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show all sequences of 1.1.1.91

Characterization of two novel alcohol short-chain dehydrogenases/reductases from Ralstonia eutropha H16 capable of stereoselective conversion of bulky substrates

Magomedova, Z.; Grecu, A.; Sensen, C.W.; Schwab, H.; Heidinger, P.; J. Biotechnol. 221, 78-90 (2016)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in Escherichia coli Top10 cells
Cupriavidus necator
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
7.1
-
(S)-2-octanol
isoform SDR B3, at pH 10.0 and 40C
Cupriavidus necator
7.7
-
(S)-2-octanol
isoform SDR A5, at pH 10.0 and 40C
Cupriavidus necator
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Cupriavidus necator
-
-
-
Cupriavidus necator H16
-
-
-
Purification (Commentary)
Commentary
Organism
Ni-Sepharose column chromatography
Cupriavidus necator
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(R)-2-octanol + NADPH + H+
-
738738
Cupriavidus necator
?
-
-
-
?
(R)-2-octanol + NADPH + H+
-
738738
Cupriavidus necator H16
?
-
-
-
?
(S)-2-octanol + NADPH + H+
-
738738
Cupriavidus necator
?
-
-
-
?
(S)-2-octanol + NADPH + H+
-
738738
Cupriavidus necator H16
?
-
-
-
?
2-methyl-propanol + NADPH + H+
-
738738
Cupriavidus necator
?
-
-
-
?
2-methyl-propanol + NADPH + H+
-
738738
Cupriavidus necator H16
?
-
-
-
?
3-methyl-butanol + NADPH + H+
-
738738
Cupriavidus necator
?
-
-
-
?
benzil + NADPH + H+
-
738738
Cupriavidus necator
benzoin + NADP+
-
-
-
?
butanol + NADPH + H+
-
738738
Cupriavidus necator
?
-
-
-
?
additional information
no activity is detected for isoform SDR A5 with isobutyraldehyde, isovaleraldehyde, 2-heptanone, 2-phenylacetaldehyde, 1-phenyl-1-butanone, 1-phenyl-1-pentanone, 1-phenyl-1-hexanone, 1-phenyl-2-propanone, 2-hydroxyacetophenone, 2'-hydroxyacetophenone, 1-phenylpropane-1,2-dione, benzophenone, (R)-(-)-benzoin, propanol, butanol, rac-2-propanol, 2-methylpropanol, 3-methylbutanol, rac-3-methyl-2-butanol, (S)-4-methyl-2-pentanol, (R)-4-methyl-2-pentanol, (R)-2-hexanol, (R)-2-octanol, rac-1-amino-2-propanol, rac-1-bromo-2-propanol, butan-2,3-diol, rac-decan-1,2-diol, 3-hydroxybutanoic acid, 2-hexyn-1-ol, (R)-1-phenylethanol, 2-phenylethanol, rac-benzoin, meso-hydrobenzoin, (S,S)-hydrobenzoin, and (R,R)-hydrobenzoin. No activity is detected for isoform SDR B3 with isobutyraldehyde, 2-hexanone, 2-heptanone, 2-octanone, ethyl acetoacetate, acetophenone, 1-phenyl-1-butanone, 1-phenyl-1-pentanone, 1-phenyl-1-hexanone, 1-phenyl-2-propanone, 2-hydroxyacetophenone, 2'-hydroxyacetophenone, 4-(4-hydroxyphenyl)-2-butanone, 1-phenylpropane-1,2-dione, benzophenone, rac-benzoin, (R)-benzoin, propanol, butanol, rac-2-propanol, 2-methylpropanol, 3-methylbutanol, (R)-4-methyl-2-pentanol, (R)-2-hexanol, rac-1-amino-2-propanol, rac-1-bromo-2-propanol, butan-2,3-diol, 3-hydroxybutanoic acid, 2-hexyn-1-ol, (R)-1-phenylethanol, 2-phenylethanol, rac-benzoin, meso-hydrobenzoin, (S,S)-hydrobenzoin, and (R,R)-hydrobenzoin
738738
Cupriavidus necator
?
