Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoic acid | - |
Homo sapiens | |
3-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoic acid | - |
Homo sapiens | |
4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzamide | - |
Homo sapiens | |
4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzene-1-sulfonamide | potent inhibitor with a moderate pharmacokinetic profile. 25% tumor growth inhibition and 30% reduction in tumor weight in a murine CT26 syngeneic model on day 18, with 100 mg/kg oral administration twice daily | Homo sapiens | |
4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoic acid | - |
Homo sapiens | |
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-chlorophenyl)urea | - |
Homo sapiens | |
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-cyanophenyl)urea | - |
Homo sapiens | |
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-fluorophenyl)urea | - |
Homo sapiens | |
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-methoxyphenyl)urea | - |
Homo sapiens | |
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-methylphenyl)urea | - |
Homo sapiens | |
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(4-chlorophenyl)urea | - |
Homo sapiens | |
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(4-methoxyphenyl)urea | - |
Homo sapiens | |
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(4-methylphenyl)urea | - |
Homo sapiens | |
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-butylurea | - |
Homo sapiens | |
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-cyclohexylurea | - |
Homo sapiens | |
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-[3-(1H-tetrazol-5-yl)phenyl]urea | - |
Homo sapiens | |
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-[4-(1H-tetrazol-5-yl)phenyl]urea | - |
Homo sapiens | |
propan-2-yl 4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoate | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | Homo sapiens | - |
N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14902 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDO | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000461 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-methoxyphenyl)urea | |
0.0000536 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-methylphenyl)urea | |
0.0000607 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(4-methoxyphenyl)urea | |
0.000065 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoic acid | |
0.0000703 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(4-methylphenyl)urea | |
0.0000726 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-[3-(1H-tetrazol-5-yl)phenyl]urea | |
0.0000787 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoic acid | |
0.0000836 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoic acid | |
0.000146 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-cyanophenyl)urea | |
0.000157 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-butylurea | |
0.000161 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-cyclohexylurea | |
0.000184 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(4-chlorophenyl)urea | |
0.000199 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzene-1-sulfonamide | |
0.0002 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzamide | |
0.000203 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzene-1-sulfonamide | |
0.000207 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-[4-(1H-tetrazol-5-yl)phenyl]urea | |
0.00023 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-chlorophenyl)urea | |
0.00048 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-fluorophenyl)urea | |
0.001202 | - |
pH and temperature not specified in the publication | Homo sapiens | propan-2-yl 4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoate |
General Information | Comment | Organism |
---|---|---|
drug target | the enzyme is an anti-cancer drug target | Homo sapiens |