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Information on EC 4.1.1.15 - glutamate decarboxylase
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4.1.1.15 glutamate decarboxylaseIUBMB Comments
A pyridoxal-phosphate protein. The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate.
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Word Map
- 4.1.1.15
-
gabaergic
-
gamma-aminobutyric
- autoimmune
- autoantibody
- islet
- mellitus
-
neurotransmitter
- synaptic
- hippocampus
-
interneurons
- cortical
- autoantigens
- choline
-
excitatory
-
dorsal
- striatum
-
insulin-dependent
-
ventral
- seizure
- parvalbumin
- epilepsy
- beta-cell
-
cholinergic
-
glutamatergic
- synapses
-
medial
-
neurotransmission
-
neurochemical
-
substantia
-
afferent
-
postsynaptic
- c-peptide
-
somata
-
chat
-
presynaptic
-
antibody-positive
-
autoreactive
- ketoacidosis
- bicuculline
- gaba-transaminase
- colliculus
-
preoptic
- gaba-t
-
calretinin
-
rostral
- muscimol
-
boutons
- reelin
- calbindin
- analysis
- synthesis
- pharmacology
- nutrition
- medicine
- food industry
- diagnostics
-
glycinergic
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
glutamic acid decarboxylase, gad65, gad67, glutamate decarboxylase, glutamic acid decarboxylase 65, glutamic acid decarboxylase 67, gad-65, gad-67, glutamate decarboxylase 67, l-glutamate decarboxylase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
65 kDa glutamic acid decarboxylase
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67 kDa glutamic acid decarboxylase
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Aspartate 1-decarboxylase
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-
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Aspartic alpha-decarboxylase
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-
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Cysteic acid decarboxylase
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Decarboxylase, glutamate
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ERT D1
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GAD
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GAD-65
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GAD-67
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GAD-alpha
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GAD-beta
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GAD-gamma
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GADCase
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gamma-Glutamate decarboxylase
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GDCase
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Glutamic acid decarboxylase
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Glutamic decarboxylase
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L-Aspartate-alpha-decarboxylase
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L-Glutamate alpha-decarboxylase
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L-Glutamate decarboxylase
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L-Glutamic acid decarboxylase
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L-Glutamic decarboxylase
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MGAD
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
decarboxylation
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-
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PATHWAY SOURCE
PATHWAYS
KEGG
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-, -, -
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SYSTEMATIC NAME
IUBMB Comments
L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)
A pyridoxal-phosphate protein. The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate.
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CAS REGISTRY NUMBER
COMMENTARY
9024-58-2
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-glutamate
4-aminobutanoate + CO2
GAD is the rate-limiting enzyme in controlling GABA synthesis, GAD65 is transiently activated in response to the extra demand of GABA in neurotransmission
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?
additional information
?
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GAD65 plays an essential role in neurotransmission, and is a typical autoantigen in several human autoimmune diseases, such as insulin-dependent diabetes mellitus, IDDM and Stiffman-Person syndrome, SPS. Posttranslational regulation of the enzyme in brain, overview
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-
?
additional information
?
-
GAD65 plays an essential role in neurotransmission, and is a typical autoantigen in several human autoimmune diseases, such as insulin-dependent diabetes mellitus, IDDM and Stiffman-Person syndrome, SPS. Posttranslational regulation of the enzyme in brain, overview
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-glutamate
4-aminobutanoate + CO2
GAD is the rate-limiting enzyme in controlling GABA synthesis, GAD65 is transiently activated in response to the extra demand of GABA in neurotransmission
-
-
?
additional information
?
-
GAD65 plays an essential role in neurotransmission, and is a typical autoantigen in several human autoimmune diseases, such as insulin-dependent diabetes mellitus, IDDM and Stiffman-Person syndrome, SPS. Posttranslational regulation of the enzyme in brain, overview
-
-
?
additional information
?
-
GAD65 plays an essential role in neurotransmission, and is a typical autoantigen in several human autoimmune diseases, such as insulin-dependent diabetes mellitus, IDDM and Stiffman-Person syndrome, SPS. Posttranslational regulation of the enzyme in brain, overview
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
ginsenosides in ginseng extract, high content of Rb1, inhibit the enzyme
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
asiaticoside
stimulates at 0.0104 mM in vitro by 22%. No stimulation is observed in the absence of pyridoxal 5'-phosphate, so it is unlikely that asiaticoside acts as a PLP mimic
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
4-aminobutyrate-2-oxoglutarate transaminase deficiency
4-Aminobutyrate aminotransferase (GABA-transaminase) deficiency.
4-aminobutyrate-2-oxoglutarate transaminase deficiency
The pediatric neurotransmitter disorders.
Acidosis
DIABETIC KETOACIDOSIS ASSOCIATED WITH ALPELISIB TREATMENT OF METASTATIC BREAST CANCER.
Acidosis
Japanese cases of acute onset diabetic ketosis without acidosis in the absence of glutamic acid decarboxylase autoantibody.
Acidosis
The first series of cases of ketosis-prone type 2 diabetes (flatbush diabetes) in Brazilian adults.
Acidosis
[The effect of chronic acidosis on the activity of renal glutamate decarboxylase and GABA-transaminase]
Addison Disease
Etiological diagnosis of primary adrenal insufficiency using an original flowchart of immune and biochemical markers.
Addison Disease
Glutamic acid decarboxylase autoantibody assay using 125I-labelled recombinant GAD65 produced in yeast.
Addison Disease
Isolation and characterization of human monoclonal autoantibodies to glutamic acid decarboxylase.
Addison Disease
Positive autoantibodies to ZnT8 indicate elevated risk for additional autoimmune conditions in patients with Addison's disease.
Adenocarcinoma
A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer.
Adenocarcinoma
Ornithine decarboxylase and glutamate decarboxylase 65 as prognostic markers of gallbladder malignancy: a clinicopathological study in benign and malignant lesions of the gallbladder.
Adenocarcinoma of Lung
Prognostic significance of GAD1 overexpression in patients with resected lung adenocarcinoma.
Adenomatous Polyps
Ornithine decarboxylase and glutamate decarboxylase 65 as prognostic markers of gallbladder malignancy: a clinicopathological study in benign and malignant lesions of the gallbladder.
Adenomyosis
Possible Loss of GABAergic Inhibition in Mice With Induced Adenomyosis and Treatment With Epigallocatechin-3-Gallate Attenuates the Loss With Improved Hyperalgesia.
Adrenoleukodystrophy
Etiological diagnosis of primary adrenal insufficiency using an original flowchart of immune and biochemical markers.
Alzheimer Disease
Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.
Alzheimer Disease
GABAergic deafferentation hypothesis of brain aging and Alzheimer's disease revisited.
Alzheimer Disease
GAD65, GAD67, and GABAT immunostaining in human brain and apparent GAD65 loss in Alzheimer's disease.
Alzheimer Disease
Gad67 haploinsufficiency reduces amyloid pathology and rescues olfactory memory deficits in a mouse model of Alzheimer's disease.
Alzheimer Disease
Glutamate and GABA-Metabolizing Enzymes in Post-mortem Cerebellum in Alzheimer's Disease: Phosphate-Activated Glutaminase and Glutamic Acid Decarboxylase.
Alzheimer Disease
Implications for altered glutamate and GABA metabolism in the dorsolateral prefrontal cortex of aged schizophrenic patients.
Alzheimer Disease
Increasing thermal stability and catalytic activity of glutamate decarboxylase in E. coli: An in silico study.
Alzheimer Disease
Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue.
Alzheimer Disease
Striatal expression of glutamic acid decarboxylase gene in Alzheimer's disease.
Alzheimer Disease
[Impaired cerebral glutamate metabolism in mental diseases (Alzheimer's disease, schizophrenia]
Amnesia
Profound amnesia after temporal lobectomy: an autoimmune process resembling patient h.m.?
Anaphylaxis
Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus.
Anemia, Hypochromic
?-Aminobutyric Acid Suppresses Iron Transportation from Roots to Shoots in Rice Seedlings by Inducing Aerenchyma Formation.
Arthritis, Rheumatoid
HLA-associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent-onset insulin-dependent diabetes mellitus.
Arthritis, Rheumatoid
Recent Patents on Immunoregulatory DNA Vaccines for Autoimmune Diseases and Allograft Rejection.
Astrocytoma
Loss of inhibitory synapses on the soma and axon initial segment of pyramidal cells in human epileptic peritumoural neocortex: implications for epilepsy.
Ataxia
Intravenous Immunoglobulin and Rituximab for Cerebellar Ataxia with Glutamic Acid Decarboxylase Autoantibodies.
Ataxia
Parkinsonian features in aging GFAP.HMOX1 transgenic mice overexpressing human HO-1 in the astroglial compartment.
Ataxia
Presentation of opsoclonus myoclonus ataxia syndrome with glutamic acid decarboxylase antibodies.
Ataxia
Suppression of detrusor-sphincter dyssynergia by herpes simplex virus vector mediated gene delivery of glutamic acid decarboxylase in spinal cord injured rats.
Atherosclerosis
Glutamic acid decarboxylase antibodies are indicators of the course, but not of the onset, of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities Study.
Autoimmune Diseases
A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region.
Autoimmune Diseases
Activation of CD8+ T lymphocytes in insulin-dependent diabetes mellitus.
Autoimmune Diseases
Autoantibodies to glutamic acid decarboxylase (GAD), 64,000-Mr islet cell protein (64K) antibodies and islet cell antibodies (ICA) in insulin-dependent diabetes mellitus with and without autoimmune diseases in Japan.
Autoimmune Diseases
Autoimmunity since the 1957 clonal selection theory: a little acorn to a large oak.
Autoimmune Diseases
Cloning and sequence analysis of a murine cDNA encoding glutamate decarboxylase (GAD65).
Autoimmune Diseases
Combined analysis of GAD65 and ICA512(IA-2) autoantibodies in organ and non-organ-specific autoimmune diseases confers high specificity for insulin-dependent diabetes mellitus.
Autoimmune Diseases
Correlations of Clusters of Non-Convulsive Seizure and Magnetic Resonance Imaging in a Case With GAD65-Positive Autoimmune Limbic Encephalitis.
Autoimmune Diseases
Detection of GAD65 antibodies in diabetes and other autoimmune diseases using a simple radioligand assay.
Autoimmune Diseases
Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome.
Autoimmune Diseases
Familial autoimmunity in neurological patients with GAD65 antibodies: an interview-based study.
Autoimmune Diseases
Fusion proteins for combined analysis of autoantibodies to the 65-kDa isoform of glutamic acid decarboxylase and islet antigen-2 in insulin-dependent diabetes mellitus.
Autoimmune Diseases
Glutamic acid decarboxylase 67-reactive T cells: a marker of insulin-dependent diabetes.
Autoimmune Diseases
Glutamic acid decarboxylase autoantibodies in stiff-man syndrome and insulin-dependent diabetes mellitus exhibit similarities and differences in epitope recognition.
Autoimmune Diseases
Human B cells secreting immunoglobulin G to glutamic acid decarboxylase-65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes.
Autoimmune Diseases
Interactions of Human Autoantibodies with Hippocampal GABAergic Synaptic Transmission - Analyzing Antibody-Induced Effects ex vivo.
Autoimmune Diseases
Monozygotic twins discordant for epilepsy differ in the levels of potentially pathogenic autoantibodies and cytokines.
Autoimmune Diseases
Primary DQ effect in the association between HLA and neurological syndromes with anti-GAD65 antibodies.
Autoimmune Diseases
Retroviral delivery of GAD-IgG fusion construct induces tolerance and modulates diabetes: a role for CD4+ regulatory T cells and TGF-beta?
Autoimmune Diseases
Role of GAD peptides p217 and p290 in the repair of INS receptor in salivary tissues of type 1 diabetic mice.
Autoimmune Diseases
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes.
Autoimmune Diseases
Stiff-person syndrome with amphiphysin antibodies: distinctive features of a rare disease.
Autoimmune Diseases
Structural model of human GAD65: prediction and interpretation of biochemical and immunogenic features.
Autoimmune Diseases
The activity of 8-iso-prostaglandin F2alpha as an oxidative stress marker in vivo in paediatric patients with type 1 diabetes mellitus and associated autoimmunities.
Autoimmune Diseases
The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.
Autoimmune Diseases
Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease.
Bradycardia
Exercise training increases GAD65 expression, restores the depressed GABAA receptor function within the PVN and reduces sympathetic modulation in hypertension.
Brain Diseases
Abnormal chloride homeostasis in the substancia nigra pars reticulata contributes to locomotor deficiency in a model of acute liver injury.
Brain Diseases
Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy.
Brain Diseases
Changes in the metabolism and binding of GABA in the rat brain in thioacetamide-induced hepatogenic encephalopathy.
Brain Diseases
Glutamic acid decarboxylase in cerebrospinal fluid in infancy and childhood Part II. Glutamic acid decarboxylase activity in cerebrospinal fluid of children with neurological diseases.
Brain Injuries
Adaptive Mechanisms of Somatostatin-Positive Interneurons after Traumatic Brain Injury through a Switch of ? Subunits in L-Type Voltage-Gated Calcium Channels.
Brain Ischemia
Age-dependent vulnerability of brain choline acetyltransferase activity to transient cerebral ischemia in rats.
Brain Ischemia
Immunocytochemical investigation of L-glutamic acid decarboxylase in the rat hippocampal formation: the influence of transient cerebral ischemia.
Brain Neoplasms
The gamma-aminobutyric acid content and glutamate decarboxylase activity of brain tumours.
Breast Neoplasms
Ornithine decarboxylase and glutamate decarboxylase 65 as prognostic markers of gallbladder malignancy: a clinicopathological study in benign and malignant lesions of the gallbladder.
Bronchopneumonia
Pathological evidence of encephalomyelitis in the stiff man syndrome with anti-GAD antibodies.
Carcinogenesis
Ornithine decarboxylase and glutamate decarboxylase 65 as prognostic markers of gallbladder malignancy: a clinicopathological study in benign and malignant lesions of the gallbladder.
Carcinoma
A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer.
Carcinoma
Atezolizumab-induced type 1 diabetes mellitus in a patient with metastatic renal cell carcinoma.
Carcinoma
Characterization of a linear epitope within the human pancreatic 64-kDa glutamic acid decarboxylase and its autoimmune recognition by sera from insulin-dependent diabetes mellitus patients.
Carcinoma
Development of autoimmune diabetes with severe diabetic ketoacidosis and immune-related thyroiditis secondary to durvalumab: a case report.
Carcinoma
Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors.
Carcinoma
Glutamic acid decarboxylase antibody-positive paraneoplastic stiff limb syndrome associated with carcinoma of the breast.
Carcinoma
Humoral immunity against glutamic acid decarboxylase and tyrosine phosphatase IA-2 in Lambert-Eaton myasthenic syndrome.
Carcinoma, Renal Cell
A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer.
Carcinoma, Renal Cell
Atezolizumab-induced type 1 diabetes mellitus in a patient with metastatic renal cell carcinoma.
Carcinoma, Renal Cell
Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors.
Carcinoma, Squamous Cell
Development of autoimmune diabetes with severe diabetic ketoacidosis and immune-related thyroiditis secondary to durvalumab: a case report.
Cardiomegaly
Apigenin Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic Paraventricular Nucleus.
Catalepsy
Expression of glutamic acid decarboxylase mRNA in striatum and pallidum in an animal model of tardive dyskinesia.
Catalepsy
Glutamate decarboxylase messenger RNA in rat pallidum: comparison of the effects of haloperidol, clozapine and combined haloperidol-scopolamine treatments.
Catalepsy
Unilateral nigrostriatal lesions induce a bilateral increase in glutamate decarboxylase messenger RNA in the reticular thalamic nucleus.
Cataplexy
Search for neuron-specific and nonneuron-specific antibodies in narcoleptic patients with and without HLA DQB1*0602.
Celiac Disease
Glutamic acid decarboxylase (anti-GAD) & tissue transglutaminase (anti-TTG) antibodies in patients with thyroid autoimmunity.
Central Nervous System Diseases
Auto-destruction of the thyroid gland and coexisting glutamic acid decarboxylase mediated neurological disease in an adolescent: an unusual presentation of autoimmunity.
Central Nervous System Diseases
High-dose intravenous immune globulin for stiff-person syndrome.
Cerebellar Ataxia
A Rare Case of Cerebellar Ataxia Due to Voltage-Gated Calcium Channel and Glutamic Acid Decarboxylase Autoantibodies.
Cerebellar Ataxia
A rare saccade velocity profile in Stiff-Person Syndrome with cerebellar degeneration.
Cerebellar Ataxia
A unique combination of autoimmune limbic encephalitis, type 1 diabetes, and Stiff person syndrome associated with GAD-65 antibody.
Cerebellar Ataxia
A Variant of Alternating Skew Deviation in GAD65 Antibody-Associated Cerebellar Ataxia.
Cerebellar Ataxia
Antibody repertoire in paraneoplastic cerebellar degeneration and small cell lung cancer.
Cerebellar Ataxia
Antigenic differences between neurological and diabetic patients with anti-glutamic acid decarboxylase antibodies.
Cerebellar Ataxia
Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy.
Cerebellar Ataxia
Autoantibodies to glutamic acid decarboxylase in three patients with cerebellar ataxia, late-onset insulin-dependent diabetes mellitus, and polyendocrine autoimmunity.
Cerebellar Ataxia
Autoimmune cerebellar ataxia with glutamic acid decarboxylase 65 antibodies associated with central vestibular symptoms.
Cerebellar Ataxia
Autoimmune encephalitis associated with glutamic acid decarboxylase antibodies: a case series.
Cerebellar Ataxia
Case Report: Autoimmune Encephalitis Associated With Anti-glutamic Acid Decarboxylase Antibodies: A Pediatric Case Series.
Cerebellar Ataxia
Cerebellar ataxia and autoantibodies restricted to glutamic acid decarboxylase 67 (GAD67).
Cerebellar Ataxia
Cerebellar ataxia and epilepsy with anti-GAD antibodies: treatment with IVIG and plasmapheresis.
Cerebellar Ataxia
Cerebellar ataxia and glutamic acid decarboxylase antibodies: immunologic profile and long-term effect of immunotherapy.
Cerebellar Ataxia
Cerebellar ataxia associated with anti-glutamic acid decarboxylase autoantibodies.
Cerebellar Ataxia
Cerebellar ataxia with anti-glutamic acid decarboxylase antibodies: study of 14 patients.
Cerebellar Ataxia
Cortical dysfunction in cerebellar ataxia with antibodies to glutamic acid decarboxylase.
Cerebellar Ataxia
Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions.
Cerebellar Ataxia
Familial autoimmunity in neurological patients with GAD65 antibodies: an interview-based study.
Cerebellar Ataxia
GABA-A receptor impairment in cerebellar ataxia with anti-glutamic acid decarboxylase antibodies.
Cerebellar Ataxia
GAD antibody-spectrum disorders: progress in clinical phenotypes, immunopathogenesis and therapeutic interventions.
Cerebellar Ataxia
Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders.
Cerebellar Ataxia
Interactions of Human Autoantibodies with Hippocampal GABAergic Synaptic Transmission - Analyzing Antibody-Induced Effects ex vivo.
Cerebellar Ataxia
Intravenous Immunoglobulin and Rituximab for Cerebellar Ataxia with Glutamic Acid Decarboxylase Autoantibodies.
Cerebellar Ataxia
Lesson of the month 2: Autoimmune sequelae of anti-GAD antibodies - thinking outside the box.
Cerebellar Ataxia
Neurochondrin Antibody Serum Positivity in Three Cases of Autoimmune Cerebellar Ataxia.
Cerebellar Ataxia
Opsoclonus in a patient with increased titers of anti-GAD antibody provides proof for the conductance-based model of saccadic oscillations.
Cerebellar Ataxia
Pathogenic Roles of Glutamic Acid Decarboxylase 65 Autoantibodies in Cerebellar Ataxias.
Cerebellar Ataxia
Presynaptic impairment of cerebellar inhibitory synapses by an autoantibody to glutamate decarboxylase.
Cerebellar Ataxia
Presynaptic inhibition of cerebellar GABAergic transmission by glutamate decarboxylase autoantibodies in progressive cerebellar ataxia.
Cerebellar Ataxia
Rapidly Progressive Cerebellar Hemiataxia with High Levels of GAD65 Reactive Antibodies.
Cerebellar Ataxia
Respective implications of glutamate decarboxylase antibodies in stiff person syndrome and cerebellar ataxia.
Cerebellar Ataxia
Selective suppression of cerebellar GABAergic transmission by an autoantibody to glutamic acid decarboxylase.
Cerebellar Ataxia
Stiff-person syndrome associated with cerebellar ataxia and high glutamic acid decarboxylase antibody titer.
Cerebellar Ataxia
T-cell reactivity to glutamic acid decarboxylase in stiff-man syndrome and cerebellar ataxia associated with polyendocrine autoimmunity.
Cerebellar Ataxia
Therapeutic plasma exchange and immunosuppressive therapy in a patient with anti-GAD antibody-related epilepsy: Quantification of the antibody response.
Cerebellar Ataxia
Transient Neurological Symptoms Preceding Cerebellar Ataxia with Glutamic Acid Decarboxylase Antibodies.
Cerebellar Ataxia
[Anti-GAD antibodies in paraneoplastic cerebellar ataxia associated with limbic encephalitis and autonomic dysfunction.]
Cerebellar Ataxia
[Stiff-person syndrome and other neurological disorders associated with anti-GAD antibodies.]
Cerebral Palsy
Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders.
Chickenpox
Reduced activity of GAD67 expressing cells in the reticular thalamus enhance thalamic excitatory activity and varicella zoster virus associated pain.
Cholangiocarcinoma
Case report: pembrolizumab-induced Type 1 diabetes in a patient with metastatic cholangiocarcinoma.
Cholecystitis
Ornithine decarboxylase and glutamate decarboxylase 65 as prognostic markers of gallbladder malignancy: a clinicopathological study in benign and malignant lesions of the gallbladder.
Cholera
Axon terminals possessing the alpha 2c-adrenergic receptor in the rat dorsal horn are predominantly excitatory.
Cholera
Bacterial and plant enterotoxin B subunit-autoantigen fusion proteins suppress diabetes insulitis.
Cholera
Cholera toxin B subunit linked to glutamic acid decarboxylase suppresses dendritic cell maturation and function.
Cholera
Cloning, expression, purification and characterization of the cholera toxin B subunit and triple glutamic acid decarboxylase epitopes fusion protein in Escherichia coli.
Cholera
GABAergic and other noncholinergic basal forebrain neurons, together with cholinergic neurons, project to the mesocortex and isocortex in the rat.
Cholera
GABAergic projection from the ventral tegmental area and substantia nigra to the periaqueductal gray region and the dorsal raphe nucleus.
Cholera
Immunotherapy of autoimmune diabetes by nasal administration of tandem glutamic acid decarboxylase 65 peptides.
Cholera
Pre-embedding staining for GAD67 versus postembedding staining for GABA as markers for central GABAergic terminals.
Cholera
Projections of GABAergic and cholinergic basal forebrain and GABAergic preoptic-anterior hypothalamic neurons to the posterior lateral hypothalamus of the rat.
Cleft Lip
Association between nonsyndromic cleft lip with or without cleft palate and the glutamic acid decarboxylase 67 gene in the Japanese population.
Cleft Palate
Association between nonsyndromic cleft lip with or without cleft palate and the glutamic acid decarboxylase 67 gene in the Japanese population.
Cleft Palate
Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy.
Cleft Palate
Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase.
Cleft Palate
Cleft palate by picrotoxin or 3-MP and palatal shelf elevation in GABA-deficient mice.
Cleft Palate
Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67.
Cleft Palate
Experimental induction of palate shelf elevation in glutamate decarboxylase 67-deficient mice with cleft palate due to vertically oriented palatal shelf.
Cleft Palate
GAD65/GAD67 double knockout mice exhibit intermediate severity in both cleft palate and omphalocele compared with GAD67 knockout and VGAT knockout mice.
Colitis, Ulcerative
Activation of GABAA Receptors in Colon Epithelium Exacerbates Acute Colitis.
Coma
Glutamate decarboxylase inhibition and vitamin B6 metabolism in brain of cirrhotic rats chronically treated with carbon tetrachloride.
Coma
Regional brain GABA metabolism and release during hepatic coma produced in rats chronically treated with carbon tetrachloride.
Coma
[Enzyme activity and level of GABA-shunt substrates in rat brain during repeated exposure to hypoglycemic doses of insulin]
Contracture
Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy.
Cystic Fibrosis
Anti-GAD65 reactive peripheral blood mononuclear cells in the pathogenesis of cystic fibrosis related diabetes mellitus.
Cystic Fibrosis
ZnT8 antibodies in patients with cystic fibrosis: An expression of secondary beta-cell damage?
Cysts
Glutamic Acid Decarboxylase Antibody in a Patient with Myelitis: A Retrospective Study.
Cysts
Toxoplasma gondii Infections Alter GABAergic Synapses and Signaling in the Central Nervous System.
Cytomegalovirus Infections
Rapid-onset type 1 diabetes associated with cytomegalovirus infection and islet autoantibody synthesis.
Deafness
THE CLINICAL AND METABOLIC CHARACTERISTICS OF YOUNG-ONSET KETOSIS-PRONE TYPE 2 DIABETES IN CHINA.
Dehydration
Nitric Oxide Signal, Nitrogen Metabolism, and Water Balance Affected by ?-Aminobutyric Acid (GABA) in Relation to Enhanced Tolerance to Water Stress in Creeping Bentgrass.
Dementia
Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.
Dementia
Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue.
Diabetes Complications
Glutamic acid decarboxylase antibodies and diabetes complications. Assay reliability and validity.
Diabetes Complications
No association of antibodies to glutamic acid decarboxylase and diabetic complications in patients with IDDM.
Diabetes Mellitus
A Triad of Ketoacidosis, Hypertriglyceridemia, and Acute Pancreatitis Associated With Sugar-Sweetened Soft Drinks Abuse in a Caucasian Patient With Undiagnosed Type 2 Diabetes Mellitus.
Diabetes Mellitus
Absence of glutamic acid decarboxylase antibodies in Pima Indian children with diabetes mellitus.
Diabetes Mellitus
Activation of CD4+ and CD8+ T-lymphocytes by insulin and GAD in patients with type 1 or 2 diabetes mellitus.
Diabetes Mellitus
Age-specific levels of diabetes-related GAD and IA-2 antibodies in healthy children and adults.
Diabetes Mellitus
An exploration of Glo-3A antibody levels in children at increased risk for type 1 diabetes mellitus.
Diabetes Mellitus
Analysis of diabetes-associated autoantibodies in children and adolescents with autoimmune thyroid diseases.
Diabetes Mellitus
Anti-glutamic acid decarboxylase antibody in Graves' disease is a possible indicator for the unlikelihood of going into remission with antithyroid agents.
Diabetes Mellitus
Antibodies to GAD65 epitopes at diagnosis and over the first 10 years of clinical type 1 diabetes mellitus.
Diabetes Mellitus
Antibodies to glutamic acid decarboxylase and diabetes mellitus in the Multiple Risk Factor Intervention Trial.
Diabetes Mellitus
Antibodies to glutamic acid decarboxylase are associated with HLA-DR genotypes in both Australians and Asians with type 1 (insulin-dependent) diabetes mellitus.
Diabetes Mellitus
Antibodies to glutamic acid decarboxylase discriminate major types of diabetes mellitus.
Diabetes Mellitus
Antibodies to glutamic acid decarboxylase in Japanese diabetic patients with secondary failure of oral hypoglycaemic therapy.
Diabetes Mellitus
Antibodies to glutamic acid decarboxylase in young Chinese diabetic patients.
Diabetes Mellitus
Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease.
Diabetes Mellitus
Antibodies to pancreatic islet cell antigens in diabetes seen in Southern India with particular reference to fibrocalculous pancreatic diabetes.
Diabetes Mellitus
Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome.
Diabetes Mellitus
Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial.
Diabetes Mellitus
Appearance of islet cell autoantibodies after clinical diagnosis of diabetes mellitus.
Diabetes Mellitus
Association between antibodies to the MR 67,000 isoform of glutamate decarboxylase (GAD) and type 1 (insulin-dependent) diabetes mellitus with coexisting autoimmune polyendocrine syndrome type II.
Diabetes Mellitus
Association between high titers of glutamic acid decarboxylase antibody and epilepsy in patients with type 1 diabetes mellitus: A cross-sectional study.
Diabetes Mellitus
Auto-immune cerebellar ataxia with anti-GAD antibodies accompanied by de novo late-onset type 1 diabetes mellitus.
Diabetes Mellitus
Autoantibodies against GAD65 rather than GAD67 precede the onset of type 1 diabetes.
Diabetes Mellitus
Autoantibodies against IA-2, GAD, and topoisomerase II in type 1 diabetic patients.
Diabetes Mellitus
Autoantibodies to GAD65 and IA-2 antibodies are increased, but not tissue transglutaminase (TTG-Ab) in type 2 diabetes mellitus (T2DM) patients from South India.
Diabetes Mellitus
Autoantibodies to glutamic acid decarboxylase and insulin in islet cell antibody positive presymptomatic type 1 diabetes mellitus: frequency and segregation by age and gender.
Diabetes Mellitus
Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I diabetes mellitus.
Diabetes Mellitus
Autoantibodies to IA-2 and GAD65 in patients with type 2 diabetes mellitus of varied duration: prevalence and correlation with clinical features.
Diabetes Mellitus
Autoantibody recognition of COOH-terminal epitopes of GAD65 marks the risk for insulin requirement in adult-onset diabetes mellitus.
Diabetes Mellitus
Autoimmune Diabetes and Thyroiditis Complicating Treatment with Nivolumab.
Diabetes Mellitus
Autoimmune polyendocrine syndrome 3 onset with severe ketoacidosis in a 74-year-old woman.
Diabetes Mellitus
Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme.
Diabetes Mellitus
Case report: pembrolizumab-induced Type 1 diabetes in a patient with metastatic cholangiocarcinoma.
Diabetes Mellitus
CD4(+) T cells from glutamic acid decarboxylase (GAD)65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transfer.
Diabetes Mellitus
Cerebellar ataxia and epilepsy with anti-GAD antibodies: treatment with IVIG and plasmapheresis.
Diabetes Mellitus
Cerebellar ataxia with anti-glutamic acid decarboxylase antibodies: study of 14 patients.
Diabetes Mellitus
Change of glutamic acid decarboxylase antibody and protein tyrosine phosphatase antibody in Chinese patients with acute-onset type 1 diabetes mellitus.
Diabetes Mellitus
Clinical and biochemical characteristics of nonobese type 2 diabetic patients with glutamic acid decarboxylase antibody in Korea.
Diabetes Mellitus
Clinical and Genetic Characteristics of Non-Insulin-Requiring Glutamic Acid Decarboxylase (GAD) Autoantibody-Positive Diabetes: A Nationwide Survey in Japan.
Diabetes Mellitus
Clinical and genetic characteristics of patients with autoimmune thyroid disease with anti-islet autoimmunity.
Diabetes Mellitus
Clinical significance and time course of antibodies to glutamic acid decarboxylase in Japanese children with type I (insulin-dependent) diabetes mellitus.
Diabetes Mellitus
Concurrent extrahepatic autoimmune disorders: unexplored dimension of autoimmune liver disease in children.
Diabetes Mellitus
Cross-reactive peptide epitopes of Enterovirus Coxsackie B4 and human glutamic acid decarboxylase detecting antibodies in latent autoimmune diabetes in adults versus type 1 diabetes.
Diabetes Mellitus
Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with type I diabetes mellitus.
Diabetes Mellitus
Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression.
Diabetes Mellitus
Detection and immunochemical characterization of glutamic acid decarboxylase autoantibodies in patients with autoimmune diabetes mellitus.
Diabetes Mellitus
Detection of recombinant GAD65 and GAD67 antibodies using a simple radioimmunoassay.
Diabetes Mellitus
Development of 2 alternative enzyme-linked immunosorbent assays for routine screening of glutamic acid decarboxylase autoantibodies.
Diabetes Mellitus
Diabetes mellitus decreases the expression of calcitonin-gene related peptide, gamma-amino butyric acid and glutamic acid decarboxylase in human pancreatic islet cells.
Diabetes Mellitus
Diagnostic role of antibodies to glutamic acid decarboxylase in latent autoimmune diabetes mellitus in adults.
Diabetes Mellitus
Differing frequency of autoantibodies to glutamic acid decarboxylase among Koreans, Thais, and Australians with diabetes mellitus.
Diabetes Mellitus
Discovery of Native Autoantigens via Antigen Surrogate Technology: Application to Type 1 Diabetes.
Diabetes Mellitus
Distribution of autoantibodies to glutamic acid decarboxylase across the spectrum of diabetes mellitus seen in South Africa.
Diabetes Mellitus
Effect of gamma aminobutyric acid (GABA) or GABA with glutamic acid decarboxylase (GAD) on the progression of type 1 diabetes mellitus in children: Trial design and methodology.
Diabetes Mellitus
Effects of postnatal stress on the development of type 1 diabetes in bank voles (Clethrionomys glareolus).
Diabetes Mellitus
Enterovirus-related type 1 diabetes mellitus and antibodies to glutamic acid decarboxylase in Japan.
Diabetes Mellitus
Epilepsy and behavioral changes, type 1 diabetes mellitus and a high titer of glutamic acid decarboxylase antibodies.
Diabetes Mellitus
Epitope spreading and a varying but not disease-specific GAD65 antibody response in Type I diabetes. The Childhood Diabetes in Finland Study Group.
Diabetes Mellitus
Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes.
Diabetes Mellitus
Evaluation of a novel radioimmunoassay using 125I-labelled human recombinant GAD65 for the determination of glutamic acid decarboxylase (GAD65) autoantibodies.
Diabetes Mellitus
Evaluation of two nonisotopic immunoassays for determination of glutamic acid decarboxylase and tyrosine phosphatase autoantibodies in serum.
Diabetes Mellitus
Expression in Saccharomyces cerevisiae of antigenically and enzymatically active recombinant glutamic acid decarboxylase.
Diabetes Mellitus
Expression of recombinant glutamic acid decarboxylase in insect larvae and its application in an immunoassay for the diagnosis of autoimmune diabetes mellitus.
Diabetes Mellitus
Fasting c-peptide and insulin-like growth factor-binding protein-1 levels help to distinguish childhood type 1 and type 2 diabetes at diagnosis.
Diabetes Mellitus
Flow cytometric microsphere-based immunoassay as a novel non-radiometric method for the detection of glutamic acid decarboxylase autoantibodies in type 1 diabetes mellitus.
Diabetes Mellitus
Flow cytometry for the analysis of T cells expressing CD69 after stimulation with glutamic acid decarboxylase.
Diabetes Mellitus
Frequency of glutamic acid decarboxylase autoantibodies in Mexican diabetic children.
Diabetes Mellitus
Frequency of latent autoimmune diabetes in adults in Asian patients diagnosed as type 2 diabetes in Birmingham, United Kingdom.
Diabetes Mellitus
GAD65 antibody prevalence and association with thyroid antibodies, HLA-DR in Chinese children with type 1 diabetes mellitus.
Diabetes Mellitus
GAD65 autoantibodies in women with gestational or insulin dependent diabetes mellitus diagnosed during pregnancy.
Diabetes Mellitus
GAD65 autoantibodies increase the predictability but not the sensitivity of islet cell and insulin autoantibodies for developing insulin dependent diabetes mellitus.
Diabetes Mellitus
Gastric parietal cell antibodies are associated with glutamic acid decarboxylase-65 antibodies and the HLA DQA1*0501-DQB1*0301 haplotype in Type 1 diabetes mellitus. Belgian Diabetes Registry.
Diabetes Mellitus
Gender differences in GAD antibody-positive diabetes mellitus in relation to age at onset, C-peptide and other endocrine autoimmune diseases.
Diabetes Mellitus
Glial fibrillary acidic protein (GFAP) is a novel biomarker for the prediction of autoimmune diabetes.
Diabetes Mellitus
Glutamate decarboxylase autoimmunity and growth hormone secretion in type I diabetes mellitus.
Diabetes Mellitus
Glutamic acid decarboxylase (anti-GAD) & tissue transglutaminase (anti-TTG) antibodies in patients with thyroid autoimmunity.
Diabetes Mellitus
Glutamic acid decarboxylase (GAD) autoantibodies are additional predictive markers of type 1 (insulin-dependent) diabetes mellitus in high risk individuals.
Diabetes Mellitus
Glutamic acid decarboxylase 65 and islet cell antigen 512/IA-2 autoantibodies in relation to human leukocyte antigen class II DR and DQ alleles and haplotypes in type 1 diabetes mellitus.
Diabetes Mellitus
Glutamic acid decarboxylase 65 autoantibody levels discriminate two subtypes of latent autoimmune diabetes in adults.
Diabetes Mellitus
Glutamic acid decarboxylase and ICA512/IA-2 autoantibodies as disease markers and relationship to residual beta-cell function and glycemic control in young type 1 diabetic patients.
Diabetes Mellitus
Glutamic Acid Decarboxylase Autoantibody Detection by Electrochemiluminescence Assay Identifies Latent Autoimmune Diabetes in Adults with Poor Islet Function.
Diabetes Mellitus
Glutamic Acid Decarboxylase Autoantibody-negative Slowly Progressive Type 1 Diabetes Mellitus: A Case Report and Literature Review.
Diabetes Mellitus
Heterogeneity in glutamic acid decarboxylase expression among single rat pancreatic beta cells.
Diabetes Mellitus
High prevalence of anti-glutamic acid decarboxylase (anti-GAD) antibodies in employees at a polychlorinated biphenyl production factory.
Diabetes Mellitus
HLA-DR, DQ and anti-GAD antibodies in first degree relatives of type I diabetes mellitus.
Diabetes Mellitus
HLA-DRB1 alleles contribute to determining the prognosis of Japanese diabetes mellitus positive for antibodies to glutamate decarboxylase.
Diabetes Mellitus
Homology modelling: a review about the method on hand of the diabetic antigen GAD 65 structure prediction.
Diabetes Mellitus
Human autoantibodies react with glutamic acid decarboxylase antigen in human and rat but not in mouse pancreatic islets.
Diabetes Mellitus
Human B cells secreting immunoglobulin G to glutamic acid decarboxylase-65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes.
Diabetes Mellitus
Hyperglycemic hyperosmolar state in an adolescent with type 1 diabetes mellitus.
Diabetes Mellitus
ICA12 autoantibodies are associated with non-DR3/non-DR4 in patients with latent autoimmune diabetes in adults from northern India.
Diabetes Mellitus
Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65).
Diabetes Mellitus
Immune reactivity to glutamic acid decarboxylase 65 in stiffman syndrome and type 1 diabetes mellitus.
Diabetes Mellitus
Immuno-chemistry of hydroxyl radical modified GAD-65: A possible role in experimental and human diabetes mellitus.
Diabetes Mellitus
Immunoglobulin variable gene analysis of human autoantibodies reveals antigen-driven immune response to glutamate decarboxylase in type 1 diabetes mellitus.
Diabetes Mellitus
Immunologic and genetic markers in insulin-dependent diabetes mellitus (type 1) in an Argentine population.
Diabetes Mellitus
Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults.
Diabetes Mellitus
Improved in planta expression of the human islet autoantigen glutamic acid decarboxylase (GAD65).
Diabetes Mellitus
Increased diagnosis of autoimmune childhood-onset Japanese type 1 diabetes using a new glutamic acid decarboxylase antibody enzyme-linked immunosorbent assay kit, compared with a previously used glutamic acid decarboxylase antibody radioimmunoassay kit.
Diabetes Mellitus
Influence of age at diagnosis and duration of diabetes on the positivity of glutamic acid decarboxylase antibody in South-Brazilian type 1 diabetes mellitus.
Diabetes Mellitus
Influence of sex and age at onset on autoantibodies against insulin, GAD65 and IA2 in recent onset type 1 diabetic patients.