-
-
-
-
additional information
the enzyme accepts both NAD+ and NADP+. However, purified enzyme shows strong preference for NADP+
738738
Cupriavidus necator
?
-
-
-
-
additional information
no activity is detected for isoform SDR A5 with isobutyraldehyde, isovaleraldehyde, 2-heptanone, 2-phenylacetaldehyde, 1-phenyl-1-butanone, 1-phenyl-1-pentanone, 1-phenyl-1-hexanone, 1-phenyl-2-propanone, 2-hydroxyacetophenone, 2'-hydroxyacetophenone, 1-phenylpropane-1,2-dione, benzophenone, (R)-(-)-benzoin, propanol, butanol, rac-2-propanol, 2-methylpropanol, 3-methylbutanol, rac-3-methyl-2-butanol, (S)-4-methyl-2-pentanol, (R)-4-methyl-2-pentanol, (R)-2-hexanol, (R)-2-octanol, rac-1-amino-2-propanol, rac-1-bromo-2-propanol, butan-2,3-diol, rac-decan-1,2-diol, 3-hydroxybutanoic acid, 2-hexyn-1-ol, (R)-1-phenylethanol, 2-phenylethanol, rac-benzoin, meso-hydrobenzoin, (S,S)-hydrobenzoin, and (R,R)-hydrobenzoin. No activity is detected for isoform SDR B3 with isobutyraldehyde, 2-hexanone, 2-heptanone, 2-octanone, ethyl acetoacetate, acetophenone, 1-phenyl-1-butanone, 1-phenyl-1-pentanone, 1-phenyl-1-hexanone, 1-phenyl-2-propanone, 2-hydroxyacetophenone, 2'-hydroxyacetophenone, 4-(4-hydroxyphenyl)-2-butanone, 1-phenylpropane-1,2-dione, benzophenone, rac-benzoin, (R)-benzoin, propanol, butanol, rac-2-propanol, 2-methylpropanol, 3-methylbutanol, (R)-4-methyl-2-pentanol, (R)-2-hexanol, rac-1-amino-2-propanol, rac-1-bromo-2-propanol, butan-2,3-diol, 3-hydroxybutanoic acid, 2-hexyn-1-ol, (R)-1-phenylethanol, 2-phenylethanol, rac-benzoin, meso-hydrobenzoin, (S,S)-hydrobenzoin, and (R,R)-hydrobenzoin
738738
Cupriavidus necator H16
?
-
-
-
-
additional information
the enzyme accepts both NAD+ and NADP+. However, purified enzyme shows strong preference for NADP+
738738
Cupriavidus necator H16
?
-
-
-
-
rac-4-methyl-2-pentanol + NADPH + H+
-
738738
Cupriavidus necator
?
-
-
-
?
rac-butan-2,3-diol + NADPH + H+
-
738738
Cupriavidus necator
?
-
-
-
?
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
40
-
isoform SDR A5
Cupriavidus necator
50
-
isoform SDR B3
Cupriavidus necator
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
4.3
-
(S)-2-octanol
isoform SDR B3, at pH 10.0 and 40C
Cupriavidus necator
13.7
-
(S)-2-octanol
isoform SDR A5, at pH 10.0 and 40C
Cupriavidus necator
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.5
-
for the reduction reaction
Cupriavidus necator
11
-
for the oxidation reaction
Cupriavidus necator
Cofactor
Cofactor
Commentary
Organism
Structure
NADP+
-
Cupriavidus necator
NADPH
preferred cofactor
Cupriavidus necator
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli Top10 cells
Cupriavidus necator
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADP+
-
Cupriavidus necator
NADPH
preferred cofactor
Cupriavidus necator
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
7.1
-
(S)-2-octanol
isoform SDR B3, at pH 10.0 and 40C
Cupriavidus necator
7.7
-
(S)-2-octanol
isoform SDR A5, at pH 10.0 and 40C
Cupriavidus necator
Purification (Commentary) (protein specific)
Commentary
Organism
Ni-Sepharose column chromatography
Cupriavidus necator
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(R)-2-octanol + NADPH + H+
-
738738
Cupriavidus necator
?
