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Literature summary for 1.14.18.1 extracted from

  • Takahashi, T.; Miyazawa, M.
    Synthesis and structure-activity relationships of phenylpropanoid amides of serotonin on tyrosinase inhibition (2011), Bioorg. Med. Chem. Lett., 21, 1983-1986.
    View publication on PubMed
Search for more literature for 1.14.18.1

Inhibitors

Inhibitors Comment Organism Structure
(2E)-3-(3,4-dihydroxyphenyl)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]prop-2-enamide
-
 Agaricus bisporus
(2E)-3-(3,4-dimethoxyphenyl)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]prop-2-enamide
-
 Agaricus bisporus
(2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]prop-2-enamide
-
 Agaricus bisporus
(2E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(3-hydroxy-4-methoxyphenyl)prop-2-enamide
-
 Agaricus bisporus
(2E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide
-
 Agaricus bisporus
(2E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxyphenyl)prop-2-enamide
-
 Agaricus bisporus
(2E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-methoxyphenyl)prop-2-enamide
-
 Agaricus bisporus
(2E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-phenylprop-2-enamide
-
 Agaricus bisporus
(2Z)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
-
 Agaricus bisporus
(2Z)-3-(3,4-dimethoxyphenyl)prop-2-enoic acid
-
 Agaricus bisporus
(2Z)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid
-
 Agaricus bisporus
(2Z)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid
-
 Agaricus bisporus
(2Z)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
-
 Agaricus bisporus
(2Z)-3-(4-hydroxyphenyl)prop-2-enoic acid
-
 Agaricus bisporus
(2Z)-3-(4-methoxyphenyl)prop-2-enoic acid
-
 Agaricus bisporus
(2Z)-3-phenylprop-2-enoic acid
-
 Agaricus bisporus
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
-
 Agaricus bisporus
arbutin
-
 Agaricus bisporus
bufobutanoic acid
-
 Agaricus bisporus
serotonin
-
 Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + O2
-
 Agaricus bisporus L-DOPA + H2O
-
 ?

Synonyms

Synonyms Comment Organism
tyrosinase
-
 Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0054
-
 in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus (2E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(3-hydroxy-4-methoxyphenyl)prop-2-enamide
0.008
-
 in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus (2E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide
0.008
-
 in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus (2E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxyphenyl)prop-2-enamide
0.0238
-
 in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus (2E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-methoxyphenyl)prop-2-enamide
0.0404
-
 in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus (2E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-phenylprop-2-enamide
0.0514
-
 in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
0.1152
-
 in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus (2Z)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid
0.1213
-
 in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus (2Z)-3-(4-hydroxyphenyl)prop-2-enoic acid
0.201
-
 in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus arbutin
0.2781
-
 in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus (2E)-3-(3,4-dihydroxyphenyl)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]prop-2-enamide
0.3218
-
 in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus (2E)-3-(3,4-dimethoxyphenyl)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]prop-2-enamide
0.35
-
 IC50 above 0.35 mM, in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus serotonin
0.35
-
 IC50 above 0.35 mM, in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]prop-2-enamide
0.35
-
 IC50 above 0.35 mM, in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus (2Z)-3-phenylprop-2-enoic acid
0.35
-
 IC50 above 0.35 mM, in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus (2Z)-3-(4-methoxyphenyl)prop-2-enoic acid
0.35
-
 IC50 above 0.35 mM, in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus (2Z)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
0.35
-
 IC50 above 0.35 mM, in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus (2Z)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
0.35
-
 IC50 above 0.35 mM, in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus (2Z)-3-(3,4-dimethoxyphenyl)prop-2-enoic acid
0.35
-
 IC50 above 0.35 mM, in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus (2Z)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid
0.35
-
 IC50 above 0.35 mM, in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus bufobutanoic acid