Diabetes Mellitus
Insulin autoantibody could help to screen latent autoimmune diabetes in adults in phenotypic type 2 diabetes mellitus in Chinese.
Diabetes Mellitus
Insulin intervention to preserve beta cells in slowly progressive insulin-dependent (type 1) diabetes mellitus.
Diabetes Mellitus
Islet cell antibodies (ICA) identify autoimmunity in children with new onset diabetes mellitus negative for other islet cell antibodies.
Diabetes Mellitus
Islet cell antibodies and antibodies against glutamic acid decarboxylase in newly diagnosed adult-onset diabetes mellitus.
Diabetes Mellitus
Islet glutamic acid decarboxylase modified by reactive oxygen species is recognized by antibodies from patients with type 1 diabetes mellitus.
Diabetes Mellitus
Latent autoimmune diabetes mellitus in adults (LADA): the role of antibodies to glutamic acid decarboxylase in diagnosis and prediction of insulin dependency.
Diabetes Mellitus
Low prevalence of islet autoimmunity in adult diabetes and low predictive value of islet autoantibodies in the general adult population of northern Italy.
Diabetes Mellitus
MHC class I chain-related gene-A is associated with IA2 and IAA but not GAD in Swedish type 1 diabetes mellitus.
Diabetes Mellitus
Molecular mimicry in diabetes mellitus: the homologous domain in coxsackie B virus protein 2C and islet autoantigen GAD65 is highly conserved in the coxsackie B-like enteroviruses and binds to the diabetes associated HLA-DR3 molecule.
Diabetes Mellitus
Molecular mimicry in type 1 diabetes mellitus revisited: T-cell clones to GAD65 peptides with sequence homology to Coxsackie or proinsulin peptides do not crossreact with homologous counterpart.
Diabetes Mellitus
Murine monoclonal glutamic acid decarboxylase (GAD)65 antibodies recognize autoimmune-associated GAD epitope regions targeted in patients with type 1 diabetes mellitus and stiff-man syndrome.
Diabetes Mellitus
No specific reactivity to E. coli glutamic acid decarboxylase from sera of newly-diagnosed insulin dependent diabetic patients.
Diabetes Mellitus
On the Occurrence of the Diabetes-Associated Antigen GAD 65 in Human Sera.
Diabetes Mellitus
Onset of type 1 diabetes mellitus during peginterferon alpha-2b plus ribavirin treatment for chronic hepatitis C.
Diabetes Mellitus
Peptide-specific cytotoxicity of T lymphocytes against glutamic acid decarboxylase and insulin in type 1 diabetes mellitus.
Diabetes Mellitus
Persisting antibodies to glutamic acid decarboxylase in type 1 (insulin-dependent) diabetes mellitus are not associated with neuropathy.
Diabetes Mellitus
Presynaptic inhibition of cerebellar GABAergic transmission by glutamate decarboxylase autoantibodies in progressive cerebellar ataxia.
Diabetes Mellitus
Prevalence and clinical characteristics of fulminant type 1 diabetes mellitus in Korean adults: A multi-institutional joint research.
Diabetes Mellitus
Prevalence of antibodies to glutamic acid decarboxylase in women who have had gestational diabetes.
Diabetes Mellitus
Prevalence of ICA and GAD antibodies at initial presentation of type 1 diabetes mellitus in Singapore children.
Diabetes Mellitus
Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cells.
Diabetes Mellitus
Primary DQ effect in the association between HLA and neurological syndromes with anti-GAD65 antibodies.
Diabetes Mellitus
Protein tyrosine phosphatase-like protein IA2-antibodies plus glutamic acid decarboxylase 65 antibodies (GADA) indicates autoimmunity as frequently as islet cell antibodies assay in children with recently diagnosed diabetes mellitus.
Diabetes Mellitus
Radioimmunoassay for glutamic acid decarboxylase (GAD65) autoantibodies as a diagnostic aid for stiff-man syndrome and a correlate of susceptibility to type 1 diabetes mellitus.
Diabetes Mellitus
Rapid Normalization of High Glutamic Acid Decarboxylase Autoantibody Titers and Preserved Endogenous Insulin Secretion in a Patient with Diabetes Mellitus: A Case Report and Literature Review.
Diabetes Mellitus
Recombinant human GAD65 accumulates to high levels in transgenic tobacco plants when expressed as an enzymatically inactive mutant.
Diabetes Mellitus
Recombinant human preproinsulin. Expression, purification and reaction with insulin autoantibodies in sera from patients with insulin-dependent diabetes mellitus.
Diabetes Mellitus
Reduced display of conformational epitopes in the N-terminal truncated GAD65 isoform: relevance for people with stiff person syndrome or DQ8/8-positive Type 1 diabetes mellitus.
Diabetes Mellitus
Reference limits for GAD65 and IA-2 autoantibodies by chemiluminescence immunoassay in Northern European adults and children.
Diabetes Mellitus
Relationship between autoantibodies against glutamic acid decarboxylase, thyroglobulin/thyroid microsome and DNA topoisomerase II in the clinical manifestation of patients with type 1 diabetes mellitus in Taiwan.
Diabetes Mellitus
Role of beta-cell autoantibodies as a predictor marker in diabetic patients and their relationship to glycemic control.
Diabetes Mellitus
Seroconversion of glutamic acid decarboxylase antibodies in a patient initially diagnosed as having type 2 diabetes mellitus.
Diabetes Mellitus
Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitis.
Diabetes Mellitus
Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus.
Diabetes Mellitus
Simultaneous triple organ specific autoantibody profiling in adult patients with type 1 diabetes mellitus and their first-degree relatives*
Diabetes Mellitus
Subtle hyperproinsulinaemia characterises the defective insulin secretory capacity in offspring of glutamic acid decarboxylase antibody-positive patients with latent autoimmune diabetes mellitus in adults.
Diabetes Mellitus
Systemic and neurologic autoimmune disorders associated with seizures or epilepsy.
Diabetes Mellitus
The association between GAD65 antibody levels and incident Type 2 Diabetes Mellitus in an adult population: A meta-analysis.
Diabetes Mellitus
THE CLINICAL AND METABOLIC CHARACTERISTICS OF YOUNG-ONSET KETOSIS-PRONE TYPE 2 DIABETES IN CHINA.
Diabetes Mellitus
The combination of antibodies to GAD-65 and IA-2ic can replace the islet-cell antibody assay to identify subjects at risk of type 1 diabetes mellitus.
Diabetes Mellitus
The Frequency of Langerhans Islets ?-Cells Autoantibodies (Anti-GAD) in Georgian Children and Adolescents with Chronic Autoimmune Thyroiditis.
Diabetes Mellitus
The prevalence of early subclinical somatic neuropathy in children and adolescents with Type 1 diabetes mellitus and its association with the persistence of autoantibodies to glutamic acid decarboxylase (GAD) and islet antigen-2 (IA-2).
Diabetes Mellitus
The prognostic significance of glutamic acid decarboxylase antibodies in patients with chronic pancreatitis undergoing total pancreatectomy with islet autotransplantation.
Diabetes Mellitus
Thyroid autoimmunity in 72 children with type 1 diabetes mellitus: relationship with pancreatic autoimmunity and child growth.
Diabetes Mellitus
Time-resolved fluorometric assay for detection of autoantibodies to glutamic acid decarboxylase (GAD65).
Diabetes Mellitus
Tolerogenic dendritic cells induce antigen-specific hyporesponsiveness in insulin- and glutamic acid decarboxylase 65-autoreactive T lymphocytes from type 1 diabetic patients.
Diabetes Mellitus
Two amino acids in glutamic acid decarboxylase act in concert for maintenance of conformational determinants recognised by Type I diabetic autoantibodies.
Diabetes Mellitus
Type 1 diabetes and epilepsy in childhood and adolescence: Do glutamic acid decarboxylase autoantibodies play a role? Data from the German/Austrian/Swiss/Luxembourgian DPV Registry.
Diabetes Mellitus
Type 1 diabetes mellitus associated with Graves' disease and Vogt-Koyanagi-Harada syndrome.
Diabetes Mellitus
Type 1 diabetes mellitus in patients with chronic hepatitis C before and after interferon therapy.
Diabetes Mellitus
Tyrosine phosphatase-like protein (IA-2) and glutamic acid decarboxylase (GAD65) autoantibodies: a study of Chinese patients with diabetes mellitus.
Diabetes Mellitus
UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group.
Diabetes Mellitus
Unique epitopes of glutamic acid decarboxylase autoantibodies in slowly progressive type 1 diabetes.
Diabetes Mellitus
[Autoimmunity and glutamate decarboxylase antibodies in the pathogenesis of type I diabetes mellitus in experimental and clinical practice]
Diabetes Mellitus
[Diagnostic efficacy of glutamic acid decarboxylase antibody and islet cell antibody in type I diabetes mellitus]
Diabetes Mellitus
[Engineered glutamic acid decarboxylase fusion protein in diagnosis of type I diabetes mellitus]
Diabetes Mellitus
[Glutamic acid decarboxylase autoantibodies (antiGAD-Ab) in patients with non-insulin dependent diabetes mellitus (NIDDM)]
Diabetes Mellitus, Lipoatrophic
Distribution of autoantibodies to glutamic acid decarboxylase across the spectrum of diabetes mellitus seen in South Africa.
Diabetes Mellitus, Type 1
A 64 kDa antigen/glutamic acid decarboxylase (GAD) in fetal pig pro-islets: co-precipitation with a 38 kDa protein and recognition by T cells in humans at risk for insulin-dependent diabetes.
Diabetes Mellitus, Type 1
A case of autoimmune polyendocrine syndrome type I with strong positive GAD antibody titer, followed up with glucose tolerance measured by oral glucose tolerance test.
Diabetes Mellitus, Type 1
A case of stiff-person syndrome, type 1 diabetes, celiac disease and dermatitis herpetiformis.
Diabetes Mellitus, Type 1
A comparison of serum and EDTA plasma in the measurement of glutamic acid decarboxylase autoantibodies (GADA) and autoantibodies to islet antigen-2 (IA-2A) using the RSR radioimmunoassay (RIA) and enzyme linked immunosorbent assay (ELISA) kits.
Diabetes Mellitus, Type 1
A comprehensive, statistically powered analysis of GAD2 in type 1 diabetes.
Diabetes Mellitus, Type 1
A convenient diagnostic tool for discriminating adult-onset glutamic acid decarboxylase antibody-positive autoimmune diabetes from type 2 diabetes: a retrospective study.
Diabetes Mellitus, Type 1
A decrease in glutamic acid decarboxylase autoantibody levels with sitagliptin use in patients with latent autoimmune diabetes in adults.
Diabetes Mellitus, Type 1
A diabetes-related epitope of GAD65: a major diabetes-related conformational epitope on GAD65.
Diabetes Mellitus, Type 1
A downstream process allowing the efficient isolation of a recombinant amphiphilic protein from tobacco leaves.
Diabetes Mellitus, Type 1
A glutamic acid decarboxylase 65-specific Th2 cell clone immunoregulates autoimmune diabetes in nonobese diabetic mice.
Diabetes Mellitus, Type 1
A highly sensitive immunoassay resistant to autoantibody interference for detection of the diabetes-associated autoantigen glutamic acid decarboxylase 65 in blood and other biological samples.
Diabetes Mellitus, Type 1
A longitudinal study of GAD65 and ICA512 autoantibodies during the progression to type 1 diabetes in Diabetes Prevention Trial-Type 1 (DPT-1) participants.
Diabetes Mellitus, Type 1
A monoclonal antibody based enzyme-linked immunosorbent assay for the determination of GAD65, the smaller isoform of glutamic acid decarboxylase.
Diabetes Mellitus, Type 1
A monoclonal antibody-based characterization of autoantibodies against glutamic acid decarboxylase in adults with latent autoimmune diabetes.
Diabetes Mellitus, Type 1
A new solid-phase radioimmunoassay to detect anti-GAD65 autoantibodies.
Diabetes Mellitus, Type 1
A novel expression platform for the production of diabetes-associated autoantigen human glutamic acid decarboxylase (hGAD65).
Diabetes Mellitus, Type 1
A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM.
Diabetes Mellitus, Type 1
A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM Study Group.
Diabetes Mellitus, Type 1
A patient with combined polycystic ovary syndrome and autoimmune polyglandular syndrome type 2.
Diabetes Mellitus, Type 1
A Plasmon-Enhanced Fluorescence Protein Microchip with High-Sensitivity for Multiple Islet Autoantibodies Measurements in Autoimmune Diabetes Diagnosis.
Diabetes Mellitus, Type 1
A sensitive method for detecting proliferation of rare autoantigen-specific human T cells.
Diabetes Mellitus, Type 1
A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region.
Diabetes Mellitus, Type 1
A sudden decline in active membrane-bound TGF-beta impairs both T regulatory cell function and protection against autoimmune diabetes.
Diabetes Mellitus, Type 1
A therapeutic DNA vaccination strategy for autoimmunity and transplantation.
Diabetes Mellitus, Type 1
A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy.
Diabetes Mellitus, Type 1
A unique combination of autoimmune limbic encephalitis, type 1 diabetes, and Stiff person syndrome associated with GAD-65 antibody.
Diabetes Mellitus, Type 1
Absence of avidity maturation of autoantibodies to the protein tyrosine phosphatase-like IA-2 molecule and glutamic acid decarboxylase (GAD65) during progression to type 1 diabetes.
Diabetes Mellitus, Type 1
Activation of CD8+ T lymphocytes in insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Activation of T lymphocyte subsets by synthetic TSH receptor peptides and recombinant glutamate decarboxylase in autoimmune thyroid disease and insulin-dependent diabetes.
Diabetes Mellitus, Type 1
Active tolerance induction and prevention of autoimmune diabetes by immunogene therapy using recombinant adenoassociated virus expressing glutamic acid decarboxylase 65 peptide GAD(500-585).
Diabetes Mellitus, Type 1
Adult-onset autoimmune diabetes identified by glutamic acid decarboxylase autoantibodies: a retrospective cohort study.
Diabetes Mellitus, Type 1
Advances and controversies in etiopathogenesis of type 1 (insulin-dependent) diabetes mellitus.
Diabetes Mellitus, Type 1
Age at Seroconversion, HLA Genotype, and Specificity of Autoantibodies in Progression of Islet Autoimmunity in Childhood.
Diabetes Mellitus, Type 1
Age-specific levels of diabetes-related GAD and IA-2 antibodies in healthy children and adults.
Diabetes Mellitus, Type 1
Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas.
Diabetes Mellitus, Type 1
An analysis of the cross-reactivity of autoantibodies to GAD65 and GAD67 in diabetes.
Diabetes Mellitus, Type 1
An ELISA for antibodies to recombinant glutamic acid decarboxylase in IDDM.
Diabetes Mellitus, Type 1
An HIV-1 tat-autoantigen fusion protein suppresses insulitis in NOD mice.
Diabetes Mellitus, Type 1
An Increased Diagnostic Sensitivity of Truncated GAD65 Autoantibodies in Type 1 Diabetes May Be Related to HLA-DQ8.
Diabetes Mellitus, Type 1
An Insulin-Inspired Supramolecular Hydrogel for Prevention of Type 1 Diabetes.
Diabetes Mellitus, Type 1
An integral membrane protein form of brain L-glutamate decarboxylase: purification, characterization and its relationship to insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Analysis of diabetes-associated autoantibodies in children and adolescents with autoimmune thyroid diseases.
Diabetes Mellitus, Type 1
Analysis of GAD65 autoantibodies in Stiff-Person syndrome patients.
Diabetes Mellitus, Type 1
Anti-GAD65 autoantibody in Taiwanese patients with insulin-dependent diabetes mellitus: effect of HLA on anti-GAD65 positivity and clinical characteristics.
Diabetes Mellitus, Type 1
Anti-GAD65 reactive peripheral blood mononuclear cells in the pathogenesis of cystic fibrosis related diabetes mellitus.
Diabetes Mellitus, Type 1
Anti-glutamic acid decarboxylase antibody in Graves' disease is a possible indicator for the unlikelihood of going into remission with antithyroid agents.
Diabetes Mellitus, Type 1
Anti-Idiotypic Antibody Specific to GAD65 Autoantibody Prevents Type 1 Diabetes in the NOD Mouse.
Diabetes Mellitus, Type 1
Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM. Studies with identical twins.
Diabetes Mellitus, Type 1
Antibodies to GAD65 epitopes at diagnosis and over the first 10 years of clinical type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Antibodies to glutamic acid decarboxylase and diabetes mellitus in the Multiple Risk Factor Intervention Trial.
Diabetes Mellitus, Type 1
Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with autoimmune polyendocrine syndrome type I.
Diabetes Mellitus, Type 1
Antibodies to glutamic acid decarboxylase and P2-C peptides in sera from coxsackie virus B4-infected mice and IDDM patients.
Diabetes Mellitus, Type 1
Antibodies to glutamic acid decarboxylase and peripheral nerve function in type 1 diabetes.
Diabetes Mellitus, Type 1
Antibodies to glutamic acid decarboxylase are associated with HLA-DR genotypes in both Australians and Asians with type 1 (insulin-dependent) diabetes mellitus.
Diabetes Mellitus, Type 1
Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease.
Diabetes Mellitus, Type 1
Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Antibodies to glutamic acid decarboxylase discriminate major types of diabetes mellitus.
Diabetes Mellitus, Type 1
Antibodies to glutamic acid decarboxylase in Australian children with insulin-dependent diabetes mellitus and their first-degree relatives.
Diabetes Mellitus, Type 1
Antibodies to glutamic acid decarboxylase in the prediction of insulin dependency.
Diabetes Mellitus, Type 1
Antibodies to glutamic acid decarboxylase in young Chinese diabetic patients.
Diabetes Mellitus, Type 1
Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease.
Diabetes Mellitus, Type 1
Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity.
Diabetes Mellitus, Type 1
Antibodies to new beta cell antigen ICA12 in Latvian diabetes patients.
Diabetes Mellitus, Type 1
Antibody cross-reactivity induced by the homologous regions in glutamic acid decarboxylase (GAD65) and 2C protein of coxsackievirus B4. Childhood Diabetes in Finland Study Group.
Diabetes Mellitus, Type 1
Antibody response to islet antigens in anti-CD4/prednisolone immune intervention of type 1 diabetes.
Diabetes Mellitus, Type 1
Antigen presentation of detergent-free glutamate decarboxylase (GAD65) is affected by human serum albumin as carrier protein.
Diabetes Mellitus, Type 1
Antigen processing patterns determine GAD65-specific regulation vs. pathogenesis.
Diabetes Mellitus, Type 1
Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial.
Diabetes Mellitus, Type 1
Antigen-specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination.
Diabetes Mellitus, Type 1
Antigenic differences between neurological and diabetic patients with anti-glutamic acid decarboxylase antibodies.
Diabetes Mellitus, Type 1
Are zinc transporter type 8 antibodies a marker of autoimmune thyroiditis in non-obese adults with new-onset diabetes?
Diabetes Mellitus, Type 1
Assessment of CD4+ T cell responses to glutamic acid decarboxylase 65 using DQ8 tetramers reveals a pathogenic role of GAD65 121-140 and GAD65 250-266 in T1D development.
Diabetes Mellitus, Type 1
Association between antibodies to the MR 67,000 isoform of glutamate decarboxylase (GAD) and type 1 (insulin-dependent) diabetes mellitus with coexisting autoimmune polyendocrine syndrome type II.
Diabetes Mellitus, Type 1
Association between autoantibody markers and subtypes of DR4 and DR4-DQ in Swedish children with insulin-dependent diabetes reveals closer association of tyrosine pyrophosphatase autoimmunity with DR4 than DQ8.
Diabetes Mellitus, Type 1
Association between high titers of glutamic acid decarboxylase antibody and epilepsy in patients with type 1 diabetes mellitus: A cross-sectional study.
Diabetes Mellitus, Type 1
Association of amino-terminal-specific antiglutamate decarboxylase (GAD65) autoantibodies with beta-cell functional reserve and a milder clinical phenotype in patients with GAD65 antibodies and ketosis-prone diabetes mellitus.
Diabetes Mellitus, Type 1
Association of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region.
Diabetes Mellitus, Type 1
Association of HLA class II alleles with different subgroups of diabetes mellitus in Eastern India identify different associations with IDDM and malnutrition-related diabetes.
Diabetes Mellitus, Type 1
Association of IA-2 autoantibodies with HLA DR4 phenotypes in IDDM.
Diabetes Mellitus, Type 1
Association of TCF7L2 gene variants with low GAD autoantibody titre in LADA subjects (NIRAD Study 5).
Diabetes Mellitus, Type 1
Association of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study.
Diabetes Mellitus, Type 1
Associations of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type I diabetic patients.
Diabetes Mellitus, Type 1
Atezolizumab-induced type 1 diabetes mellitus in a patient with metastatic renal cell carcinoma.
Diabetes Mellitus, Type 1
Auto-immune cerebellar ataxia with anti-GAD antibodies accompanied by de novo late-onset type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Autoantibodies against aromatic L-amino acid decarboxylase in autoimmune polyendocrine syndrome type I.
Diabetes Mellitus, Type 1
Autoantibodies against GAD65 rather than GAD67 precede the onset of type 1 diabetes.
Diabetes Mellitus, Type 1
Autoantibodies against glutamic acid decarboxylase 65 in Japanese patients with insulin-dependent diabetes mellitus (IDDM).
Diabetes Mellitus, Type 1
Autoantibodies against glutamic acid decarboxylase and 21-hydroxylase in Brazilian patients with type 1 diabetes or autoimmune thyroid diseases.
Diabetes Mellitus, Type 1
Autoantibodies against IA-2, GAD, and topoisomerase II in type 1 diabetic patients.
Diabetes Mellitus, Type 1
Autoantibodies against islet cell antigens in children with type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Autoantibodies and HLA susceptibility markers in Canadian first-degree relatives of patients with type 1 diabetes.
Diabetes Mellitus, Type 1
Autoantibodies in IDDM primarily recognize the 65,000-M(r) rather than the 67,000-M(r) isoform of glutamic acid decarboxylase.
Diabetes Mellitus, Type 1
Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome.
Diabetes Mellitus, Type 1
Autoantibodies to glutamic acid decarboxylase (GAD) detected by an immuno-trapping enzyme activity assay: relation to insulin-dependent diabetes mellitus and islet cell antibodies.
Diabetes Mellitus, Type 1
Autoantibodies to glutamic acid decarboxylase (GAD), 64,000-Mr islet cell protein (64K) antibodies and islet cell antibodies (ICA) in insulin-dependent diabetes mellitus with and without autoimmune diseases in Japan.
Diabetes Mellitus, Type 1
Autoantibodies to glutamic acid decarboxylase and insulin in islet cell antibody positive presymptomatic type 1 diabetes mellitus: frequency and segregation by age and gender.
Diabetes Mellitus, Type 1
Autoantibodies to glutamic acid decarboxylase in patients with epilepsy and their relationship with type 1 diabetes: a pilot study.
Diabetes Mellitus, Type 1
Autoantibodies to glutamic acid decarboxylase in patients with IDDM and autoimmune thyroid disease.
Diabetes Mellitus, Type 1
Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy.
Diabetes Mellitus, Type 1
Autoantibodies to glutamic acid decarboxylase in three patients with cerebellar ataxia, late-onset insulin-dependent diabetes mellitus, and polyendocrine autoimmunity.
Diabetes Mellitus, Type 1
Autoantibodies to IA-2 in insulin-dependent diabetes mellitus. Measurements with a new immunoprecipitation assay.
Diabetes Mellitus, Type 1
Autoantibodies to N-terminally truncated GAD improve clinical phenotyping of individuals with adult-onset diabetes: Action LADA 12.
Diabetes Mellitus, Type 1
Autoantibodies to the GM2-1 islet ganglioside and to GAD-65 at type 1 diabetes onset.
Diabetes Mellitus, Type 1
Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes.
Diabetes Mellitus, Type 1
Autoantibodies to tissue transglutaminase in patients from eastern India with malnutrition-modulated diabetes mellitus, insulin-dependent diabetes mellitus, and non-insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Autoantibody against IA-2 improves the test sensitivity for insulin-dependent diabetes mellitus in Japanese patients of child onset.
Diabetes Mellitus, Type 1
Autoantibody epitopes to the smaller isoform of glutamate decarboxylase do not differ in Swedish and Japanese type 1 diabetes patients and may be associated with high-risk human leucocyte antigen class II alleles.
Diabetes Mellitus, Type 1
Autoantibody recognition of COOH-terminal epitopes of GAD65 marks the risk for insulin requirement in adult-onset diabetes mellitus.
Diabetes Mellitus, Type 1
Autoantigenic reactivity of diabetes sera with a hybrid glutamic acid decarboxylase GAD67-65 molecule GAD67(1-101)/GAD65(96-585).
Diabetes Mellitus, Type 1
Autoantigens in insulin-dependent diabetes mellitus: molecular cloning and characterization of human IA-2 beta.
Diabetes Mellitus, Type 1
Autoimmune adrenocortical failure in Norway autoantibodies and human leukocyte antigen class II associations related to clinical features.
Diabetes Mellitus, Type 1
Autoimmune characteristics in Japanese children diagnosed with type 1 diabetes before 5 years of age.
Diabetes Mellitus, Type 1
Autoimmune Diabetes and Thyroiditis Complicating Treatment with Nivolumab.
Diabetes Mellitus, Type 1
Autoimmune Limbic Encephalitis Associated With Type 1 Diabetes Mellitus.
Diabetes Mellitus, Type 1
Autoimmune polyendocrine syndrome 3 onset with severe ketoacidosis in a 74-year-old woman.
Diabetes Mellitus, Type 1
Autoimmunity plays a role in the onset of diabetes after 40 years of age.
Diabetes Mellitus, Type 1
Autoimmunity to glutamic acid decarboxylase (GAD) in Stiff-Man syndrome and insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Autoimmunity to glutamic acid decarboxylase in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Diabetes Mellitus, Type 1
Autoimmunity to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease.
Diabetes Mellitus, Type 1
Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Autonomic dysfunction in the Lambert-Eaton myasthenic syndrome: serologic and clinical correlates.
Diabetes Mellitus, Type 1
Autonomic function and autoantibodies to autonomic nervous structures, glutamic acid decarboxylase and islet tyrosine phosphatase in adolescent patients with IDDM.
Diabetes Mellitus, Type 1
Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase.
Diabetes Mellitus, Type 1
Autoreactive human T-cell receptor initiates insulitis and impaired glucose tolerance in HLA DR4 transgenic mice.
Diabetes Mellitus, Type 1
Autoreactive T cell response in CD25-negative fraction of peripheral blood mononuclear cells in established type 1 diabetes.
Diabetes Mellitus, Type 1
Bacteria of food and human intestine are the most possible sources of the gad-trigger of type 1 diabetes.
Diabetes Mellitus, Type 1
Baculovirus-mediated expression of human 65 kDa and 67 kDa glutamic acid decarboxylases in SF9 insect cells and their relevance in diagnosis of insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune diabetes in southern India.
Diabetes Mellitus, Type 1
Bead injection ELISA for the determination of antibodies implicated in type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Beta-cell autoantibodies in infants and toddlers without IDDM relatives: diabetes autoimmunity study in the young (DAISY).
Diabetes Mellitus, Type 1
Brain-reactive autoantibodies in BB/d rats do not recognize glutamic acid decarboxylase.
Diabetes Mellitus, Type 1
Breaking ? Cell Tolerance After 100 Years of Life: Intratumoral Immunotherapy-Induced Diabetes Mellitus.
Diabetes Mellitus, Type 1
Case report: pembrolizumab-induced Type 1 diabetes in a patient with metastatic cholangiocarcinoma.
Diabetes Mellitus, Type 1
CD226 rs763361 is associated with the susceptibility to type 1 diabetes and greater frequency of GAD65 autoantibody in a Brazilian cohort.
Diabetes Mellitus, Type 1
CD4+ and CD8+ T-cell clones from congenital rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes. Implications for HLA class I and II allelic linkage to disease susceptibility.
Diabetes Mellitus, Type 1
CD4+ T cells recognize diverse epitopes within GAD65: implications for repertoire development and diabetes monitoring.
Diabetes Mellitus, Type 1
CD8+ T lymphocytes specific for glutamic acid decarboxylase 90-98 epitope mediate diabetes in NOD SCID mouse.
Diabetes Mellitus, Type 1
Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4(+) T cells.
Diabetes Mellitus, Type 1
Change of glutamic acid decarboxylase antibody and protein tyrosine phosphatase antibody in Chinese patients with acute-onset type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Changes in autoreactive T cell avidity during type 1 diabetes development.
Diabetes Mellitus, Type 1
Changes in GAD65Ab-Specific Antiidiotypic Antibody Levels Correlate with Changes in C-Peptide Levels and Progression to Islet Cell Autoimmunity.
Diabetes Mellitus, Type 1
Characterisation of peptide microarrays for studying antibody-antigen binding using surface plasmon resonance imagery.
Diabetes Mellitus, Type 1
Characteristics of Caucasian type 2 diabetic patients during ketoacidosis and at follow-up.
Diabetes Mellitus, Type 1
Characteristics of in-vitro phenotypes of glutamic acid decarboxylase 65 autoantibodies in high-titre individuals.
Diabetes Mellitus, Type 1
Characterization of a linear epitope within the human pancreatic 64-kDa glutamic acid decarboxylase and its autoimmune recognition by sera from insulin-dependent diabetes mellitus patients.
Diabetes Mellitus, Type 1
Characterization of CD4+ T cells specific for glutamic acid decarboxylase (GAD65) and proinsulin in a patient with stiff-person syndrome but without type 1 diabetes.
Diabetes Mellitus, Type 1
Characterization of human DNA topoisomerase II as an autoantigen recognized by patients with IDDM.
Diabetes Mellitus, Type 1
Characterization of hydroxyl radical modified GAD65: a potential autoantigen in type 1 diabetes.
Diabetes Mellitus, Type 1
Characterization of novel T-cell epitopes on 65 kDa and 67 kDa glutamic acid decarboxylase relevant in autoimmune responses in NOD mice.
Diabetes Mellitus, Type 1
Characterization of preparations of GAD65, proinsulin, and the islet tyrosine phosphatase IA-2 for use in detection of autoreactive T-cells in type 1 diabetes: report of phase II of the Second International Immunology of Diabetes Society Workshop for Standardization of T-cell assays in type 1 diabetes.
Diabetes Mellitus, Type 1
Characterization of self-glutamic acid decarboxylase 65-reactive CD4+ T-cell clones established from Japanese patients with insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Characterization of the humoral immune response to glutamic acid decarboxylase in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and/or type 1 diabetes.
Diabetes Mellitus, Type 1
Characterization of the humoral immune response to islet antigen 2 in children with newly diagnosed type 1 diabetes.
Diabetes Mellitus, Type 1
Characterization of the MODY3 phenotype. Early-onset diabetes caused by an insulin secretion defect.
Diabetes Mellitus, Type 1
Chronic complications and mortality in community-based patients with latent autoimmune diabetes in adults: the Fremantle Diabetes Study.
Diabetes Mellitus, Type 1
Circulating antibodies to nephrin in patients with type 1 diabetes.
Diabetes Mellitus, Type 1
Class II HLA genotype in fulminant type 1 diabetes: A nationwide survey with reference to glutamic acid decarboxylase antibodies.
Diabetes Mellitus, Type 1
Clinical and genetic characteristics of patients with autoimmune thyroid disease with anti-islet autoimmunity.
Diabetes Mellitus, Type 1
Clinical characteristics of patients with the initial diagnosis of NIDDM with positivity for antibodies to glutamic acid decarboxylase.
Diabetes Mellitus, Type 1
Clinical characteristics, and time course of pancreatic beta-cell function and glutamic acid decarboxylase antibodies in Thai patients with adult-onset Type 1 diabetes: distinction between patients of rapid- and slow-onset.
Diabetes Mellitus, Type 1
Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes.
Diabetes Mellitus, Type 1
Clinical optimization of antigen specific modulation of type 1 diabetes with the plasmid DNA platform.
Diabetes Mellitus, Type 1
Clinical Update on the use of Immuno Modulators anticd3, GAD, Diapep277, Anti-IL1 in Type 1 Diabetes.
Diabetes Mellitus, Type 1
Clinical utility of measuring both glutamic acid decarboxylase antibodies and islet cell antibodies in the diagnosis of latent autoimmune diabetes in adults - is it cost-effective?
Diabetes Mellitus, Type 1
Cloning and expression of large isoform of glutamic acid decarboxylase from human pancreatic islet.
Diabetes Mellitus, Type 1
Cloning of candidate autoantigen carboxypeptidase H from a human islet library: sequence identity with human brain CPH.
Diabetes Mellitus, Type 1
Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Cloning, expression, purification and characterization of the cholera toxin B subunit and triple glutamic acid decarboxylase epitopes fusion protein in Escherichia coli.
Diabetes Mellitus, Type 1
Coexpression of CD25 and OX40 (CD134) Receptors Delineates Autoreactive T-cells in Type 1 Diabetes.
Diabetes Mellitus, Type 1
Combined analysis and single-step detection of GAD65 and IA2 autoantibodies in IDDM can replace the histochemical islet cell antibody test.
Diabetes Mellitus, Type 1
Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives.
Diabetes Mellitus, Type 1
Combined analysis of GAD65 and ICA512(IA-2) autoantibodies in organ and non-organ-specific autoimmune diseases confers high specificity for insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Combined analysis of islet cell antibodies which cross-react with mouse pancreas, antibodies to the M(r) 64,000 islet protein, and antibodies to glutamate decarboxylase in subjects at risk for IDDM.
Diabetes Mellitus, Type 1
Combined Etanercept, GAD-alum and vitamin D treatment: an open pilot trial to preserve beta cell function in recent onset type 1 diabetes.
Diabetes Mellitus, Type 1
Combined measurements of GAD65 and ICA512 antibodies in acute onset and slowly progressive IDDM.
Diabetes Mellitus, Type 1
Combined screening for autoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. The DENIS Study Group. Deutsche Nikotinamid Interventions-Studie.
Diabetes Mellitus, Type 1
Comparative analysis of different biofactories for the production of a major diabetes autoantigen.
Diabetes Mellitus, Type 1
Comparative analysis of epitope recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different autoimmune disorders.
Diabetes Mellitus, Type 1
Comparative expression and purification of human glutamic acid decarboxylase from Saccharomyces cerevisiae and Pichia pastoris.
Diabetes Mellitus, Type 1
Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects.
Diabetes Mellitus, Type 1
Comparison of Adults with Insulin Resistance (IR) in Latent Autoimmune Diabetes Versus IR in Glutamic Acid Decarboxylase Antibody-negative Diabetes.
Diabetes Mellitus, Type 1
Comparison of autoantibodies to IA-2 and GAD65 in the rapid- and the slow-onset, adult Type 1 diabetes in Thailand.
Diabetes Mellitus, Type 1
Comparison of measurements of autoantibodies to glutamic acid decarboxylase and islet antigen-2 in whole blood eluates from dried blood spots using the RSR-enzyme linked immunosorbent assay kits and in-house radioimmunoassays.
Diabetes Mellitus, Type 1
Comparison of radioimmunoprecipitation with luciferase immunoprecipitation for autoantibodies to GAD65 and IA-2beta.
Diabetes Mellitus, Type 1
Comparison of radioimmunoprecipitation with luciferase immunoprecipitation for autoantibodies to GAD65 and IA-2{beta}
Diabetes Mellitus, Type 1
Complexity of human immune response profiles for CD4+ T cell epitopes from the diabetes autoantigen GAD65.
Diabetes Mellitus, Type 1
Conformational epitopes on the diabetes autoantigen GAD65 identified by peptide phage display and molecular modeling.
Diabetes Mellitus, Type 1
Control of autoimmune diabetes in NOD mice by GAD expression or suppression in beta cells.
Diabetes Mellitus, Type 1
Controlling the controls: GAD65 autoreactive T cells in type 1 diabetes.
Diabetes Mellitus, Type 1
COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity.
Diabetes Mellitus, Type 1
Correlation between the prevalence of type 1 diabetes with the daily insulin dose and the autoimmune process against glutamic acid decarboxylase in adults.
Diabetes Mellitus, Type 1
Could ZnT8 antibodies replace ICA, GAD, IA2 and insulin antibodies in the diagnosis of type 1 diabetes?
Diabetes Mellitus, Type 1
Course of islet autoantibody titers during Ig-immunoadsorption in a patient with newly diagnosed type 1 diabetes.
Diabetes Mellitus, Type 1
COVID-19 infection as a trigger for new-onset type 1 diabetes in a susceptible individual - or just coincidence?
Diabetes Mellitus, Type 1
Coxsackie B virus infection and beta cell autoantibodies in newly diagnosed IDDM adult patients.
Diabetes Mellitus, Type 1
Coxsackievirus B4 alters pancreatic glutamate decarboxylase expression in mice soon after infection.
Diabetes Mellitus, Type 1
Cross-reactive peptide epitopes of Enterovirus Coxsackie B4 and human glutamic acid decarboxylase detecting antibodies in latent autoimmune diabetes in adults versus type 1 diabetes.
Diabetes Mellitus, Type 1
CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers. The Belgian Diabetes Registry.
Diabetes Mellitus, Type 1
CTLA-4 gene polymorphism contributes to the genetic risk for latent autoimmune diabetes in adults.
Diabetes Mellitus, Type 1
CTLA-4 gene polymorphisms and susceptibility to type 1 diabetes mellitus: a HuGE Review and meta-analysis.
Diabetes Mellitus, Type 1
Cytokine regulation of glutamate decarboxylase biosynthesis in isolated rat islets of Langerhans.
Diabetes Mellitus, Type 1
Cytoplasmic islet cell antibodies recognize distinct islet antigens in IDDM but not in stiff man syndrome.
Diabetes Mellitus, Type 1
Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes.
Diabetes Mellitus, Type 1
Cytotoxic T lymphocyte antigen 4 gene polymorphism confers susceptibility to type 1 diabetes in Japanese children: analysis of association with HLA genotypes and autoantibodies.
Diabetes Mellitus, Type 1
Danish children born with glutamic acid decarboxylase-65 and islet antigen-2 autoantibodies at birth had an increased risk to develop type 1 diabetes.
Diabetes Mellitus, Type 1
Decline in titers of anti-idiotypic antibodies specific to autoantibodies to GAD65 (GAD65Ab) precedes development of GAD65Ab and type 1 diabetes.
Diabetes Mellitus, Type 1
Decreased HLA-DQ expression on peripheral blood cells in children with varying number of beta cell autoantibodies.
Diabetes Mellitus, Type 1
DELISA: sensitive nonisotopic assay for GAD65 autoantibodies, a key risk-assessment marker for insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression.
Diabetes Mellitus, Type 1
Detection and Characterization of CD8+ Autoreactive Memory Stem T Cells in Patients with Type 1 Diabetes.
Diabetes Mellitus, Type 1
Detection and immunochemical characterization of glutamic acid decarboxylase autoantibodies in patients with autoimmune diabetes mellitus.
Diabetes Mellitus, Type 1
Detection of antibodies against both isoforms of glutamate decarboxylase in BB/OK rats by western blotting and immuno trapping enzyme activity assay.
Diabetes Mellitus, Type 1
Detection of autoantibodies against reactive oxygen species modified glutamic acid decarboxylase-65 in type 1 diabetes associated complications.
Diabetes Mellitus, Type 1
Detection of autoantibodies to protein tyrosine phosphatase-like protein IA-2 with a novel time-resolved fluorimetric assay.
Diabetes Mellitus, Type 1
Detection of autoantibodies to the pancreatic islet heat shock protein 60 in insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Detection of GAD65 antibodies in diabetes and other autoimmune diseases using a simple radioligand assay.
Diabetes Mellitus, Type 1
Determination of glutamic acid decarboxylase (GAD65) in pancreatic islets and its in vitro and in vivo degradation kinetics in serum using a highly sensitive enzyme immunoassay.
Diabetes Mellitus, Type 1
Determination of glutamic acid decarboxylase antibodies (GADA) IgG subclasses - comparison of three immunoprecipitation assays (IPAs).
