Information on EC 4.2.1.56 - Itaconyl-CoA hydratase

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The expected taxonomic range for this enzyme is: Proteobacteria

EC NUMBER
COMMENTARY hide
4.2.1.56
-
RECOMMENDED NAME
GeneOntology No.
Itaconyl-CoA hydratase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Citramalyl-CoA = itaconyl-CoA + H2O
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
elimination
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
C5-Branched dibasic acid metabolism
-
-
itaconate degradation
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-
SYSTEMATIC NAME
IUBMB Comments
citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
37290-83-8
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-citramalyl-CoA
itaconyl-CoA + H2O
show the reaction diagram
itaconyl-CoA + H2O
(S)-citramalyl-CoA
show the reaction diagram
Itaconyl-CoA + H2O
?
show the reaction diagram
Itaconyl-CoA + H2O
Citramalyl-CoA
show the reaction diagram
mesaconyl-C4-CoA + H2O
itaconyl-CoA
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
itaconyl-CoA + H2O
(S)-citramalyl-CoA
show the reaction diagram
Itaconyl-CoA + H2O
?
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.14 - 0.49
(S)-citramalyl-CoA
0.034 - 0.12
itaconyl-CoA
0.31 - 0.51
mesaconyl-C4-CoA
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4.4 - 415.4
(S)-citramalyl-CoA
52.2 - 415
itaconyl-CoA
98.8 - 4651
mesaconyl-C4-CoA
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells