vessels Mus musculus
physiological function the mitochondrial thioredoxin/peroxiredoxin system encompasses NADPH, thioredoxin reductase 2 (TrxR2), thioredoxin 2, and peroxiredoxins 3 and 5 (Prx3 and Prx5) and is crucial to regulate cell redox homeostasis via the efficient catabolism of peroxides. Endothelial TrxR2 controls both the steady-state concentration of peroxynitrite, the product of the reaction of superoxide radical and nitric oxide, and the integrity of the vascular system Mus musculus