-
-
-
?
(R)-2-octanol + NADPH + H+
-
738738
Cupriavidus necator H16
?
-
-
-
?
(S)-2-octanol + NADPH + H+
-
738738
Cupriavidus necator
?
-
-
-
?
(S)-2-octanol + NADPH + H+
-
738738
Cupriavidus necator H16
?
-
-
-
?
2-methyl-propanol + NADPH + H+
-
738738
Cupriavidus necator
?
-
-
-
?
2-methyl-propanol + NADPH + H+
-
738738
Cupriavidus necator H16
?
-
-
-
?
3-methyl-butanol + NADPH + H+
-
738738
Cupriavidus necator
?
-
-
-
?
benzil + NADPH + H+
-
738738
Cupriavidus necator
benzoin + NADP+
-
-
-
?
butanol + NADPH + H+
-
738738
Cupriavidus necator
?
-
-
-
?
additional information
no activity is detected for isoform SDR A5 with isobutyraldehyde, isovaleraldehyde, 2-heptanone, 2-phenylacetaldehyde, 1-phenyl-1-butanone, 1-phenyl-1-pentanone, 1-phenyl-1-hexanone, 1-phenyl-2-propanone, 2-hydroxyacetophenone, 2'-hydroxyacetophenone, 1-phenylpropane-1,2-dione, benzophenone, (R)-(-)-benzoin, propanol, butanol, rac-2-propanol, 2-methylpropanol, 3-methylbutanol, rac-3-methyl-2-butanol, (S)-4-methyl-2-pentanol, (R)-4-methyl-2-pentanol, (R)-2-hexanol, (R)-2-octanol, rac-1-amino-2-propanol, rac-1-bromo-2-propanol, butan-2,3-diol, rac-decan-1,2-diol, 3-hydroxybutanoic acid, 2-hexyn-1-ol, (R)-1-phenylethanol, 2-phenylethanol, rac-benzoin, meso-hydrobenzoin, (S,S)-hydrobenzoin, and (R,R)-hydrobenzoin. No activity is detected for isoform SDR B3 with isobutyraldehyde, 2-hexanone, 2-heptanone, 2-octanone, ethyl acetoacetate, acetophenone, 1-phenyl-1-butanone, 1-phenyl-1-pentanone, 1-phenyl-1-hexanone, 1-phenyl-2-propanone, 2-hydroxyacetophenone, 2'-hydroxyacetophenone, 4-(4-hydroxyphenyl)-2-butanone, 1-phenylpropane-1,2-dione, benzophenone, rac-benzoin, (R)-benzoin, propanol, butanol, rac-2-propanol, 2-methylpropanol, 3-methylbutanol, (R)-4-methyl-2-pentanol, (R)-2-hexanol, rac-1-amino-2-propanol, rac-1-bromo-2-propanol, butan-2,3-diol, 3-hydroxybutanoic acid, 2-hexyn-1-ol, (R)-1-phenylethanol, 2-phenylethanol, rac-benzoin, meso-hydrobenzoin, (S,S)-hydrobenzoin, and (R,R)-hydrobenzoin
738738
Cupriavidus necator
?
-
-
-
-
additional information
the enzyme accepts both NAD+ and NADP+. However, purified enzyme shows strong preference for NADP+
738738
Cupriavidus necator
?
