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Literature summary for 1.4.3.3 extracted from

  • Liu, Q.; Chen, L.; Zhang, Z.; Du, B.; Xiao, Y.; Yang, K.; Gong, L.; Wu, L.; Li, X.; He, Y.
    pH-Dependent enantioselectivity of D-amino acid oxidase in aqueous solution (2017), Sci. Rep., 7, 2994 .
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.33
-
D-Pro at pH 8.0 and 37°C Sus scrofa
0.38
-
D-Pro at pH 7.5 and 37°C Sus scrofa
0.85
-
D-Pro at pH 8.5 and 37°C Sus scrofa
20
-
L-Pro at pH 8.0 and 37°C Sus scrofa
30.5
-
D-Ala at pH 7.0 and 37°C Sus scrofa
38.2
-
D-Ala at pH 9.8 and 37°C Sus scrofa
43
-
D-Asp at pH 8.0 and 37°C Sus scrofa
43.11
-
L-Ala at pH 9.8 and 37°C Sus scrofa
45
-
L-Asp at pH 8.0 and 37°C Sus scrofa
252
-
L-Pro at pH 7.5 and 37°C Sus scrofa
362
-
L-Ala at pH 7.0 and 37°C Sus scrofa
1800
-
L-Pro at pH 8.5 and 37°C Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-Ala + H2O + O2 Sus scrofa
-
pyruvate + NH3 + H2O2
-
?
D-Arg + H2O + O2 Sus scrofa
-
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
?
D-Asn + H2O + O2 Sus scrofa
-
2-oxosuccinamate + NH3 + H2O2
-
?
D-Asp + H2O + O2 Sus scrofa
-
oxaloacetate + NH3 + H2O2
-
?
D-Gln + H2O + O2 Sus scrofa
-
2-oxoglutaramate + NH3 + H2O2
-
?
D-Glu + H2O + O2 Sus scrofa
-
alpha-ketoglutarate + NH3 + H2O2
-
?
D-His + H2O + O2 Sus scrofa
-
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
?
D-Ile + H2O + O2 Sus scrofa
-
3-methyl-2-oxopentanoate + NH3 + H2O2
-
?
D-Leu + H2O + O2 Sus scrofa
-
4-methyl-2-oxopentanoate + NH3 + H2O2
-
?
D-Lys + H2O + O2 Sus scrofa
-
6-amino-2-oxohexanoic acid + NH3 + H2O2
-
?
D-Met + H2O + O2 Sus scrofa
-
4-methylthio-2-oxobutanoate + NH3 + H2O2
-
?
D-Phe + H2O + O2 Sus scrofa
-
phenylpyruvate + NH3 + H2O2
-
?
D-Pro + H2O + O2 Sus scrofa
-
2-oxopentanoic acid + NH3 + H2O2
-
?
D-Ser + H2O + O2 Sus scrofa
-
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
?
D-Thr + H2O + O2 Sus scrofa
-
2-oxo-3-hydroxybutyrate + NH3 + H2O2
-
?
D-Trp + H2O + O2 Sus scrofa
-
indol-3-pyruvate + NH3 + H2O2
-
?
D-Tyr + H2O + O2 Sus scrofa
-
4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
D-Val + H2O + O2 Sus scrofa
-
2-oxoisovalerate + NH3 + H2O2
-
?
Gly + H2O + O2 Sus scrofa
-
acetate + NH3 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Ala + H2O + O2
-
Sus scrofa pyruvate + NH3 + H2O2
-
?
D-Arg + H2O + O2
-
Sus scrofa 5-guanidino-2-oxopentanoate + NH3 + H2O2
-
?
D-Asn + H2O + O2
-
Sus scrofa 2-oxosuccinamate + NH3 + H2O2
-
?
D-Asp + H2O + O2
-
Sus scrofa oxaloacetate + NH3 + H2O2
-
?
D-Gln + H2O + O2
-
Sus scrofa 2-oxoglutaramate + NH3 + H2O2
-
?
D-Glu + H2O + O2
-
Sus scrofa alpha-ketoglutarate + NH3 + H2O2
-
?
D-His + H2O + O2
-
Sus scrofa 3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
?
D-Ile + H2O + O2
-
Sus scrofa 3-methyl-2-oxopentanoate + NH3 + H2O2
-
?
D-Leu + H2O + O2
-
Sus scrofa 4-methyl-2-oxopentanoate + NH3 + H2O2
-
?
D-Lys + H2O + O2
-
Sus scrofa 6-amino-2-oxohexanoic acid + NH3 + H2O2
-
?
D-Met + H2O + O2
-
Sus scrofa 4-methylthio-2-oxobutanoate + NH3 + H2O2
-
?
D-Phe + H2O + O2
-
Sus scrofa phenylpyruvate + NH3 + H2O2
-
?
D-Pro + H2O + O2
-
Sus scrofa 2-oxopentanoic acid + NH3 + H2O2
-
?
D-Ser + H2O + O2
-
Sus scrofa 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
?
D-Thr + H2O + O2
-
Sus scrofa 2-oxo-3-hydroxybutyrate + NH3 + H2O2
-
?
D-Trp + H2O + O2
-
Sus scrofa indol-3-pyruvate + NH3 + H2O2
-
?
D-Tyr + H2O + O2
-
Sus scrofa 4-hydroxyphenylpyruvate + NH3 + H2O2
-
?
D-Val + H2O + O2
-
Sus scrofa 2-oxoisovalerate + NH3 + H2O2
-
?
Gly + H2O + O2
-
Sus scrofa acetate + NH3 + H2O2
-
?
L-Ala + H2O + O2 low activity Sus scrofa pyruvate + NH3 + H2O2
-
?
L-Asp + H2O + O2 low activity Sus scrofa oxaloacetate + NH3 + H2O2
-
?
L-Pro + H2O + O2 low activity Sus scrofa 2-oxopentanoic acid + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
DAAO
-
Sus scrofa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.09
-
L-Ala at pH 7.0 and 37°C Sus scrofa
0.4
-
L-Pro at pH 8.5 and 37°C Sus scrofa
0.7
-
L-Pro at pH 7.5 and 37°C Sus scrofa
0.89
-
L-Asp at pH 8.0 and 37°C Sus scrofa
0.95
-
D-Asp at pH 8.0 and 37°C Sus scrofa
6.71
-
L-Pro at pH 8.0 and 37°C Sus scrofa
9.4
-
L-Ala at pH 9.8 and 37°C Sus scrofa
43.3
-
D-Pro at pH 8.5 and 37°C Sus scrofa
50.2
-
D-Pro at pH 7.5 and 37°C Sus scrofa
107.3
-
D-Pro at pH 8.0 and 37°C Sus scrofa
133.3
-
D-Ala at pH 9.8 and 37°C Sus scrofa
151.2
-
D-Ala at pH 7.0 and 37°C Sus scrofa

Cofactor

Cofactor Comment Organism Structure
FAD
-
Sus scrofa