Information on EC 4.1.1.30 - pantothenoylcysteine decarboxylase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
4.1.1.30
-
RECOMMENDED NAME
GeneOntology No.
pantothenoylcysteine decarboxylase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N-[(R)-pantothenoyl]-L-cysteine = pantetheine + CO2
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Pantothenate and CoA biosynthesis
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-
SYSTEMATIC NAME
IUBMB Comments
N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase (pantetheine-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
9024-65-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
no activity in Lactobacillus acidophilus
-
-
-
Manually annotated by BRENDA team
no activity in Lactobacillus arabinosus
-
-
-
Manually annotated by BRENDA team
no activity in Lactobacillus casei
-
-
-
Manually annotated by BRENDA team
no activity in Lactobacillus delbrueckii
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
N-[(R)-pantothenoyl]-L-cysteine
pantetheine + CO2
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
N-[(R)-pantothenoyl]-L-cysteine
pantetheine + CO2
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
MgCl2
protamine
additional information
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.5 - 7.5
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.5 - 7.5
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
dialysed at 4°C, pH 5.5-7.5, without loss in activity, cell extract
MgCl2 and protamine inactivate
no loss in activity after dialysis against Versene
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
no loss in activity at 4°C or -20°C, pH 7.0, crude extract, 10-20 mg protein/ml