-
-
-
-
additional information
no activity is detected for isoform SDR A5 with isobutyraldehyde, isovaleraldehyde, 2-heptanone, 2-phenylacetaldehyde, 1-phenyl-1-butanone, 1-phenyl-1-pentanone, 1-phenyl-1-hexanone, 1-phenyl-2-propanone, 2-hydroxyacetophenone, 2'-hydroxyacetophenone, 1-phenylpropane-1,2-dione, benzophenone, (R)-(-)-benzoin, propanol, butanol, rac-2-propanol, 2-methylpropanol, 3-methylbutanol, rac-3-methyl-2-butanol, (S)-4-methyl-2-pentanol, (R)-4-methyl-2-pentanol, (R)-2-hexanol, (R)-2-octanol, rac-1-amino-2-propanol, rac-1-bromo-2-propanol, butan-2,3-diol, rac-decan-1,2-diol, 3-hydroxybutanoic acid, 2-hexyn-1-ol, (R)-1-phenylethanol, 2-phenylethanol, rac-benzoin, meso-hydrobenzoin, (S,S)-hydrobenzoin, and (R,R)-hydrobenzoin. No activity is detected for isoform SDR B3 with isobutyraldehyde, 2-hexanone, 2-heptanone, 2-octanone, ethyl acetoacetate, acetophenone, 1-phenyl-1-butanone, 1-phenyl-1-pentanone, 1-phenyl-1-hexanone, 1-phenyl-2-propanone, 2-hydroxyacetophenone, 2'-hydroxyacetophenone, 4-(4-hydroxyphenyl)-2-butanone, 1-phenylpropane-1,2-dione, benzophenone, rac-benzoin, (R)-benzoin, propanol, butanol, rac-2-propanol, 2-methylpropanol, 3-methylbutanol, (R)-4-methyl-2-pentanol, (R)-2-hexanol, rac-1-amino-2-propanol, rac-1-bromo-2-propanol, butan-2,3-diol, 3-hydroxybutanoic acid, 2-hexyn-1-ol, (R)-1-phenylethanol, 2-phenylethanol, rac-benzoin, meso-hydrobenzoin, (S,S)-hydrobenzoin, and (R,R)-hydrobenzoin
738738
Cupriavidus necator H16
?
-
-
-
-
additional information
the enzyme accepts both NAD+ and NADP+. However, purified enzyme shows strong preference for NADP+
738738
Cupriavidus necator H16
?
-
-
-
-
rac-4-methyl-2-pentanol + NADPH + H+
-
738738
Cupriavidus necator
?
-
-
-
?
rac-butan-2,3-diol + NADPH + H+
-
738738
Cupriavidus necator
?
-
-
-
?
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
40
-
isoform SDR A5
Cupriavidus necator
50
-
isoform SDR B3
Cupriavidus necator
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
4.3
-
(S)-2-octanol
isoform SDR B3, at pH 10.0 and 40C
Cupriavidus necator
13.7
-
(S)-2-octanol
isoform SDR A5, at pH 10.0 and 40C
Cupriavidus necator
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.5
-
for the reduction reaction
Cupriavidus necator
11
-
for the oxidation reaction
Cupriavidus necator
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
0.6
-
(S)-2-octanol
isoform SDR B3, at pH 10.0 and 40C
Cupriavidus necator
1.8
-
(S)-2-octanol
isoform SDR A5, at pH 10.0 and 40C
Cupriavidus necator
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
0.6
-
(S)-2-octanol
isoform SDR B3, at pH 10.0 and 40C
Cupriavidus necator
1.8
-
(S)-2-octanol
isoform SDR A5, at pH 10.0 and 40C
Cupriavidus necator
Other publictions for EC 1.1.1.91
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738738
Magomedova
Characterization of two novel ...
Cupriavidus necator, Cupriavidus necator H16
J. Biotechnol.
221
78-90
2016
-
-
1
-
-
-
-
2
-
-
-
-
-
38
-
-
1
-
-
-
-
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15
-
2
-
-
2
2
-
-
2
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-
1
2
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2
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1
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15
-
2
-
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2
2
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-
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2
2
739695
Kovi
Global transcriptome changes i ...
Lolium perenne
Sci. Rep.
6
28702
2016
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4
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1
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1
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-
735498
Ying
Characterization of an allylic ...
Yokenella sp. WZY002
Appl. Environ. Microbiol.
80
2399-2409
2014
3
-
1
-
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-
7
6
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3
1
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4
1
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1
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13
1
2
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1
6
2
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2
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3
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1
2
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7
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6
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3
1
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4
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1
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13
1
2
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1
6
2
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6
6
737956
Ken
-
Biochemical characterization o ...
