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Information on EC 4.1.3.6 - citrate (pro-3S)-lyase and Organism(s) Homo sapiens and UniProt Accession Q8N0X4

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.3 Oxo-acid-lyases
                4.1.3.6 citrate (pro-3S)-lyase
IUBMB Comments
The enzyme can be dissociated into components, two of which are identical with EC 2.8.3.10 (citrate CoA-transferase) and EC 4.1.3.34 (citryl-CoA lyase). EC 3.1.2.16, citrate lyase deacetylase, deacetylates and inactivates the enzyme.
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This record set is specific for:
Homo sapiens
UNIPROT: Q8N0X4
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Reaction Schemes
Synonyms
citrate (pro-3s)-lyase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
citrase
-
-
-
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citratase
-
-
-
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citrate (pro-3S)-lyase
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citrate aldolase
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-
-
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citrate lyase
citrate oxaloacetate-lyase(pro-3S-COO- --> acetate)
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-
-
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citric aldolase
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-
-
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citridesmolase
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-
-
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citritase
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-
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lyase, citrate
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
elimination
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-
SYSTEMATIC NAME
IUBMB Comments
citrate oxaloacetate-lyase (forming acetate from the pro-S carboxymethyl group of citrate)
The enzyme can be dissociated into components, two of which are identical with EC 2.8.3.10 (citrate CoA-transferase) and EC 4.1.3.34 (citryl-CoA lyase). EC 3.1.2.16, citrate lyase deacetylase, deacetylates and inactivates the enzyme.
CAS REGISTRY NUMBER
COMMENTARY hide
9012-83-3
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
citrate
acetate + oxaloacetate
show the reaction diagram
citrate
acetate + oxaloacetate
show the reaction diagram
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-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
citrate
acetate + oxaloacetate
show the reaction diagram
citrate fermentation pathway
-
r
citrate
acetate + oxaloacetate
show the reaction diagram
-
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
for DNA isolation
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CLYBL_HUMAN
340
0
37359
Swiss-Prot
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
beta-subunit
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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polymorphisms of the citrate lyase gene, may be involved in appetite regulation and antipsychotic induced metabolic syndrome with olanzapine-induced weight gain, are analysed
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Morikawa, J.; Nishimura, Y.; Uchida, A.; Tanaka, T.
Molecular cloning of novel mouse and human putative citrate lyase beta-subunit
Biochem. Biophys. Res. Commun.
289
1282-1286
2001
Homo sapiens (Q8N0X4), Mus musculus (Q8R4N0)
Manually annotated by BRENDA team
Srivastava, V.; Deshpande, S.N.; Nimgaonkar, V.L.; Lerer, B.; Thelma, B.
Genetic correlates of olanzapine-induced weight gain in schizophrenia subjects from north India: role of metabolic pathway genes
Pharmacogenomics
9
1055-1068
2008
Homo sapiens
Manually annotated by BRENDA team