Literature summary for 1.14.18.1 extracted from

Liu, J.; Cao, R.; Yi, W.; Ma, C.; Wan, Y.; Zhou, B.; Ma, L.; Song, H.
A class of potent tyrosinase inhibitors: Alkylidenethiosemicarbazide compounds (2009), Eur. J. Med. Chem., 44, 1773-1778.

Search for more literature for 1.14.18.1

Inhibitors

Inhibitors	Comment	Organism	Structure
1-(1-(4-methoxyphenyl)propan-2-ylidene)-thiosemicarbazide	-	Agaricus bisporus
1-(2,5-dimethyl-1H-pyrrol-1-yl)thiourea	-	Agaricus bisporus
1-(3-methylbutylidene)thiosemicarbazide	-	Agaricus bisporus
1-(3-oxocyclohexylidene)thiosemicarbazide	-	Agaricus bisporus
1-(3-phenylallylidene)thiosemicarbazide	-	Agaricus bisporus
1-(4-(4-hydroxyphenyl)butan-2-ylidene)-thiosemicarbazide	-	Agaricus bisporus
1-(4-methylpent-3-en-2-ylidene) thiosemicarbazide	-	Agaricus bisporus
1-(but-2-enylidene)thiosemicarbazide	-	Agaricus bisporus
1-(butan-2-ylidene)thiosemicarbazide	-	Agaricus bisporus
1-(propan-2-ylidene)thiosemicarbazide	most potent inhibitor	Agaricus bisporus
1-cyclohexylidenethiosemicarbazide	-	Agaricus bisporus
1-cyclopentylidenethiosemicarbazide	-	Agaricus bisporus
1-ethylidenethiosemicarbazide	-	Agaricus bisporus
1-propylidenethiosemicarbazide	-	Agaricus bisporus
4-methoxycinnamic acid	-	Agaricus bisporus
arbutin	-	Agaricus bisporus

Organism

Organism	UniProt	Comment	Textmining
Agaricus bisporus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Agaricus bisporus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
5360	-	-	Agaricus bisporus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-dopa + 1/2 O2	-	Agaricus bisporus	L-dopaquinone + H2O	-	?

Synonyms

Synonyms	Comment	Organism
tyrosinase	-	Agaricus bisporus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.8	-	assay at	Agaricus bisporus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000086	-	most potent inhibitor	Agaricus bisporus	1-(propan-2-ylidene)thiosemicarbazide
0.00017	-	-	Agaricus bisporus	1-cyclopentylidenethiosemicarbazide
0.0002	-	-	Agaricus bisporus	1-propylidenethiosemicarbazide
0.00023	-	-	Agaricus bisporus	1-ethylidenethiosemicarbazide
0.00028	-	-	Agaricus bisporus	1-(butan-2-ylidene)thiosemicarbazide
0.00042	-	-	Agaricus bisporus	1-(1-(4-methoxyphenyl)propan-2-ylidene)-thiosemicarbazide
0.00054	-	-	Agaricus bisporus	1-(4-(4-hydroxyphenyl)butan-2-ylidene)-thiosemicarbazide
0.00062	-	-	Agaricus bisporus	1-(3-methylbutylidene)thiosemicarbazide
0.00085	-	-	Agaricus bisporus	1-(2,5-dimethyl-1H-pyrrol-1-yl)thiourea
0.00095	-	-	Agaricus bisporus	1-cyclohexylidenethiosemicarbazide
0.001	-	-	Agaricus bisporus	1-(but-2-enylidene)thiosemicarbazide
0.0027	-	-	Agaricus bisporus	1-(3-phenylallylidene)thiosemicarbazide
0.0115	-	-	Agaricus bisporus	1-(4-methylpent-3-en-2-ylidene) thiosemicarbazide
0.0151	-	-	Agaricus bisporus	1-(3-oxocyclohexylidene)thiosemicarbazide
0.41	-	-	Agaricus bisporus	4-methoxycinnamic acid
10.4	-	-	Agaricus bisporus	arbutin

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)