Diabetes Mellitus, Type 1
Determination of mRNA expression for IFN-gamma and IL-4 in lymphocytes from children with IDDM by RT-PCR technique.
Diabetes Mellitus, Type 1
Development of 2 alternative enzyme-linked immunosorbent assays for routine screening of glutamic acid decarboxylase autoantibodies.
Diabetes Mellitus, Type 1
Development of Autoantibodies in the TrialNet Natural History Study.
Diabetes Mellitus, Type 1
Development of autoimmune diabetes in glutamic acid decarboxylase 65 (GAD65) knockout NOD mice.
Diabetes Mellitus, Type 1
Development of glutamic acid decarboxylase 65 (GAD65) autoantibody assay using biotin-GAD65 fusion protein.
Diabetes Mellitus, Type 1
Diabetes in Danish Bank Voles (M. glareolus): Survivorship, Influence on Weight, and Evaluation of Polydipsia as a Screening Tool for Hyperglycaemia.
Diabetes Mellitus, Type 1
Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry.
Diabetes Mellitus, Type 1
Diabetes-related autoantibodies in cord blood from children of healthy mothers have disappeared by the time the child is one year old.
Diabetes Mellitus, Type 1
Diabetic sera react with the glutamic acid decarboxylase molecule in a dimeric-oligomeric form.
Diabetes Mellitus, Type 1
Diagnostic role of antibodies to glutamic acid decarboxylase in latent autoimmune diabetes mellitus in adults.
Diabetes Mellitus, Type 1
Diagnostic sensitivity of immunodominant epitopes of glutamic acid decarboxylase (GAD65) autoantibodies in childhood IDDM.
Diabetes Mellitus, Type 1
Diamyd, an alum-formulated recombinant human GAD65 for the prevention of autoimmune diabetes.
Diabetes Mellitus, Type 1
Dietary risk factors for the emergence of type 1 diabetes-related autoantibodies in 21/2 year-old Swedish children.
Diabetes Mellitus, Type 1
Differential detection of rat islet and brain glutamic acid decarboxylase (GAD) isoforms with sequence-specific peptide antibodies.
Diabetes Mellitus, Type 1
Differential presentation of glutamic acid decarboxylase 65 (GAD65) T cell epitopes among HLA-DRB1*0401-positive individuals.
Diabetes Mellitus, Type 1
Differing frequency of autoantibodies to glutamic acid decarboxylase among Koreans, Thais, and Australians with diabetes mellitus.
Diabetes Mellitus, Type 1
Diminished Th1-like response to autoantigens in children with a high risk of developing type 1 diabetes.
Diabetes Mellitus, Type 1
Discovery of Native Autoantigens via Antigen Surrogate Technology: Application to Type 1 Diabetes.
Diabetes Mellitus, Type 1
Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies.
Diabetes Mellitus, Type 1
Disease sensitivity and specificity of 52 assays for glutamic acid decarboxylase antibodies. The Second International GADAB Workshop.
Diabetes Mellitus, Type 1
Disease-associated autoantibodies and HLA-DQB1 genotypes in children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). The Childhood Diabetes in Finland Study Group.
Diabetes Mellitus, Type 1
Disease-associated autoantibodies as surrogate markers of type 1 diabetes in young children at increased genetic risk. Childhood Diabetes in Finland Study Group.
Diabetes Mellitus, Type 1
Disease-associated autoantibodies during pregnancy and at birth in families affected by type 1 diabetes.
Diabetes Mellitus, Type 1
Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions.
Diabetes Mellitus, Type 1
Do glutamic acid decarboxylase antibodies improve the prediction of IDDM in first-degree relatives at risk for IDDM?
Diabetes Mellitus, Type 1
Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?
Diabetes Mellitus, Type 1
Does epilepsy occur more frequently in children with Type 1 diabetes?
Diabetes Mellitus, Type 1
Does immune-tolerance treatment with Alum-formulated GAD65 protect insulin-production in the pancreatic islet ß cells?
Diabetes Mellitus, Type 1
DPD epitope-specific glutamic acid decarboxylase (GAD)65 autoantibodies in children with Type 1 diabetes.
Diabetes Mellitus, Type 1
Dulaglutide treatment results in effective glycaemic control in latent autoimmune diabetes in adults (LADA): A post-hoc analysis of the AWARD-2, -4 and -5 Trials.
Diabetes Mellitus, Type 1
Dynamic changes of GAD65 autoantibody epitope specificities in individuals at risk of developing type 1 diabetes.
Diabetes Mellitus, Type 1
Dynamic pattern of disease-associated autoantibodies in siblings of children with type 1 diabetes: a population-based study.
Diabetes Mellitus, Type 1
Dynamics of diabetes-associated autoantibodies in young children with human leukocyte antigen-conferred risk of type 1 diabetes recruited from the general population.
Diabetes Mellitus, Type 1
Early epitope- and isotype-specific humoral immune responses to GAD65 in young children with genetic susceptibility to type 1 diabetes.
Diabetes Mellitus, Type 1
Early induction of GAD(65)-reactive Th2 response in type 1 diabetic children treated with alum-formulated GAD(65).
Diabetes Mellitus, Type 1
Editing of an immunodominant epitope of glutamate decarboxylase by HLA-DM.
Diabetes Mellitus, Type 1
Effect of extract from Boswellia serrata gum resin on decrease of GAD65 autoantibodies in a patient with Latent Autoimmune Diabetes in Adults.
Diabetes Mellitus, Type 1
Effect of gamma aminobutyric acid (GABA) or GABA with glutamic acid decarboxylase (GAD) on the progression of type 1 diabetes mellitus in children: Trial design and methodology.
Diabetes Mellitus, Type 1
Effects of plasmid DNA injection on cyclophosphamide-accelerated diabetes in NOD mice.
Diabetes Mellitus, Type 1
Effects of postnatal stress on the development of type 1 diabetes in bank voles (Clethrionomys glareolus).
Diabetes Mellitus, Type 1
eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of Type 1 Diabetes.
Diabetes Mellitus, Type 1
Electrochemical and Surface-Plasmon Correlation of a Serum-Autoantibody Immunoassay with Binding Insights: Graphenyl Surface versus Mercapto-Monolayer Surface.
Diabetes Mellitus, Type 1
Electrochemiluminescence assays for insulin and glutamic Acid decarboxylase autoantibodies improve prediction of type 1 diabetes risk.
Diabetes Mellitus, Type 1
Elevated histone H3 acetylation is associated with genes involved in T lymphocyte activation and glutamate decarboxylase antibody production in patients with type 1 diabetes.
Diabetes Mellitus, Type 1
Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome.
Diabetes Mellitus, Type 1
Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4, and 5 Include Potentially Causal Residues Responsible for the Risk of Childhood Type 1 Diabetes.
Diabetes Mellitus, Type 1
Elimination of islet cell antibodies and glutamic acid decarboxylase antibodies II in a patient with newly diagnosed insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: addition of IL-4 increases safety.
Diabetes Mellitus, Type 1
Endogenous immune response to glutamic acid decarboxylase (GAD67) in NOD mice is modulated by adjuvant immunotherapy.
Diabetes Mellitus, Type 1
Engineered variants of human glutamic acid decarboxylase (GAD) and autoantibody epitope recognition.
Diabetes Mellitus, Type 1
Enhanced GAD65 production in plants using the MagnICON transient expression system: Optimization of upstream production and downstream processing.
Diabetes Mellitus, Type 1
Enterovirus infections with beta-cell tropic strains are frequent in siblings of children diagnosed with type 1 diabetes children and in association with elevated levels of GAD65 antibodies.
Diabetes Mellitus, Type 1
Enterovirus markers and serum CXCL10 in children with type 1 diabetes.
Diabetes Mellitus, Type 1
Enterovirus-related type 1 diabetes mellitus and antibodies to glutamic acid decarboxylase in Japan.
Diabetes Mellitus, Type 1
Enzymatic characterization of a recombinant isoform hybrid of glutamic acid decarboxylase (rGAD67/65) expressed in yeast.
Diabetes Mellitus, Type 1
Epidemiology, clinical aspects, and biology of IDDM patients under age 40 years. Comparison of data from Antwerp with complete ascertainment with data from Belgium with 40% ascertainment. The Belgian Diabetes Registry.
Diabetes Mellitus, Type 1
Epilepsy and behavioral changes, type 1 diabetes mellitus and a high titer of glutamic acid decarboxylase antibodies.
Diabetes Mellitus, Type 1
Epilepsy in patients with insulin-dependent diabetes and relation to glutamic acid decarboxylase 65.
Diabetes Mellitus, Type 1
Epitope analysis of GAD65 autoantibodies in adult-onset type 1 diabetes and latent autoimmune diabetes in adults with thyroid autoimmunity.
Diabetes Mellitus, Type 1
Epitope analysis of GAD65 autoantibodies in Japanese patients with autoimmune diabetes.
Diabetes Mellitus, Type 1
Epitope analysis of GAD65 binding in both cord blood and at the time of clinical diagnosis of childhood type 1 diabetes.
Diabetes Mellitus, Type 1
Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes.
Diabetes Mellitus, Type 1
Erythrocyte membrane omega-3 fatty acid levels and omega-3 fatty acid intake are not associated with conversion to type 1 diabetes in children with islet autoimmunity: The Diabetes Autoimmunity Study in the Young (DAISY).
Diabetes Mellitus, Type 1
Establishment of an expression cloning system for CD4+ T cell epitopes.
Diabetes Mellitus, Type 1
Ethnic differences in the associations between the HLA-DRB1*04 subtypes and type 1 diabetes.
Diabetes Mellitus, Type 1
Evaluation of a novel radioimmunoassay using 125I-labelled human recombinant GAD65 for the determination of glutamic acid decarboxylase (GAD65) autoantibodies.
Diabetes Mellitus, Type 1
Evaluation of insulin secretion and sensitivity in a patient with slowly progressive type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Evaluation of islet-specific autoantibodies in Japanese patients with insulin-dependent diabetes mellitus: a comparison between autoantibodies to glutamic acid decarboxylase, autoantibodies to 64 kDa islet cell protein and islet cell antibodies.
Diabetes Mellitus, Type 1
Evaluation of the efficacy of the combination of multiple autoantibodies to islet-specific antigens in Korean type 1 diabetic patients.
Diabetes Mellitus, Type 1
Evaluation of two nonisotopic immunoassays for determination of glutamic acid decarboxylase and tyrosine phosphatase autoantibodies in serum.
Diabetes Mellitus, Type 1
Evidence for complement-dependent and -independent inhibition of insulin secretion from clonal beta-cells incubated in the presence of sera of newly diagnosed IDDM patients.
Diabetes Mellitus, Type 1
Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetes.
Diabetes Mellitus, Type 1
Evidence for molecular mimicry between human T cell epitopes in rotavirus and pancreatic islet autoantigens.
Diabetes Mellitus, Type 1
Evidence from twins for acquired cellular immune hyperactivity in type 1 diabetes.
Diabetes Mellitus, Type 1
Exponential increase of glutamic acid decarboxylase (GAD) antibody titer after initiating and stopping insulin in a patient with slowly progressive type 1 diabetes.
Diabetes Mellitus, Type 1
Expression of properly folded human glutamate decarboxylase 65 as a fusion protein in Escherichia coli.
Diabetes Mellitus, Type 1
Expression of recombinant glutamic acid decarboxylase in insect larvae and its application in an immunoassay for the diagnosis of autoimmune diabetes mellitus.
Diabetes Mellitus, Type 1
Expression of recombinant human glutamic acid decarboxylase (GAD) in myeloma cells and enzyme-linked immunosorbent assay (ELISA) for autoantibodies to GAD.
Diabetes Mellitus, Type 1
Extended evaluation of the safety and efficacy of GAD treatment of children and adolescents with recent-onset type 1 diabetes: a randomised controlled trial.
Diabetes Mellitus, Type 1
Factors associated with the presence of glutamic acid decarboxylase and islet antigen-2 autoantibodies in patients with long-standing type 1 diabetes.
Diabetes Mellitus, Type 1
Failure to detect anti-idiotypic antibodies in the autoimmune response to IA-2 in Type 1 diabetes.
Diabetes Mellitus, Type 1
Fine Mapping of Glutamate Decarboxylase 65 Epitopes Reveals Dependency on Hydrophobic Amino Acids for Specific Interactions.
Diabetes Mellitus, Type 1
Flow cytometric microsphere-based immunoassay as a novel non-radiometric method for the detection of glutamic acid decarboxylase autoantibodies in type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Flow cytometry for the analysis of T cells expressing CD69 after stimulation with glutamic acid decarboxylase.
Diabetes Mellitus, Type 1
Fluctuations in GAD65 antibodies after clinical diagnosis of IDDM in young children.
Diabetes Mellitus, Type 1
Four IgG anti-islet human monoclonal antibodies isolated from a type 1 diabetes patient recognize distinct epitopes of glutamic acid decarboxylase 65 and are somatically mutated.
Diabetes Mellitus, Type 1
Frequency of glutamic acid decarboxylase autoantibodies in Mexican diabetic children.
Diabetes Mellitus, Type 1
Functional state of the beta cell affects expression of both forms of glutamic acid decarboxylase.
Diabetes Mellitus, Type 1
Fusion proteins for combined analysis of autoantibodies to the 65-kDa isoform of glutamic acid decarboxylase and islet antigen-2 in insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
GAD autoantibodies in IDDM, stiff-man syndrome, and autoimmune polyendocrine syndrome type I recognize different epitopes.
Diabetes Mellitus, Type 1
GAD autoantibody affinity and epitope specificity identify distinct immunization profiles in children at risk for type 1 diabetes.
Diabetes Mellitus, Type 1
GAD Autoantibody Affinity in Adult Patients With Latent Autoimmune Diabetes, the Study Participants of a GAD65 Vaccination Trial.
Diabetes Mellitus, Type 1
GAD autoantibody epitope pattern after GAD-alum treatment in children and adolescents with type 1 diabetes.
Diabetes Mellitus, Type 1
GAD treatment and insulin secretion in recent-onset type 1 diabetes.
Diabetes Mellitus, Type 1
GAD-alum (Diamyd)--a new concept for preservation of residual insulin secretion.
Diabetes Mellitus, Type 1
GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD65 enzyme activity and humoral response.
Diabetes Mellitus, Type 1
GAD-alum treatment induces GAD(65)-specific CD4(+)CD25(high)FOXP3(+) cells in type 1 diabetic patients.
Diabetes Mellitus, Type 1
GAD-specific T cells are induced by GAD-alum treatment in Type-1 diabetes patients.
Diabetes Mellitus, Type 1
GAD-treatment of children and adolescents with recent-onset Type 1 diabetes preserves residual insulin secretion after 30?months.
Diabetes Mellitus, Type 1
GAD65 and ICA512 antibodies in undernourished and normally nourished south Indian patients with diabetes.
Diabetes Mellitus, Type 1
GAD65 and insulin B chain peptide (9-23) are not primary autoantigens in the type 1 diabetes syndrome of the BB rat.
Diabetes Mellitus, Type 1
GAD65 antibody epitope patterns of type 1.5 diabetic patients are consistent with slow-onset autoimmune diabetes.
Diabetes Mellitus, Type 1
GAD65 antibody prevalence and association with thyroid antibodies, HLA-DR in Chinese children with type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
GAD65 autoantibodies and its role as biomarker of Type 1 diabetes and Latent Autoimmune Diabetes in Adults (LADA).
Diabetes Mellitus, Type 1
GAD65 Autoantibodies Detected By Electrochemiluminescence (ECL) Assay Identify High Risk For Type 1 Diabetes.
Diabetes Mellitus, Type 1
GAD65 autoantibodies in women with gestational or insulin dependent diabetes mellitus diagnosed during pregnancy.
Diabetes Mellitus, Type 1
GAD65 autoantibody characteristics in patients with co-occurring type 1 diabetes and epilepsy may help identify underlying epilepsy etiologies.
Diabetes Mellitus, Type 1
GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination.
Diabetes Mellitus, Type 1
GAD65 autoantibody responses in Japanese latent autoimmune diabetes in adult patients.
Diabetes Mellitus, Type 1
GAD65 is recognized by T-cells, but not by antibodies from NOD-mice.
Diabetes Mellitus, Type 1
GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes.
Diabetes Mellitus, Type 1
GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects.
Diabetes Mellitus, Type 1
GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes.
Diabetes Mellitus, Type 1
GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65.
Diabetes Mellitus, Type 1
GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes.
Diabetes Mellitus, Type 1
GAD65-Specific Cytotoxic T Lymphocytes Mediate Beta-Cell Death and Loss of Function.
Diabetes Mellitus, Type 1
GADA Titer-Related Risk for Organ-Specific Autoimmunity in LADA Subjects Subdivided according to Gender (NIRAD Study 6).
Diabetes Mellitus, Type 1
Gastric parietal cell antibodies are associated with glutamic acid decarboxylase-65 antibodies and the HLA DQA1*0501-DQB1*0301 haplotype in Type 1 diabetes mellitus. Belgian Diabetes Registry.
Diabetes Mellitus, Type 1
Generation and expansion of regulatory human CD4(+) T-cell clones specific for pancreatic islet autoantigens.
Diabetes Mellitus, Type 1
Genetic and immunological markers of insulin dependent diabetes in Black Americans.
Diabetes Mellitus, Type 1
Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes.
Diabetes Mellitus, Type 1
Genetic markers for glutamic acid decarboxylase do not predict insulin-dependent diabetes mellitus in pairs of affected siblings.
Diabetes Mellitus, Type 1
Genetic markers for glutamic acid decarboxylase do not predict insulin-dependent diabetes mellitus in pairs of affected siblings. The Danish Study Group of Diabetes in Childhood.
Diabetes Mellitus, Type 1
Genetic-induced Variations in the GAD65 T-cell Repertoire Governs Efficacy of Anti-CD3/GAD65 Combination Therapy in New-onset Type 1 Diabetes.
Diabetes Mellitus, Type 1
Gestational respiratory infections interacting with offspring HLA and CTLA-4 modifies incident ?-cell autoantibodies.
Diabetes Mellitus, Type 1
Glucose intolerance and diabetes following antigen-specific insulitis in diabetes-susceptible "humanized" transgenic mice.
Diabetes Mellitus, Type 1
Glutamate cysteine ligase catalytic subunit promoter polymorphisms and associations with type 1 diabetes age-at-onset and GAD65 autoantibody levels.
Diabetes Mellitus, Type 1
Glutamate decarboxylase (GAD) autoantibody epitope shift during the first year of type 1 diabetes.
Diabetes Mellitus, Type 1
Glutamate decarboxylase and GABA in pancreatic islets: lessons from knock-out mice.
Diabetes Mellitus, Type 1
Glutamate decarboxylase-reactive peripheral blood lymphocytes from patients with IDDM express gut-specific homing receptor alpha4beta7-integrin.
Diabetes Mellitus, Type 1
Glutamate-induced over-expression of GAD is down-regulated by acetyl-L-carnitine in rat islet cells.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase (anti-GAD) & tissue transglutaminase (anti-TTG) antibodies in patients with thyroid autoimmunity.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase (GAD65) autoantibodies in prediction of beta-cell function and remission in recent-onset IDDM after cyclosporin treatment. The Canadian-European Randomized Control Trial Group.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase 65 and islet cell antigen 512/IA-2 autoantibodies in relation to human leukocyte antigen class II DR and DQ alleles and haplotypes in type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase 65 autoantibody levels discriminate two subtypes of latent autoimmune diabetes in adults.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase and IA-2 autoantibodies in type 1 diabetes: comparing sample substrates for autoantibody determinations.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase and ICA512/IA-2 autoantibodies as disease markers and relationship to residual beta-cell function and glycemic control in young type 1 diabetic patients.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase antibodies (GADA) is the most important factor for prediction of insulin therapy within 3 years in young adult diabetic patients not classified as Type 1 diabetes on clinical grounds.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase antibodies are more frequent than islet cell antibodies in islet transplanted IDDM patients and persist or occur despite immunosuppression.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase antibodies in idiopathic generalized epilepsy and type 1 diabetes.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase antibodies in relation to other autoantibodies and genetic risk markers in children with newly diagnosed insulin-dependent diabetes. Childhood Diabetes in Finland Study Group.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase antibodies in screening for autoimmune diabetes: influence of comorbidity, age, and sex on specificity and threshold values.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase autoantibodies are dominant but insufficient to identify most Chinese with adult-onset non-insulin requiring autoimmune diabetes: LADA China study 5.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase autoantibodies in saliva of children with type 1 diabetes.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase autoantibodies in stiff-man syndrome and insulin-dependent diabetes mellitus exhibit similarities and differences in epitope recognition.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase autoantibody assay using 125I-labelled recombinant GAD65 produced in yeast.
Diabetes Mellitus, Type 1
Glutamic Acid Decarboxylase Autoantibody Detection by Electrochemiluminescence Assay Identifies Latent Autoimmune Diabetes in Adults with Poor Islet Function.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase autoantibody prevalence and association with HLA genotype in patients with younger-onset type 1 diabetes and proliferative diabetic retinopathy.
Diabetes Mellitus, Type 1
Glutamic Acid Decarboxylase Autoantibody-negative Slowly Progressive Type 1 Diabetes Mellitus: A Case Report and Literature Review.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase epitope protects against autoimmune diabetes through activation of Th2 immune response and induction of possible regulatory mechanism.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase in insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Glutamic Acid Decarboxylase Injection Into Lymph Nodes: Beta Cell Function and Immune Responses in Recent Onset Type 1 Diabetes Patients.
Diabetes Mellitus, Type 1
Glutamic Acid decarboxylase therapy for recent-onset type 1 diabetes: are we at the end or the beginning of finding a cure?
Diabetes Mellitus, Type 1
Heat shock protein studies in type 1 and type 2 diabetes and human islet cell culture.
Diabetes Mellitus, Type 1
Heritability of levels of autoantibodies using the method of plotting regression of offspring on midparent (ROMP).
Diabetes Mellitus, Type 1
Heterogeneity in the occurrence of a subset of autoantibodies to glutamic acid decarboxylase in autoimmune polyendocrine patients with islet cell antibodies.
Diabetes Mellitus, Type 1
High affinity presentation of an autoantigenic peptide in type I diabetes by an HLA class II protein encoded in a haplotype protecting from disease.
Diabetes Mellitus, Type 1
High diagnostic sensitivity of glutamate decarboxylase autoantibodies in insulin-dependent diabetes mellitus with clinical onset between age 20 and 40 years. The Belgian Diabetes Registry.
Diabetes Mellitus, Type 1
High frequency of diabetes-specific autoantibodies in parents of children with type 1 diabetes. DENIS study group.
Diabetes Mellitus, Type 1
High frequency of persisting or increasing islet-specific autoantibody levels after diagnosis of type 1 diabetes presenting before 40 years of age. The Belgian Diabetes Registry.
Diabetes Mellitus, Type 1
High GADA titer increases the risk of insulin requirement in LADA patients: a 7-year follow-up (NIRAD study 7).
Diabetes Mellitus, Type 1
High level of concordance between assays for glutamic acid decarboxylase antibodies. The First International Glutamic Acid Decarboxylase Antibody Workshop.
Diabetes Mellitus, Type 1
High prevalence of antibodies to glutamic acid decarboxylase in comparison to islet cell antibodies in patients with long-standing insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
High prevalence of autoantibodies to glutamic acid decarboxylase in long-standing IDDM is not a marker of symptomatic autonomic neuropathy.
Diabetes Mellitus, Type 1
High prevalence of GAD65 (and IA-2) antibodies in Japanese IDDM patients by a new immunoprecipitation assay based on recombinant human GAD65.
Diabetes Mellitus, Type 1
High prevalence of humoral autoimmunity in first-degree relatives of Mexican type 1 diabetes patients.
Diabetes Mellitus, Type 1
High T cell responses to the glutamic acid decarboxylase (GAD) isoform 67 reflect a hyperimmune state that precedes the onset of insulin-dependent diabetes.
Diabetes Mellitus, Type 1
High Titers of Autoantibodies to Glutamate Decarboxylase in Type 1 Diabetes Patients: Epitope Analysis and Inhibition of Enzyme Activity.
Diabetes Mellitus, Type 1
High-titer GAD65 autoantibodies detected in adult diabetes patients using a high efficiency expression vector and cold GAD65 displacement.
Diabetes Mellitus, Type 1
Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Higher prevalence of autoantibodies to insulin and GAD65 in Swedish compared to Lithuanian children with type 1 diabetes.
Diabetes Mellitus, Type 1
Highly-sensitive and specific enzyme-linked immunosorbent assays for GAD65 autoantibodies using a thioredoxin-GAD65 fusion antigen.
Diabetes Mellitus, Type 1
HLA and glutamic acid decarboxylase in human insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
HLA class II is associated with the frequency of glutamic acid decarboxylase M(r) 65,000 autoantibodies in Japanese patients with insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
HLA-associated cellular response to GAD in type 2 diabetes with antibodies to GAD.
Diabetes Mellitus, Type 1
HLA-associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent-onset insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
HLA-DQ genotypes are associated with autoimmunity to glutamic acid decarboxylase in insulin-dependent diabetes mellitus patients.
Diabetes Mellitus, Type 1
HLA-DR-DQ haplotypes and specificity of the initial autoantibody in islet specific autoimmunity.
Diabetes Mellitus, Type 1
HLA-DRB1 alleles contribute to determining the prognosis of Japanese diabetes mellitus positive for antibodies to glutamate decarboxylase.
Diabetes Mellitus, Type 1
Human autoantibodies react with glutamic acid decarboxylase antigen in human and rat but not in mouse pancreatic islets.
Diabetes Mellitus, Type 1
Human B cells secreting immunoglobulin G to glutamic acid decarboxylase-65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes.
Diabetes Mellitus, Type 1
Human Leukocyte Antigen (HLA) and Islet Autoantibodies Are Tools to Characterize Type 1 Diabetes in Arab Countries: Emphasis on Kuwait.
Diabetes Mellitus, Type 1
Human mesenchymal stem cell-derived microvesicles modulate T cell response to islet antigen glutamic acid decarboxylase in patients with type 1 diabetes.
Diabetes Mellitus, Type 1
Human mesenchymal stem cells modulate cellular immune response to islet antigen glutamic acid decarboxylase in type 1 diabetes.
Diabetes Mellitus, Type 1
Human monoclonal islet cell antibodies from a patient with insulin-dependent diabetes mellitus reveal glutamate decarboxylase as the target antigen.
Diabetes Mellitus, Type 1
Humoral autoimmune responses to glutamic acid decarboxylase have similar target epitopes and subclass that show titer-dependent disease association.
Diabetes Mellitus, Type 1
Humoral immune response to islet autoantigens in Japanese patients with type 1 diabetes.
Diabetes Mellitus, Type 1
Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes.
Diabetes Mellitus, Type 1
Hyperglycemic hyperosmolar state in an adolescent with type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
IA-2 and IA-2 beta are major autoantigens in IDDM and the precursors of the 40 kDa and 37 kDa tryptic fragments.
Diabetes Mellitus, Type 1
IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71).
Diabetes Mellitus, Type 1
IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
ICA12 autoantibodies are associated with non-DR3/non-DR4 in patients with latent autoimmune diabetes in adults from northern India.
Diabetes Mellitus, Type 1
Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes.
Diabetes Mellitus, Type 1
Identification and functional analysis of mutations in the hepatocyte nuclear factor-1alpha gene in anti-islet autoantibody-negative Japanese patients with type 1 diabetes.
Diabetes Mellitus, Type 1
Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65).
Diabetes Mellitus, Type 1
Identification of a subgroup of black South Africans with type 1 diabetes who are older at diagnosis but have lower levels of glutamic acid decarboxylase and islet antigen 2 autoantibodies.
Diabetes Mellitus, Type 1
Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice.
Diabetes Mellitus, Type 1
Identification of immunogenic epitopes of GAD 65 presented by Ag7 in non-obese diabetic mice.
Diabetes Mellitus, Type 1
Identification of mimicry peptides based on sequential motifs of epitopes derived from 65-kDa glutamic acid decarboxylase.
Diabetes Mellitus, Type 1
Identification of monogenic gene mutations in Japanese subjects diagnosed with type 1B diabetes between >5 and 15.1 years of age.
Diabetes Mellitus, Type 1
Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients.
Diabetes Mellitus, Type 1
Identification of peptides from autoantigens GAD65 and IA-2 that bind to HLA class II molecules predisposing to or protecting from type 1 diabetes.
Diabetes Mellitus, Type 1
Identification of protein tyrosine phosphatase-like IA2 (islet cell antigen 512) as the insulin-dependent diabetes-related 37/40K autoantigen and a target of islet-cell antibodies.
Diabetes Mellitus, Type 1
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase.
Diabetes Mellitus, Type 1
Identification of the GABAA receptor subtype mRNA in human pancreatic tissue.
Diabetes Mellitus, Type 1
IgG subclass antibodies to glutamic acid decarboxylase and risk for progression to clinical insulin-dependent diabetes.
Diabetes Mellitus, Type 1
IgG1 is the dominant subclass of antibody against glutamic acid decarboxylase among type 1 diabetes in Japanese.
Diabetes Mellitus, Type 1
IgG4 subclass glutamic acid decarboxylase antibodies (GADA) are associated with a reduced risk of developing type 1 diabetes as well as increased C-peptide levels in GADA positive gestational diabetes.
Diabetes Mellitus, Type 1
IgG4-subclass of glutamic acid decarboxylase antibody is more frequent in latent autoimmune diabetes in adults than in type 1 diabetes.
Diabetes Mellitus, Type 1
Immune modulation induced by tuberculosis DNA vaccine protects non-obese diabetic mice from diabetes progression.
Diabetes Mellitus, Type 1
Immune reactivity of diabetes-associated human monoclonal autoantibodies defines multiple epitopes and detects two domain boundaries in glutamate decarboxylase.
Diabetes Mellitus, Type 1
Immune reactivity to glutamic acid decarboxylase 65 in stiffman syndrome and type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Immunization with the larger isoform of mouse glutamic acid decarboxylase (GAD67) prevents autoimmune diabetes in NOD mice.
Diabetes Mellitus, Type 1
Immuno-chemistry of hydroxyl radical modified GAD-65: A possible role in experimental and human diabetes mellitus.
Diabetes Mellitus, Type 1
Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Immunoglobulin variable gene analysis of human autoantibodies reveals antigen-driven immune response to glutamate decarboxylase in type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Immunohistochemical detection of the enzyme glutamic acid decarboxylase and hormones of the islets of Langerhans in spontaneous insulin-dependent diabetes mellitus in cattle.
Diabetes Mellitus, Type 1
Immunohistochemical differentiation of monoclonal GAD antibodies recognizing linear or conformational epitope regions.
Diabetes Mellitus, Type 1
Immunologic and genetic markers in insulin-dependent diabetes mellitus (type 1) in an Argentine population.
Diabetes Mellitus, Type 1
Immunopathogenic role of TH1 cells in autoimmune diabetes: evidence from a T1 and T2 doubly transgenic non-obese diabetic mouse model.
Diabetes Mellitus, Type 1
Immunotherapy of autoimmune diabetes by nasal administration of tandem glutamic acid decarboxylase 65 peptides.
Diabetes Mellitus, Type 1
Impaired vibrotactile sense showed no association with insulinoma associated protein 2 and glutamic acid decarboxylase autoantibodies in paediatric type 1 diabetes.
Diabetes Mellitus, Type 1
Importance of GAD65 peptides and I-Ag7 in the development of insulitis in nonobese diabetic mice.
Diabetes Mellitus, Type 1
Improved in planta expression of the human islet autoantigen glutamic acid decarboxylase (GAD65).
Diabetes Mellitus, Type 1
Improving clinical utility of GAD65 autoantibodies by electrochemiluminescence assay and clinical phenotype when identifying autoimmune adult-onset diabetes.
Diabetes Mellitus, Type 1
In vitro stimulation with glutamic acid decarboxylase (GAD65) leads to an oligoclonal response of peripheral T-cells in an IDDM patient.
Diabetes Mellitus, Type 1
Increased risk for endocrine autoimmunity in Italian type 2 diabetic patients with GAD65 autoantibodies.
Diabetes Mellitus, Type 1
Induction of anti-whole GAD65 reactivity in vivo results in disease suppression in type 1 diabetes.
Diabetes Mellitus, Type 1
Induction of autoimmune diabetes through insulin (but not GAD65) DNA vaccination in nonobese diabetic and in RIP-B7.1 mice.
Diabetes Mellitus, Type 1
Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice.
Diabetes Mellitus, Type 1
Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent.
Diabetes Mellitus, Type 1
Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4.
Diabetes Mellitus, Type 1
Influence of age at diagnosis and duration of diabetes on the positivity of glutamic acid decarboxylase antibody in South-Brazilian type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Influence of sex and age at onset on autoantibodies against insulin, GAD65 and IA2 in recent onset type 1 diabetic patients.
Diabetes Mellitus, Type 1
Inhibition of mitochondrial oxidative phosphorylation induces hyper-expression of glutamic acid decarboxylase in pancreatic islet cells.
Diabetes Mellitus, Type 1
Insulin autoantibodies: evidence of autoimmune disease among a group of Puerto Rican children with newly diagnosed type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Insulin VNTR I/III genotype is associated with autoantibodies against glutamic acid decarboxylase in newly diagnosed type 1 diabetes.
Diabetes Mellitus, Type 1
Insulin-dependent diabetes mellitus during alpha-interferon therapy for chronic viral hepatitis.
Diabetes Mellitus, Type 1
International Workshop on Lessons From Animal Models for Human Type 1 Diabetes: identification of insulin but not glutamic acid decarboxylase or IA-2 as specific autoantigens of humoral autoimmunity in nonobese diabetic mice.
Diabetes Mellitus, Type 1
Intradermal or oral delivery of GAD-encoding genetic vaccines suppresses type 1 diabetes.
Diabetes Mellitus, Type 1
Intradermal skin test with diabetes specific antigens in patients with type 1 diabetes.
Diabetes Mellitus, Type 1
Intralymphatic Glutamic Acid Decarboxylase With Vitamin D Supplementation in Recent-Onset Type 1 Diabetes: A Double-Blind, Randomized, Placebo-Controlled Phase IIb Trial.
Diabetes Mellitus, Type 1
Investigating the potential impact of post translational modification of auto-antigens by tissue transglutaminase on humoral islet autoimmunity in type 1 diabetes.
Diabetes Mellitus, Type 1
Islet autoantibodies are associated with HLA-DQ genotypes in Han Chinese patients with type 1 diabetes and their relatives.
Diabetes Mellitus, Type 1
Islet autoantibodies in cord blood from patients who developed type 1 diabetes mellitus at 15-30 years of age.
Diabetes Mellitus, Type 1
Islet autoantibodies in Latvian subjects with non-insulin-dependent diabetes mellitus: slow-onset type 1 diabetes or polyendocrine autoimmunity?
Diabetes Mellitus, Type 1
Islet autoantibody markers in IDDM: risk assessment strategies yielding high sensitivity.
Diabetes Mellitus, Type 1
Islet cell and glutamic acid decarboxylase antibodies and heat-shock protein 65 responses in children with newly diagnosed insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Islet cell antibodies and glutamic acid decarboxylase antibodies in patients with insulin-dependent diabetes mellitus undergoing kidney and islet-after-kidney transplantation.
Diabetes Mellitus, Type 1
Islet cell antibodies, but not glutamic acid decarboxylase antibodies, are decreased by plasmapheresis in patients with newly diagnosed insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Islet cell autoantibodies in African patients with Type 1 and Type 2 diabetes in Dar es Salaam Tanzania: a cross sectional study.
Diabetes Mellitus, Type 1
Islet cell autoimmunity in white and black children and adolescents with IDDM.
Diabetes Mellitus, Type 1
Islet glutamic acid decarboxylase modified by reactive oxygen species is recognized by antibodies from patients with type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells.
Diabetes Mellitus, Type 1
Isolation and functional characterization of recombinant GAD65 autoantibodies derived by IgG repertoire cloning from patients with type 1 diabetes.
Diabetes Mellitus, Type 1
Isolation by anion-exchange of immunologically and enzymatically active human islet glutamic acid decarboxylase 65 overexpressed in Sf9 insect cells.
Diabetes Mellitus, Type 1
Knock-out of the histidine decarboxylase gene modifies the repertoire of natural autoantibodies.
Diabetes Mellitus, Type 1
Lack of antibodies to glutamic acid decarboxylase in young adults of the high diabetes prevalence Wanigela people of Papua New Guinea.
Diabetes Mellitus, Type 1
Lack of association between CTLA-4 gene polymorphism and IDDM in Japanese subjects.
Diabetes Mellitus, Type 1
Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with beta-selective GAD-specific islet cell antibodies.
Diabetes Mellitus, Type 1
Latent autoimmune diabetes and limbic encephalitis with antibodies against glutamic acid decarboxylase.
Diabetes Mellitus, Type 1
Latent autoimmune diabetes in adults (LADA) in Asian and European populations.
Diabetes Mellitus, Type 1
Latent Autoimmune Diabetes in Adults in North Indian Region: Assessment of ?-Cell Function, Metabolic and Immunological Features.
Diabetes Mellitus, Type 1
Latent autoimmune diabetes mellitus in adults (LADA): the role of antibodies to glutamic acid decarboxylase in diagnosis and prediction of insulin dependency.
Diabetes Mellitus, Type 1
Latent autoimmune diabetes of adults is phenotypically similar to type 1 diabetes in a minority population.
Diabetes Mellitus, Type 1
Limbic encephalitis and type 1 diabetes with glutamic acid decarboxylase 65 (GAD65) autoimmunity: improvement with high-dose intravenous immunoglobulin therapy.
Diabetes Mellitus, Type 1
Linkage and association studies in insulin-dependent diabetes with a new dinucleotide repeat polymorphism at the GAD65 locus.
Diabetes Mellitus, Type 1
Localization of glutamic acid decarboxylase in the kidneys of nonobese diabetic mice.
Diabetes Mellitus, Type 1
Long-lasting immune responses 4 years after GAD-alum treatment in children with type 1 diabetes.
Diabetes Mellitus, Type 1
Long-term risk of stroke in type 2 diabetes patients with diabetic ketoacidosis: A population-based, propensity score-matched, longitudinal follow-up study.
Diabetes Mellitus, Type 1
Low C-peptide together with a high glutamic acid decarboxylase autoantibody level predicts progression to insulin dependence in latent autoimmune diabetes in adults: The HUNT study.
Diabetes Mellitus, Type 1
Low prevalence of islet autoantibodies in patients with gestational diabetes mellitus.
Diabetes Mellitus, Type 1
Mapping of an autoreactive epitope within glutamate decarboxylase using a diabetes-associated human monoclonal autoantibody and an epitope cDNA library.
Diabetes Mellitus, Type 1
Measurement of antibodies against glutamic acid decarboxylase 65 (GADA): two new 125I assays compared with [35S]GAD 65-ligand binding assay.
Diabetes Mellitus, Type 1
Measurement of islet cell antibodies in the Type 1 Diabetes Genetics Consortium: efforts to harmonize procedures among the laboratories.
Diabetes Mellitus, Type 1
Metabolic Characteristics of Recently Diagnosed Adult-Onset Autoimmune Diabetes Mellitus.
Diabetes Mellitus, Type 1
Metabolite Profiling of LADA Challenges the View of a Metabolically Distinct Subtype.
Diabetes Mellitus, Type 1
MHC class I chain-related gene-A is associated with IA2 and IAA but not GAD in Swedish type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
MHC class I-restricted determinants on the glutamic acid decarboxylase 65 molecule induce spontaneous CTL activity.
Diabetes Mellitus, Type 1
Modulation of diabetes in NOD mice by GAD65-specific monoclonal antibodies is epitope specific and accompanied by anti-idiotypic antibodies.
Diabetes Mellitus, Type 1
Molecular and cellular analyses of HLA class II-associated susceptibility to autoimmune diseases in the Japanese population.
