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Literature summary for 1.14.11.54 extracted from

  • Ueda, Y.; Ooshio, I.; Fusamae, Y.; Kitae, K.; Kawaguchi, M.; Jingushi, K.; Hase, H.; Harada, K.; Hirata, K.; Tsujikawa, K.
    AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells (2017), Sci. Rep., 7, 42271 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.54

Organism

Organism UniProt Comment Textmining
Bombyx mori
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ALKBH3 demethylates 3-meC, 1-meA, and N6-meA in the presence of 2-oxoglutarate and Fe(II). ALKBH3 preferentially demethylates N6-meA in tRNA Bombyx mori ?
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-
N1-methyladenine in mRNA + 2-oxoglutarate + O2
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 Bombyx mori adenine in mRNA + formaldehyde + succinate + CO2
-
 ?
N3-methylcytidine in mRNA + 2-oxoglutarate + O2
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 Bombyx mori cytidine in mRNA + formaldehyde + succinate + CO2
-
 ?
N6-methyladenine in tRNA + 2-oxoglutarate + O2
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 Bombyx mori adenine in tRNA + formaldehyde + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
AlkB homolog 3
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 Bombyx mori
ALKBH3
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 Bombyx mori

General Information

General Information Comment Organism
physiological function ALKBH3 effectively demethylates 1-meA and 3-meC within endogenously methylated RNA and also N6-methyladenine (N6-meA) in mammalian transfer RNA. ALKBH3-demethylated tRNA significantly enhances protein translation efficiency. ALKBH3 knockdown in human cancer cells impairs cellular proliferation and suppresses the nascent protein synthesis that is usually accompanied by accumulation of the methylated RNAs Bombyx mori