Application | Comment | Organism |
---|---|---|
degradation | decreased activity of DLDH induced by valproic acid metabolites may, at least in part, account for the impaired rate of oxygen consumption and ATP synthesis in mitochondria if 2-oxoglutarate or glutamate are used as respiratory substrates, thus limiting the flux of these substrates through the citric acid cycle | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
valproyl-CoA | competitive inhibitor, 0.5-1.0 mM inhibit DLDH activity | Rattus norvegicus | |
valproyl-dephosphoCoA | uncompetitive inhibitor, 0.5-1.0 mM inhibit DLDH activity | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydrolipoamide + NAD+ | - |
Rattus norvegicus | lipoamide + NADH | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dihydrolipoamide dehydrogenase | - |
Rattus norvegicus |
DLDH | - |
Rattus norvegicus |
E3 | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
1.43 | - |
valproyl-CoA | - |
Rattus norvegicus | |
1.6 | - |
valproyl-dephosphoCoA | - |
Rattus norvegicus |