Diabetes Mellitus, Type 1
Molecular mimicry in diabetes mellitus: the homologous domain in coxsackie B virus protein 2C and islet autoantigen GAD65 is highly conserved in the coxsackie B-like enteroviruses and binds to the diabetes associated HLA-DR3 molecule.
Diabetes Mellitus, Type 1
Molecular mimicry in type 1 diabetes mellitus revisited: T-cell clones to GAD65 peptides with sequence homology to Coxsackie or proinsulin peptides do not crossreact with homologous counterpart.
Diabetes Mellitus, Type 1
Molecular profile of the T cell receptors of regulatory and effector CD4+ T cells recognizing overlapping determinants on glutamic acid decarboxylase (524-543).
Diabetes Mellitus, Type 1
Most Women with Previous Gestational Diabetes Mellitus Have Impaired Glucose Metabolism after a Decade.
Diabetes Mellitus, Type 1
Moving towards efficient therapies in type 1 diabetes: to combine or not to combine?
Diabetes Mellitus, Type 1
Multiple microRNAs within the 14q32 cluster target the mRNAs of major type 1 diabetes autoantigens IA-2, IA-2?, and GAD65.
Diabetes Mellitus, Type 1
Murine monoclonal glutamic acid decarboxylase (GAD)65 antibodies recognize autoimmune-associated GAD epitope regions targeted in patients with type 1 diabetes mellitus and stiff-man syndrome.
Diabetes Mellitus, Type 1
Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.
Diabetes Mellitus, Type 1
Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.
Diabetes Mellitus, Type 1
Negativation of Type 1 Diabetes Associated Autoantibodies to Glutamic Acid Decarboxylase and Insulin in Children Treated with Oral Calcitriol.
Diabetes Mellitus, Type 1
Neutralizing Ljungan virus antibodies in children with newly diagnosed type 1 diabetes.
Diabetes Mellitus, Type 1
Newly diagnosed latent autoimmune diabetes in adults (LADA) is associated with low level glutamate decarboxylase (GAD65) and IA-2 autoantibodies. Diabetes Incidence Study in Sweden (DISS).
Diabetes Mellitus, Type 1
Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes.
Diabetes Mellitus, Type 1
No association of antibodies to glutamic acid decarboxylase and diabetic complications in patients with IDDM.
Diabetes Mellitus, Type 1
No association of type 1 diabetes with a microsatellite marker for CTLA-4 in a Japanese population.
Diabetes Mellitus, Type 1
No Contribution of GAD-65 and IA-2 Autoantibodies around Time of Diagnosis to the Increasing Incidence of Juvenile Type 1 Diabetes: A 9-Year Nationwide Danish Study.
Diabetes Mellitus, Type 1
No evidence of autoimmunity in 6-year-old children immunized at birth with recombinant hepatitis B vaccine.
Diabetes Mellitus, Type 1
No specific reactivity to E. coli glutamic acid decarboxylase from sera of newly-diagnosed insulin dependent diabetic patients.
Diabetes Mellitus, Type 1
NOD background genes influence T cell responses to GAD 65 in HLA-DQ8 transgenic mice.
Diabetes Mellitus, Type 1
Non-food/feed seeds as biofactories for the high-yield production of recombinant pharmaceuticals.
Diabetes Mellitus, Type 1
Non-HLA type 1 diabetes genes modulate disease risk together with HLA-DQ and islet autoantibodies.
Diabetes Mellitus, Type 1
Normal values of first-phase insulin response to intravenous glucose in healthy Italian children and adolescents. The Prediabetes Study Group of the Italian Society for Pediatric Endocrinology and Diabetology (SIEDP).
Diabetes Mellitus, Type 1
Novel fusion proteins in the analysis of diabetes-associated autoantibodies to GAD65 and IA-2.
Diabetes Mellitus, Type 1
Number of autoantibodies and HLA genotype, more than high titers of glutamic acid decarboxylase autoantibodies, predict insulin dependence in latent autoimmune diabetes of adults.
Diabetes Mellitus, Type 1
Nutrient regulation of gamma-aminobutyric acid release from islet beta cells.
Diabetes Mellitus, Type 1
Occurrence of type 1 diabetes in graves' disease patients who are positive for antiglutamic Acid decarboxylase antibodies: an 8-year followup study.
Diabetes Mellitus, Type 1
Onset age-dependent variations of three islet specific autoantibodies in Japanese IDDM patients.
Diabetes Mellitus, Type 1
Optimal cutoff point of glutamate decarboxylase antibody titers in differentiating two subtypes of adult-onset latent autoimmune diabetes.
Diabetes Mellitus, Type 1
Optimized Peptide-MHC Multimer Protocols for Detection and Isolation of Autoimmune T-Cells.
Diabetes Mellitus, Type 1
Oral Administration of Silkworm-Produced GAD65 and Insulin Bi-Autoantigens against Type 1 Diabetes.
Diabetes Mellitus, Type 1
Pancreatic autoantibodies in Italian patients with newly diagnosed type 1 diabetes mellitus under the age of 20 years.
Diabetes Mellitus, Type 1
Pancreatic autoantibodies in Tunisian children with newly diagnosed type 1 diabetes.
Diabetes Mellitus, Type 1
Pancreatic beta cell function and antibodies to glutamic acid decarboxylase (anti-GAD) in Chinese patients with clinical diagnosis of insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Pancreatic islet cell cytoplasmic antibody in diabetes is represented by antibodies to islet cell antigen 512 and glutamic acid decarboxylase.
Diabetes Mellitus, Type 1
Pediatric fulminant type 1 diabetes with glutamic acid decarboxylase antibody.
Diabetes Mellitus, Type 1
Peptide from glutamic acid decarboxylase similar to coxsackie B virus stimulates IFN-gamma mRNA expression in Th1-like lymphocytes from children with recent-onset insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Peptide specificity of high-titer anti-glutamic acid decarboxylase (GAD)65 autoantibodies.
Diabetes Mellitus, Type 1
Peptide-specific cytotoxicity of T lymphocytes against glutamic acid decarboxylase and insulin in type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Periodontal conditions, retinopathy, and serum markers in individuals with type 1 diabetes.
Diabetes Mellitus, Type 1
Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated {beta}-Cell Death.
Diabetes Mellitus, Type 1
Persistence of glutamic acid decarboxylase antibody (GADA) is associated with clinical characteristics of latent autoimmune diabetes in adults: a prospective study with 3-year follow-up.
Diabetes Mellitus, Type 1
Persistent GAD 65 antibodies in longstanding IDDM are not associated with residual beta-cell function, neuropathy or HLA-DR status.
Diabetes Mellitus, Type 1
Plasma GAD65, a Marker for Early ?-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients.
Diabetes Mellitus, Type 1
Plasmapheresis as an Early Treatment for Severe Hypertriglyceridemia, Acute Pancreatitis, and Diabetic Ketoacidosis.
Diabetes Mellitus, Type 1
Plasmid DNAs encoding insulin and glutamic acid decarboxylase 65 have distinct effects on the progression of autoimmune diabetes in nonobese diabetic mice.
Diabetes Mellitus, Type 1
Positive autoantibodies to ZnT8 indicate elevated risk for additional autoimmune conditions in patients with Addison's disease.
Diabetes Mellitus, Type 1
Possible human leukocyte antigen-mediated genetic interaction between type 1 and type 2 Diabetes.
Diabetes Mellitus, Type 1
Potential autoantigens in IDDM. Expression of carboxypeptidase-H and insulin but not glutamate decarboxylase on the beta-cell surface.
Diabetes Mellitus, Type 1
Prediction and diagnosis of type 1 diabetes using beta-cell autoantibodies.
Diabetes Mellitus, Type 1
Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. A population-based study. The Childhood Diabetes in Finland Study Group.
Diabetes Mellitus, Type 1
Predictive Characteristics of Diabetes-Associated Autoantibodies Among Children With HLA-Conferred Disease Susceptibility in the General Population.
Diabetes Mellitus, Type 1
Predictive value of human leukocyte antigen class II typing for the development of islet autoantibodies and insulin-dependent diabetes postpartum in women with gestational diabetes.
Diabetes Mellitus, Type 1
Preservation of enzyme activity and antigenicity after mutagenesis of the membrane anchoring domain of GAD65.
Diabetes Mellitus, Type 1
Prevalence of antibodies to glutamic acid decarboxylase in women who have had gestational diabetes.
Diabetes Mellitus, Type 1
Prevalence of autoantibodies to the 65- and 67-kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Prevalence of diabetes-associated autoantibodies among patients presenting with type 2 diabetes and related metabolic differences.
Diabetes Mellitus, Type 1
Prevalence of diabetes-specific autoantibodies in patients at risk for adult onset diabetes mellitus.
Diabetes Mellitus, Type 1
Prevalence of GAD65 and IA-2 autoantibodies in IDDM patients affected by diabetic nephropathy.
Diabetes Mellitus, Type 1
Prevalence of ICA-12 and other autoantibodies in north Indian patients with early-onset diabetes.
Diabetes Mellitus, Type 1
Prevalence of zinc transporter 8 antibodies in gestational diabetes mellitus.
Diabetes Mellitus, Type 1
Prevalence of ZnT8 antibody in relation to phenotype and SLC30A8 polymorphism in adult autoimmune diabetes: results from the HUNT study, Norway.
Diabetes Mellitus, Type 1
Prevalence, characteristics and diabetes risk associated with transient maternally acquired islet antibodies and persistent islet antibodies in offspring of parents with type 1 diabetes.
Diabetes Mellitus, Type 1
Prevention of autoimmune diabetes by immunogene therapy using recombinant vaccinia virus expressing glutamic acid decarboxylase.
Diabetes Mellitus, Type 1
Prevention of autoimmune diabetes in nonobese diabetic female mice by treatment with recombinant glutamic acid decarboxylase (GAD 65).
Diabetes Mellitus, Type 1
Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cells.
Diabetes Mellitus, Type 1
Primary DQ effect in the association between HLA and neurological syndromes with anti-GAD65 antibodies.
Diabetes Mellitus, Type 1
Pro-apoptotic DNA vaccination ameliorates new onset of autoimmune diabetes in NOD mice and induces foxp3+ regulatory T cells in vitro.
Diabetes Mellitus, Type 1
Programmed Cell Death-1 Inhibitor-Induced Type 1 Diabetes Mellitus.
Diabetes Mellitus, Type 1
Programmed death-1 ligands-transfected dendritic cells loaded with glutamic acid decarboxylase 65 (GAD65) inhibit both the alloresponse and the GAD65-reactive lymphocyte response.
Diabetes Mellitus, Type 1
Progression to type 1 diabetes is associated with a change in the immunoglobulin isotype profile of autoantibodies to glutamic acid decarboxylase (GAD65). Childhood Diabetes in Finland Study Group.
Diabetes Mellitus, Type 1
Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease.
Diabetes Mellitus, Type 1
Proinsulin/Insulin Autoantibodies Measured With Electrochemiluminescent Assay Are the Earliest Indicator of Prediabetic Islet Autoimmunity.
Diabetes Mellitus, Type 1
Proliferative lymphocyte responses to virus antigens homologous to GAD65 in IDDM.
Diabetes Mellitus, Type 1
Prospective evaluation of beta-cell function in insulin autoantibody-positive relatives of insulin-dependent diabetic patients.
Diabetes Mellitus, Type 1
Protein-engineered molecules carrying GAD65 epitopes and targeting CD35 selectively down-modulate disease-associated human B lymphocytes.
Diabetes Mellitus, Type 1
Quantitative analysis of glutamate decarboxylase (GAD 65) gene expression in NOD mouse pancreas.
Diabetes Mellitus, Type 1
Quantitative analysis of islet glutamic acid decarboxylase p64 autoantibodies in insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Radioimmunoassay detects the frequent occurrence of autoantibodies to the Mr 65,000 isoform of glutamic acid decarboxylase in Japanese insulin-dependent diabetes.
Diabetes Mellitus, Type 1
Radioimmunoassay for glutamic acid decarboxylase (GAD65) autoantibodies as a diagnostic aid for stiff-man syndrome and a correlate of susceptibility to type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Radioimmunoassays for glutamic acid decarboxylase (GAD65) and GAD65 autoantibodies using 35S or 3H recombinant human ligands.
Diabetes Mellitus, Type 1
Radioimmunoprecipitation assay for glutamic acid decarboxylase antibodies evaluated clinically with sera from patients with insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Rapid-onset type 1 diabetes associated with cytomegalovirus infection and islet autoantibody synthesis.
Diabetes Mellitus, Type 1
Reactivity to human islets and fetal pig proislets by peripheral blood mononuclear cells from subjects with preclinical and clinical insulin-dependent diabetes.
Diabetes Mellitus, Type 1
Recent Patents on Immunoregulatory DNA Vaccines for Autoimmune Diseases and Allograft Rejection.
Diabetes Mellitus, Type 1
Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes.
Diabetes Mellitus, Type 1
Recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different GAD antibody-positive phenotypes.
Diabetes Mellitus, Type 1
Recognition of post-translationally modified glutamic acid decarboxylase 65 epitopes in subjects with type 1 diabetes.
Diabetes Mellitus, Type 1
Recombinant human GAD65 accumulates to high levels in transgenic tobacco plants when expressed as an enzymatically inactive mutant.
Diabetes Mellitus, Type 1
Recurrence of autoreactive antigen-specific CD4+ T cells in autoimmune diabetes after pancreas transplantation.
Diabetes Mellitus, Type 1
Recurrence of immunological markers for type 1 (insulin-dependent) diabetes mellitus in immunosuppressed patients after pancreas transplantation.
Diabetes Mellitus, Type 1
Reduced display of conformational epitopes in the N-terminal truncated GAD65 isoform: relevance for people with stiff person syndrome or DQ8/8-positive Type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Reference limits for GAD65 and IA-2 autoantibodies by chemiluminescence immunoassay in Northern European adults and children.
Diabetes Mellitus, Type 1
Regulation of GAD expression in rat pancreatic islets and brain by gamma-vinyl-GABA and glucose.
Diabetes Mellitus, Type 1
Regulation of GAD65 expression by SMAR1 and p53 upon Streptozotocin treatment.
Diabetes Mellitus, Type 1
Regulatory and effector CD4 T cells in nonobese diabetic mice recognize overlapping determinants on glutamic acid decarboxylase and use distinct V beta genes.
Diabetes Mellitus, Type 1
Regulatory T cell phenotype and function 4 years after GAD-alum treatment in children with type 1 diabetes.
Diabetes Mellitus, Type 1
Relation between cellular and humoral immunity to islet cell antigens in type 1 diabetes.
Diabetes Mellitus, Type 1
Relation between T-cell responses to glutamate decarboxylase and coxsackievirus B4 in patients with insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Relationship between autoantibodies against glutamic acid decarboxylase, thyroglobulin/thyroid microsome and DNA topoisomerase II in the clinical manifestation of patients with type 1 diabetes mellitus in Taiwan.
Diabetes Mellitus, Type 1
Relationship between the prevalence of anti-glutamic acid decarboxylase autoantibodies and duration of type 1 diabetes mellitus in Brazilian patients.
Diabetes Mellitus, Type 1
Replacement of methionine-161 with threonine eliminates a major by-product of human glutamate decarboxylase 65-kDa variant expression in Escherichia coli.
Diabetes Mellitus, Type 1
Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study.
Diabetes Mellitus, Type 1
Responses of NOD congenic mice to a glutamic acid decarboxylase-derived peptide.
Diabetes Mellitus, Type 1
Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice.
Diabetes Mellitus, Type 1
Reversal of Hyperglycemia and Suppression of Type 1 Diabetes in the NOD Mouse with Apoptotic DNA Immunotherapy (ADi), ADi-100.
Diabetes Mellitus, Type 1
Risk for developing type 1 (insulin-dependent) diabetes mellitus and the presence of islet 64K antibodies.
Diabetes Mellitus, Type 1
Role of glutamic acid decarboxylase in the pathogenesis of type 1 diabetes.
Diabetes Mellitus, Type 1
Rotavirus Infection Enhances Levels of Autoantibodies Against Islet Cell Antigens GAD65 and IA-2 in Children with Type 1 Diabetes.
Diabetes Mellitus, Type 1
Safety and efficacy of autoantigen-specific therapy with 2 doses of alum-formulated glutamate decarboxylase in children with multiple islet autoantibodies and risk for type 1 diabetes: A randomized clinical trial.
Diabetes Mellitus, Type 1
Sardinia: a battlefield approach to type I diabetes epidemiology. Sardinia-IDDM Study Groups.
Diabetes Mellitus, Type 1
Screening for preclinical type 1 diabetes in a discrete population with an apparent increased disease incidence.
Diabetes Mellitus, Type 1
Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes.
Diabetes Mellitus, Type 1
Selective screening of secretory vesicle-associated proteins for autoantigens in type 1 diabetes: VAMP2 and NPY are new minor autoantigens.
Diabetes Mellitus, Type 1
Self and viral peptides can initiate lysis by autologous natural killer cells.
Diabetes Mellitus, Type 1
Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs.
Diabetes Mellitus, Type 1
Sequence homology of the diabetes-associated autoantigen glutamate decarboxylase with coxsackie B4-2C protein and heat shock protein 60 mediates no molecular mimicry of autoantibodies.
Diabetes Mellitus, Type 1
Sequential elevation of autoantibodies to thyroglobulin and glutamic acid decarboxylase in type 1 diabetes.
Diabetes Mellitus, Type 1
Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitis.
Diabetes Mellitus, Type 1
Several different enterovirus serotypes can be associated with prediabetic autoimmune episodes and onset of overt IDDM. Childhood Diabetes in Finland (DiMe) Study Group.
Diabetes Mellitus, Type 1
Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Significance of IA-2 antibody in Japanese type 1 diabetes: its association with GAD antibody.
Diabetes Mellitus, Type 1
Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes.
Diabetes Mellitus, Type 1
Simultaneous occurrence of diabetes mellitus and juvenile dermatomyositis: report of two cases.
Diabetes Mellitus, Type 1
Simultaneous triple organ specific autoantibody profiling in adult patients with type 1 diabetes mellitus and their first-degree relatives*
Diabetes Mellitus, Type 1
Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding.
Diabetes Mellitus, Type 1
Six-year follow-up of pancreatic beta cell function in adults with latent autoimmune diabetes.
Diabetes Mellitus, Type 1
Small Cell Lung Cancer Expressing Glutamate Decarboxylase with Latent Autoimmune Diabetes in Adults.
Diabetes Mellitus, Type 1
Smoking Is Associated With Reduced Risk of Autoimmune Diabetes in Adults Contrasting With Increased Risk in Overweight Men With Type 2 Diabetes: A 22-year follow-up of the HUNT study.
Diabetes Mellitus, Type 1
Species and epitope specificity of two 65 kDa glutamate decarboxylase time-resolved fluorometric immunoassays.
Diabetes Mellitus, Type 1
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes.
Diabetes Mellitus, Type 1
ss-cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.
Diabetes Mellitus, Type 1
Stable GAD65 autoantibody epitope patterns in type 1 diabetes children five years after onset.
Diabetes Mellitus, Type 1
Stiff-person syndrome (SPS) and anti-GAD-related CNS degenerations: Protean additions to the autoimmune central neuropathies.
Diabetes Mellitus, Type 1
Stiff-person syndrome associated with cerebellar ataxia and high glutamic acid decarboxylase antibody titer.
Diabetes Mellitus, Type 1
Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics.
Diabetes Mellitus, Type 1
Streptococcus pneumoniae type 3 encodes a protein highly similar to the human glutamate decarboxylase (GAD65).
Diabetes Mellitus, Type 1
Structural model of human GAD65: prediction and interpretation of biochemical and immunogenic features.
Diabetes Mellitus, Type 1
Subtle hyperproinsulinaemia characterises the defective insulin secretory capacity in offspring of glutamic acid decarboxylase antibody-positive patients with latent autoimmune diabetes mellitus in adults.
Diabetes Mellitus, Type 1
Suppression of hyperglycemia in NOD mice after inoculation with recombinant vaccinia viruses.
Diabetes Mellitus, Type 1
Synaptic vesicle-associated glutamate decarboxylase: identification and relationship to insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
T cell autoimmunity to glutamic acid decarboxylase in human insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
T cell clones to epitopes of glutamic acid decarboxylase 65 raised from normal subjects and patients with insulin-dependent diabetes.
Diabetes Mellitus, Type 1
T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele.
Diabetes Mellitus, Type 1
T cell immunity to glutamic acid decarboxylase in fulminant type 1 diabetes without significant elevation of serum amylase.
Diabetes Mellitus, Type 1
T cell proliferative responses to glutamic acid decarboxylase-65 in IDDM are negatively associated with HLA DR3/4.
Diabetes Mellitus, Type 1
T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10.
Diabetes Mellitus, Type 1
T cell responses to type 1 diabetes related peptides sharing homologous regions.
Diabetes Mellitus, Type 1
T cells recognize multiple GAD65 and proinsulin epitopes in human type 1 diabetes, suggesting determinant spreading.
Diabetes Mellitus, Type 1
T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: potential for mimicry with rotavirus and other environmental agents.
Diabetes Mellitus, Type 1
T-cell reactivity to GAD65 peptide sequences shared with coxsackie virus protein in recent-onset IDDM, post-onset IDDM patients and control subjects.
Diabetes Mellitus, Type 1
T-lymphocyte lines specific for glutamic acid decarboxylase (GAD) the 64K beta-cell antigen of IDDM.
Diabetes Mellitus, Type 1
The 12th International Immunology and Diabetes Workshop. Orlando, Florida.
Diabetes Mellitus, Type 1
The age of onset of diabetes and glutamic acid decarboxylase titer measured long after diagnosis are associated with the clinical stage of slow-onset type 1 diabetes.
Diabetes Mellitus, Type 1
The association between the PTPN22 1858C>T variant and type 1 diabetes depends on HLA risk and GAD65 autoantibodies.
Diabetes Mellitus, Type 1
The clinical and immunological significance of GAD-specific autoantibody and T-cell responses in type 1 diabetes.
Diabetes Mellitus, Type 1
THE CLINICAL AND METABOLIC CHARACTERISTICS OF YOUNG-ONSET KETOSIS-PRONE TYPE 2 DIABETES IN CHINA.
Diabetes Mellitus, Type 1
The combination of antibodies to GAD-65 and IA-2ic can replace the islet-cell antibody assay to identify subjects at risk of type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
The effect of cytokines on expression of glutamic acid decarboxylase-65 in cultured islets.
Diabetes Mellitus, Type 1
The ethnic distribution of antibodies to glutamic acid decarboxylase: presence and levels of insulin-dependent diabetes mellitus in Europid and Asian subjects.
Diabetes Mellitus, Type 1
The first 142 amino acids of glutamate decarboxylase do not contribute to epitopes recognized by autoantibodies associated with Type 1 diabetes.
Diabetes Mellitus, Type 1
The Frequency of Langerhans Islets ?-Cells Autoantibodies (Anti-GAD) in Georgian Children and Adolescents with Chronic Autoimmune Thyroiditis.
Diabetes Mellitus, Type 1
The glutamate decarboxylase and 38KD autoantigens in type 1 diabetes: aspects of structure and epitope recognition.
Diabetes Mellitus, Type 1
The glutamic acid decarboxylase 65 immunoglobulin G subclass profile differs between adult-onset type 1 diabetes and latent autoimmune diabetes in adults (LADA) up to 3 years after clinical onset.
Diabetes Mellitus, Type 1
The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.
Diabetes Mellitus, Type 1
The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes.
Diabetes Mellitus, Type 1
The Melbourne Pre-Diabetes Study: prediction of type 1 diabetes mellitus using antibody and metabolic testing.
Diabetes Mellitus, Type 1
The modulation of mature dendritic cells from patients with type 1 diabetes using human periodontal ligament stem cells. An in-vitro study.
Diabetes Mellitus, Type 1
The PEVKEK region of the pyridoxal phosphate binding domain of GAD65 expresses a dominant B cell epitope for type 1 diabetes sera.
Diabetes Mellitus, Type 1
The prevalence and predictive value of the SLC30A8 R325W polymorphism and zinc transporter 8 autoantibodies in the development of GDM and postpartum type 1 diabetes.
Diabetes Mellitus, Type 1
The prevalence of early subclinical somatic neuropathy in children and adolescents with Type 1 diabetes mellitus and its association with the persistence of autoantibodies to glutamic acid decarboxylase (GAD) and islet antigen-2 (IA-2).
Diabetes Mellitus, Type 1
The prevalence of the 65-kilodalton isoform of glutamic acid decarboxylase autoantibodies by glucose tolerance status in elderly patients from the cardiovascular health study.
Diabetes Mellitus, Type 1
The prevalence, immune profile, and clinical characteristics of children with celiac disease and type 1 diabetes mellitus in the state of Qatar.
Diabetes Mellitus, Type 1
The prognostic significance of glutamic acid decarboxylase antibodies in patients with chronic pancreatitis undergoing total pancreatectomy with islet autotransplantation.
Diabetes Mellitus, Type 1
The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening.
Diabetes Mellitus, Type 1
The three ZNT8 autoantibody variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes.
Diabetes Mellitus, Type 1
Therapeutic alteration of insulin-dependent diabetes mellitus progression by T cell tolerance to glutamic acid decarboxylase 65 peptides in vitro and in vivo.
Diabetes Mellitus, Type 1
Thyroid and Islet Autoantibodies Predict Autoimmune Thyroid Disease at Type 1 Diabetes Diagnosis.
Diabetes Mellitus, Type 1
Thyroid autoantibodies in Thai type 1 diabetic patients: clinical significance and their relationship with glutamic acid decarboxylase antibodies.
Diabetes Mellitus, Type 1
Thyroid autoimmunity in 72 children with type 1 diabetes mellitus: relationship with pancreatic autoimmunity and child growth.
Diabetes Mellitus, Type 1
Time dynamics of autoantibodies are coupled to phenotypes and add to the heterogeneity of autoimmune diabetes in adults: the HUNT study, Norway.
Diabetes Mellitus, Type 1
Time-resolved fluorescence imaging in islet cell autoantibody quantitation.
Diabetes Mellitus, Type 1
Time-resolved fluorometric assay for detection of autoantibodies to glutamic acid decarboxylase (GAD65).
Diabetes Mellitus, Type 1
Time-resolved immunofluorometric dual-label assay for simultaneous detection of autoantibodies to GAD65 and IA-2 in children with type 1 diabetes.
Diabetes Mellitus, Type 1
Titre and combination of ICA and autoantibodies to glutamic acid decarboxylase discriminate two clinically distinct types of latent autoimmune diabetes in adults (LADA).
Diabetes Mellitus, Type 1
Tolerogenic dendritic cells induce antigen-specific hyporesponsiveness in insulin- and glutamic acid decarboxylase 65-autoreactive T lymphocytes from type 1 diabetic patients.
Diabetes Mellitus, Type 1
Transcription factor jun-B is target of autoreactive T-cells in IDDM.
Diabetes Mellitus, Type 1
Transfer of type 1 (insulin-dependent) diabetes mellitus associated autoimmunity to mice with severe combined immunodeficiency (SCID).
Diabetes Mellitus, Type 1
Transgenic plants expressing human glutamic acid decarboxylase (GAD65), a major autoantigen in insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Treatment outcome for IDDM patients in relation to glutamic acid decarboxylase autoantibodies and serum IgG to periodontal pathogens.
Diabetes Mellitus, Type 1
Treatment with GAD65 or BSA does not protect against diabetes in BB rats.
Diabetes Mellitus, Type 1
Trimming of two major type 1 diabetes driving antigens, GAD65 and IA-2, allows for successful expression in Lactococcus lactis.
Diabetes Mellitus, Type 1
Two distinct glutamic acid decarboxylase auto-antibody specificities in IDDM target different epitopes.
Diabetes Mellitus, Type 1
Two-step islet autoantibody screening for risk assessment of type 1 diabetes in relatives.
Diabetes Mellitus, Type 1
Type 1 diabetes and epilepsy in childhood and adolescence: Do glutamic acid decarboxylase autoantibodies play a role? Data from the German/Austrian/Swiss/Luxembourgian DPV Registry.
Diabetes Mellitus, Type 1
Type 1 diabetes and GAD65 limbic encephalitis: a case report of a 10-year-old girl.
Diabetes Mellitus, Type 1
Type 1 diabetes genetic risk score discriminates between monogenic and Type 1 diabetes in children diagnosed at the age of <5 years in the Iranian population.
Diabetes Mellitus, Type 1
Type 1 diabetes mellitus associated with Graves' disease and Vogt-Koyanagi-Harada syndrome.
Diabetes Mellitus, Type 1
Type 1 diabetes mellitus in patients with chronic hepatitis C before and after interferon therapy.
Diabetes Mellitus, Type 1
Type 1 diabetes-related antibodies in the fetal circulation: prevalence and influence on cord insulin and birth weight in offspring of mothers with type 1 diabetes.
Diabetes Mellitus, Type 1
Type 1 diabetes-related autoantibodies in different forms of diabetes.
Diabetes Mellitus, Type 1
Tyrosine phosphatase-like protein (IA-2) and glutamic acid decarboxylase (GAD65) autoantibodies: a study of Chinese patients with diabetes mellitus.
Diabetes Mellitus, Type 1
Unique epitopes of glutamic acid decarboxylase autoantibodies in slowly progressive type 1 diabetes.
Diabetes Mellitus, Type 1
Use of an islet cell antibody assay to identify type 1 diabetic patients with rapid decrease in C-peptide levels after clinical onset. Belgian Diabetes Registry.
Diabetes Mellitus, Type 1
Vaccination with a co-expression DNA plasmid containing GAD65 fragment gene and IL-10 gene induces regulatory CD4(+) T cells that prevent experimental autoimmune diabetes.
Diabetes Mellitus, Type 1
Vaccination with glutamic acid decarboxylase plasmid DNA protects mice from spontaneous autoimmune diabetes and B7/CD28 costimulation circumvents that protection.
Diabetes Mellitus, Type 1
Value of antibodies to GAD65 combined with islet cell cytoplasmic antibodies for predicting IDDM in a childhood population.
Diabetes Mellitus, Type 1
Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes.
Diabetes Mellitus, Type 1
Variation of C peptide decay rate in diabetic patients with positive glutamic acid decarboxylase antibody: better discrimination with initial fasting C peptide.
Diabetes Mellitus, Type 1
Vitamin D receptor gene polymorphisms influence susceptibility to type 1 diabetes mellitus in the Taiwanese population.
Diabetes Mellitus, Type 1
What are the characteristics of phenotypic type 2 diabetic patients with low-titer GAD65 antibodies?
Diabetes Mellitus, Type 1
Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease.
Diabetes Mellitus, Type 1
Women diagnosed with gestational diabetes mellitus do not carry antibodies against minor islet cell antigens.
Diabetes Mellitus, Type 1
Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies.
Diabetes Mellitus, Type 1
[A young woman with metabolic acidosis and recently discovered IDDM without ketonuria. A rare autoimmune (?) combination of hypothyroidism, diabetes mellitus and distal renal tubular acidosis]
Diabetes Mellitus, Type 1
[Antibodies to glutamic acid decarboxylase (GADA) as markers of risk for development of insulin-dependent diabetes mellitus]
Diabetes Mellitus, Type 1
[Association of autoantibody and cytokines with latent autoimmune diabetes in adults]
Diabetes Mellitus, Type 1
[Auto-antibodies against glutamic acid decarboxylase and diabetes]
Diabetes Mellitus, Type 1
[Autoantibodies to GAD65, IA2 and insulin in Czech children with type 1 diabetes]
Diabetes Mellitus, Type 1
[Autoantibodies to glutamate decarboxylase in children with newly detected insulin-dependent diabetes mellitus]
Diabetes Mellitus, Type 1
[Construction and identification of 2 secreted human GAD65 fragment DNA vaccines]
Diabetes Mellitus, Type 1
[Detection of GAD65 reactive T cells in some Chinese subjects initially diagnosed as with idiopathic type 1 diabetes]
Diabetes Mellitus, Type 1
[Expression of autoantibodies to ICA512 and GAD in the sera of patients with diabetic ketoacidosis or ketonemia]
Diabetes Mellitus, Type 1
[Genetic engineering approaches to the study of insulin-dependent diabetes mellitus markers]
Diabetes Mellitus, Type 1
[Glutamate decarboxylase (GAD)--an autoantigen in insulin-dependent diabetes mellitus (IDDM)]
Diabetes Mellitus, Type 1
[Identification of the two subtypes of latent autoimmune diabetes in adults by glutamic acid decarboxylase 65 antibody titers]
Diabetes Mellitus, Type 1
[Immunologic and genetic aspects of latent autoimmune diabetes in the adult]
Diabetes Mellitus, Type 1
[Islet beta cell function in latent autoimmune diabetes in adults with islet cell antibodies]
Diabetes Mellitus, Type 1
[Latent autoimmune diabetes in adults(LADA): part of the clinical spectrum of type-1 diabetes mellitus of autoimmune origin]
Diabetes Mellitus, Type 1
[Plasma levels of interleukin-1beta, interleukin-2 and interleukin-4 in recently diagnosed type 1 diabetic children and their association with beta-pancreatic autoantibodies]
Diabetes Mellitus, Type 1
[Prevalence and predictive value of GAD65 autoantibodies and their correlation with HLA DR-DQ genotypes in children with type-1 diabetes]
Diabetes Mellitus, Type 1
[Relation between insulin resistance and glutamic acid decarboxylase antibody titers in latent autoimmune diabetes in adults]
Diabetes Mellitus, Type 1
[Value of glutamic acid decarboxylase autoantibody detection for early diagnosis of latent autoimmune diabetes in adults]
Diabetes Mellitus, Type 2
A convenient diagnostic tool for discriminating adult-onset glutamic acid decarboxylase antibody-positive autoimmune diabetes from type 2 diabetes: a retrospective study.
Diabetes Mellitus, Type 2
A Triad of Ketoacidosis, Hypertriglyceridemia, and Acute Pancreatitis Associated With Sugar-Sweetened Soft Drinks Abuse in a Caucasian Patient With Undiagnosed Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy.
Diabetes Mellitus, Type 2
Activation of CD4+ and CD8+ T-lymphocytes by insulin and GAD in patients with type 1 or 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Altered natural killer (NK) cell frequency and phenotype in latent autoimmune diabetes in adults (LADA) prior to insulin deficiency.
Diabetes Mellitus, Type 2
ANNALS EXPRESS: Development of a novel ultra-sensitive enzyme immunoassay for human GAD65 antibody.
Diabetes Mellitus, Type 2
Antibodies to glutamic acid decarboxylase in the prediction of insulin dependency.
Diabetes Mellitus, Type 2
Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes: isotype restriction and polyclonality.
Diabetes Mellitus, Type 2
Antibodies to new beta cell antigen ICA12 in Latvian diabetes patients.
Diabetes Mellitus, Type 2
Association of HLA class II alleles with different subgroups of diabetes mellitus in Eastern India identify different associations with IDDM and malnutrition-related diabetes.
Diabetes Mellitus, Type 2
Atezolizumab-induced type 1 diabetes mellitus in a patient with metastatic renal cell carcinoma.
Diabetes Mellitus, Type 2
Autoantibodies against glutamic acid decarboxylase 65 in Japanese patients with insulin-dependent diabetes mellitus (IDDM).
Diabetes Mellitus, Type 2
Autoantibodies to GAD65 and IA-2 antibodies are increased, but not tissue transglutaminase (TTG-Ab) in type 2 diabetes mellitus (T2DM) patients from South India.
Diabetes Mellitus, Type 2
Autoantibodies to glutamic acid decarboxylase and phenotypic features associated with early insulin treatment in individuals with adult-onset diabetes mellitus.
Diabetes Mellitus, Type 2
Autoantibodies to IA-2 and GAD65 in patients with type 2 diabetes mellitus of varied duration: prevalence and correlation with clinical features.
Diabetes Mellitus, Type 2
Autoantibodies to N-terminally truncated GAD improve clinical phenotyping of individuals with adult-onset diabetes: Action LADA 12.
Diabetes Mellitus, Type 2
Autoantibody recognition of COOH-terminal epitopes of GAD65 marks the risk for insulin requirement in adult-onset diabetes mellitus.
Diabetes Mellitus, Type 2
Autoimmunity plays a role in the onset of diabetes after 40 years of age.
Diabetes Mellitus, Type 2
BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune diabetes in southern India.
Diabetes Mellitus, Type 2
Clinical and biochemical characteristics of nonobese type 2 diabetic patients with glutamic acid decarboxylase antibody in Korea.
Diabetes Mellitus, Type 2
Clinical and genetic characteristics of diabetic patients with high-titer (>10,000 U/ml) of antibodies to glutamic acid decarboxylase.
Diabetes Mellitus, Type 2
Clinical and genetic characteristics of GAD-antibody positive patients initially diagnosed as having type 2 diabetes.
Diabetes Mellitus, Type 2
Clinical and Genetic Characteristics of Non-Insulin-Requiring Glutamic Acid Decarboxylase (GAD) Autoantibody-Positive Diabetes: A Nationwide Survey in Japan.
Diabetes Mellitus, Type 2
Clinical characteristics of patients with the initial diagnosis of NIDDM with positivity for antibodies to glutamic acid decarboxylase.
Diabetes Mellitus, Type 2
Clinical evaluation of non-insulin-dependent diabetes mellitus patients with autoantibodies to glutamic acid decarboxylase.
Diabetes Mellitus, Type 2
Crucial points at diagnosis. Type 2 diabetes or slow type 1 diabetes.
Diabetes Mellitus, Type 2
DIABETIC KETOACIDOSIS: A COMMON DEBUT OF DIABETES AMONG AFRICAN AMERICANS WITH TYPE 2 DIABETES.
Diabetes Mellitus, Type 2
Diagnostic role of antibodies to glutamic acid decarboxylase in latent autoimmune diabetes mellitus in adults.
Diabetes Mellitus, Type 2
Diagnostic significance of antibodies to glutamic acid decarboxylase in Japanese diabetic patients with secondary oral hypoglycemic agents failure.
Diabetes Mellitus, Type 2
Engineered variants of human glutamic acid decarboxylase (GAD) and autoantibody epitope recognition.
Diabetes Mellitus, Type 2
Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset Sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes.
Diabetes Mellitus, Type 2
Evaluation of a novel radioimmunoassay using 125I-labelled human recombinant GAD65 for the determination of glutamic acid decarboxylase (GAD65) autoantibodies.
Diabetes Mellitus, Type 2
Evidence of islet cell autoimmunity in elderly patients with type 2 diabetes.
Diabetes Mellitus, Type 2
Expression of recombinant human glutamic acid decarboxylase (GAD) in myeloma cells and enzyme-linked immunosorbent assay (ELISA) for autoantibodies to GAD.
Diabetes Mellitus, Type 2
Fasting c-peptide and insulin-like growth factor-binding protein-1 levels help to distinguish childhood type 1 and type 2 diabetes at diagnosis.
Diabetes Mellitus, Type 2
Frequency of latent autoimmune diabetes in adults in Asian patients diagnosed as type 2 diabetes in Birmingham, United Kingdom.
Diabetes Mellitus, Type 2
Frequency, clinical features, inflammatory cytokines and genetic background of latent autoimmune diabetes in youth in youth-onset type 2 diabetes (LADA China study): a nationwide, multicenter, clinic-based cross-sectional study.
Diabetes Mellitus, Type 2
Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY).
Diabetes Mellitus, Type 2
GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetes.
Diabetes Mellitus, Type 2
GAD65 and IA-2 autoantibodies are common in a subset of siblings of Sardinian Type 2 diabetes families.
Diabetes Mellitus, Type 2
GAD65 Antibodies, Chronic Psychosis, and Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
GADA Titer-Related Risk for Organ-Specific Autoimmunity in LADA Subjects Subdivided according to Gender (NIRAD Study 6).
Diabetes Mellitus, Type 2
Genetic and clinical characteristics of maturity-onset diabetes of the young in Chinese patients.
