Application | Comment | Organism |
---|---|---|
drug development | enzyme DES1 inhibition is used in treatment of cancer | Mus musculus |
drug development | enzyme DES1 inhibition is used in treatment of cancer, it is a target for fenretinide and fenretinide metabolites | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-oxo-N-(4-hydroxyphenyl)retinamide | - |
Homo sapiens | |
4-oxo-N-(4-hydroxyphenyl)retinamide | leads to an increase in C16 and C18 dihydroceramide substrate accumulation | Mus musculus | |
fenretinide | i.e. N-(4-hydroxyphenyl)retinamide, a synthetic retinoid, leads to an increase in C16 and C18 dihydroceramide substrate accumulation | Homo sapiens | |
fenretinide | i.e. N-(4-hydroxyphenyl)retinamide, a synthetic retinoid, leads to an increase in C16 and C18 dihydroceramide substrate accumulation | Mus musculus | |
additional information | no inhibition of the enzyme by N-[4-methoxyphenyl]retinamide and by non-retinoid RBP4 ligand A1120, RBP4 is a serum retinol-binding protein. The presence of fenretinide or 4-oxo-N-(4-hydroxyphenyl)retinamide leads to 2.7 and 3fold increases in ratio for C16 and C18 ceramides ratio respectively | Homo sapiens | |
additional information | no inhibition of the enzyme by N-[4-methoxyphenyl]retinamide and by non-retinoid RBP4 ligand A1120, RBP4 is a serum retinol-binding protein. The presence of fenretinide or 4-oxo-N-(4-hydroxyphenyl)retinamide leads to 2.7 and 3fold increases in ratio for C16 and C18 ceramides ratio respectively | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15121 | - |
- |
Mus musculus | O09005 | - |
- |
Mus musculus C57BL/6 | O09005 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ARPE-19 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Degs1 | - |
Homo sapiens |
Degs1 | - |
Mus musculus |
DES1 | - |
Homo sapiens |
DES1 | - |
Mus musculus |
dihydroceramide DELTA4-desaturase 1 | - |
Homo sapiens |
dihydroceramide DELTA4-desaturase 1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
additional information | lipid and ceramide content analysis in untreated and inhibitor-treated ARPE-19 cells, overview | Homo sapiens |