Literature summary for 1.8.1.9 extracted from

Liao, X.; Yang, F.; Li, H.; So, P.K.; Yao, Z.; Xia, W.; Sun, H.
Targeting the thioredoxin reductase-thioredoxin system from Staphylococcus aureus by silver ions (2017), Inorg. Chem., 56, 14823-14830 .

Search for more literature for 1.8.1.9

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli BL21	Staphylococcus aureus

Inhibitors

Inhibitors	Comment	Organism	Structure
Ag+	silver ions bind to the active sites of thioredoxin reductase with dissociation constants of 0.0014 mM and stoichiometries of 1 Ag+ ion per protein	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	-	-	-
Staphylococcus aureus Newman	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Staphylococcus aureus

Synonyms

Synonyms	Comment	Organism
TrxR	-	Staphylococcus aureus

General Information

General Information	Comment	Organism
drug target	drug-resistant Staphylococcus aureus, especially methicillin-resistant (MRSA) and vancomycin-resistant Staphylococcus aureus (VRSA), pose a great threat to human health globally. The Trx system in GSH-deficient pathogens is a viable antibacterial drug target	Staphylococcus aureus
physiological function	the thioredoxin system, which is composed of NADPH, thioredoxin reductase (TrxR), and thioredoxin (Trx), is one of the major disulfide reductase systems used by bacteria against oxidative stress. This reductase system is crucial for the survival of the pathogenic bacterium Staphylococcus aureus, which lacks a natural glutathione/glutaredoxin (Grx) system	Staphylococcus aureus

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Release 2023.1 (January 2023)