Diabetes Mellitus, Type 2
Glutamic acid decarboxylase 65 autoantibody levels discriminate two subtypes of latent autoimmune diabetes in adults.
Diabetes Mellitus, Type 2
Glutamic acid decarboxylase and islet antigen 2 antibody profiles in people with adult-onset diabetes mellitus: a comparison between mixed ethnic populations in Singapore and Germany.
Diabetes Mellitus, Type 2
Glutamic Acid Decarboxylase Autoantibody Detection by Electrochemiluminescence Assay Identifies Latent Autoimmune Diabetes in Adults with Poor Islet Function.
Diabetes Mellitus, Type 2
Glutamic acid decarboxylase65 (GAD65) antibodies and insulin auto-antibodies in Japanese patients with non-insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
High-titer GAD65 autoantibodies detected in adult diabetes patients using a high efficiency expression vector and cold GAD65 displacement.
Diabetes Mellitus, Type 2
HLA-associated cellular response to GAD in type 2 diabetes with antibodies to GAD.
Diabetes Mellitus, Type 2
HLA-DRB1 alleles contribute to determining the prognosis of Japanese diabetes mellitus positive for antibodies to glutamate decarboxylase.
Diabetes Mellitus, Type 2
IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71).
Diabetes Mellitus, Type 2
Immune Checkpoint Inhibitor-Induced Diabetic Ketoacidosis: A Report of Four Cases and Literature Review.
Diabetes Mellitus, Type 2
Incremental cost-effectiveness of algorithm-driven genetic testing versus no testing for Maturity Onset Diabetes of the Young (MODY) in Singapore.
Diabetes Mellitus, Type 2
Insulin autoantibody could help to screen latent autoimmune diabetes in adults in phenotypic type 2 diabetes mellitus in Chinese.
Diabetes Mellitus, Type 2
Insulin intervention to preserve beta cells in slowly progressive insulin-dependent (type 1) diabetes mellitus.
Diabetes Mellitus, Type 2
Interaction Between Overweight and Genotypes of HLA, TCF7L2, and FTO in Relation to the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes.
Diabetes Mellitus, Type 2
Islet autoantibodies in Latvian subjects with non-insulin-dependent diabetes mellitus: slow-onset type 1 diabetes or polyendocrine autoimmunity?
Diabetes Mellitus, Type 2
Islet cell antibodies and antibodies against glutamic acid decarboxylase in newly diagnosed adult-onset diabetes mellitus.
Diabetes Mellitus, Type 2
Islet cell antibodies and glutamic acid decarboxylase antibodies, but not the clinical phenotype, help to identify type 1(1/2) diabetes in patients presenting with type 2 diabetes.
Diabetes Mellitus, Type 2
Latent autoimmune diabetes in adults (LADA) in Asian and European populations.
Diabetes Mellitus, Type 2
Latent autoimmune diabetes in adults (LADA) in South Wales: incidence and characterization.
Diabetes Mellitus, Type 2
Longitudinal changes in epitope recognition of autoantibodies against glutamate decarboxylase 65 (GAD65Ab) in prediabetic adults developing diabetes.
Diabetes Mellitus, Type 2
Low agreement between radio binding assays in analyzing glutamic acid decarboxylase (GAD65Ab) autoantibodies in patients classified with type 2 diabetes.
Diabetes Mellitus, Type 2
Metabolic Characteristics of Recently Diagnosed Adult-Onset Autoimmune Diabetes Mellitus.
Diabetes Mellitus, Type 2
MHC class I chain-related gene a alleles distinguish malnutrition-modulated diabetes, insulin-dependent diabetes, and non-insulin- dependent diabetes mellitus patients from eastern India.
Diabetes Mellitus, Type 2
Microsatellite allele A5.1 of MHC class I chain-related gene A is associated with latent autoimmune diabetes in adults in Latvia.
Diabetes Mellitus, Type 2
Most Women with Previous Gestational Diabetes Mellitus Have Impaired Glucose Metabolism after a Decade.
Diabetes Mellitus, Type 2
Past, present and future of latent autoimmune diabetes in adults.
Diabetes Mellitus, Type 2
Possible human leukocyte antigen-mediated genetic interaction between type 1 and type 2 Diabetes.
Diabetes Mellitus, Type 2
Prevalence and correlates of latent autoimmune diabetes in adults in Tianjin, China: a population based cross-sectional study.
Diabetes Mellitus, Type 2
Prevalence of diabetes-associated autoantibodies among patients presenting with type 2 diabetes and related metabolic differences.
Diabetes Mellitus, Type 2
Prevalence of GAD65 antibodies in lean subjects with type 2 diabetes.
Diabetes Mellitus, Type 2
Relationship between serum GAD-Ab and the genetic polymorphisms of GAD2 and type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Retinopathy in latent autoimmune diabetes of adults: the Fremantle Diabetes Study.
Diabetes Mellitus, Type 2
Saxagliptin improves glycaemic control and C-peptide secretion in latent autoimmune diabetes in adults (LADA).
Diabetes Mellitus, Type 2
Sequencing reveals protective and pathogenic effects on development of diabetes of rare GLIS3 variants.
Diabetes Mellitus, Type 2
Seroconversion of glutamic acid decarboxylase antibodies in a patient initially diagnosed as having type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Smoking Is Associated With Reduced Risk of Autoimmune Diabetes in Adults Contrasting With Increased Risk in Overweight Men With Type 2 Diabetes: A 22-year follow-up of the HUNT study.
Diabetes Mellitus, Type 2
The association between GAD65 antibody levels and incident Type 2 Diabetes Mellitus in an adult population: A meta-analysis.
Diabetes Mellitus, Type 2
THE CLINICAL AND METABOLIC CHARACTERISTICS OF YOUNG-ONSET KETOSIS-PRONE TYPE 2 DIABETES IN CHINA.
Diabetes Mellitus, Type 2
The first series of cases of ketosis-prone type 2 diabetes (flatbush diabetes) in Brazilian adults.
Diabetes Mellitus, Type 2
The prevalence of the 65-kilodalton isoform of glutamic acid decarboxylase autoantibodies by glucose tolerance status in elderly patients from the cardiovascular health study.
Diabetes Mellitus, Type 2
The relationship of insulin secretion and GAD65 antibody levels at diagnosis on glycemic control in type 2 diabetes.
Diabetes Mellitus, Type 2
UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group.
Diabetes Mellitus, Type 2
ZnT8 Autoantibodies Complement GAD and IA-2 Autoantibodies in the Identification and Characterization of Japanese Type 1 Diabetes.
Diabetes Mellitus, Type 2
[A cost analysis of diagnostic screening for the differentiation of type-1 and type-2 diabetics aged 30 to 45. A health economics modelling calculation]
Diabetes Mellitus, Type 2
[Identification of the two subtypes of latent autoimmune diabetes in adults by glutamic acid decarboxylase 65 antibody titers]
Diabetes Mellitus, Type 2
[Immunologic and genetic aspects of latent autoimmune diabetes in the adult]
Diabetes Mellitus, Type 2
[Latent autoimmune diabetes in adults(LADA): part of the clinical spectrum of type-1 diabetes mellitus of autoimmune origin]
Diabetes, Gestational
Clinical characteristics and outcome of pregnancy in women with gestational hyperglycaemia with and without antibodies to beta-cell antigens.
Diabetes, Gestational
Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY).
Diabetes, Gestational
GAD65 autoantibodies in women with gestational or insulin dependent diabetes mellitus diagnosed during pregnancy.
Diabetes, Gestational
Glutamic acid decarboxylase autoantibody-positivity post-partum is associated with impaired ?-cell function in women with gestational diabetes mellitus.
Diabetes, Gestational
HLA-DQB1 genotypes and islet cell autoantibodies against GAD65 and IA-2 in relation to development of diabetes post partum in women with gestational diabetes mellitus.
Diabetes, Gestational
IgG4 subclass glutamic acid decarboxylase antibodies (GADA) are associated with a reduced risk of developing type 1 diabetes as well as increased C-peptide levels in GADA positive gestational diabetes.
Diabetes, Gestational
Immune responses to glutamic acid decarboxylase and insulin in patients with gestational diabetes.
Diabetes, Gestational
Low frequency of autoantibodies to islet cell, glutamic acid decarboxylase, and second-islet antigen in patients with gestational diabetes mellitus: a follow-up study.
Diabetes, Gestational
Prevalence of antibodies to glutamic acid decarboxylase in women who have had gestational diabetes.
Diabetes, Gestational
Prevalence of zinc transporter 8 antibodies in gestational diabetes mellitus.
Diabetes, Gestational
The prevalence of GAD antibodies in Korean women with gestational diabetes mellitus and their clinical characteristics during and after pregnancy.
Diabetic Ketoacidosis
Association of amino-terminal-specific antiglutamate decarboxylase (GAD65) autoantibodies with beta-cell functional reserve and a milder clinical phenotype in patients with GAD65 antibodies and ketosis-prone diabetes mellitus.
Diabetic Ketoacidosis
Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes.
Diabetic Ketoacidosis
Coexistence of Immune Checkpoint Inhibitor-Induced Autoimmune Diabetes and Pancreatitis.
Diabetic Ketoacidosis
Combined immune checkpoint inhibitor therapy with nivolumab and ipilimumab causing acute-onset type 1 diabetes mellitus following a single administration: two case reports.
Diabetic Ketoacidosis
Development of autoimmune diabetes with severe diabetic ketoacidosis and immune-related thyroiditis secondary to durvalumab: a case report.
Diabetic Ketoacidosis
DIABETIC KETOACIDOSIS: A COMMON DEBUT OF DIABETES AMONG AFRICAN AMERICANS WITH TYPE 2 DIABETES.
Diabetic Ketoacidosis
Islet autoantibody types mark differential clinical characteristics at diagnosis of pediatric type 1 diabetes.
Diabetic Ketoacidosis
Japanese cases of acute onset diabetic ketosis without acidosis in the absence of glutamic acid decarboxylase autoantibody.
Diabetic Ketoacidosis
One year remission of type 1 diabetes mellitus in a patient treated with sitagliptin.
Diabetic Ketoacidosis
Outcomes after simultaneous pancreas and kidney transplantation and the discriminative ability of the C-peptide measurement pretransplant among type 1 and type 2 diabetes mellitus.
Diabetic Ketoacidosis
Progression of autoimmune diabetes: slowly progressive insulin-dependent diabetes mellitus or latent autoimmune diabetes of adult.
Diabetic Ketoacidosis
THE CLINICAL AND METABOLIC CHARACTERISTICS OF YOUNG-ONSET KETOSIS-PRONE TYPE 2 DIABETES IN CHINA.
Diabetic Nephropathies
Prevalence of GAD65 and IA-2 autoantibodies in IDDM patients affected by diabetic nephropathy.
Diabetic Neuropathies
Expression of glutamic acid decarboxylase in nervous tissue structures targeted by autoantibodies in patients with diabetic autonomic neuropathy.
Diabetic Neuropathies
High prevalence of autoantibodies to glutamic acid decarboxylase in long-standing IDDM is not a marker of symptomatic autonomic neuropathy.
Diabetic Neuropathies
Phospholipid and glutamic acid decarboxylase autoantibodies in diabetic neuropathy.
Diabetic Neuropathies
Vector-mediated release of GABA attenuates pain-related behaviors and reduces Na(V)1.7 in DRG neurons.
Diabetic Retinopathy
Development and progression of diabetic retinopathy in patients with Type 1 diabetes who are positive for GAD autoantibody.
Diabetic Retinopathy
Glutamic acid decarboxylase autoantibody prevalence and association with HLA genotype in patients with younger-onset type 1 diabetes and proliferative diabetic retinopathy.
Diphtheria
Ascending midbrain dopaminergic axons require descending GAD65 axon fascicles for normal pathfinding.
Disorders of Excessive Somnolence
Glutamic Acid Decarboxylase (GAD-65) Autoimmunity Associated With Profound Daytime Hypersomnia, Nighttime Insomnia, Mild Autonomic Neuropathy and Axonal Sensori-Motor Polyneuropathy: A Case Report on a New Phenotype.
Down Syndrome
Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.
Down Syndrome
Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models.
Drug Resistant Epilepsy
Alterations of GABA-mediated synaptic transmission in human epilepsy.
Drug Resistant Epilepsy
Autoimmune encephalitis associated with glutamic acid decarboxylase antibodies: a case series.
Drug Resistant Epilepsy
Case Report: Autoimmune Encephalitis Associated With Anti-glutamic Acid Decarboxylase Antibodies: A Pediatric Case Series.
Drug Resistant Epilepsy
Clinical Management of Epilepsy With Glutamic Acid Decarboxylase Antibody Positivity: The Interplay Between Immunotherapy and Anti-epileptic Drugs.
Drug Resistant Epilepsy
Glutamic acid decarboxylase autoantibodies in controlled and uncontrolled epilepsy: a pilot study.
Drug Resistant Epilepsy
MRI findings in glutamic acid decarboxylase associated autoimmune epilepsy.
Drug Resistant Epilepsy
Refractory status epilepticus and glutamic acid decarboxylase antibodies in adults: presentation, treatment and outcomes.
Dysarthria
Intravenous Immunoglobulin and Rituximab for Cerebellar Ataxia with Glutamic Acid Decarboxylase Autoantibodies.
Dysgeusia
Altered taste function in mice deficient in the 65-kDa isoform of glutamate decarboxylase.
Dyskinesias
Adenosine A2A Receptor Gene Knockout Prevents l-3,4-Dihydroxyphenylalanine-Induced Dyskinesia by Downregulation of Striatal GAD67 in 6-OHDA-Lesioned Parkinson's Mice.
Dyskinesias
Effects of 5-HT1A receptor stimulation on D1 receptor agonist-induced striatonigral activity and dyskinesia in hemiparkinsonian rats.
Dyskinesias
L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA.
Dyskinesias
Loss of glutamic acid decarboxylase (Gad67) in striatal neurons expressing the Drdr1a dopamine receptor prevents L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned mice.
Dyskinesias
Metabotropic glutamate mGluR5 receptor blockade opposes abnormal involuntary movements and the increases in glutamic acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats.
Dyskinesias
Neuroleptic-induced oral dyskinesias: effects of progabide and lack of correlation with regional changes in glutamic acid decarboxylase and choline acetyltransferase activities.
Dyskinesias
Reduction of nigral glutamic acid decarboxylase in rats with neuroleptic-induced oral dyskinesia.
Dyskinesias
Unilateral nigrostriatal lesions induce a bilateral increase in glutamate decarboxylase messenger RNA in the reticular thalamic nucleus.
Dyskinesias
Validation of the l-dopa-induced dyskinesia in the 6-OHDA model and evaluation of the effects of selective dopamine receptor agonists and antagonists.
Dyskinesias
[Serum dopamine-beta-hydroxylase, glutamic acid decarboxylase and 1-aromatic amino acid decarboxylase in involuntary movement disorders (author's transl)]
Dyslipidemias
Metabolic profile and cardiovascular risk patterns of an Indian tribe living in the Amazon Region of Brazil.
Dystonia
Differential expression of glutamate decarboxylase messenger RNA in cerebellar Purkinje cells and deep cerebellar nuclei of the genetically dystonic rat.
Dystonia
Glutamic acid decarboxylase activity in micropunches of the deep cerebellar nuclei of the genetically dystonic (dt) rat.
Dystonia Musculorum Deformans
Alterations in cerebellar glutamic acid decarboxylase (GAD) activity in a genetic model of torsion dystonia (rat).
Dystonia Musculorum Deformans
Linkage analysis in a family with dominantly inherited torsion dystonia: exclusion of the pro-opiomelanocortin and glutamic acid decarboxylase genes and other chromosomal regions using DNA polymorphisms.
Encephalitis
A Case of Immunotherapy-responsive Non-paraneoplastic Encephalitis with Antibodies Against GAD, LGI1, and GABAA Receptor.
Encephalitis
Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen.
Encephalitis
Antiglutamic Acid Decarboxylase Antibodies in Children With Encephalitis and Status Epilepticus.
Encephalitis
Autoimmune encephalitis associated with glutamic acid decarboxylase antibodies: a case series.
Encephalitis
Case of Bickerstaff encephalitis with positive glutamic acid decarboxylase antibodies.
Encephalitis
Case Report: Autoimmune Encephalitis Associated With Anti-glutamic Acid Decarboxylase Antibodies: A Pediatric Case Series.
Encephalitis
Encephalitis associated with glutamic Acid decarboxylase autoantibodies in a child: a treatable condition?
Encephalitis
Extralimbic autoimmune encephalitis associated with glutamic acid decarboxylase antibodies: an underdiagnosed entity?
Encephalitis
GAD65 Autoimmune Encephalitis: A Cause of Rapidly Evolving Frontotemporal Atrophy.
Encephalitis
Glutamic acid decarboxylase 65-positive autoimmune encephalitis presenting with gelastic seizure, responsive to steroid: A case report.
Encephalitis
How Much GAD65 Do You Have? High Levels of GAD65 Antibodies in Autoimmune Encephalitis.
Encephalitis
Immunological GABAergic interactions and therapeutic applications in autoimmune diseases.
Encephalitis
Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis.
Encephalitis
Neurofilament light chain levels reflect outcome in a patient with glutamic acid decarboxylase 65 antibody-positive autoimmune encephalitis under immune checkpoint inhibitor therapy.
Encephalitis
Non-convulsive status epilepticus associated with glutamic acid decarboxylase antibody.
Encephalitis
Opercular myoclonic-anarthric status epilepticus due to glutamic acid decarboxylase antibody-associated encephalitis.
Encephalitis
Refractory status epilepticus and autoimmune encephalitis with GABAAR and GAD65 antibodies: A case report.
Encephalitis
Serum anti-ganglioside antibodies in patients with autoimmune limbic encephalitis.
Encephalitis, Viral
Ketogenic Diet Therapy for the Treatment of Post-encephalitic and Autoimmune-Associated Epilepsies.
Encephalomyelitis
Antibodies against glutamic acid decarboxylase: prevalence in neurological diseases.
Encephalomyelitis
Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4(+) T cells.
Encephalomyelitis
Glycine receptor antibodies are detected in progressive encephalomyelitis with rigidity and myoclonus (PERM) but not in saccadic oscillations.
Encephalomyelitis
Stiff-person syndromes: motor cortex hyperexcitability correlates with anti-GAD autoimmunity.
Enterovirus Infections
Enterovirus infections with beta-cell tropic strains are frequent in siblings of children diagnosed with type 1 diabetes children and in association with elevated levels of GAD65 antibodies.
Enterovirus Infections
First-degree relatives of persons with type 1 diabetes: insulin resistance and enterovirus infection are associated with different patterns of islet cell autoimmunity.
Enterovirus Infections
Relation between T-cell responses to glutamate decarboxylase and coxsackievirus B4 in patients with insulin-dependent diabetes mellitus.
Eosinophilia
The role of interleukin-4Ralpha in the induction of glutamic acid decarboxylase in airway epithelium following acute house dust mite exposure.
Epilepsies, Partial
Antiphospholipid and glutamic acid decarboxylase antibodies in patients with focal epilepsy.
Epilepsies, Partial
Brain FDG-PET findings in glutamic acid decarboxylase antibody-associated epilepsy.
Epilepsies, Partial
Differential and time-dependent changes in gene expression for type II calcium/calmodulin-dependent protein kinase, 67 kDa glutamic acid decarboxylase, and glutamate receptor subunits in tetanus toxin-induced focal epilepsy.
Epilepsies, Partial
Hippocampus and Insula Are Targets in Epileptic Patients With Glutamic Acid Decarboxylase Antibodies.
Epilepsies, Partial
Hippocampus of the seizure-sensitive gerbil is a specific site for anatomical changes in the GABAergic system.
Epilepsies, Partial
Neuronal autoantibodies in focal epilepsy with or without mesial temporal sclerosis.
Epilepsies, Partial
New-onset focal epilepsy with palatal tremor and glutamic acid decarboxylase antibodies responding to intravenous immunoglobulin.
Epilepsies, Partial
Time course of the reduction of GABA terminals in a model of focal epilepsy: a glutamic acid decarboxylase immunocytochemical study.
Epilepsy
Activity-dependent expression of GAD67 in the granule cells of the rat hippocampus.
Epilepsy
Altered pharmacology and GABA-A receptor subunit expression in dorsal midline thalamic neurons in limbic epilepsy.
Epilepsy
Anticardiolipin, glutamic acid decarboxylase, and antinuclear antibodies in epileptic patients.
Epilepsy
Antigenic differences between neurological and diabetic patients with anti-glutamic acid decarboxylase antibodies.
Epilepsy
Association between high titers of glutamic acid decarboxylase antibody and epilepsy in patients with type 1 diabetes mellitus: A cross-sectional study.
Epilepsy
Author Correction: Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy.
Epilepsy
Auto-destruction of the thyroid gland and coexisting glutamic acid decarboxylase mediated neurological disease in an adolescent: an unusual presentation of autoimmunity.
Epilepsy
Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome.
Epilepsy
Autoantibodies to glutamic acid decarboxylase (GAD) in focal and generalized epilepsy: A study on 233 patients.
Epilepsy
Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I diabetes mellitus.
Epilepsy
Autoantibodies to glutamic acid decarboxylase in patients with epilepsy and their relationship with type 1 diabetes: a pilot study.
Epilepsy
Autoantibodies to glutamic acid decarboxylase in patients with epilepsy are associated with low cortical GABA levels.
Epilepsy
Autoantibodies to glutamic acid decarboxylase in patients with epilepsy: what is their clinical relevance?
Epilepsy
Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy.
Epilepsy
Basal expression and induction of glutamate decarboxylase and GABA in excitatory granule cells of the rat and monkey hippocampal dentate gyrus.
Epilepsy
Brain FDG-PET findings in glutamic acid decarboxylase antibody-associated epilepsy.
Epilepsy
Brain-responsive neurostimulation treatment in patients with GAD65 antibody-associated autoimmune mesial temporal lobe epilepsy.
Epilepsy
Calcium binding protein (calbindin-D28k) and glutamate decarboxylase gene expression after kindling induced seizures.
Epilepsy
Cerebellar ataxia and epilepsy with anti-GAD antibodies: treatment with IVIG and plasmapheresis.
Epilepsy
Choline acetyltransferase, glutamic acid decarboxylase and somatostatin in the kainic acid model for chronic temporal lobe epilepsy.
Epilepsy
Clinical Management of Epilepsy With Glutamic Acid Decarboxylase Antibody Positivity: The Interplay Between Immunotherapy and Anti-epileptic Drugs.
Epilepsy
Clinical significance of glutamic acid decarboxylase antibodies in patients with epilepsy.
Epilepsy
Concomitant increase of somatostatin, neuropeptide Y and glutamate decarboxylase in the frontal cortex of rats with decreased seizure threshold.
Epilepsy
Conjoint glutamic acid decarboxylase 65 and P/Q voltage gated calcium channel antibodies in autoimmune epilepsy: A case report.
Epilepsy
Efficient therapeutic gene expression in cultured rat hippocampal neurons mediated by human foamy virus vectors: a potential for the treatment of neurological diseases.
Epilepsy
Epilepsy and behavioral changes, type 1 diabetes mellitus and a high titer of glutamic acid decarboxylase antibodies.
Epilepsy
Epilepsy and hippocampal neurodegeneration induced by glutamate decarboxylase inhibitors in awake rats.
Epilepsy
Epilepsy in patients with insulin-dependent diabetes and relation to glutamic acid decarboxylase 65.
Epilepsy
Evaluation of Glutamic Acid Decarboxylase Antibody Levels in Patients with Juvenile Myoclonic Epilepsy and Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis.
Epilepsy
Fulminant Anti-GAD antibody encephalitis presenting with status epilepticus requiring aggressive immunosuppression.
Epilepsy
GAD antibody-spectrum disorders: progress in clinical phenotypes, immunopathogenesis and therapeutic interventions.
Epilepsy
GAD65 antibody-associated autoimmune epilepsy with unique independent bitemporal-onset ictal asystole.
Epilepsy
GAD65 autoantibody characteristics in patients with co-occurring type 1 diabetes and epilepsy may help identify underlying epilepsy etiologies.
Epilepsy
Gad67 haploinsufficiency reduces amyloid pathology and rescues olfactory memory deficits in a mouse model of Alzheimer's disease.
Epilepsy
Garcinol Upregulates GABAA and GAD65 Expression, Modulates BDNF-TrkB Pathway to Reduce Seizures in Pentylenetetrazole (PTZ)-Induced Epilepsy.
Epilepsy
Glutamate decarboxylase67 is expressed in hippocampal mossy fibers of temporal lobe epilepsy patients.
Epilepsy
Glutamic acid decarboxylase (GAD) antibodies in epilepsy: diagnostic yield and therapeutic implications.
Epilepsy
Glutamic acid decarboxylase autoantibodies in controlled and uncontrolled epilepsy: a pilot study.
Epilepsy
Glutamic acid decarboxylase in cerebrospinal fluid in infancy and childhood Part II. Glutamic acid decarboxylase activity in cerebrospinal fluid of children with neurological diseases.
Epilepsy
Hippocampal granule cells express glutamic acid decarboxylase-67 after limbic seizures in the rat.
Epilepsy
Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders.
Epilepsy
Immunological GABAergic interactions and therapeutic applications in autoimmune diseases.
Epilepsy
Lack of antibodies to NMDAR or VGKC-complex in GAD and cardiolipin antibody-positive refractory epilepsy.
Epilepsy
Long-term increase of glutamate decarboxylase mRNA in a rat model of temporal lobe epilepsy.
Epilepsy
Long-term outcomes in temporal lobe epilepsy with glutamate decarboxylase antibodies.
Epilepsy
Low rate of glutamic acid decarboxylase 65 (GAD-65) antibodies in chronic epilepsy.
Epilepsy
Musicogenic epilepsy: Expanding the spectrum of glutamic acid decarboxylase 65 neurological autoimmunity.
Epilepsy
Musicogenic reflex seizures in epilepsy with glutamic acid decarbocylase antibodies.
Epilepsy
Newly-diagnosed pediatric epilepsy is associated with elevated autoantibodies to glutamic acid decarboxylase but not cardiolipin.
Epilepsy
Novel clinical features of glycine receptor antibody syndrome: A series of 17 cases.
Epilepsy
Pinellia Total Alkaloids Modulate the GABAergic System in Hippocampal Formation on Pilocarpine-Induced Epileptic Rats.
Epilepsy
Prevalence and immunological spectrum of temporal lobe epilepsy with glutamic acid decarboxylase antibodies.
Epilepsy
Pyramidal cell activity levels affect the polarity of activity-induced gene transcription changes in interneurons.
Epilepsy
Seizure control and cognitive improvement via immunotherapy in late onset epilepsy patients with paraneoplastic versus GAD65 autoantibody-associated limbic encephalitis.
Epilepsy
Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra.
Epilepsy
Serum from a Patient with GAD65 Antibody-Associated Limbic Encephalitis Did Not Alter GABAergic Neurotransmission in Cultured Hippocampal Networks.
Epilepsy
Structural network topology in limbic encephalitis is associated with amygdala enlargement, memory performance and serostatus.
Epilepsy
Systemic and neurologic autoimmune disorders associated with seizures or epilepsy.
Epilepsy
The activity of some neurotransmitter-synthetizing enzymes in experimental cobalt epilepsy.
Epilepsy
The growing recognition of immunotherapy-responsive seizure disorders with autoantibodies to specific neuronal proteins.
Epilepsy
The prevalence of neural antibodies in temporal lobe epilepsy and the clinical characteristics of seropositive patients.
Epilepsy
Therapeutic plasma exchange and immunosuppressive therapy in a patient with anti-GAD antibody-related epilepsy: Quantification of the antibody response.
Epilepsy
Treating a GAD65 Antibody-Associated Limbic Encephalitis with Basiliximab: A Case Study.
Epilepsy
Type 1 diabetes and epilepsy in childhood and adolescence: Do glutamic acid decarboxylase autoantibodies play a role? Data from the German/Austrian/Swiss/Luxembourgian DPV Registry.
Epilepsy
Up-regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal lobe epilepsy.
Epilepsy
Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy.
Epilepsy
[Stiff-person syndrome and other neurological disorders associated with anti-GAD antibodies.]
Epilepsy, Absence
Evaluation of GAD67 immunoreactivity in the region of substantia nigra pars reticulata in resistance to development of convulsive seizure in genetic absence epilepsy rats.
Epilepsy, Generalized
Autoantibodies to glutamic acid decarboxylase (GAD) in focal and generalized epilepsy: A study on 233 patients.
Epilepsy, Generalized
Glutamic acid decarboxylase antibodies in idiopathic generalized epilepsy and type 1 diabetes.
Epilepsy, Reflex
Musicogenic epilepsy: Expanding the spectrum of glutamic acid decarboxylase 65 neurological autoimmunity.
Epilepsy, Reflex
Musicogenic reflex seizure with positive antiglutamic decarboxylase antibody: A case report.
Epilepsy, Temporal Lobe
Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis.
Epilepsy, Temporal Lobe
Author Correction: Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy.
Epilepsy, Temporal Lobe
Brain-responsive neurostimulation treatment in patients with GAD65 antibody-associated autoimmune mesial temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Choline acetyltransferase, glutamic acid decarboxylase and somatostatin in the kainic acid model for chronic temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Evaluation of Glutamic Acid Decarboxylase Antibody Levels in Patients with Juvenile Myoclonic Epilepsy and Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis.
Epilepsy, Temporal Lobe
Fulminant Anti-GAD antibody encephalitis presenting with status epilepticus requiring aggressive immunosuppression.
Epilepsy, Temporal Lobe
Glutamate decarboxylase67 is expressed in hippocampal mossy fibers of temporal lobe epilepsy patients.
Epilepsy, Temporal Lobe
Hippocampal granule cells express glutamic acid decarboxylase-67 after limbic seizures in the rat.
Epilepsy, Temporal Lobe
Long-term increase of glutamate decarboxylase mRNA in a rat model of temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Long-term outcomes in temporal lobe epilepsy with glutamate decarboxylase antibodies.
Epilepsy, Temporal Lobe
Low rate of glutamic acid decarboxylase 65 (GAD-65) antibodies in chronic epilepsy.
Epilepsy, Temporal Lobe
Musicogenic epilepsy: Expanding the spectrum of glutamic acid decarboxylase 65 neurological autoimmunity.
Epilepsy, Temporal Lobe
Prevalence and immunological spectrum of temporal lobe epilepsy with glutamic acid decarboxylase antibodies.
Epilepsy, Temporal Lobe
Temporal lobe epilepsy and anti glutamic acid decarboxylase autoimmunity.
Epilepsy, Temporal Lobe
The prevalence of neural antibodies in temporal lobe epilepsy and the clinical characteristics of seropositive patients.
Epilepsy, Temporal Lobe
Treatment of immune-mediated temporal lobe epilepsy with GAD antibodies.
Epilepsy, Temporal Lobe
Up-regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy.
Esophageal Achalasia
Esophagogastric junction outflow obstruction: Characterization of a new entity? Clinical, manometric, and neuroimmunological description.
Fasciculation
Ascending midbrain dopaminergic axons require descending GAD65 axon fascicles for normal pathfinding.
Fibromyalgia
Possible role for glutamic acid decarboxylase in fibromyalgia symptoms: A conceptual model for chronic pain.
Ganglioglioma
Neurochemical profile of glioneuronal lesions from patients with pharmacoresistant focal epilepsies.
Gangliosidosis, GM1
Neurotransmitter chemistry in feline GM1 gangliosidosis: a model for human ganglioside storage disease.
Gastritis
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
Glioma
Autoimmune epilepsy in children: case series and proposed guidelines for identification.
Glioma
Characterization of the rat GAD67 gene promoter reveals elements important for basal transcription and glucose responsiveness.
Glioma
Diagnostic challenges in patients with temporal lobe seizures and features of autoimmune limbic encephalitis.
Glioma
Febrile Infection-Related Epilepsy Syndrome without Detectable Autoantibodies and Response to Immunotherapy: A Case Series and Discussion of Epileptogenesis in FIRES.
Glioma
Investigation of neuronal auto-antibodies in systemic lupus erythematosus patients with epilepsy.
Glioma
Neural Autoantibodies in Cerebrospinal Fluid and Serum in Clinical High Risk for Psychosis, First-Episode Psychosis, and Healthy Volunteers.
Glioma
Neuronal antibodies in pediatric epilepsy: Clinical features and long-term outcomes of a historical cohort not treated with immunotherapy.
Glioma
Prevalence of Neural Autoantibodies in Epilepsy of Unknown Etiology: Systematic Review and Meta-Analysis.
Glioma
Seizures associated with antibodies against cell surface antigens are acute symptomatic and not indicative of epilepsy: insights from long-term data.
Glucose Intolerance
Acanthosis Nigricans Identifies Youth at High Risk for Metabolic Abnormalities.
Glucose Intolerance
Clinical characteristics and outcome of pregnancy in women with gestational hyperglycaemia with and without antibodies to beta-cell antigens.
Glucose Intolerance
Frequency of latent autoimmune diabetes in adults in Asian patients diagnosed as type 2 diabetes in Birmingham, United Kingdom.
Glucose Intolerance
GAD65 antibodies among Greenland Inuit and its relation to glucose intolerance.
Glucose Intolerance
Glucose intolerance and diabetes following antigen-specific insulitis in diabetes-susceptible "humanized" transgenic mice.
Glucose Intolerance
Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index.
Glucose Intolerance
Islet Autoimmunity in Adults With Impaired Glucose Tolerance and Recently Diagnosed, Treatment Naïve Type 2 Diabetes in the Restoring Insulin SEcretion (RISE) Study.
Glucose Intolerance
Low prevalence of islet autoantibodies in patients with gestational diabetes mellitus.
Glucose Intolerance
Prevalence of diabetes-specific autoantibodies in patients at risk for adult onset diabetes mellitus.
glutamate decarboxylase deficiency
Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy.
glutamate decarboxylase deficiency
Cortical glutamic acid decarboxylase 67 deficiency results in lower cannabinoid 1 receptor messenger RNA expression: implications for schizophrenia.
glutamate decarboxylase deficiency
Development of autoimmune diabetes in glutamic acid decarboxylase 65 (GAD65) knockout NOD mice.
glutamate decarboxylase deficiency
GAD67 Deficiency in Parvalbumin Interneurons Produces Deficits in Inhibitory Transmission and Network Disinhibition in Mouse Prefrontal Cortex.
glutamate decarboxylase deficiency
Glutamate Decarboxylase 67 Deficiency in a Subset of GABAergic Neurons Induces Schizophrenia-Related Phenotypes.
glutamate decarboxylase deficiency
Glutamic acid decarboxylase 65 - a link between GABAergic synaptic plasticity in the lateral amygdala and conditioned fear generalization.
glutamate decarboxylase deficiency
Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar cortices.
glutamate decarboxylase deficiency
Rats deficient in the GAD65 isoform exhibit epilepsy and premature lethality.
Goiter, Nodular
Activation of T lymphocyte subsets by synthetic TSH receptor peptides and recombinant glutamate decarboxylase in autoimmune thyroid disease and insulin-dependent diabetes.
Graves Disease
Activation of T lymphocyte subsets by synthetic TSH receptor peptides and recombinant glutamate decarboxylase in autoimmune thyroid disease and insulin-dependent diabetes.
Graves Disease
Autoantibodies against glutamic acid decarboxylase and 21-hydroxylase in Brazilian patients with type 1 diabetes or autoimmune thyroid diseases.
Graves Disease
Autoantibodies to glutamic acid decarboxylase in patients with autoimmune thyroid disease: relation to competitive insulin autoantibodies.
Graves Disease
Autoimmune thyroid disease correlates to islet autoimmunity on zinc transporter 8 autoantibody.
Graves Disease
Clinical and genetic characteristics of patients with autoimmune thyroid disease with anti-islet autoimmunity.
Graves Disease
Glutamic acid decarboxylase autoantibody assay using 125I-labelled recombinant GAD65 produced in yeast.
Graves Disease
Human B cells secreting immunoglobulin G to glutamic acid decarboxylase-65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes.
Graves Disease
IL-18 gene polymorphism confers susceptibility to the development of anti-GAD65 antibody in Graves' disease.
Graves Disease
Islet cell and glutamic acid decarboxylase antibodies in hyperthyroid patients: at diagnosis and following treatment.
Graves Disease
Prevalence of diabetes and presence of autoantibodies against zinc transporter 8 and glutamic decarboxylase at diagnosis and at follow up of Graves' disease.
Hashimoto Disease
Heritability of levels of autoantibodies using the method of plotting regression of offspring on midparent (ROMP).
Hearing Loss, Noise-Induced
Tinnitus Correlates with Downregulation of Cortical Glutamate Decarboxylase 65 Expression But Not Auditory Cortical Map Reorganization.
Hearing Loss, Unilateral
Stimulation by cochlear implant in unilaterally deaf rats reverses the decrease of inhibitory transmission in the inferior colliculus.
Heart Arrest
GAD65 antibody-associated autoimmune epilepsy with unique independent bitemporal-onset ictal asystole.
Heart Failure
c-Jun N-terminal Kinase mediates prostaglandin-induced sympathoexcitation in rats with chronic heart failure by reducing GAD1 and GABRA1 expression.
Heart Failure
Effect of the changes of NMDA receptor in hypothalamic paraventricular nucleus on cardiac function and sympathetic nervous activity in rats with heart failure.
Heart Failure
NF-?B in the paraventricular nucleus modulates neurotransmitters and contributes to sympathoexcitation in heart failure.
Hepatic Encephalopathy
Activities of neuronal and astrocytic marker enzymes in autopsied brain tissue from patients with hepatic encephalopathy.
Hepatic Encephalopathy
Alterations of GABA-A and dopamine D-2 brain receptors in dogs with portal-systemic encephalopathy.
Hepatic Encephalopathy
Expression of Glutamate Decarboxylase (GAD) mRNA in the Brain of Bile Duct Ligated Rats Serving as a Model of Hepatic Encephalopathy.
Hepatic Encephalopathy
Hepatic encephalopathy in cirrhotic and portacaval shunted dogs: lack of changes in brain GABA uptake, brain GABA levels, brain glutamic acid decarboxylase activity and brain postsynaptic GABA receptors.
Hepatic Encephalopathy
Metabolism and brain uptake of gamma-aminobutyric acid in galactosamine-induced hepatic encephalopathy in rats.
Hepatitis
Antibodies to glutamic acid decarboxylase induced by interferon-alpha therapy for chronic viral hepatitis.
Hepatitis
Monogenic Diabetes Secondary to Congenital Lipodystrophy in a 14-year-old Yemeni Girl.
Hepatitis B
IGRP and insulin vaccination induce CD8+ T cell-mediated autoimmune diabetes in the RIP-CD80GP mouse.
Hernia, Umbilical
Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy.
Hernia, Umbilical
GAD65/GAD67 double knockout mice exhibit intermediate severity in both cleft palate and omphalocele compared with GAD67 knockout and VGAT knockout mice.
Herpes Simplex
Alteration in tyrosine hydroxylase, glutamic acid decarboxylase and choline acetyltransferase in basal ganglia following herpes simplex virus inoculation in rat neostriatum.
Herpes Simplex
Audiogenic seizure activity following HSV-1 GAD65 sense or antisense injection into inferior colliculus of Long-Evans rat.
Herpes Simplex
Enhancement of neuronal protection from oxidative stress by glutamic acid decarboxylase delivery with a defective herpes simplex virus vector.
Herpes Simplex
GABA synthesis in astrocytes after infection with defective herpes simplex virus vectors expressing glutamic acid decarboxylase 65 or 67.
Herpes Simplex
Gene Transfer of Glutamic Acid Decarboxylase 67 by Herpes Simplex Virus Vectors Suppresses Neuropathic Pain Induced by Human Immunodeficiency Virus gp120 Combined with ddC in Rats.
Herpes Simplex
Glutamatergic or GABAergic neuron-specific, long-term expression in neocortical neurons from helper virus-free HSV-1 vectors containing the phosphate-activated glutaminase, vesicular glutamate transporter-1, or glutamic acid decarboxylase promoter.