Taiwanofungus camphoratus
Bot. Stud.
55
14
2014
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1
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1
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1
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1
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1
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8
1
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1
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1
1
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3
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1
3
-
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1
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1
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1
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8
1
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1
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1
1
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-
-
737897
Lerchner
Crystallographic analysis and ...
Ralstonia sp., Ralstonia sp. DSMZ 6428
Biotechnol. Bioeng.
110
2803-2814
2013
-
-
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1
3
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12
-
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2
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4
-
-
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12
-
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-
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1
3
-
-
-
-
12
-
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-
-
-
4
-
-
-
-
12
-
-
-
-
-
-
-
-
12
12
724669
Yang
Cloning, expression and charac ...
Phanerochaete chrysosporium
BMC Microbiol.
12
126
2012
-
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1
-
-
-
8
14
-
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1
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1
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1
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-
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27
-
1
-
-
14
2
-
-
-
8
-
-
-
-
1
-
-
-
-
-
8
8
14
-
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1
-
-
-
-
1
-
-
-
-
27
-
1
-
-
14
2
-
-
-
-
-
-
-
14
14
389607
Gutierrez
Anisaldehyde production and ar ...
Pleurotus pulmonarius
Appl. Environ. Microbiol.
60
1783-1788
1994
-
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1
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1
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1
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1
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1
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-
-
-
-
-
-
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-
389606
Muheim
Purification and properties of ...
Phanerochaete chrysosporium
Eur. J. Biochem.
195
369-375
1991
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-
-
-
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-
5
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-
2
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1
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-
1
-
-
-
-
2
11
1
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-
1
1
-
1
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1
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-
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5
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2
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1
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-
-
2
11
1
-
-
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-
1
1
-
-
-
-
-
-
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-
288179
Kato
-
Reductive transformation of be ...
Nocardia asteroides, Nocardia asteroides JCM3016
J. Ferment. Bioeng.
69
220-223
1990
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1
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3
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2
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1
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3
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1
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1
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3
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1
-
3
-
1
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-
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-
-
-
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389479
Dalkin
Stress responses in alfalfa (M ...
Medicago sativa
Plant Physiol.
92
440-446
1990
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-
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1
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1
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-
1
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-
389592
Jaaska
-
Isoenzymes of aromatic alcohol ...
Dasypyrum villosum, Elymus repens, Secale cereale, Secale montanum, Secale sylvestre, Triticale turgidocereale, Triticum monococcum subsp. aegilopoides, Triticum turgidum
Biochem. Physiol. Pflanz.
179
21-30
1984
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16
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8
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8
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1
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16
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8
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-
1
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389602
Rhodes
-
Changes in the activity of enz ...
Solanum lycopersicum
Phytochemistry
16
655-659
1977
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-
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1
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1
1
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1
1
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389603
Mansell
-
Multiple forms and specificity ...
Picea abies
Phytochemistry
15
1849-1853
1976
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1
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1
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1
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2
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2
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1
-
1
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389601
Rhodes
-
Enzymes involved in the reduct ...
Brassica napus subsp. rapifera
Phytochemistry
14
1235-1240
1975
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4
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1
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1
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1
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1
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2
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2
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4
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1
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1
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1
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-
389598
Davies
-
Aromatic alcohol dehydrogenase ...
Solanum tuberosum
Phytochemistry
12
531-536
1973
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21
-
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1
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1
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1
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1
15
-
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2
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2
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21
-
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1
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1
-
1
15
-
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389605
Sloane
Metabolites of p-aminobenzoic ...
Mycobacterium tuberculosis
Biochim. Biophys. Acta
327
11-19
1973
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-
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2
2
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1
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1
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2
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1
3
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3
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3
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2
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2
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1
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2
-
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1
3
-
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389599
Gross
Reduction of aromatic acids to ...
Neurospora crassa
Eur. J. Biochem.
8
420-425
1969
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-
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2
5
-
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1
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1
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1
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1
1
1
11
-
1
1
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2
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2
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-
2
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2
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5
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1
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1
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1
1
1
11
-
1
1
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2
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