Herpes Simplex
Herpes simplex virus vector-mediated gene delivery of glutamic acid decarboxylase reduces detrusor overactivity in spinal cord-injured rats.
Herpes Simplex
HSV vector-mediated GAD67 suppresses neuropathic pain induced by perineural HIV gp120 in rats through inhibition of ROS and Wnt5a.
Herpes Simplex
Novel synthesis and release of GABA in cerebellar granule cell cultures after infection with defective herpes simplex virus vectors expressing glutamic acid decarboxylase.
Herpes Simplex
Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain.
Herpes Simplex
Release of GABA from sensory neurons transduced with a GAD67-expressing vector occurs by non-vesicular mechanisms.
Herpes Simplex
Suppression of detrusor-sphincter dyssynergia by herpes simplex virus vector mediated gene delivery of glutamic acid decarboxylase in spinal cord injured rats.
Herpes Simplex
Vector-mediated gene transfer to express inhibitory neurotransmitters in dorsal root ganglion reduces pain in a rodent model of lumbar radiculopathy.
Herpes Simplex
Vector-mediated release of GABA attenuates pain-related behaviors and reduces Na(V)1.7 in DRG neurons.
Herpes Zoster
Biochemical changes accompanying unilateral 6-hydroxydopamine lesions in the rat substantia nigra.
Herpes Zoster
Development of direct GABAergic projections from the zona incerta to the somatosensory cortex of the rat.
Herpes Zoster
Effect of gonadal steroids and gamma-aminobutyric acid on LH release and dopamine expression and activity in the zona incerta in rats.
Herpes Zoster
Immunohistochemical studies on distribution of GABAA receptor complex in the rat brain using antibody against purified GABAA receptor complex.
Herpes Zoster
Luteinizing hormone-releasing hormone and gamma-aminobutyric acid neurons in the medial preoptic area are synaptic targets of dopamine axons originating in anterior periventricular areas.
Herpes Zoster
Ovarian steroid regulation of glutamic Acid decarboxylase gene expression in individual hypothalamic nuclei.
Herpes Zoster
Reduced activity of GAD67 expressing cells in the reticular thalamus enhance thalamic excitatory activity and varicella zoster virus associated pain.
Huntington Disease
Analysis of glutamate decarboxylase in post-mortem brain tissue in Huntington's chorea.
Huntington Disease
Choline acetylase and glutamic acid decarboxylase in Huntington's chorea. A preliminary study.
Huntington Disease
Differential effects of agonal status on measurements of GABA and glutamate decarboxylase in human post-mortem brain tissue from control and Huntington's chorea subjects.
Huntington Disease
Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.
Huntington Disease
GABA content and glutamic acid decarboxylase activity in brain of Huntington's chorea patients and control subjects.
Huntington Disease
gamma-Glutamyltransferase activity is unchanged in acutely quinolinate-lesioned rat neostriatum but is elevated in Huntington's disease caudate.
Huntington Disease
Glutamic acid decarboxylase and gamma-aminobutyric acid in Huntington's disease fibroblasts and other cultured cells, determined by a [3H]muscimol radioreceptor assay.
Huntington Disease
Huntington's chorea. Post-mortem measurement of glutamic acid decarboxylase, choline acetyltransferase and dopamine in basal ganglia.
Huntington Disease
Inhibition of brain glutamate decarboxylase by glutarate, glutaconate, and beta-hydroxyglutarate: explanation of the symptoms in glutaric aciduria?
Huntington Disease
Intrastriatal infusion of nerve growth factor after quinolinic acid prevents reduction of cellular expression of choline acetyltransferase messenger RNA and trkA messenger RNA, but not glutamate decarboxylase messenger RNA.
Huntington Disease
Long term treatment of Huntington disease with L-glutamate and pyridoxine.
Huntington Disease
Neurochemical alterations in Huntington's chorea: a study of post-mortem brain tissue.
Huntington Disease
Normal glutamic acid decarboxylase activity in kidney tissue from patients with Huntington's Disease.
Huntington Disease
Palmitoylation and trafficking of GAD65 are impaired in a cellular model of Huntington's disease.
Huntington Disease
Pharmacodynamic effects and possible therapeutic uses of THIP, a specific GABA-agonist.
Huntington Disease
Phosphate-activated glutaminase in relation to Huntington's disease and agonal state.
Huntington Disease
Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease.
Hydrocephalus
Glutamic acid decarboxylase in cerebrospinal fluid in infancy and childhood Part II. Glutamic acid decarboxylase activity in cerebrospinal fluid of children with neurological diseases.
Hydrocephalus
Progressive loss of glutamic acid decarboxylase, parvalbumin, and calbindin D28K immunoreactive neurons in the cerebral cortex and hippocampus of adult rat with experimental hydrocephalus.
Hyperalgesia
Comparative effectiveness of antinociceptive gene therapies in animal models of diabetic neuropathic pain.
Hyperalgesia
Effects of electroacupuncture on pain sensation in a rat model of hyperalgesia with nicotine dependence.
Hyperalgesia
Exercise training modulates glutamic acid decarboxylase-65/67 expression through TrkB signaling to ameliorate neuropathic pain in rats with spinal cord injury.
Hyperalgesia
Gene therapy for neuropathic pain using dorsal root ganglion-targeted helper-dependent adenoviral vectors with GAD67 expression.
Hyperalgesia
HSV vector-mediated GAD67 suppresses neuropathic pain induced by perineural HIV gp120 in rats through inhibition of ROS and Wnt5a.
Hyperalgesia
Nigrostriatal dopamine depletion promoted an increase in inhibitory markers (parvalbumin, GAD67, VGAT) and cold allodynia.
Hyperalgesia
Normalizing HDAC2 Levels in the Spinal Cord Alleviates Thermal and Mechanical Hyperalgesia After Peripheral Nerve Injury and Promotes GAD65 and KCC2 Expression.
Hyperalgesia
Possible Loss of GABAergic Inhibition in Mice With Induced Adenomyosis and Treatment With Epigallocatechin-3-Gallate Attenuates the Loss With Improved Hyperalgesia.
Hyperalgesia
Possible role for glutamic acid decarboxylase in fibromyalgia symptoms: A conceptual model for chronic pain.
Hyperalgesia
Swimming Training Attenuates Allodynia and Hyperalgesia Induced by Peripheral Nerve Injury in an Adult Male Rat Neuropathic Model: Effects on Irisin and GAD65.
Hyperalgesia
Thermal hyperalgesia via supraspinal mechanisms in mice lacking glutamate decarboxylase 65.
Hypercalcemia
[The effect of vibration on brain GABA metabolism in rats with hypo- and hypercalcemia]
Hyperglycemia
A patient with combined polycystic ovary syndrome and autoimmune polyglandular syndrome type 2.
Hyperglycemia
Antibodies to glutamic acid decarboxylase and P2-C peptides in sera from coxsackie virus B4-infected mice and IDDM patients.
Hyperglycemia
Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus.
Hyperglycemia
Co-infusion of autologous adipose tissue derived insulin-secreting mesenchymal stem cells and bone marrow derived hematopoietic stem cells: viable therapy for type III.C. a diabetes mellitus.
Hyperglycemia
Coexistence of Immune Checkpoint Inhibitor-Induced Autoimmune Diabetes and Pancreatitis.
Hyperglycemia
DIABETIC KETOACIDOSIS ASSOCIATED WITH ALPELISIB TREATMENT OF METASTATIC BREAST CANCER.
Hyperglycemia
GAD65-Specific Cytotoxic T Lymphocytes Mediate Beta-Cell Death and Loss of Function.
Hyperglycemia
Lessons From Pancreas Transplantation in Type 1 Diabetes: Recurrence of Islet Autoimmunity.
Hyperglycemia
Response of glutamic acid decarboxylase to glucose but not arginine in islets.
Hyperglycemia
The Effect of Immunosuppressive Adjuvant Kynurenine on Type 1 Diabetes Vaccine.
Hyperglycemia
The first series of cases of ketosis-prone type 2 diabetes (flatbush diabetes) in Brazilian adults.
Hyperhomocysteinemia
Maternal vitamin B6 deficient or supplemented diets on expression of genes related to GABAergic, serotonergic or glutamatergic pathways in hippocampus of rat dams and their offspring.
Hyperinsulinism
Type 1 diabetes-related antibodies in the fetal circulation: prevalence and influence on cord insulin and birth weight in offspring of mothers with type 1 diabetes.
Hyperkinesis
Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease.
Hyperlipidemias
Diabetes in Danish Bank Voles (M. glareolus): Survivorship, Influence on Weight, and Evaluation of Polydipsia as a Screening Tool for Hyperglycaemia.
Hyperprolactinemia
Comparative effects of estrogens and prolactin on nigral and striatal GAD activity.
Hyperprolactinemia
GABAergic biochemical parameters of the tuberoinfundibular neurons following chronic hyperprolactinemia.
Hyperprolactinemia
Influence of hyperprolactinemia induced by adenopituitary transplantation under the kidney capsule on the glutamic acid decarboxylase activity in various brain regions.
Hypersensitivity
High expression of hippocampal glutamic acid decarboxylase 67 mediates hypersensitivity of the hypothalamic-pituitary-adrenal axis in response to prenatal caffeine exposure in rats.
Hypersensitivity
Programming for increased expression of hippocampal GAD67 mediated the hypersensitivity of the hypothalamic-pituitary-adrenal axis in male offspring rats with prenatal ethanol exposure.
Hypertension
Angiotensin-II is a putative neurotransmitter in lactate-induced panic-like responses in rats with disruption of GABAergic inhibition in the dorsomedial hypothalamus.
Hypertension
Chronic exercise increases GAD gene expression in the caudal hypothalamus of spontaneously hypertensive rats.
Hypertension
Comparative Peptidomic and Metatranscriptomic Analyses Reveal Improved Gamma-Amino Butyric Acid Production Machinery in Levilactobacillus brevis Strain NPS-QW 145 Cocultured with Streptococcus thermophilus Strain ASCC1275 during Milk Fermentation.
Hypertension
Exercise training increases GAD65 expression, restores the depressed GABAA receptor function within the PVN and reduces sympathetic modulation in hypertension.
Hypertension
Metabolic profile and cardiovascular risk patterns of an Indian tribe living in the Amazon Region of Brazil.
Hypertension
Renal sympathetic denervation lowers arterial pressure in canines with obesity-induced hypertension by regulating GAD65 and AT
Hyperthyroidism
Activation of T lymphocyte subsets by synthetic TSH receptor peptides and recombinant glutamate decarboxylase in autoimmune thyroid disease and insulin-dependent diabetes.
Hyperthyroidism
Islet cell and glutamic acid decarboxylase antibodies in hyperthyroid patients: at diagnosis and following treatment.
Hypertriglyceridemia
A Triad of Ketoacidosis, Hypertriglyceridemia, and Acute Pancreatitis Associated With Sugar-Sweetened Soft Drinks Abuse in a Caucasian Patient With Undiagnosed Type 2 Diabetes Mellitus.
Hypoglycemia
Effects of high-dose oral insulin on immune responses in children at high risk for type 1 diabetes: the Pre-POINT randomized clinical trial.
Hypoglycemia
Influence of serum glucose on glutamate decarboxylase activity in the ventromedial nucleus of rats.
Hypoglycemia
Relationship of family history of type 2 diabetes, hypoglycemia, and autoantibodies to weight gain and lipids with intensive and conventional therapy in the Diabetes Control and Complications Trial.
Hypoparathyroidism
PTH hypersecretion triggered by a GABAB1 and Ca2+-sensing receptor heterocomplex in hyperparathyroidism.
Hypotension, Orthostatic
[Topographic and chemical study of the GABA synthetizing enzyme in Parkinsonian syndromes]
Hypothyroidism
A patient with combined polycystic ovary syndrome and autoimmune polyglandular syndrome type 2.
Ileus
Pathological evidence of encephalomyelitis in the stiff man syndrome with anti-GAD antibodies.
Immune System Diseases
CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers. The Belgian Diabetes Registry.
Infarction, Middle Cerebral Artery
Elevated immunoreactivity for glutamic acid decarboxylase in the rat cerebral cortex following transient middle cerebral artery occlusion.
Infarction, Middle Cerebral Artery
Estradiol alters only GAD67 mRNA levels in ischemic rat brain with no consequent effects on GABA.
Infections
A conditional tetracycline-regulated increase in Gamma amino butyric acid production near luteinizing hormone-releasing hormone nerve terminals disrupts estrous cyclicity in the rat.
Infections
Antibodies to glutamic acid decarboxylase and P2-C peptides in sera from coxsackie virus B4-infected mice and IDDM patients.
Infections
Audiogenic seizure activity following HSV-1 GAD65 sense or antisense injection into inferior colliculus of Long-Evans rat.
Infections
Coxsackievirus B4 alters pancreatic glutamate decarboxylase expression in mice soon after infection.
Infections
Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes.
Infections
Effect of Venezuelan equine encephalomyelitis virus infection on brain choline acetyltransferase and acetylcholinesterase activities.
Infections
Enhancement of neuronal protection from oxidative stress by glutamic acid decarboxylase delivery with a defective herpes simplex virus vector.
Infections
Enterovirus infections with beta-cell tropic strains are frequent in siblings of children diagnosed with type 1 diabetes children and in association with elevated levels of GAD65 antibodies.
Infections
GABA synthesis in astrocytes after infection with defective herpes simplex virus vectors expressing glutamic acid decarboxylase 65 or 67.
Infections
Glutamate decarboxylase-dependent acid resistance in Brucella spp.: distribution and contribution to fitness under extremely acidic conditions.
Infections
Improved in planta expression of the human islet autoantigen glutamic acid decarboxylase (GAD65).
Infections
Investigation of enterovirus infections, autoimmune factors and HLA genotypes in patients with T1DM.
Infections
Novel synthesis and release of GABA in cerebellar granule cell cultures after infection with defective herpes simplex virus vectors expressing glutamic acid decarboxylase.
Infections
Prenatal exposure to bacterial endotoxin reduces the number of GAD67- and reelin-immunoreactive neurons in the hippocampus of rat offspring.
Infections
Several different enterovirus serotypes can be associated with prediabetic autoimmune episodes and onset of overt IDDM. Childhood Diabetes in Finland (DiMe) Study Group.
Infections
The fate of glutamate in different brain regions of the chick during Newcastle disease virus infection.
Infections
The glutamic acid decarboxylase system of the new species Brucella microti contributes to its acid resistance and to oral infection of mice.
Infections
The PEVKEK region of the pyridoxal phosphate binding domain of GAD65 expresses a dominant B cell epitope for type 1 diabetes sera.
Infections
Toxoplasma gondii Infections Alter GABAergic Synapses and Signaling in the Central Nervous System.
Infections
Toxoplasma infection induces microglia-neuron contact and the loss of perisomatic inhibitory synapses.
Influenza, Human
A Novel Approach of Identifying Immunodominant Self and Viral Antigen Cross-Reactive T Cells and Defining the Epitopes They Recognize.
Insulin Resistance
Acanthosis Nigricans Identifies Youth at High Risk for Metabolic Abnormalities.
Insulin Resistance
Antibodies against glutamic acid decarboxylase and indices of insulin resistance and insulin secretion in nondiabetic adults: a cross-sectional study.
Insulin Resistance
Application of new international classification of adult-onset diabetes in Chinese inpatients with diabetes mellitus.
Insulin Resistance
Association between insulin resistance and GAD65-autoantibody levels--a pilot study in an adult non-diabetic population.
Insulin Resistance
Comparison of Adults with Insulin Resistance (IR) in Latent Autoimmune Diabetes Versus IR in Glutamic Acid Decarboxylase Antibody-negative Diabetes.
Insulin Resistance
First-degree relatives of persons with type 1 diabetes: insulin resistance and enterovirus infection are associated with different patterns of islet cell autoimmunity.
Insulin Resistance
GAD65 autoantibodies, beta-cell function, and insulin resistance in Japanese-Brazilian adults. Centro de Estudos da Comunidade Nipo Brasileira de Bauru.
Insulin Resistance
Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index.
Insulin Resistance
Glutamic acid decarboxylase autoantibody-positivity post-partum is associated with impaired ?-cell function in women with gestational diabetes mellitus.
Insulin Resistance
Identification of two novel subgroups in patients with diabetes mellitus and their association with clinical outcomes: A two-step cluster analysis.
Insulin Resistance
Metabolic Characteristics of Recently Diagnosed Adult-Onset Autoimmune Diabetes Mellitus.
Insulin Resistance
Metabolic profile and cardiovascular risk patterns of an Indian tribe living in the Amazon Region of Brazil.
Insulin Resistance
Novel Reclassification of Adult Diabetes Is Useful to Distinguish Stages of ?-Cell Function Linked to the Risk of Vascular Complications: The DOLCE Study From Northern Ukraine.
Insulin Resistance
Prevalence of glutamic acid decarboxylase antibody positivity and its association with insulin secretion and sensitivity in autoimmune thyroid disease: A pilot study.
Insulin Resistance
Single Islet Autoantibody at Diagnosis of Clinical Type 1 Diabetes is Associated with Older Age and Insulin Resistance.
Insulin Resistance
Validation of the Swedish Diabetes Re-Grouping Scheme in Adult-Onset Diabetes in China.
Insulin Resistance
[Relation between insulin resistance and glutamic acid decarboxylase antibody titers in latent autoimmune diabetes in adults]
Insulinoma
Analysis of diabetes-associated autoantibodies in children and adolescents with autoimmune thyroid diseases.
Insulinoma
Beta-cell autoantibodies and their function in Taiwanese children with type 1 diabetes mellitus.
Insulinoma
Compartmentalization of GABA Synthesis by GAD67 Differs between Pancreatic Beta Cells and Neurons.
Insulinoma
Confirmation and Identification of Biomarkers Implicating Environmental Triggers in the Pathogenesis of Type 1 Diabetes.
Insulinoma
Development of autoantibodies to islet antigens during childhood: implications for preclinical type 1 diabetes screening.
Insulinoma
Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes.
Insulinoma
Etiology of early-onset type 2 diabetes in Indians: islet autoimmunity and mutations in hepatocyte nuclear factor 1alpha and mitochondrial gene.
Insulinoma
Evaluating the Prognostic Value of Islet Autoantibody Monitoring in Islet Transplant Recipients with Long-Standing Type 1 Diabetes Mellitus.
Insulinoma
Evidence for molecular mimicry between human T cell epitopes in rotavirus and pancreatic islet autoantigens.
Insulinoma
Frequencies of CD8 and DN MAIT Cells Among Children Diagnosed With Type 1 Diabetes Are Similar to Age-Matched Controls.
Insulinoma
High concentration of GABA and high glutamate decarboxylase activity in rat pancreatic islets and human insulinoma.
Insulinoma
High prevalence of humoral autoimmunity in first-degree relatives of Mexican type 1 diabetes patients.
Insulinoma
HLA-DQB1 genotypes and islet cell autoantibodies against GAD65 and IA-2 in relation to development of diabetes post partum in women with gestational diabetes mellitus.
Insulinoma
HLA-DR-restricted T cell lines from newly diagnosed type 1 diabetic patients specific for insulinoma and normal islet beta cell proteins: lack of reactivity to glutamic acid decarboxylase.
Insulinoma
Human Leukocyte Antigen (HLA) and Islet Autoantibodies Are Tools to Characterize Type 1 Diabetes in Arab Countries: Emphasis on Kuwait.
Insulinoma
IGRP and insulin vaccination induce CD8+ T cell-mediated autoimmune diabetes in the RIP-CD80GP mouse.
Insulinoma
Impaired vibrotactile sense showed no association with insulinoma associated protein 2 and glutamic acid decarboxylase autoantibodies in paediatric type 1 diabetes.
Insulinoma
Investigation of CTLA-4-318C/T gene polymorphism in cases with type 1 diabetes of Azerbaijan, Northwest Iran.
Insulinoma
Islet autoantibody positivity in overweight and obese adults with type 2 diabetes.
Insulinoma
Islet cell autoantibodies in African patients with Type 1 and Type 2 diabetes in Dar es Salaam Tanzania: a cross sectional study.
Insulinoma
Low prevalence of GAD and IA2 antibodies in schoolchildren from a village in the southwestern section of the Netherlands.
Insulinoma
Maternal type 1 diabetes reduces the risk of islet autoantibodies: relationships with birthweight and maternal HbA(1c).
Insulinoma
Neuropeptide Y is a minor autoantigen in newly diagnosed type 1 diabetes patients.
Insulinoma
No Contribution of GAD-65 and IA-2 Autoantibodies around Time of Diagnosis to the Increasing Incidence of Juvenile Type 1 Diabetes: A 9-Year Nationwide Danish Study.
Insulinoma
Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY).
Insulinoma
Organ-specific autoantibodies in Chinese patients newly diagnosed with type 1 diabetes mellitus.
Insulinoma
Organ-specific autoimmunity in relation to clinical characteristics in children with long-lasting type 1 diabetes.
Insulinoma
Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes.
Insulinoma
Pancreatic Islet Autoantibodies as Predictors of Type 1 Diabetes in the Diabetes Prevention Trial-Type 1 (DPT-1).
Insulinoma
Prevalence of ZnT8 antibody in relation to phenotype and SLC30A8 polymorphism in adult autoimmune diabetes: results from the HUNT study, Norway.
Insulinoma
Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients.
Insulinoma
Streptozotocin induced diabetes in minipig: a case report of a possible model for type 1 diabetes?
Insulinoma
Weight gain in early life predicts risk of islet autoimmunity in children with a first-degree relative with type 1 diabetes.
Intellectual Disability
Presence of GAD65 autoantibodies in the serum of children with autism or ADHD.
Iron Deficiencies
Effects of iron deficiency on iron distribution and gamma-aminobutyric acid (GABA) metabolism in young rat brain tissues.
Isaacs Syndrome
Sequential antibodies to potassium channels and glutamic acid decarboxylase in neuromyotonia.
Ischemic Attack, Transient
Glutamate decarboxylase-immunoreactive neurons in the aging rat hippocampus are more resistant to ischemia than CA1 pyramidal cells.
Ischemic Attack, Transient
Immunocytochemical investigation of L-glutamic acid decarboxylase in the rat hippocampal formation: the influence of transient cerebral ischemia.
Ischemic Attack, Transient
Temporal profile of neurochemical recovery following injury by transient cerebral ischemia.
Ischemic Attack, Transient
Transient increases of glutamic acid decarboxylase 67 immunoreactivity and its protein levels in the somatosensory cortex after transient cerebral ischemia in gerbils.
Kernicterus
Kernicterus: effect on choline acetyltransferase, glutamic acid decarboxylase and tyrosine hydroxylase activities in the brain of the Gunn rat.
Kernicterus
Kernicterus: enzymatic evidence for difference between the development of cholinergic and GABAergic innervations in the brain of the Gunn rat.
Ketosis
Autoimmune polyendocrine syndrome induced by immune checkpoint inhibitors: a systematic review.
Ketosis
Bone mineral density at time of clinical diagnosis of adult-onset type 1 diabetes mellitus.
Ketosis
Clinical parameters (body mass index and age) are the best predictors for the need of insulin therapy during the first 18 months of diabetes mellitus in young adult patients.
Ketosis
DIABETIC KETOACIDOSIS ASSOCIATED WITH ALPELISIB TREATMENT OF METASTATIC BREAST CANCER.
Ketosis
Epidemiology, clinical aspects, and biology of IDDM patients under age 40 years. Comparison of data from Antwerp with complete ascertainment with data from Belgium with 40% ascertainment. The Belgian Diabetes Registry.
Ketosis
Fulminant type 1 diabetes mellitus induced by pembrolizumab in a patient with urothelial carcinoma: A case report.
Ketosis
Inhibition of brain glutamic acid decarboxylase by phenylalanine, valine, and leucine derivatives: a suggestion concerning the etiology of the neurological defect in phenylketonuria and branched-chain ketonuria.
Ketosis
Ketosis with enhanced GABAergic tone promotes physiological changes in transcendental meditation.
Ketosis
Non-tropical fibrocalculous pancreatic diabetes: case reports and review of recent literature.
Ketosis
Rapid Normalization of High Glutamic Acid Decarboxylase Autoantibody Titers and Preserved Endogenous Insulin Secretion in a Patient with Diabetes Mellitus: A Case Report and Literature Review.
Ketosis
The first series of cases of ketosis-prone type 2 diabetes (flatbush diabetes) in Brazilian adults.
Ketosis
Three cases of GAD65 antibody-positive diabetes with ketosis and abrupt onset resulting in non-insulin-dependent state.
Ketosis
[Expression of autoantibodies to ICA512 and GAD in the sera of patients with diabetic ketoacidosis or ketonemia]
Kidney Diseases
Harmonization of Glutamic Acid Decarboxylase and Islet Antigen-2 Autoantibody Assays for National Institute of Diabetes and Digestive and Kidney Diseases Consortia.
Lambert-Eaton Myasthenic Syndrome
Humoral immunity against glutamic acid decarboxylase and tyrosine phosphatase IA-2 in Lambert-Eaton myasthenic syndrome.
Lambert-Eaton Myasthenic Syndrome
Lambert-Eaton Myasthenic syndrome in a child with an autoimmune phenotype.
Latent Autoimmune Diabetes in Adults
A decrease in glutamic acid decarboxylase autoantibody levels with sitagliptin use in patients with latent autoimmune diabetes in adults.
Latent Autoimmune Diabetes in Adults
Changes in GAD65Ab-Specific Antiidiotypic Antibody Levels Correlate with Changes in C-Peptide Levels and Progression to Islet Cell Autoimmunity.
Latent Autoimmune Diabetes in Adults
Chronic complications and mortality in community-based patients with latent autoimmune diabetes in adults: the Fremantle Diabetes Study.
Latent Autoimmune Diabetes in Adults
Clinical utility of measuring both glutamic acid decarboxylase antibodies and islet cell antibodies in the diagnosis of latent autoimmune diabetes in adults - is it cost-effective?
Latent Autoimmune Diabetes in Adults
Cross-reactive peptide epitopes of Enterovirus Coxsackie B4 and human glutamic acid decarboxylase detecting antibodies in latent autoimmune diabetes in adults versus type 1 diabetes.
Latent Autoimmune Diabetes in Adults
CTLA-4 gene polymorphism contributes to the genetic risk for latent autoimmune diabetes in adults.
Latent Autoimmune Diabetes in Adults
Diagnostic role of antibodies to glutamic acid decarboxylase in latent autoimmune diabetes mellitus in adults.
Latent Autoimmune Diabetes in Adults
Effect of extract from Boswellia serrata gum resin on decrease of GAD65 autoantibodies in a patient with Latent Autoimmune Diabetes in Adults.
Latent Autoimmune Diabetes in Adults
Epitope analysis of GAD65 autoantibodies in adult-onset type 1 diabetes and latent autoimmune diabetes in adults with thyroid autoimmunity.
Latent Autoimmune Diabetes in Adults
GAD65 autoantibodies and its role as biomarker of Type 1 diabetes and Latent Autoimmune Diabetes in Adults (LADA).
Latent Autoimmune Diabetes in Adults
GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination.
Latent Autoimmune Diabetes in Adults
Glutamic acid decarboxylase 65 autoantibody levels discriminate two subtypes of latent autoimmune diabetes in adults.
Latent Autoimmune Diabetes in Adults
Glutamic Acid Decarboxylase Autoantibody Detection by Electrochemiluminescence Assay Identifies Latent Autoimmune Diabetes in Adults with Poor Islet Function.
Latent Autoimmune Diabetes in Adults
High GADA titer increases the risk of insulin requirement in LADA patients: a 7-year follow-up (NIRAD study 7).
Latent Autoimmune Diabetes in Adults
High-titer GAD65 autoantibodies detected in adult diabetes patients using a high efficiency expression vector and cold GAD65 displacement.
Latent Autoimmune Diabetes in Adults
IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71).
Latent Autoimmune Diabetes in Adults
IgG4-subclass of glutamic acid decarboxylase antibody is more frequent in latent autoimmune diabetes in adults than in type 1 diabetes.
Latent Autoimmune Diabetes in Adults
Ketoacidosis in type 2 diabetes--is it type 1 and 1/2 diabetes?
Latent Autoimmune Diabetes in Adults
Latent Autoimmune Diabetes in Adults in North Indian Region: Assessment of ?-Cell Function, Metabolic and Immunological Features.
Latent Autoimmune Diabetes in Adults
Low C-peptide together with a high glutamic acid decarboxylase autoantibody level predicts progression to insulin dependence in latent autoimmune diabetes in adults: The HUNT study.
Latent Autoimmune Diabetes in Adults
Metabolic syndrome and autoimmune diabetes: action LADA 3.
Latent Autoimmune Diabetes in Adults
Metabolite Profiling of LADA Challenges the View of a Metabolically Distinct Subtype.
Latent Autoimmune Diabetes in Adults
Newly diagnosed latent autoimmune diabetes in adults (LADA) is associated with low level glutamate decarboxylase (GAD65) and IA-2 autoantibodies. Diabetes Incidence Study in Sweden (DISS).
Latent Autoimmune Diabetes in Adults
Number of autoantibodies and HLA genotype, more than high titers of glutamic acid decarboxylase autoantibodies, predict insulin dependence in latent autoimmune diabetes of adults.
Latent Autoimmune Diabetes in Adults
Persistence of glutamic acid decarboxylase antibody (GADA) is associated with clinical characteristics of latent autoimmune diabetes in adults: a prospective study with 3-year follow-up.
Latent Autoimmune Diabetes in Adults
Small Cell Lung Cancer Expressing Glutamate Decarboxylase with Latent Autoimmune Diabetes in Adults.
Latent Autoimmune Diabetes in Adults
The glutamic acid decarboxylase 65 immunoglobulin G subclass profile differs between adult-onset type 1 diabetes and latent autoimmune diabetes in adults (LADA) up to 3 years after clinical onset.
Latent Autoimmune Diabetes in Adults
Titre and combination of ICA and autoantibodies to glutamic acid decarboxylase discriminate two clinically distinct types of latent autoimmune diabetes in adults (LADA).
Latent Autoimmune Diabetes in Adults
Variation of C peptide decay rate in diabetic patients with positive glutamic acid decarboxylase antibody: better discrimination with initial fasting C peptide.
Latent Autoimmune Diabetes in Adults
[Association of autoantibody and cytokines with latent autoimmune diabetes in adults]
Latent Autoimmune Diabetes in Adults
[Identification of the two subtypes of latent autoimmune diabetes in adults by glutamic acid decarboxylase 65 antibody titers]
Latent Autoimmune Diabetes in Adults
[Islet beta cell function in latent autoimmune diabetes in adults with islet cell antibodies]
Latent Autoimmune Diabetes in Adults
[Metabolic syndrome and latent autoimmune diabetes in adults]
Latent Autoimmune Diabetes in Adults
[Relation between insulin resistance and glutamic acid decarboxylase antibody titers in latent autoimmune diabetes in adults]
Latent Autoimmune Diabetes in Adults
[Value of glutamic acid decarboxylase autoantibody detection for early diagnosis of latent autoimmune diabetes in adults]
Leprosy
Glutamic acid decarboxylase activity of Mycobacterium leprae and occurrence of gamma-amino butyric acid in skin lesions of leprosy.
Leukemia
Glutamate-modulated production of GABA in immortalized astrocytes transduced by a glutamic acid decarboxylase-expressing retrovirus.
Leukemia
Glutamic acid decarboxylase in cerebrospinal fluid in infancy and childhood Part II. Glutamic acid decarboxylase activity in cerebrospinal fluid of children with neurological diseases.
Leukemia
No Evidence of Antibodies against GAD65 and Other Specific Antigens in Children with Autism.
Leukocytosis
Acute psychosis in a pregnant patient with Graves' hyperthyroidism and anti-NMDA receptor encephalitis.
Limbic Encephalitis
A Survival Case of Super-refractory Status Epilepticus due to Glutamic Acid Decarboxylase Antibodies-associated Limbic Encephalitis.
Limbic Encephalitis
A unique combination of autoimmune limbic encephalitis, type 1 diabetes, and Stiff person syndrome associated with GAD-65 antibody.
Limbic Encephalitis
Acute limbic encephalitis and glutamic acid decarboxylase antibodies: A reality?
Limbic Encephalitis
Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis.
Limbic Encephalitis
Antibodies to voltage-gated potassium and calcium channels in epilepsy.
Limbic Encephalitis
Are onconeural antibodies a clinical phenomenology in paraneoplastic limbic encephalitis?
Limbic Encephalitis
Autoimmune Limbic Encephalitis Associated With Type 1 Diabetes Mellitus.
Limbic Encephalitis
Blood and cerebrospinal fluid immune cell profiles in patients with temporal lobe epilepsy of different etiologies.
Limbic Encephalitis
Cerebellar ataxia and epilepsy with anti-GAD antibodies: treatment with IVIG and plasmapheresis.
Limbic Encephalitis
Correlation between neuronal antibodies and limbic encephalitis in Chinese Han subjects.
Limbic Encephalitis
Correlations of Clusters of Non-Convulsive Seizure and Magnetic Resonance Imaging in a Case With GAD65-Positive Autoimmune Limbic Encephalitis.
Limbic Encephalitis
Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions.
Limbic Encephalitis
Distinct white matter integrity in glutamic acid decarboxylase and voltage-gated potassium channel-complex antibody-associated limbic encephalitis.
Limbic Encephalitis
Familial autoimmunity in neurological patients with GAD65 antibodies: an interview-based study.
Limbic Encephalitis
Fulminant Anti-GAD antibody encephalitis presenting with status epilepticus requiring aggressive immunosuppression.
Limbic Encephalitis
GABA(B) receptor antibodies in limbic encephalitis and anti-GAD-associated neurologic disorders.
Limbic Encephalitis
GAD antibody-spectrum disorders: progress in clinical phenotypes, immunopathogenesis and therapeutic interventions.
Limbic Encephalitis
GAD65 antibody-associated autoimmune epilepsy with unique independent bitemporal-onset ictal asystole.
Limbic Encephalitis
GAD65 Positive Autoimmune Limbic Encephalitis: A Case Report and Review of Literature.
Limbic Encephalitis
Hippocampus and Insula Are Targets in Epileptic Patients With Glutamic Acid Decarboxylase Antibodies.
Limbic Encephalitis
Idiopathic limbic encephalitis associated with antibodies to glutamic acid decarboxylase.
Limbic Encephalitis
Immunotherapy-responsive limbic encephalitis with antibodies to glutamic acid decarboxylase.
Limbic Encephalitis
Interactions of Human Autoantibodies with Hippocampal GABAergic Synaptic Transmission - Analyzing Antibody-Induced Effects ex vivo.
Limbic Encephalitis
Lack of antibodies to NMDAR or VGKC-complex in GAD and cardiolipin antibody-positive refractory epilepsy.
Limbic Encephalitis
Latent autoimmune diabetes and limbic encephalitis with antibodies against glutamic acid decarboxylase.
Limbic Encephalitis
Limbic encephalitis and type 1 diabetes with glutamic acid decarboxylase 65 (GAD65) autoimmunity: improvement with high-dose intravenous immunoglobulin therapy.
Limbic Encephalitis
Limbic Encephalitis Associated With GAD65 Antibodies: Brief Review of the Relevant literature.
Limbic Encephalitis
Limbic encephalitis associated with glutamic acid decarboxylase antibodies in a young adolescent.
Limbic Encephalitis
Limbic encephalitis with antibodies to glutamic acid decarboxylase presenting with brainstem symptoms.
Limbic Encephalitis
Loss of Autonoetic Awareness of Recent Autobiographical Episodes and Accelerated Long-Term Forgetting in a Patient with Previously Unrecognized Glutamic Acid Decarboxylase Antibody Related Limbic Encephalitis.
Limbic Encephalitis
Neuropsychological course of voltage-gated potassium channel and glutamic acid decarboxylase antibody related limbic encephalitis.
Limbic Encephalitis
Paraneoplastic stiff-person syndrome: passive transfer to rats by means of IgG antibodies to amphiphysin.
Limbic Encephalitis
Predictive value of high titer of GAD65 antibodies in a case of limbic encephalitis.
Limbic Encephalitis
Psychiatric symptoms in anti glutamic acid decarboxylase associated limbic encephalitis in adults: a systematic review.
Limbic Encephalitis
Seizure control and cognitive improvement via immunotherapy in late onset epilepsy patients with paraneoplastic versus GAD65 autoantibody-associated limbic encephalitis.
Limbic Encephalitis
Serum from a Patient with GAD65 Antibody-Associated Limbic Encephalitis Did Not Alter GABAergic Neurotransmission in Cultured Hippocampal Networks.
Limbic Encephalitis
Super refractory status epilepticus secondary to anti-GAD antibody encephalitis successfully treated with aggressive immunotherapy.
Limbic Encephalitis
The growing recognition of immunotherapy-responsive seizure disorders with autoantibodies to specific neuronal proteins.
Limbic Encephalitis
Therapeutic plasma exchange and immunosuppressive therapy in a patient with anti-GAD antibody-related epilepsy: Quantification of the antibody response.
Limbic Encephalitis
Treating a GAD65 Antibody-Associated Limbic Encephalitis with Basiliximab: A Case Study.
Limbic Encephalitis
Type 1 diabetes and GAD65 limbic encephalitis: a case report of a 10-year-old girl.
Liver Failure, Acute
Abnormal chloride homeostasis in the substancia nigra pars reticulata contributes to locomotor deficiency in a model of acute liver injury.
Liver Failure, Acute
Amino acid neurotransmitters and their receptors in the brain synaptosomes of acute hepatic failure rats.
Lordosis
Anti-sense oligonucleotides, for progestin receptors in the VMH and glutamic acid decarboxylase in the VTA, attenuate progesterone-induced lordosis in hamsters and rats.
Lordosis
Effects of estrogen on dopamine turnover, glutamic acid decarboxylase activity and lordosis behavior in septal lesioned female rats.
Lordosis
GABA(A), D1, and D5, but not progestin receptor, antagonist and anti-sense oligonucleotide infusions to the ventral tegmental area of cycling rats and hamsters attenuate lordosis.
Lordosis
Intracerebral administration of antisense oligodeoxynucleotides to GAD65 and GAD67 mRNAs modulate reproductive behavior in the female rat.
Lung Neoplasms
GABA(B) receptor antibodies in limbic encephalitis and anti-GAD-associated neurologic disorders.
Lung Neoplasms
Small Cell Lung Cancer Expressing Glutamate Decarboxylase with Latent Autoimmune Diabetes in Adults.
Lymphatic Metastasis
Gamma-aminobutyric acid as a promoting factor of cancer metastasis; induction of matrix metalloproteinase production is potentially its underlying mechanism.
Malnutrition
Effect of undernutrition in early life on glutamate decarboxylase activity in the adult brain.
Malnutrition
Effect of undernutrition on the regional development of transmitter enzymes: glutamate decarboxylase and choline acetyltransferase.
Malnutrition
Protein malnutrition differentially alters the number of glutamic acid decarboxylase-67 interneurons in dentate gyrus and CA1-3 subfields of the dorsal hippocampus.
Medulloblastoma
Glutamic acid decarboxylase and gamma-aminobutyric acid in Huntington's disease fibroblasts and other cultured cells, determined by a [3H]muscimol radioreceptor assay.
Melanoma
Combined immune checkpoint inhibitor therapy with nivolumab and ipilimumab causing acute-onset type 1 diabetes mellitus following a single administration: two case reports.
Memory Disorders
Amelioration of oxidative stress-induced phenotype loss of parvalbumin interneurons might contribute to the beneficial effects of environmental enrichment in a rat model of post-traumatic stress disorder.
Memory Disorders
Comparison of glutamic acid decarboxylase 67 immunoreactive neurons in the hippocampal CA1 region at various age stages in dogs.
Memory Disorders
Critical role of the 65-kDa isoform of glutamic acid decarboxylase in consolidation and generalization of Pavlovian fear memory.
Memory Disorders
Gad67 haploinsufficiency reduces amyloid pathology and rescues olfactory memory deficits in a mouse model of Alzheimer's disease.
Memory Disorders
Reversal of brain injury-induced prefrontal glutamic acid decarboxylase expression and working memory deficits by D1 receptor antagonism.
Memory Disorders
Synaptic biomarker reduction and impaired cognition in the sub-chronic PCP mouse model for schizophrenia.
Meningoencephalitis
Glutamic acid decarboxylase in cerebrospinal fluid in infancy and childhood Part II. Glutamic acid decarboxylase activity in cerebrospinal fluid of children with neurological diseases.
Metabolic Syndrome
Clinical characteristics and outcome of pregnancy in women with gestational hyperglycaemia with and without antibodies to beta-cell antigens.
Metabolic Syndrome
Comparison of Adults with Insulin Resistance (IR) in Latent Autoimmune Diabetes Versus IR in Glutamic Acid Decarboxylase Antibody-negative Diabetes.
Metabolic Syndrome
Upregulation of GAD65 mRNA in the medulla of the rat model of metabolic syndrome.
Metabolic Syndrome
[Latent autoimmune diabetes in adults(LADA): part of the clinical spectrum of type-1 diabetes mellitus of autoimmune origin]
Migraine Disorders
?6GABAA Receptor Positive Modulators Alleviate Migraine-like Grimaces in Mice via Compensating GABAergic Deficits in Trigeminal Ganglia.
Migraine Disorders
Attenuation by valproate of c-fos immunoreactivity in trigeminal nucleus caudalis induced by intracisternal capsaicin.
Migraine Disorders
Peripheral GABAA receptor-mediated effects of sodium valproate on dural plasma protein extravasation to substance P and trigeminal stimulation.
Movement Disorders
GABA levels and GAD immunoreactivity in the deep cerebellar nuclei of rats with altered olivo-cerebellar function.
Movement Disorders
Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders.
Movement Disorders
Inhibition of brain glutamate decarboxylase by glutarate, glutaconate, and beta-hydroxyglutarate: explanation of the symptoms in glutaric aciduria?
Movement Disorders
Monoclonal antibodies to 65kDa glutamate decarboxylase induce epitope specific effects on motor and cognitive functions in rats.
Movement Disorders
[Serum dopamine-beta-hydroxylase, glutamic acid decarboxylase and 1-aromatic amino acid decarboxylase in involuntary movement disorders (author's transl)]
MPTP Poisoning
Alterations in expression of messenger RNAs encoding two isoforms of glutamic acid decarboxylase in the globus pallidus and entopeduncular nucleus in animals symptomatic for and recovered from experimental Parkinsonism.
Multiple Sclerosis
Gene transfer of Ig-fusion proteins into B cells prevents and treats autoimmune diseases.
Multiple Sclerosis
Molecular and cellular analyses of HLA class II-associated susceptibility to autoimmune diseases in the Japanese population.
Multiple Sclerosis
Recent Patents on Immunoregulatory DNA Vaccines for Autoimmune Diseases and Allograft Rejection.
Multiple Sclerosis
[Determination of gamma-aminobutyric acid concentration and activity of glutamate decarboxylase in blood serum of patients with multiple sclerosis]
Muscle Rigidity
A rare saccade velocity profile in Stiff-Person Syndrome with cerebellar degeneration.
Muscle Rigidity
Opsoclonus in a patient with increased titers of anti-GAD antibody provides proof for the conductance-based model of saccadic oscillations.
Muscle Rigidity
[A case of progressive continuous muscular rigidity and painless and rhythmic muscle spasm associated with autoantibody against glutamic acid decarboxylase]
Muscle Spasticity
Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders.
Myasthenia Gravis
Glutamic acid decarboxylase autoantibody assay using 125I-labelled recombinant GAD65 produced in yeast.
Myelitis
Glutamic Acid Decarboxylase Antibody in a Patient with Myelitis: A Retrospective Study.
Myoclonic Epilepsy, Juvenile
Evaluation of Glutamic Acid Decarboxylase Antibody Levels in Patients with Juvenile Myoclonic Epilepsy and Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis.
Myoclonus
A unique combination of autoimmune limbic encephalitis, type 1 diabetes, and Stiff person syndrome associated with GAD-65 antibody.
Myoclonus
Antibodies against glutamic acid decarboxylase: prevalence in neurological diseases.
Myoclonus
Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4(+) T cells.
Myoclonus
Glycine receptor antibodies are detected in progressive encephalomyelitis with rigidity and myoclonus (PERM) but not in saccadic oscillations.
Myopia
GABA and GABA receptors alterations in the primary visual cortex of concave lens-induced myopic model.
Narcolepsy
A/H1N1 antibodies and TRIB2 autoantibodies in narcolepsy patients diagnosed in conjunction with the Pandemrix vaccination campaign in Sweden 2009-2010.
Nasopharyngeal Carcinoma
Glutamate Decarboxylase 1 Overexpression as a Poor Prognostic Factor in Patients with Nasopharyngeal Carcinoma.
Neoplasm Metastasis
Gamma-aminobutyric acid as a promoting factor of cancer metastasis; induction of matrix metalloproteinase production is potentially its underlying mechanism.
Neoplasm Metastasis
Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors.
Neoplasms
A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer.
Neoplasms
A pilot study on neurological manifestations and antibodies against antigens in children with hematological and other cancers.
Neoplasms
Antibody repertoire in paraneoplastic cerebellar degeneration and small cell lung cancer.
Neoplasms
Association of CTLA-4 polymorphisms and clinical-immunologic characteristics at onset of type 1 diabetes mellitus in children.
Neoplasms
Blockade of TLR4 Within the Paraventricular Nucleus Attenuates Blood Pressure by Regulating ROS and Inflammatory Cytokines in Prehypertensive Rats.
Neoplasms
CD4(+) T cells from glutamic acid decarboxylase (GAD)65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transfer.
Neoplasms
Cholinergic neurons of fetal rat telencephalon in aggregating cell culture respond to NGF as well as to protein kinase C-activating tumor promoters.
Neoplasms
Comparative and correlative assessments of cytokine, complement and antibody patterns in paediatric type 1 diabetes.
Neoplasms
Cytokine regulation of glutamate decarboxylase biosynthesis in isolated rat islets of Langerhans.
Neoplasms
Effects of N6-monobutyryl-cyclic AMP on glutamate decarboxylase activity in fetal rat brain cells and glial tumor cells in culture.
Neoplasms
GAD 67KD antisense in colon cancer cells inhibits cell growth and sensitizes to butyrate and pH reduction and H2O2 and gamma-radiation.
Neoplasms
Gamma-aminobutyric acid as a promoting factor of cancer metastasis; induction of matrix metalloproteinase production is potentially its underlying mechanism.
Neoplasms
Gene expression profile of metastatic colon cancer cells resistant to cisplatin-induced apoptosis.
Neoplasms
Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors.
Neoplasms
Glutamic Acid Decarboxylase Antibody in a Patient with Myelitis: A Retrospective Study.
Neoplasms
High T-helper-1 cytokines but low T-helper-3 cytokines, inflammatory cytokines and chemokines in children with high risk of developing type 1 diabetes.
Neoplasms
Hippocampal and Cerebellar Changes in Acute Restraint Stress and the Impact of Pretreatment with Ceftriaxone.
Neoplasms
Improving accuracy of myasthenia gravis autoantibody testing by reflex algorithm.
Neoplasms
Leucoencephalopathy, transverse myelopathy, and peripheral neuropathy in association with glutamic acid decarboxylase-65 (GAD) antibodies in children with cancer.
Neoplasms
Nicotine stimulates pancreatic cancer xenografts by systemic increase in stress neurotransmitters and suppression of the inhibitory neurotransmitter gamma-aminobutyric acid.
Neoplasms
No Evidence of Antibodies against GAD65 and Other Specific Antigens in Children with Autism.
Neoplasms
Ornithine decarboxylase and glutamate decarboxylase 65 as prognostic markers of gallbladder malignancy: a clinicopathological study in benign and malignant lesions of the gallbladder.
Neoplasms
Potential autoantigens in IDDM. Expression of carboxypeptidase-H and insulin but not glutamate decarboxylase on the beta-cell surface.
Neoplasms
Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention.
Neoplasms
Social stress promotes and ?-aminobutyric acid inhibits tumor growth in mouse models of non-small cell lung cancer.
Neoplasms
The role of glutamate decarboxylase 65 in gastric cancer development, progression, and prognosis.
Neoplasms
Unsuspected Protumorigenic Signaling Role for the Oncometabolite GABA in Advanced Prostate Cancer.
Neoplasms
[Effect of mechanical stretch preconditioning on pathological stretch-induced activation of ?-aminobutyric acid signaling pathway in human type II alveolar epithelial cells].
Nephrosis
Erythrocytic enzymes and amino acids related to glutamic acid metabolism in childhood hypoproteinemic states.
Nervous System Diseases
Abundant glutamic acid decarboxylase (GAD)-reactive B cells in gad-antibody-associated neurological disorders.
Nervous System Diseases
Adenovirus-mediated transfer of a functional GAD gene into nerve cells: potential for the treatment of neurological diseases.
Nervous System Diseases
Anti-GAD65 Containing Cerebrospinal Fluid Does not Alter GABAergic Transmission.
Nervous System Diseases
Antigenic differences between neurological and diabetic patients with anti-glutamic acid decarboxylase antibodies.
Nervous System Diseases
Association of Paraneoplastic Neurological Disorders With Glutamic Acid Decarboxylase Antibodies.
Nervous System Diseases
Autoimmunity to GABAA-receptor-associated protein in stiff-person syndrome.
Nervous System Diseases
Cerebellar ataxia and autoantibodies restricted to glutamic acid decarboxylase 67 (GAD67).
Nervous System Diseases
Cortical Deficits of Glutamic Acid Decarboxylase 67 Expression in Schizophrenia: Clinical, Protein, and Cell Type-Specific Features.
Nervous System Diseases
Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions.
Nervous System Diseases
Does epilepsy occur more frequently in children with Type 1 diabetes?
Nervous System Diseases
Efficient therapeutic gene expression in cultured rat hippocampal neurons mediated by human foamy virus vectors: a potential for the treatment of neurological diseases.
Nervous System Diseases
Epitope-specific glutamic acid decarboxylase-65 autoantibodies in intravenous immunoglobulin preparations.
Nervous System Diseases
Familial autoimmunity in neurological patients with GAD65 antibodies: an interview-based study.
Nervous System Diseases
GAD65 as a potential marker for cognitive performance in an adult population with prediabetes.
Nervous System Diseases
GAD65 autoantibody characteristics in patients with co-occurring type 1 diabetes and epilepsy may help identify underlying epilepsy etiologies.
Nervous System Diseases
GAD65 epitope mapping and search for novel autoantibodies in GAD-associated neurological disorders.
Nervous System Diseases
Gad67 haploinsufficiency reduces amyloid pathology and rescues olfactory memory deficits in a mouse model of Alzheimer's disease.
Nervous System Diseases
Glutamic acid decarboxylase autoantibodies and neurological disorders.
Nervous System Diseases
High Titers of Autoantibodies to Glutamate Decarboxylase in Type 1 Diabetes Patients: Epitope Analysis and Inhibition of Enzyme Activity.
Nervous System Diseases
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase.
Nervous System Diseases
Intrathecal-specific glutamic acid decarboxylase antibodies at low titers in autoimmune neurological disorders.
Nervous System Diseases
Levels of glutamic acid decarboxylase (GAD), gamma amino butyric acid transaminase (GABA-T), glutamic acid dehydrogenase (GLDH) and proteins in cerebrospinal fluid of certain neurological disorders.
Nervous System Diseases
Mapping of an autoreactive epitope within glutamate decarboxylase using a diabetes-associated human monoclonal autoantibody and an epitope cDNA library.
Nervous System Diseases
Neurological Disorders Associated with Glutamic Acid Decarboxylase Antibodies.
Nervous System Diseases
Neurological disorders associated with glutamic acid decarboxylase antibodies: a Brazilian series.
Nervous System Diseases
Presence of GAD65 autoantibodies in the serum of children with autism or ADHD.
Nervous System Diseases
Removal kinetics of antibodies against glutamic acid decarboxylase by various plasmapheresis modalities in the treatment of neurological disorders.
Nervous System Diseases
Rituximab treatment of stiff-person syndrome in a patient with thymoma, diabetes mellitus and autoimmune thyroiditis.
Nervous System Diseases
Serum glutamate decarboxylase antibodies and neurological disorders: when to suspect their association?
Nervous System Diseases
Subcutaneous Immunoglobulin Therapy with IgPro20 in Patients with Stiff Person Syndrome and Primary Immunodeficiency Disease.
Nervous System Diseases
Therapeutic plasma exchange and immunosuppressive therapy in a patient with anti-GAD antibody-related epilepsy: Quantification of the antibody response.
Neuralgia
A novel human foamy virus mediated gene transfer of GAD67 reduces neuropathic pain following spinal cord injury.
Neuralgia
AAV-Mediated Combination Gene Therapy for Neuropathic Pain: GAD65, GDNF, and IL-10.
Neuralgia
Constitutive GABA expression via a recombinant adeno-associated virus consistently attenuates neuropathic pain.
Neuralgia
Correction: Shuanglin Hao, Marina Mata, Darren Wolfe, Joseph C. Glorioso, David J. Fink. Gene transfer of glutamic acid decarboxylase reduces neuropathic pain. Ann Neurol 2005; 57: 914-918.
Neuralgia
Distribution and colocalisation of glutamate decarboxylase isoforms in the rat spinal cord.
Neuralgia
Exercise training modulates glutamic acid decarboxylase-65/67 expression through TrkB signaling to ameliorate neuropathic pain in rats with spinal cord injury.
Neuralgia
Gene therapy for neuropathic pain using dorsal root ganglion-targeted helper-dependent adenoviral vectors with GAD67 expression.
Neuralgia
Gene Transfer of Glutamic Acid Decarboxylase 67 by Herpes Simplex Virus Vectors Suppresses Neuropathic Pain Induced by Human Immunodeficiency Virus gp120 Combined with ddC in Rats.
Neuralgia
HSV vector-mediated GAD67 suppresses neuropathic pain induced by perineural HIV gp120 in rats through inhibition of ROS and Wnt5a.
Neuralgia
Improvements in impaired GABA and GAD65/67 production in the spinal dorsal horn contribute to exercise-induced hypoalgesia in a mouse model of neuropathic pain.
Neuralgia
Menin regulates spinal glutamate-GABA balance through GAD65 contributing to neuropathic pain.
Neuralgia
Normalizing HDAC2 Levels in the Spinal Cord Alleviates Thermal and Mechanical Hyperalgesia After Peripheral Nerve Injury and Promotes GAD65 and KCC2 Expression.
Neuralgia
Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain.
Neuralgia
Spinal GABAergic Mechanisms in the Effects of Spinal Cord Stimulation in a Rodent Model of Neuropathic Pain: Is GABA Synthesis Involved?
Neuralgia
Swimming Training Attenuates Allodynia and Hyperalgesia Induced by Peripheral Nerve Injury in an Adult Male Rat Neuropathic Model: Effects on Irisin and GAD65.
Neuralgia
The etiological changes of acetylation in peripheral nerve injury-induced neuropathic hypersensitivity.
Neuralgia
The etiological contribution of GABAergic plasticity to the pathogenesis of neuropathic pain.
Neuralgia
The Role of Ventral Tegmental Area GABA on the Chronic Neuropathic Pain Following Spinal Cord Injury in Rat.
Neuroblastoma
A pilot study on neurological manifestations and antibodies against antigens in children with hematological and other cancers.
Neuroblastoma
Adrenergic, cholinergic, and inactive human neuroblastoma cell lines with the action-potential Na+ ionophore.
Neuroblastoma
Changes in glycolipid glycosyltransferases and glutamate decarboxylase and their relationship to differentiation in neuroblastoma cells.
Neuroblastoma
Downregulation of glutamic acid decarboxylase in Drosophila TDP-43-null brains provokes paralysis by affecting the organization of the neuromuscular synapses.
Neuroblastoma
Function coupling of otoferlin with GAD65 acts to modulate GABAergic activity.
Neuroblastoma
Glutamic acid decarboxylase and gamma-aminobutyric acid in Huntington's disease fibroblasts and other cultured cells, determined by a [3H]muscimol radioreceptor assay.
Neurodegenerative Diseases
An autoantibody inhibitory to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease.
Neurodegenerative Diseases
Autoimmunity to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease.
Neurodegenerative Diseases
Distinct patterns of serum immunoreactivity as evidence for multiple brain-directed autoantibodies in juvenile neuronal ceroid lipofuscinosis.
Neurodegenerative Diseases
Glutamic acid decarboxylase autoimmunity with brainstem, extrapyramidal, and spinal cord dysfunction.
Neuroinflammatory Diseases
Alpha-asarone Improves Cognitive Function of APP/PS1 Mice and Reducing A?42, P-tau and Neuroinflammation, and Promoting Neuron Survival in the Hippocampus.
Neuroinflammatory Diseases
Evidence of parallels between mercury intoxication and the brain pathology in autism.
Neuroinflammatory Diseases
Immunomodulation for treatment of drug and device refractory gastroparesis.
Neuroinflammatory Diseases
Neuroinflammation versus decreased Zif268 mRNA expression as causal mediators of decreased GAD67 mRNA expression within dorsolateral prefrontal cortex in schizophrenia.
Neuroinflammatory Diseases
Repeated psychosocial stress causes glutamic acid decarboxylase isoform-67, oxidative-Nox-2 changes and neuroinflammation in mice: Prevention by treatment with a neuroactive flavonoid, morin.
Neuroinflammatory Diseases
Very low doses of muscimol and baclofen ameliorate cognitive deficits and regulate protein expression in the brain of a rat model of streptozocin-induced Alzheimer's disease.
Neurologic Manifestations
A pilot study on neurological manifestations and antibodies against antigens in children with hematological and other cancers.
Neurologic Manifestations
Glutamic acid decarboxylase autoimmunity with brainstem, extrapyramidal, and spinal cord dysfunction.
Neurologic Manifestations
Paraneoplastic autoimmunity and small-cell lung cancer: Neurological and serological accompaniments.
Neurologic Manifestations
Serum glutamate decarboxylase antibodies and neurological disorders: when to suspect their association?
Neuromyelitis Optica
No Overlap among Serum GAD65, NMDAR and AQP4 Antibodies in Patients with Neuromyelitis Optica Spectrum Disorders.
Neuronal Ceroid-Lipofuscinoses
An autoantibody inhibitory to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease.
Neuronal Ceroid-Lipofuscinoses
An autoantibody to GAD65 in sera of patients with juvenile neuronal ceroid lipofuscinoses.
Neuronal Ceroid-Lipofuscinoses
Autoimmunity to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease.
Neuronal Ceroid-Lipofuscinoses
Distinct patterns of serum immunoreactivity as evidence for multiple brain-directed autoantibodies in juvenile neuronal ceroid lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
Glutamic acid decarboxylase autoimmunity in Batten disease and other disorders.
Neuronal Ceroid-Lipofuscinoses
Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders.
Neuronal Ceroid-Lipofuscinoses
Identification of alpha-fetoprotein as an autoantigen in juvenile Batten disease.
Neuronal Ceroid-Lipofuscinoses
IgG entry and deposition are components of the neuroimmune response in Batten disease.
Neuronal Ceroid-Lipofuscinoses
Intermittent prednisolone and autoantibodies to GAD65 in juvenile neuronal ceroid lipofuscinosis.
Nystagmus, Pathologic
Vertical nystagmus associated with glutamic acid decarboxylase antibodies responding to cyclophosphamide.
Obesity
Association of genetic polymorphisms of glutamate decarboxylase 2 and the dopamine D2 receptor with obesity in Taiwanese subjects.
Obesity
Association of the -243 A-->G polymorphism of the glutamate decarboxylase 2 gene with obesity in girls with premature pubarche.
Obesity
Association of the -243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian Population.
Obesity
Fasting c-peptide and insulin-like growth factor-binding protein-1 levels help to distinguish childhood type 1 and type 2 diabetes at diagnosis.
Obesity
Geographic location determines beta-cell autoimmunity among adult Ghanaians: Findings from the RODAM study.
Obesity
Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index.
Obesity
Is glutamate decarboxylase 2 (GAD2) a genetic link between low birth weight and subsequent development of obesity in children?
Obesity
Lack of association of glutamate decarboxylase 2 gene polymorphisms with severe obesity in utah.
Obesity
Lack of support for the association between GAD2 polymorphisms and severe human obesity.
Obesity
Metabolic profile and cardiovascular risk patterns of an Indian tribe living in the Amazon Region of Brazil.
Obesity, Abdominal
Metabolic profile and cardiovascular risk patterns of an Indian tribe living in the Amazon Region of Brazil.
Obesity, Morbid
Lack of association of glutamate decarboxylase 2 gene polymorphisms with severe obesity in utah.
Ocular Motility Disorders
A Variant of Alternating Skew Deviation in GAD65 Antibody-Associated Cerebellar Ataxia.
Oligodendroglioma
Neural antigens in oligodendrogliomas and dysembryoplastic neuroepithelial tumors.
Opsoclonus-Myoclonus Syndrome
A pilot study on neurological manifestations and antibodies against antigens in children with hematological and other cancers.
Opsoclonus-Myoclonus Syndrome
Paraneoplastic opsoclonus myoclonus with autoantibodies to glutamic acid decarboxylase.
Opsoclonus-Myoclonus Syndrome
Presentation of opsoclonus myoclonus ataxia syndrome with glutamic acid decarboxylase antibodies.
Optic Nerve Injuries
Increased expression of GABA transporters, GAT-1 and GAT-3, in the deafferented superior colliculus of the rat.
Optic Nerve Injuries
Reductions in N-acetylaspartylglutamate and the 67 kDa form of glutamic acid decarboxylase immunoreactivities in the visual system of albino and pigmented rats after optic nerve transections.
Overweight
Metabolic profile and cardiovascular risk patterns of an Indian tribe living in the Amazon Region of Brazil.
Overweight
The first series of cases of ketosis-prone type 2 diabetes (flatbush diabetes) in Brazilian adults.
Pancreatic Neoplasms
Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention.
Pancreatitis, Chronic
A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM Study Group.
Pancreatitis, Chronic
The prognostic significance of glutamic acid decarboxylase antibodies in patients with chronic pancreatitis undergoing total pancreatectomy with islet autotransplantation.
Paralysis
Alterations of GABAergic neurons in the basal ganglia of patients with progressive supranuclear palsy: an in situ hybridization study of GAD67 messenger RNA.
Paralysis
Auto-destruction of the thyroid gland and coexisting glutamic acid decarboxylase mediated neurological disease in an adolescent: an unusual presentation of autoimmunity.
Paralysis
Downregulation of glutamic acid decarboxylase in Drosophila TDP-43-null brains provokes paralysis by affecting the organization of the neuromuscular synapses.
Paralysis
Pathological evidence of encephalomyelitis in the stiff man syndrome with anti-GAD antibodies.
Paraneoplastic Syndromes
Anti-glutamic acid decarboxylase antibody paraneoplastic limbic encephalitis associated with Acute Myeloid Leukemia.
Paraneoplastic Syndromes
Paraneoplastic stiff-person syndrome: passive transfer to rats by means of IgG antibodies to amphiphysin.
Paraneoplastic Syndromes, Nervous System
Paraneoplastic Encephalomyelitis With Glutamic Acid Decarboxylase Antibodies Presenting as Longitudinal Pyramidal Tract Hyperintensity.
Parathyroid Neoplasms
A Possible Link Between Parathyroid Hormone Secretion and Local Regulation of GABA in Human Parathyroid Adenomas.
Parkinson Disease
Alterations in GAD67, dynorphin and enkephalin mRNA in striatal output neurons following priming in the 6-OHDA model of Parkinson's disease.
Parkinson Disease
Alterations in prodynorphin, proenkephalin, and GAD67 mRNA levels in the aged human putamen: correlation with Parkinson's disease.
Parkinson Disease
Brain glutamate decarboxylase in Parkinson's disease with particular reference to a premortem severity index.
Parkinson Disease
Consequence of nigrostriatal denervation and L-dopa therapy on the expression of glutamic acid decarboxylase messenger RNA in the pallidum.
Parkinson Disease
Consequences of nigrostriatal denervation on the gamma-aminobutyric acidic neurons of substantia nigra pars reticulata and superior colliculus in parkinsonian syndromes.
Parkinson Disease
Decreased glutamic acid decarboxylase mRNA expression in prefrontal cortex in Parkinson's disease.
Parkinson Disease
Decreased parvalbumin mRNA expression in dorsolateral prefrontal cortex in Parkinson's disease.
Parkinson Disease
Effects of globus pallidus lesions and Parkinson's disease on brain glutamic acid decarboxylase.
Parkinson Disease
Effects of nigrostriatal denervation and L-dopa therapy on the GABAergic neurons in the striatum in MPTP-treated monkeys and Parkinson's disease: an in situ hybridization study of GAD67 mRNA.
Parkinson Disease
Efficient therapeutic gene expression in cultured rat hippocampal neurons mediated by human foamy virus vectors: a potential for the treatment of neurological diseases.
Parkinson Disease
Enhanced expression of glutamate decarboxylase 65 improves symptoms of rat parkinsonian models.
Parkinson Disease
Expression of GAD65 and GAD67 immunoreactivity in MPTP-treated monkeys with or without L-DOPA administration.
Parkinson Disease
GABAA receptor but not muscarinic receptor density was decreased in the brain of patients with Parkinson's disease.
Parkinson Disease
Glutamic acid decarboxylase mRNA expression in medial and lateral pallidal neurons in the MPTP-treated monkey and patients with Parkinson's disease.
Parkinson Disease
Knock down of GAD67 protein levels normalizes neuronal activity in a rat model of Parkinson's disease.
Parkinson Disease
L-glutamic acid decarboxylase in Parkinson's disease: effect of L-dopa therapy.
Parkinson Disease
Long-term follow-up of a randomized AAV2-GAD gene therapy trial for Parkinson's disease.
Parkinson Disease
Loss of glutamic acid decarboxylase (Gad67) in striatal neurons expressing the Drdr1a dopamine receptor prevents L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned mice.
Parkinson Disease
Mapping Spatiotemporal Microproteomics Landscape in Experimental Model of Traumatic Brain Injury Unveils a link to Parkinson's Disease.
Parkinson Disease
NLX-P101, an adeno-associated virus gene therapy encoding glutamic acid decarboxylase, for the potential treatment of Parkinson's disease.
Parkinson Disease
Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial.
Parkinson Disease
Striatal dopamine depletion, dopamine receptor stimulation, and GABA metabolism: implications for the therapy of Parkinson's disease.
Parkinson Disease
Striatal GABAergic neuronal activity is not reduced in Parkinson's disease.
Parkinson Disease
Subthalamic hGAD65 gene therapy and striatum TH gene transfer in a Parkinson's disease rat model.
Parkinson Disease
[Advances in the application of gene therapy for Parkinson's disease with adeno-associated virus].
Parkinson Disease
[Topographic and chemical study of the GABA synthetizing enzyme in Parkinsonian syndromes]
Parkinsonian Disorders
AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial.
Parkinsonian Disorders
Alterations in expression of messenger RNAs encoding two isoforms of glutamic acid decarboxylase in the globus pallidus and entopeduncular nucleus in animals symptomatic for and recovered from experimental Parkinsonism.
Parkinsonian Disorders
Alterations in prodynorphin, proenkephalin, and GAD67 mRNA levels in the aged human putamen: correlation with Parkinson's disease.
Parkinsonian Disorders
Atypical parkinsonism and intrathecal anti-glutamic acid decarboxylase antibodies - an unusual association: a case report.
Parkinsonian Disorders
Experimental parkinsonism is associated with increased pallidal GAD gene expression and is reversed by site-directed antisense gene therapy.
Parkinsonian Disorders
Increased glutamate decarboxylase mRNA levels in the striatum and pallidum of MPTP-treated primates.
Parkinsonian Disorders
Novel clinical features of glycine receptor antibody syndrome: A series of 17 cases.
Periodontal Pocket
Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitis.
Periodontitis
Negative effects of chronic inflammatory periodontal disease on diabetes mellitus.
Periodontitis
Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitis.
Peripheral Nerve Injuries
Distribution and colocalisation of glutamate decarboxylase isoforms in the rat spinal cord.
Peripheral Nerve Injuries
Normalizing HDAC2 Levels in the Spinal Cord Alleviates Thermal and Mechanical Hyperalgesia After Peripheral Nerve Injury and Promotes GAD65 and KCC2 Expression.
Peripheral Nerve Injuries
Swimming Training Attenuates Allodynia and Hyperalgesia Induced by Peripheral Nerve Injury in an Adult Male Rat Neuropathic Model: Effects on Irisin and GAD65.
Peripheral Nervous System Diseases
Autoantibodies to glutamate decarboxylase in a patient with cerebellar cortical atrophy, peripheral neuropathy, and slow eye movements.
Peripheral Nervous System Diseases
Leucoencephalopathy, transverse myelopathy, and peripheral neuropathy in association with glutamic acid decarboxylase-65 (GAD) antibodies in children with cancer.
Peripheral Nervous System Diseases
Peripheral neuropathy associated with antiglutamic acid decarboxylase antibodies.
Phenylketonurias
Inhibition of brain glutamic acid decarboxylase by phenylalanine, valine, and leucine derivatives: a suggestion concerning the etiology of the neurological defect in phenylketonuria and branched-chain ketonuria.
Pheochromocytoma
Nerve growth factor-mediated stimulation of tyrosine hydroxylase activity in a clonal rat pheochromocytoma cell line.
Pheochromocytoma
POSTTRANSLATIONAL MODIFICATION OF GLUTAMIC ACID DECARBOXYLASE 67 BY INTERMITTENT HYPOXIA: Evidence for the involvement of dopamine D1 receptor signaling($).
Pick Disease of the Brain
Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.
Picornaviridae Infections
Picornavirus proteins share antigenic determinants with heat shock proteins 60/65.
Polycystic Kidney Diseases
Type III Cells in Anterior Taste Fields Are More Immunohistochemically Diverse Than Those of Posterior Taste Fields in Mice.
Polyendocrinopathies, Autoimmune
Autoantibodies in autoimmune polyglandular syndrome type I patients react with major brain neurotransmitter systems.
Polyendocrinopathies, Autoimmune
Autoimmunity to glutamic acid decarboxylase in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Polyendocrinopathies, Autoimmune
Characterization of the humoral immune response to glutamic acid decarboxylase in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and/or type 1 diabetes.
Polyendocrinopathies, Autoimmune
Reduction of Total Brain and Cerebellum Volumes Associated With Neuronal Autoantibodies in Patients With APECED.
Polyneuropathies
Glutamic Acid Decarboxylase (GAD-65) Autoimmunity Associated With Profound Daytime Hypersomnia, Nighttime Insomnia, Mild Autonomic Neuropathy and Axonal Sensori-Motor Polyneuropathy: A Case Report on a New Phenotype.
Prediabetic State
GAD65 as a potential marker for cognitive performance in an adult population with prediabetes.
Prediabetic State
Identification of glutamic acid decarboxylase autoantibody heterogeneity and epitope regions in type I diabetes.
Prediabetic State
Prevalence of diabetes-specific autoantibodies in patients at risk for adult onset diabetes mellitus.
Prostatic Hyperplasia
Gamma-aminobutyric acid as a promoting factor of cancer metastasis; induction of matrix metalloproteinase production is potentially its underlying mechanism.
Prostatic Neoplasms
Glutamate Decarboxylase 65 Signals through the Androgen Receptor to Promote Castration Resistance in Prostate Cancer.
Protein-Energy Malnutrition
Erythrocytic enzymes and amino acids related to glutamic acid metabolism in childhood hypoproteinemic states.
Pseudorabies
Medullary pathways mediating specific sympathetic responses to activation of dorsomedial hypothalamus.
Pseudorabies
Nicotine enhances inhibition of mouse vagal motor neurons by modulating excitability of premotor GABAergic neurons in the nucleus tractus solitarii.
Radiculopathy
Vector-mediated gene transfer to express inhibitory neurotransmitters in dorsal root ganglion reduces pain in a rodent model of lumbar radiculopathy.
Respiratory Insufficiency
Respiratory activity in brainstem of fetal mice lacking glutamate decarboxylase 65/67 and vesicular GABA transporter.
Retinitis Pigmentosa
Photoreceptor degeneration and loss of immunoreactive GABA in the Abyssinian cat retina.
Rotavirus Infections
Rotavirus Infection Enhances Levels of Autoantibodies Against Islet Cell Antigens GAD65 and IA-2 in Children with Type 1 Diabetes.
Rubella
CD4+ and CD8+ T-cell clones from congenital rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes. Implications for HLA class I and II allelic linkage to disease susceptibility.
Rubella
Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with type I diabetes mellitus.
Rubella
Humoral beta-cell autoimmunity is rare in patients with the congenital rubella syndrome.
Rubella Syndrome, Congenital
CD4+ and CD8+ T-cell clones from congenital rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes. Implications for HLA class I and II allelic linkage to disease susceptibility.
Sarcoma, Avian
Adenovirus-mediated transfer of a functional GAD gene into nerve cells: potential for the treatment of neurological diseases.
Sarcoma, Avian
Glutamic acid decarboxylase activity is stimulated in quail retina neuronal cells transformed by Rous sarcoma virus and is regulated by pp60v-src.
Scrapie
Changes in tyrosine hydroxylase, glutamic acid decarboxylase and choline acetyltransferase after local microinoculation of scrapie agent into the nigrostriatal system of the golden hamster.
Scrapie
Early changes in tyrosine hydroxylase and glutamate decarboxylase activity in the golden hamster striatum after intracerebral inoculation of the nigrostriatal system with scrapie agent (strain 263 K).
Scrapie
Influence of stereotaxically injected scrapie on neurotransmitter systems of mouse cerebellum.
Seizures
A comparison of the effects of allylglycine and 2-keto-4-pentenoic acid on cerebral glutamic acid decarboxylase activity and convulsions in mice [proceedings]
Seizures
Activity-dependent expression of GAD67 in the granule cells of the rat hippocampus.
Seizures
Acute changes in the neuronal expression of GABA and glutamate decarboxylase isoforms in the rat piriform cortex following status epilepticus.
Seizures
Alterations in seizure mechanisms caused by oxygen high pressure, 1,1-dimethylhydrazine, and pyridoxine.
Seizures
Alterations of the neocortical GABAergic system in the pilocarpine model of temporal lobe epilepsy: neuronal damage and immunocytochemical changes in chronic epileptic rats.
Seizures
Altered hippocampal expression of neuropeptide Y, somatostatin, and glutamate decarboxylase in Ihara's epileptic rats and spontaneously epileptic rats.
Seizures
Amygdala-kindling does not induce a persistent loss of GABA neurons in the substantia nigra pars reticulata of rats.
Seizures
Anticardiolipin, glutamic acid decarboxylase, and antinuclear antibodies in epileptic patients.
Seizures
Anticonvulsant effect of neural regeneration peptide 2945 on pentylenetetrazol-induced seizures in rats.
Seizures
Antiepileptic activity of total triterpenes isolated from Poria cocos is mediated by suppression of aspartic and glutamic acids in the brain.
Seizures
Audiogenic seizure activity following HSV-1 GAD65 sense or antisense injection into inferior colliculus of Long-Evans rat.
Seizures
Calcium binding protein (calbindin-D28k) and glutamate decarboxylase gene expression after kindling induced seizures.
Seizures
Cerebral Dopamine Neurotrophic Factor Regulates Multiple Neuronal Subtypes and Behavior.
Seizures
Cerebral glutamic acid decarboxylase activity and gamma-aminobutyric acid concentrations in mice susceptible or resistant to audiogenic seizures.
Seizures
Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase.
Seizures
Concomitant increase of somatostatin, neuropeptide Y and glutamate decarboxylase in the frontal cortex of rats with decreased seizure threshold.
Seizures
Convulsions and inhibition of glutamate decarboxylase by pyridoxal phosphate-gamma-glutamyl hydrazone in the developing rat.
Seizures
Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients?
Seizures
Correlations of Clusters of Non-Convulsive Seizure and Magnetic Resonance Imaging in a Case With GAD65-Positive Autoimmune Limbic Encephalitis.
Seizures
Correlative changes of pyridoxal kinase pyridoxal-5'-phosphate and glutamate decarboxylase in brain, during drug-induced convulsions.
Seizures
Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish.
Seizures
CSF glutamate/GABA concentrations in pyridoxine-dependent seizures: etiology of pyridoxine-dependent seizures and the mechanisms of pyridoxine action in seizure control.
Seizures
Decrease of glutamate decarboxylase activity after in vivo cortical infusion of gamma-aminobutyric acid.
Seizures
Developmental PCB Exposure Increases Audiogenic Seizures and Decreases Glutamic Acid Decarboxylase in the Inferior Colliculus.
Seizures
Differential regulation of adult and embryonic glutamate decarboxylases in rat dentate granule cells after kainate-induced limbic seizures.
Seizures
Distribution of GABAergic neurons in the striatum of amygdala-kindled rats: An immunohistochemical and in situ hybridization study.
Seizures
Effect of anticonvulsant treatment on kainic acid-induced increases in peptide levels.
Seizures
Effect of mannitol treatment on brain neurotransmitter markers in kainic acid-induced epilepsy.
Seizures
Effect of single and repeated convulsions on glutamate decarboxylase (GAD) activity and [3H]muscimol binding in the rat brain.
Seizures
Effects of amygdala kindling and electroconvulsive seizures on the expression of corticotropin-releasing hormone in the rat brain.
Seizures
Effects of antisense glutamic acid decarboxylase oligodeoxynucleotide on epileptic rats induced by pentylenetetrazol.
Seizures
Effects of Jobelyn® on Isoniazid-Induced Seizures, Biomarkers of Oxidative Stress and Glutamate Decarboxylase Activity in Mice.
Seizures
Effects of toluene exposure during brain growth spurt on GABA(A) receptor-mediated functions in juvenile rats.
Seizures
Evaluation of anticonvulsant activity of QUAN-0806 in various murine experimental seizure models.
Seizures
Evaluation of GAD67 immunoreactivity in the region of substantia nigra pars reticulata in resistance to development of convulsive seizure in genetic absence epilepsy rats.
Seizures
Evidence for the involvement of a GABA-mediated inhibition in the hypovolaemia-induced vasopressin release.
Seizures
Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo.
Seizures
Exogenous protein Hsp70/Hsc70 can penetrate into brain structures and attenuate the severity of chemically-induced seizures.
Seizures
Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures.
Seizures
Extralimbic autoimmune encephalitis associated with glutamic acid decarboxylase antibodies: an underdiagnosed entity?
Seizures
Free amino acids and glutamate decarboxylase activity in brain of mice during drug-induced convulsions.
Seizures
GABA and epileptogenesis: comparing gabrb3 gene-deficient mice with Angelman syndrome in man.
Seizures
GABA-mediated responses are not selectively depressed by 3-mercaptopropionic acid in the spinal cord.
Seizures
GAD-immunoreactive neurons are preserved in the hippocampus of rats with spontaneous recurrent seizures.
Seizures
GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activity.
Seizures
gamma-Aminobutyric acid metabolism in subcellular particles of mouse brain and its relationship to convulsions.
Seizures
Garcinol Upregulates GABAA and GAD65 Expression, Modulates BDNF-TrkB Pathway to Reduce Seizures in Pentylenetetrazole (PTZ)-Induced Epilepsy.
Seizures
Genetic variability in glutamic acid decarboxylase genes: Associations with post-traumatic seizures after severe TBI.
Seizures
Glutamate decarboxylase and GABA aminotransferase levels in different regions of rat brain on the onset of Leptazol induced convulsions.
Seizures
Glutamate decarboxylase is not genetically linked to pyridoxine-dependent seizures.
Seizures
Glutamate decarboxylase isoforms in thalamic nuclei in lethargic mouse model of absence seizures.
Seizures
Glutamic acid decarboxylase (GAD) in mammalian tissue outside the central nervous system, and its possible relevance to hereditary vitamin B6 dependency with seizures.
Seizures
Glutamic acid decarboxylase (GAD)67, but not GAD65, is constitutively expressed during development and transiently overexpressed by activity in the granule cells of the rat.
Seizures
Glutamic acid decarboxylase 65-positive autoimmune encephalitis presenting with gelastic seizure, responsive to steroid: A case report.
Seizures
Glutamic acid decarboxylase immunoreactivity in the mossy fiber terminals of the hippocampus of genetic absence epileptic rats.
Seizures
Hippocampal electrical activity and gamma-aminobutyrate metabolism in brain tissue following administration of homocysteine.
Seizures
Hippocampal glutamate decarboxylase activity is not altered in gerbils with high seizure susceptibility.
Seizures
Hippocampal granule cells express glutamic acid decarboxylase-67 after limbic seizures in the rat.
Seizures
ICA69(null) nonobese diabetic mice develop diabetes, but resist disease acceleration by cyclophosphamide.
Seizures
Impact of Dysfunctional Feed-Forward Inhibition on Glutamate Decarboxylase Isoforms and ?-Aminobutyric Acid Transporters.
Seizures
In contrast to kindled seizures, the frequency of spontaneous epilepsy in the limbic status model correlates with greater aberrant fascia dentata excitatory and inhibitory axon sprouting, and increased staining for N-methyl-D-aspartate, AMPA and GABA(A) receptors.
Seizures
Increase in taurine content before onset of seizures induced by a glutamate decarboxylase inhibitor.
Seizures
Influence of convulsants on rat brain activities of alanine aminotransferase and aspartate aminotransferase.
Seizures
Inhibition of glutamate decarboxylase (GAD) by ethyl ketopentenoate (EKP) induces treatment-resistant epileptic seizures in zebrafish.
Seizures
Inhibition of glutamate decarboxylase activity by 3-mercaptopropionic acid has different time course in the immature and adult rat brains.
Seizures
Inhibition of the rate of GABA synthesis in regions of rat brain following a convulsion.
Seizures
Long-term increase of glutamate decarboxylase mRNA in a rat model of temporal lobe epilepsy.
Seizures
Loss of glutamate decarboxylase mRNA-containing neurons in the rat dentate gyrus following pilocarpine-induced seizures.
Seizures
MDMA decreases glutamic acid decarboxylase (GAD) 67-immunoreactive neurons in the hippocampus and increases seizure susceptibility: Role for glutamate.
Seizures
Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures.
Seizures
Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus.
Seizures
Neurochemical effects of nicotine on glutamate and GABA mechanisms in the rat brain.
Seizures
Neuropsychological course of voltage-gated potassium channel and glutamic acid decarboxylase antibody related limbic encephalitis.
Seizures
Non-convulsive status epilepticus associated with glutamic acid decarboxylase antibody.
Seizures
Oxygen-induced seizures and inhibition of human glutamate decarboxylase and porcine cysteine sulfinic acid decarboxylase by oxygen and nitric oxide.
Seizures
Penicillin-induced convulsions and inhibition of glutamate decarboxylase [proceedings]
Seizures
Pre- and long-term postoperative courses of hippocampus-associated memory impairment in epilepsy patients with antibody-associated limbic encephalitis and selective amygdalohippocampectomy.
Seizures
Profound amnesia after temporal lobectomy: an autoimmune process resembling patient h.m.?
Seizures
Pyridoxal phosphate and glutamate decarboxylase in subcellular particles of mouse brain and their relationship to convulsions.
Seizures
Pyridoxal phosphate-unrelated inhibition of hippocampal glutamic acid decarboxylase by convulsant pyridoxal sulphate.
Seizures
Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice.
Seizures
Rapid decrease of GAD 67 content before the convulsion induced by hyperbaric oxygen exposure.
Seizures
Reduced glucose utilization underlies seizure protection with dietary therapy in epileptic EL mice.
Seizures
Relationship between gamma-aminobutyric acid metabolism and antivitamin B6-induced convulsions.
Seizures
S-nitrosylation of GAD65 is implicated in decreased GAD activity and oxygen-induced seizures.
Seizures
Seizure control and cognitive improvement via immunotherapy in late onset epilepsy patients with paraneoplastic versus GAD65 autoantibody-associated limbic encephalitis.
Seizures
Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra.
Seizures
Seizure susceptibility in the developing mouse and its relationship to glutamate decarboxylase and pyridoxal phosphate in brain.
Seizures
Seizures induced by allylglycine, 3-mercaptopropionic acid and 4-deoxypyridoxine in mice and photosensitive baboons, and different modes of inhibition of cerebral glutamic acid decarboxylase.
Seizures
Seizures induced by intracerebral administration of pyridoxal-5'-phosphate: effect of GABAergic drugs and glutamate receptor antagonists.
Seizures
Seizures produced by pilocarpine: neuropathological sequelae and activity of glutamate decarboxylase in the rat forebrain.
Seizures
Selective resistance of taurine-fed mice to isoniazide-potentiated seizures: In vivo functional test for the activity of glutamic acid decarboxylase.
Seizures
Selective susceptibility to inhibitors of GABA synthesis and antagonists of GABA(A) receptor in rats with genetic absence epilepsy.
Seizures
Some correlations between local anesthetic-induced convulsions and gamma-aminobutyric acid in rat spinal cord.
Seizures
Susceptibility to seizures produced by pilocarpine in rats after microinjection of isoniazid or gamma-vinyl-GABA into the substantia nigra.
Seizures
The anticonvulsant activity of ketamine agains siezures induced by pentylenetetrazol and mercaptopropionic acid.
Seizures
The effect of exercise on GABA signaling pathway in the model of chemically induced seizures.
Seizures
The inferior colliculus of GEPRs contains greater numbers of cells that express glutamate decarboxylase (GAD67) mRNA.
Seizures
The mode of action of homocysteine on mouse brain glutamic decarboxylase and gamma-aminobutyrate aminotransferase.
Seizures
The selective inhibition of hippocampal glutamic acid decarboxylase in zinc-induced epileptic seizures.
Seizures
The specific protective effect of diazepam and valproate against isoniazid-induced seizures is not correlated with increased GABA levels.
Seizures
The temporal alteration of GAD67/GAD65 ratio in the gerbil hippocampal complex following seizure.
Seizures
Toxoplasma gondii Infections Alter GABAergic Synapses and Signaling in the Central Nervous System.
Seizures
Transient increase in expression of a glutamate decarboxylase (GAD) mRNA during the postnatal development of the rat striatum.
Seizures
Transplantation of M213-2O cells with enhanced GAD67 expression into the inferior colliculus alters audiogenic seizures.
Seizures
Treadmill exercise prevents GABAergic neuronal loss with suppression of neuronal activation in the pilocarpine-induced epileptic rats.
Seizures
Up-regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal lobe epilepsy.
Seizures
Vigabatrin protects against hippocampal damage but is not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy.
Seizures
Vitamin B 6 -dependency of glutamic acid decarboxylase in the kidney from a patient with vitamin B 6 dependent convulsion.
Seizures
Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures.
Seizures
[Metabolic investigations of epileptic seizures. The activity of the glutamate decarboxylase prior to and during experimentally produced convulsions]
Seizures
[The possible participation of the GABA metabolic system in the mechanisms of the protective action of L-aspartate in hypoxia in an enclosed space]
Seizures, Febrile
Glutamic acid decarboxylase in cerebrospinal fluid in infancy and childhood Part II. Glutamic acid decarboxylase activity in cerebrospinal fluid of children with neurological diseases.
Seizures, Febrile
Inhibition of brain glutamate decarboxylase activity is related to febrile seizures in rat pups.
Siderosis
Parkinsonian features in aging GFAP.HMOX1 transgenic mice overexpressing human HO-1 in the astroglial compartment.
Sleep Deprivation
Increased levels of tyrosine hydroxylase and glutamic acid decarboxylase in locus coeruleus neurons after rapid eye movement sleep deprivation in rats.
Sleep Deprivation
Sleep modifies glutamate decarboxylase mRNA within the barrel cortex of rats after a mystacial whisker trim.
Sleep Initiation and Maintenance Disorders
Glutamic Acid Decarboxylase (GAD-65) Autoimmunity Associated With Profound Daytime Hypersomnia, Nighttime Insomnia, Mild Autonomic Neuropathy and Axonal Sensori-Motor Polyneuropathy: A Case Report on a New Phenotype.
Sleep Wake Disorders
Glutamic Acid Decarboxylase (GAD-65) Autoimmunity Associated With Profound Daytime Hypersomnia, Nighttime Insomnia, Mild Autonomic Neuropathy and Axonal Sensori-Motor Polyneuropathy: A Case Report on a New Phenotype.
Small Cell Lung Carcinoma
Small Cell Lung Cancer Expressing Glutamate Decarboxylase with Latent Autoimmune Diabetes in Adults.
Spasm
A rare saccade velocity profile in Stiff-Person Syndrome with cerebellar degeneration.
Spasm
Clinically disparate stiff-person syndrome with GAD65 autoantibody in a father and daughter.
Spasm
Opsoclonus in a patient with increased titers of anti-GAD antibody provides proof for the conductance-based model of saccadic oscillations.
Spasm
Rituximab treatment of stiff-person syndrome in a patient with thymoma, diabetes mellitus and autoimmune thyroiditis.
Spasm
Stiff-person syndrome with amphiphysin antibodies: distinctive features of a rare disease.
Spasm
Subcutaneous Immunoglobulin Therapy with IgPro20 in Patients with Stiff Person Syndrome and Primary Immunodeficiency Disease.
Spasm
[A case of progressive continuous muscular rigidity and painless and rhythmic muscle spasm associated with autoantibody against glutamic acid decarboxylase]
Spinal Cord Diseases
Leucoencephalopathy, transverse myelopathy, and peripheral neuropathy in association with glutamic acid decarboxylase-65 (GAD) antibodies in children with cancer.
Spinal Cord Injuries
A novel human foamy virus mediated gene transfer of GAD67 reduces neuropathic pain following spinal cord injury.
Spinal Cord Injuries
Correlation of changes in the GABA-ergic system with the development of spasticity in paraplegic cats.
Spinal Cord Injuries
Effect of intravenous transplantation of bone marrow mesenchymal stem cells on neurotransmitters and synapsins in rats with spinal cord injury.
Spinal Cord Injuries
Exercise training modulates glutamic acid decarboxylase-65/67 expression through TrkB signaling to ameliorate neuropathic pain in rats with spinal cord injury.
Spinal Cord Injuries
GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats.
Spinal Cord Injuries
Herpes simplex virus vector-mediated gene delivery of glutamic acid decarboxylase reduces detrusor overactivity in spinal cord-injured rats.
Spinal Cord Injuries
Increased expression of glutamate decarboxylase (GAD(67)) in feline lumbar spinal cord after complete thoracic spinal cord transection.
Spinal Cord Injuries
Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain.
Spinal Cord Injuries
Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat.
Spinal Cord Injuries
Suppression of detrusor-sphincter dyssynergia by herpes simplex virus vector mediated gene delivery of glutamic acid decarboxylase in spinal cord injured rats.
Spinal Cord Injuries
Transplantation of embryonic Raphe cells regulates the modifications of the gabaergic phenotype occurring in the injured spinal cord.
Spinal Cord Injuries
Use-dependent modulation of inhibitory capacity in the feline lumbar spinal cord.
Spinocerebellar Degenerations
[Autoantibody to glutamate decarboxylase in a patient with spinocerebellar degeneration and Sjögren syndrome]
Starvation
[The effect of starvation on GABA-transaminase and glutamate decarboxylase activity on mitochondria of dog limbic structures during postnatal ontogenesis]
Status Epilepticus
Acute changes in the neuronal expression of GABA and glutamate decarboxylase isoforms in the rat piriform cortex following status epilepticus.
Status Epilepticus
Antiglutamic Acid Decarboxylase Antibodies in Children With Encephalitis and Status Epilepticus.
Status Epilepticus
GAD-immunoreactive neurons are preserved in the hippocampus of rats with spontaneous recurrent seizures.
Status Epilepticus
Non-convulsive status epilepticus associated with glutamic acid decarboxylase antibody.
Status Epilepticus
Opercular myoclonic-anarthric status epilepticus due to glutamic acid decarboxylase antibody-associated encephalitis.
Status Epilepticus
Refractory status epilepticus and autoimmune encephalitis with GABAAR and GAD65 antibodies: A case report.
Status Epilepticus
Refractory status epilepticus and glutamic acid decarboxylase antibodies in adults: presentation, treatment and outcomes.
Status Epilepticus
Susceptibility to seizures produced by pilocarpine in rats after microinjection of isoniazid or gamma-vinyl-GABA into the substantia nigra.
Stiff-Person Syndrome
11C-flumazenil positron emission tomography demonstrates reduction of both global and local cerebral benzodiazepine receptor binding in a patient with Stiff Person Syndrome.
Stiff-Person Syndrome
A case of stiff-person syndrome, type 1 diabetes, celiac disease and dermatitis herpetiformis.
Stiff-Person Syndrome
A Case of Treatment Resistance and Complications in a Patient with Stiff Person Syndrome and Cerebellar Ataxia.
Stiff-Person Syndrome
A new solid-phase radioimmunoassay to detect anti-GAD65 autoantibodies.
Stiff-Person Syndrome
A rare saccade velocity profile in Stiff-Person Syndrome with cerebellar degeneration.
Stiff-Person Syndrome
A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region.
Stiff-Person Syndrome
A unique combination of autoimmune limbic encephalitis, type 1 diabetes, and Stiff person syndrome associated with GAD-65 antibody.
Stiff-Person Syndrome
Anti-GAD65 Containing Cerebrospinal Fluid Does not Alter GABAergic Transmission.
Stiff-Person Syndrome
Antibodies against glutamic acid decarboxylase: prevalence in neurological diseases.
Stiff-Person Syndrome
Antibodies to 125I-glutamic acid decarboxylase in patients with stiff man syndrome.
Stiff-Person Syndrome
Antigenic differences between neurological and diabetic patients with anti-glutamic acid decarboxylase antibodies.
Stiff-Person Syndrome
Association of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region.
Stiff-Person Syndrome
Auto-immune cerebellar ataxia with anti-GAD antibodies accompanied by de novo late-onset type 1 diabetes mellitus.
Stiff-Person Syndrome
Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome.
Stiff-Person Syndrome
Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I diabetes mellitus.
Stiff-Person Syndrome
Autoantibodies to glutamic acid decarboxylase in palatal myoclonus and epilepsy.
Stiff-Person Syndrome
Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy.
Stiff-Person Syndrome
Autoantibodies to glutamic acid decarboxylase in three patients with cerebellar ataxia, late-onset insulin-dependent diabetes mellitus, and polyendocrine autoimmunity.
Stiff-Person Syndrome
Autoimmune encephalitis associated with glutamic acid decarboxylase antibodies: a case series.
Stiff-Person Syndrome
Autoimmunity to GABAA-receptor-associated protein in stiff-person syndrome.
Stiff-Person Syndrome
Autoimmunity to glutamic acid decarboxylase (GAD) in Stiff-Man syndrome and insulin-dependent diabetes mellitus.
Stiff-Person Syndrome
Autoimmunity to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease.
Stiff-Person Syndrome
Case Report: Autoimmune Encephalitis Associated With Anti-glutamic Acid Decarboxylase Antibodies: A Pediatric Case Series.
Stiff-Person Syndrome
Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4(+) T cells.
Stiff-Person Syndrome
Cerebellar ataxia and epilepsy with anti-GAD antibodies: treatment with IVIG and plasmapheresis.
Stiff-Person Syndrome
Cerebellar ataxia with anti-glutamic acid decarboxylase antibodies: study of 14 patients.
Stiff-Person Syndrome
Cerebrospinal fluid T cell responses against glutamic acid decarboxylase 65 in patients with stiff person syndrome.
Stiff-Person Syndrome
Characteristics of in-vitro phenotypes of glutamic acid decarboxylase 65 autoantibodies in high-titre individuals.
Stiff-Person Syndrome
Characterization of CD4+ T cells specific for glutamic acid decarboxylase (GAD65) and proinsulin in a patient with stiff-person syndrome but without type 1 diabetes.
Stiff-Person Syndrome
Characterization of continuous B-cell epitopes in the N-terminus of glutamate decarboxylase67 using monoclonal antibodies.
Stiff-Person Syndrome
Clinical spectrum of glutamic acid decarboxylase antibodies in a Taiwanese population.
Stiff-Person Syndrome
Clinically disparate stiff-person syndrome with GAD65 autoantibody in a father and daughter.
Stiff-Person Syndrome
Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase.
Stiff-Person Syndrome
Differential detection of rat islet and brain glutamic acid decarboxylase (GAD) isoforms with sequence-specific peptide antibodies.
Stiff-Person Syndrome
Direct evidence for limited clonality of antibodies to glutamic acid decarboxylase (GAD) in stiff man syndrome using baculovirus expressed GAD.
Stiff-Person Syndrome
Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions.
Stiff-Person Syndrome
Distinct antigenic features of linear epitopes at the N-terminus and C-terminus of 65 kDa glutamic acid decarboxylase (GAD65): implications for autoantigen modification during pathogenesis.
Stiff-Person Syndrome
Distinct patterns of serum immunoreactivity as evidence for multiple brain-directed autoantibodies in juvenile neuronal ceroid lipofuscinosis.
Stiff-Person Syndrome
Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome.
Stiff-Person Syndrome
Epitope spreading and a varying but not disease-specific GAD65 antibody response in Type I diabetes. The Childhood Diabetes in Finland Study Group.
Stiff-Person Syndrome
GAD antibody-spectrum disorders: progress in clinical phenotypes, immunopathogenesis and therapeutic interventions.
Stiff-Person Syndrome
GAD autoantibodies in IDDM, stiff-man syndrome, and autoimmune polyendocrine syndrome type I recognize different epitopes.
Stiff-Person Syndrome
GAD65 autoantibody characteristics in patients with co-occurring type 1 diabetes and epilepsy may help identify underlying epilepsy etiologies.
Stiff-Person Syndrome
GAD65 IgG autoantibodies in stiff person syndrome: clonality, avidity and persistence.
Stiff-Person Syndrome
Glutamic acid decarboxylase autoantibodies in stiff-man syndrome and insulin-dependent diabetes mellitus exhibit similarities and differences in epitope recognition.
Stiff-Person Syndrome
Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.
Stiff-Person Syndrome
Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders.
Stiff-Person Syndrome
Human autoantibodies react with glutamic acid decarboxylase antigen in human and rat but not in mouse pancreatic islets.
Stiff-Person Syndrome
Human B cells secreting immunoglobulin G to glutamic acid decarboxylase-65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes.
Stiff-Person Syndrome
Humoral autoimmune responses to glutamic acid decarboxylase have similar target epitopes and subclass that show titer-dependent disease association.
Stiff-Person Syndrome
Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in stiff-man syndrome.
Stiff-Person Syndrome
Identification of autoantibody epitopes of glutamic acid decarboxylase in stiff-man syndrome patients.
Stiff-Person Syndrome
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase.
Stiff-Person Syndrome
Immune reactivity to glutamic acid decarboxylase 65 in stiffman syndrome and type 1 diabetes mellitus.
Stiff-Person Syndrome
Immunohistochemical differentiation of monoclonal GAD antibodies recognizing linear or conformational epitope regions.
Stiff-Person Syndrome
Immunological GABAergic interactions and therapeutic applications in autoimmune diseases.
Stiff-Person Syndrome
Inhibition of gamma-aminobutyric acid synthesis by glutamic acid decarboxylase autoantibodies in stiff-man syndrome.
Stiff-Person Syndrome
Islet Autoantibodies in the Patients with Sjogren's Syndrome and Thyroid Disease and Risk of Progression to Latent Autoimmune Diabetes in Adults: A Case Series.
Stiff-Person Syndrome
McArdle Disease vs. Stiff-Person Syndrome: A Case Report Highlighting the Similarities Between Two Rare and Distinct Disorders.
Stiff-Person Syndrome
Monoclonal antibodies to 65kDa glutamate decarboxylase induce epitope specific effects on motor and cognitive functions in rats.
Stiff-Person Syndrome
Murine monoclonal glutamic acid decarboxylase (GAD)65 antibodies recognize autoimmune-associated GAD epitope regions targeted in patients with type 1 diabetes mellitus and stiff-man syndrome.
Stiff-Person Syndrome
Neurological disorders associated with glutamic acid decarboxylase antibodies: a Brazilian series.
Stiff-Person Syndrome
Neuronal Surface and Glutamic Acid Decarboxylase Autoantibodies in Nonparaneoplastic Stiff Person Syndrome.
Stiff-Person Syndrome
Novel clinical features of glycine receptor antibody syndrome: A series of 17 cases.
Stiff-Person Syndrome
Pathological evidence of encephalomyelitis in the stiff man syndrome with anti-GAD antibodies.
Stiff-Person Syndrome
Presynaptic impairment of cerebellar inhibitory synapses by an autoantibody to glutamate decarboxylase.
Stiff-Person Syndrome
Presynaptic inhibition of cerebellar GABAergic transmission by glutamate decarboxylase autoantibodies in progressive cerebellar ataxia.
Stiff-Person Syndrome
Prevalence and immunological spectrum of temporal lobe epilepsy with glutamic acid decarboxylase antibodies.
Stiff-Person Syndrome
Protective and detrimental immunity: lessons from stiff person syndrome and multiple sclerosis.
Stiff-Person Syndrome
Quantitative Assessment of Response to Long-Term Treatment with Intravenous Immunoglobulin in Patients with Stiff Person Syndrome.
Stiff-Person Syndrome
Radioimmunoassay for glutamic acid decarboxylase (GAD65) autoantibodies as a diagnostic aid for stiff-man syndrome and a correlate of susceptibility to type 1 diabetes mellitus.
Stiff-Person Syndrome
Redefining progressive encephalomyelitis with rigidity and myoclonus after the discovery of antibodies to glycine receptors.
Stiff-Person Syndrome
Reduced display of conformational epitopes in the N-terminal truncated GAD65 isoform: relevance for people with stiff person syndrome or DQ8/8-positive Type 1 diabetes mellitus.
Stiff-Person Syndrome
Respective implications of glutamate decarboxylase antibodies in stiff person syndrome and cerebellar ataxia.
Stiff-Person Syndrome
Rituximab treatment of stiff-person syndrome in a patient with thymoma, diabetes mellitus and autoimmune thyroiditis.
Stiff-Person Syndrome
Selective suppression of cerebellar GABAergic transmission by an autoantibody to glutamic acid decarboxylase.
Stiff-Person Syndrome
Severe insulin resistance in a patient with type 1 diabetes and stiff-man syndrome treated with insulin lispro.
Stiff-Person Syndrome
Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association.
Stiff-Person Syndrome
Stiff Person syndrome and other anti-GAD-associated neurologic disorders.
Stiff-Person Syndrome
Stiff person syndrome and other immune-mediated movement disorders - new insights.
Stiff-Person Syndrome
Stiff person syndrome does not always occur with maternal passive transfer of GAD65 antibodies.
Stiff-Person Syndrome
Stiff person syndrome with elevated titers of antibodies against cardiolipin and ?2 glycoprotein 1: a case report and literature review.
Stiff-Person Syndrome
Stiff person syndrome: quantification, specificity, and intrathecal synthesis of GAD65 antibodies.
Stiff-Person Syndrome
Stiff-man syndrome associated with antecedent myasthenia gravis and organ-specific autoimmunopathy.
Stiff-Person Syndrome
Stiff-man syndrome: identification of 17 beta-hydroxysteroid dehydrogenase type 4 as a novel 80-kDa antineuronal antigen.
Stiff-Person Syndrome
Stiff-person syndrome (SPS) and anti-GAD-related CNS degenerations: Protean additions to the autoimmune central neuropathies.
Stiff-Person Syndrome
Stiff-person syndrome associated with cerebellar ataxia and high glutamic acid decarboxylase antibody titer.
Stiff-Person Syndrome
Stiff-person syndrome with amphiphysin antibodies: distinctive features of a rare disease.
Stiff-Person Syndrome
Stiff-person syndrome: persistent elevation of glutamic acid decarboxylase antibodies despite successful treatment with rituximab.
Stiff-Person Syndrome
Stiff-person syndromes: motor cortex hyperexcitability correlates with anti-GAD autoimmunity.
Stiff-Person Syndrome
Structural model of human GAD65: prediction and interpretation of biochemical and immunogenic features.
Stiff-Person Syndrome
Subcutaneous Immunoglobulin Therapy with IgPro20 in Patients with Stiff Person Syndrome and Primary Immunodeficiency Disease.
Stiff-Person Syndrome
T-cell reactivity to glutamic acid decarboxylase in stiff-man syndrome and cerebellar ataxia associated with polyendocrine autoimmunity.
Stiff-Person Syndrome
The clinical significance of an autoimmune response against glutamic acid decarboxylase.
Stiff-Person Syndrome
The stiff-person syndrome: an autoimmune disorder affecting neurotransmission of gamma-aminobutyric acid.
Stiff-Person Syndrome
Therapeutic plasma exchange and immunosuppressive therapy in a patient with anti-GAD antibody-related epilepsy: Quantification of the antibody response.
Stiff-Person Syndrome
Treatment and Resolution of Filamentary Keratitis in a Patient with Stiff Person Syndrome.
Stiff-Person Syndrome
Two amino acids in glutamic acid decarboxylase act in concert for maintenance of conformational determinants recognised by Type I diabetic autoantibodies.
Stiff-Person Syndrome
[Diagnostic usefulness of glutamic acid decarboxylase antibodies in stiff-man syndrome]
Stiff-Person Syndrome
[Isaacs' syndrome, stiff person syndrome and Satoyoshi disease: pathomechanisms and treatment]
Stiff-Person Syndrome
[Stiff-person syndrome and other neurological disorders associated with anti-GAD antibodies.]
Stiff-Person Syndrome
[Successful treatment with rituximab in a refractory Stiff-person syndrome.]
Stomach Neoplasms
The role of glutamate decarboxylase 65 in gastric cancer development, progression, and prognosis.
Stroke
Effect of Anti-inflammatory Treatment with AMD3100 and CX3CR1 Deficiency on GABAA Receptor Subunit and Expression of Glutamate Decarboxylase Isoforms After Stroke.
succinate-semialdehyde dehydrogenase [nad(p)+] deficiency
The pediatric neurotransmitter disorders.
Supranuclear Palsy, Progressive
Alterations of GABAergic neurons in the basal ganglia of patients with progressive supranuclear palsy: an in situ hybridization study of GAD67 messenger RNA.
Tachycardia
Angiotensin-II is a putative neurotransmitter in lactate-induced panic-like responses in rats with disruption of GABAergic inhibition in the dorsomedial hypothalamus.
Tardive Dyskinesia
Association with persistent neuroleptic-induced dyskinesia of regional changes in brain GABA synthesis.
Tardive Dyskinesia
Expression of glutamic acid decarboxylase mRNA in striatum and pallidum in an animal model of tardive dyskinesia.
Tardive Dyskinesia
Glutamic acid decarboxylase (GAD) antibodies in tardive dyskinesia (TD) as compared to patients with schizophrenia without TD and normal controls.
Tardive Dyskinesia
Reduced glutamate decarboxylase activity in the subthalamic nucleus in patients with tardive dyskinesia.
Tetanus
Association of T-cell reactivity with beta-cell function in recent onset type 1 diabetes patients.
Tetanus
Clinical aspects of multifocal or generalized tonic dystonia in reflex sympathetic dystrophy.
Tetanus
Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells. Report of the third immunology of diabetes society T-cell workshop.
Tetanus
Differential and time-dependent changes in gene expression for type II calcium/calmodulin-dependent protein kinase, 67 kDa glutamic acid decarboxylase, and glutamate receptor subunits in tetanus toxin-induced focal epilepsy.
Tetanus
Expression of neuronal markers in chick and quail embryo neuroretina cultures infected with Rous sarcoma virus.
Tetanus
GABAA receptors modulate early spontaneous excitatory activity in differentiating P19 neurons.
Tetanus
Immunological efficacy of heat shock protein 60 peptide DiaPep277 therapy in clinical type I diabetes.
Tetanus
Increased expression of GAD mRNA during the chronic epileptic syndrome due to intrahippocampal tetanus toxin.
Tetanus
TH1/TH2 cytokine balance in patients with both type 1 diabetes mellitus and asthma.
Tetanus
[Increase in glutamate decarboxylase activity in the synaptosomes after treatment with tetanus toxin]
Thymoma
GAD1 expression and its methylation as indicators of malignant behavior in thymic epithelial tumors.
Thyroid Diseases
Activation of T lymphocyte subsets by synthetic TSH receptor peptides and recombinant glutamate decarboxylase in autoimmune thyroid disease and insulin-dependent diabetes.
Thyroid Diseases
Anti-glutamic acid decarboxylase antibody in Graves' disease is a possible indicator for the unlikelihood of going into remission with antithyroid agents.
Thyroid Diseases
Antigenic determinants to GAD autoantibodies in patients with type 1 diabetes with and without autoimmune thyroid disease.
Thyroid Diseases
Autoantibodies against glutamic acid decarboxylase and 21-hydroxylase in Brazilian patients with type 1 diabetes or autoimmune thyroid diseases.
Thyroid Diseases
Autoantibodies to glutamic acid decarboxylase in patients with autoimmune thyroid disease: relation to competitive insulin autoantibodies.
Thyroid Diseases
Autoantibodies to glutamic acid decarboxylase in patients with IDDM and autoimmune thyroid disease.
Thyroid Diseases
Clinical and genetic characteristics of patients with autoimmune thyroid disease with anti-islet autoimmunity.
Thyroid Diseases
Engineered variants of human glutamic acid decarboxylase (GAD) and autoantibody epitope recognition.
Thyroid Diseases
High prevalence of GAD65 (and IA-2) antibodies in Japanese IDDM patients by a new immunoprecipitation assay based on recombinant human GAD65.
Thyroid Diseases
Humoral beta-cell autoimmunity is rare in patients with the congenital rubella syndrome.
Thyroid Diseases
Prevalence of glutamic acid decarboxylase antibody positivity and its association with insulin secretion and sensitivity in autoimmune thyroid disease: A pilot study.
Thyroid Diseases
Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance.
Thyroid Diseases
Sequential elevation of autoantibodies to thyroglobulin and glutamic acid decarboxylase in type 1 diabetes.
Thyroid Diseases
Thyroid profile and autoantibodies in Type 1 diabetes subjects: A perspective from Eastern India.
Thyroiditis
Activation of T lymphocyte subsets by synthetic TSH receptor peptides and recombinant glutamate decarboxylase in autoimmune thyroid disease and insulin-dependent diabetes.
Thyroiditis
Autoantibodies against glutamic acid decarboxylase and 21-hydroxylase in Brazilian patients with type 1 diabetes or autoimmune thyroid diseases.
Thyroiditis
Autoantibodies to glutamic acid decarboxylase in patients with autoimmune thyroid disease: relation to competitive insulin autoantibodies.
Thyroiditis
Autoimmune thyroid disease correlates to islet autoimmunity on zinc transporter 8 autoantibody.
Thyroiditis
Glutamic acid decarboxylase autoantibody assay using 125I-labelled recombinant GAD65 produced in yeast.
Thyroiditis
Prevalence of glutamic acid decarboxylase antibody positivity and its association with insulin secretion and sensitivity in autoimmune thyroid disease: A pilot study.
Thyroiditis, Autoimmune
A patient with combined polycystic ovary syndrome and autoimmune polyglandular syndrome type 2.
Thyroiditis, Autoimmune
Autoimmune thyroiditis in non-obese subjects with initial diagnosis of Type 2 diabetes mellitus.
Thyroiditis, Autoimmune
Glutamic acid decarboxylase (anti-GAD) & tissue transglutaminase (anti-TTG) antibodies in patients with thyroid autoimmunity.
Thyroiditis, Autoimmune
Glutamic acid decarboxylase antibody positivity is associated with an impaired insulin response to glucose and arginine in nondiabetic patients with autoimmune thyroiditis.
Thyroiditis, Autoimmune
Simultaneous triple organ specific autoantibody profiling in adult patients with type 1 diabetes mellitus and their first-degree relatives*
Thyroiditis, Autoimmune
The Frequency of Langerhans Islets ?-Cells Autoantibodies (Anti-GAD) in Georgian Children and Adolescents with Chronic Autoimmune Thyroiditis.
Thyrotoxicosis
Heritability of levels of autoantibodies using the method of plotting regression of offspring on midparent (ROMP).
Tinnitus
Glutamic acid decarboxylase levels in the cochlear nucleus of rats with acoustic trauma-induced chronic tinnitus.
Tinnitus
Stimulation by cochlear implant in unilaterally deaf rats reverses the decrease of inhibitory transmission in the inferior colliculus.
Tinnitus
Tinnitus Correlates with Downregulation of Cortical Glutamate Decarboxylase 65 Expression But Not Auditory Cortical Map Reorganization.
Tremor
New-onset focal epilepsy with palatal tremor and glutamic acid decarboxylase antibodies responding to intravenous immunoglobulin.
Trochlear Nerve Diseases
Auto-destruction of the thyroid gland and coexisting glutamic acid decarboxylase mediated neurological disease in an adolescent: an unusual presentation of autoimmunity.
Vaccinia
Prevention of autoimmune diabetes by immunogene therapy using recombinant vaccinia virus expressing glutamic acid decarboxylase.
Vaccinia
Protection of NOD mice from type 1 diabetes after oral inoculation with vaccinia viruses expressing adjuvanted islet autoantigens.
Vaccinia
Suppression of hyperglycemia in NOD mice after inoculation with recombinant vaccinia viruses.
Virus Diseases
Glial fibrillary acidic protein and glutamic acid decarboxylase 65 and 67 kDa proteins are increased in brains of neonatal BALB/c mice following viral infection in utero.
Vitamin B 6 Deficiency
Novel metabolic disturbances in marginal vitamin B6-deficient rat heart.
Whooping Cough
Differential regulation of glutamate decarboxylase and preproenkephalin mRNA levels in the rat striatum.
Wiskott-Aldrich Syndrome
Cellular gene expression survey of vaccinia virus infection of human HeLa cells.
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
palmitoylated GAD65 co-localizes with Rab5 in Golgi membranes and axons, and Rab5 regulates the trafficking of palmitoylated GAD65 from Golgi membranes to axons in an endosomal trafficking pathway
brenda
palmitoylated GAD65 co-localizes with Rab5 in Golgi membranes and axons, and Rab5 regulates the trafficking of palmitoylated GAD65 from Golgi membranes to axons in an endosomal trafficking pathway
brenda
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
physiological function
malfunction
disturbances in GABA levels are responsible for a host of neurologic diseases. A reduction in GABA is also implicated in certain anxiety states such as panic disorder (PD). People suffering from PD have 22% lower GABA levels in the occipital cortex
malfunction
phosphorylation site mutation T95A abolishes the phosphorylation and its effects on enzyme activity. When the phosphorylation site T95 is mutated to glutamic acid, which mimics the phosphorylation status of hGAD65, the enzyme activity is greatly increased. An increase of GAD65 activity by 55% compared to the wild type hGAD65 is observed indicating that mutation of T95 to glutamic acid mimics the effect of phosphorylation
physiological function
glutamic acid decarboxylase (GAD) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme responsible for the synthesis of gamma-aminobutyric acid (GABA), a crucial inhibitory neurotransmitter in vertebrate brain. GAD produces GABA from the decarboxylation of glutamic acid. GABA is involved in development and regulation of neuroendocrine function
physiological function
isozyme GAD65 is activated by phosphorylation on Thr95. Protein kinase C isoform epsilon is the protein kinase responsible for phosphorylation and regulation of GAD65. Role of phosphorylation of GAD65 in regulation of GABA neurotransmission. Effect of neuronal stimulation on the level of membrane associated GAD (mGAD and GAD65) and soluble GAD (sGAD and GAD67), overview
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). DCE2_HUMAN
585
0
65411
Swiss-Prot
other Location (Reliability: 2)
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
lipoprotein
palmitoylation of cysteines 30 and 45 is critical for post-Golgi trafficking of GAD65 to presynaptic sites and for its relative dendritic exclusion, leading to the presynaptic clustering of GAD65
phosphoprotein
isozyme GAD65 is activated by phosphorylation at Thr95, while isozyme GAD67 is inhibited by phosphorylation. Gad65 is also phosphorylated at Ser417. The effect of phosphorylation on GAD65 and GAD67 can be reversed by treatment with protein phosphatases. Protein kinase A (PKA) and protein kinase C isoform epsilon are the protein kinases responsible for phosphorylation and regulation of GAD67 and GAD65, respectively
proteolytic modification
conversion of full-length GAD65 to truncated GAD65 is not the result of random post-mortem degradation, but that it is an intracellular process that is highly regulated. The cleavage is mediated by calpain, a Ca2+-dependent cysteine protease
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
C30A
mutation of Cys30 to Ala abolishes the presynaptic clustering of GAD65 in primary hippocampal neurons
C45A
mutation of Cys30 to Ala abolishes the presynaptic clustering of GAD65 in primary hippocampal neurons
T95A
site-directed mutagenesis, the mutation T95A of the phosphorylation site abolishes the phosphorylation and its effects on enzyme activity
T95E
site-directed mutagenesis, when the phosphorylation site T95 is mutated to glutamic acid, which mimics the phosphorylation status of hGAD65, the enzyme activity is greatly increased. An increase of GAD65 activity by 55% compared to the wild type hGAD65 is observed indicating that mutation of T95 to glutamic acid mimics the effect of phosphorylation
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant GST-tagged enzyme from Escherichia coli strain DH5alpha by glutathione affinity chromatography, recombinant MBP-tagged enzyme from Escherichia coli strain DH5alpha by amylose affinity chromatography
recombinant GST-tagged wild-type isozyme GAD65 from Escherichia coli strain DH5alpha by glutathione affinity chromatography and cleavage of the GST-tag by Factor Xa, followed by another step of glutathione affinity chromatography, or recombinant GST-tagged wild-type isozyme GAD65 from Escherichia coli strain BL21 by glutathione affinity chromatography and cleavage of the GST-tag by PreScission protease cleavage
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene GAD65, recombinant expression of GST-tagged or MBP-fusion wild-type enzyme, a 1757-bp hGAD65 insert from the pET-5C plasmid subcloned into the pMAL-c2X protein fusion system, in Escherichia coli strain DH5alpha, 1.6fold higher hGAD65 activity of the purified MBP-tagged enzyme construct compared to GST-tagged enzyme
gene GAD65, recombinant expression of GST-tagged wild-type and mutant isozymes in Escherichia coli strain DH5alpha or strain BL21
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wei, J.; Wu, J.Y.
Post-translational regulation of L-glutamic acid decarboxylase in the brain
Neurochem. Res.
33
1459-1465
2008
Mus musculus, Rattus norvegicus, Homo sapiens (Q05329), Homo sapiens (Q99259)
brenda
Chou, C.C.; Modi, J.P.; Wang, C.Y.; Hsu, P.C.; Lee, Y.H.; Huang, K.F.; Wang, A.H.; Nan, C.; Huang, X.; Prentice, H.; Wei, J.; Wu, J.Y.
Activation of brain L-glutamate decarboxylase 65 isoform (GAD65) by phosphorylation at threonine 95 (T95)
Mol. Neurobiol.
54
866-873
2017
Homo sapiens (Q05329), Homo sapiens (Q99259), Homo sapiens, Rattus norvegicus (Q05683), Rattus norvegicus Sprague Dawley (Q05683)
brenda
Awad, R.; Crump, K.; Mullally, M.; Sardana, R.K.; Arnason, J.T.; Trudeau, V.L.
An improved method for production of recombinant human glutamic acid decarboxylase 65 for use in phytopharmaceutical assessment
Pharm. Biol.
46
72-81
2008
Homo sapiens (Q05329)
-
brenda
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Release 2023.1 (January 2023)
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