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thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
CTP + H2O
CDP + phosphate
GTP + H2O
GDP + phosphate
ITP + H2O
IDP + phosphate
-
18% of the activity with thiamine triphosphate with liver enzyme, no activity with brain enzyme
-
-
?
thiamin triphosphate + H2O
thiamine diphosphate + phosphate
-
-
-
-
?
thiamine diphosphate + H2O
thiamine monophosphate + phosphate
-
28% of the activity with thiamine triphosphate with liver enzyme, 6% of the activity with thiamine triphosphate with brain enzyme
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
UTP + H2O
UDP + phosphate
additional information
?
-
Thtpa is known to decrease the levels of the energy currency molecule, thiamine triphosphate
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
no activity with enzyme from brain and liver
-
-
?
ATP + H2O
ADP + phosphate
-
4% of the activity with thiamine triphosphate
-
-
?
CTP + H2O
CDP + phosphate
-
-
-
-
?
CTP + H2O
CDP + phosphate
-
at 13% of the activity with thiamine triphosphate
-
-
?
CTP + H2O
CDP + phosphate
-
18% of the activity with thiamine triphosphate with liver enzyme, no activity with brain enzyme
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
at 13% of the activity with thiamine triphosphate
-
-
?
GTP + H2O
GDP + phosphate
-
14% of the activity with thiamine triphosphate with liver enzyme, no activity with brain enzyme
-
-
?
GTP + H2O
GDP + phosphate
-
at 4% of the activity with thiamine triphosphate
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
-
210008, 210009, 210010, 210011, 210012, 210013, 210014, 210015, 210016, 210017, 210018, 656873, 668963 -
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
enzyme is involved in thiamine metabolism
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
the enzyme may play a general role in neuronal metabolism rather than a specific role in excitability. There is no apparent correlation between enzyme expression and selective vulnerability of certain brain regions to thiamine deficiency
-
-
?
thiamine triphosphate + H2O
thiamine diphosphate + phosphate
-
thiamine triphosphate as Mg2+-thiamine triphosphate complex
-
-
?
UTP + H2O
UDP + phosphate
-
-
-
-
?
UTP + H2O
UDP + phosphate
-
no activity
-
-
?
UTP + H2O
UDP + phosphate
-
29% of the activitry with thiamine triphosphate with liver enzyme, no activity with brain enzyme
-
-
?
UTP + H2O
UDP + phosphate
-
at 2% of the activity with thiamine triphosphate
-
-
?
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Br-
-
stimulation by anions with the following order of effectiveness: SCN-, I-, NO3-, Br-, Cl-, membrane-associated enzyme
Cl-
-
stimulation by anions with the following decreasing order of effectiveness: SCN-, I-, NO3-, Br-, Cl-, membrane-associated enzyme
I-
-
stimulation by anions with the following decreasing order of effectiveness: SCN-, I-, NO3-, Br-, Cl-, membrane-associated enzyme
NO3-
-
stimulation by anions with the following decreasing order of effectiveness: SCN-, I-, NO3-, Br-, Cl-, membrane-associated enzyme. The effect of NO3- is maximal at pH 7-8, it is negligible at pH 6.5
SCN-
-
stimulation by anions with the following decreasing order of effectiveness: SCN-, I-, NO3-, Br-, Cl-, membrane-associated enzyme
Ca2+
-
divalent cation requirement is fullfilled by Mg2+ or Ca2+ in microsomes and by Mg2+ but not Ca2+ in soluble fraction
Ca2+
-
divalent cation requirement is satisfied by Mg2+ or Ca2+
Ca2+
-
maximal activation occurs at a cation to substrate ratio of 1:1
Ca2+
-
divalent cation requirement is satisfied by Mg2+, Mn2+ or Ca2+
Ca2+
-
activates membrane-associated enzyme
Mg2+
-
divalent cation requirement is fullfilled by Mg2+ or Ca2+ in microsomes and by Mg2+ but not Ca2+ in soluble fraction
Mg2+
-
divalent cation requirement is satisfied by Mg2+ or Ca2+
Mg2+
-
the true substrate may be the Mg2+-thiamine-triphosphate complex
Mg2+
-
maximal activation occurs at a cation to substrate ratio of 1:1
Mg2+
-
divalent cation requirement is satisfied by Mg2+, Mn2+ or Ca2+
Mn2+
-
maximal activation occurs at a cation to substrate ratio of 1:1
Mn2+
-
divalent cation requirement is satisfied by Mg2+, Mn2+ or Ca2+
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4,4'-diisothiocyanostilbene-2,2'-disulfonic acid
-
1.0 mM, 62% inhibition of membrane-associated enzyme
4-acetamide-4'-isothiocyanostilbene-2,2'-disulfonic acid
-
1.0 mM, 36% inhibition of membrane-associated enzyme
Colchicine
-
1.0 mM, 16% inhibition
F-
-
5 mM, 55% inhibition
imipramine
-
microsomal and soluble enzyme
Mg2+
-
excess of Mg2+ over thiamine triphosphate inhibits
thiamine beta,gamma-methylene phosphonate
-
-
thiamine phosphate
-
0.75 mM, 12% inhibition
thiamine triphosphate
-
substrate inhibition
vanadate
-
1.0 mM, 27% inhibition of membrane-associated enzyme
Zn2+
-
0.5 mM, 59% inhibition of membrane-associated enzyme
ADP
-
-
ADP
-
1 mM, strongly inhibits membrane-associated enzyme, soluble enzyme is unaffected
ADP
-
0.001-1 mM, strong inhibition
ATP
-
-
ATP
-
1 mM, strongly inhibits membrane-associated enzyme, soluble enzyme is unaffected
Ca2+
-
-
Ca2+
-
0.2 mM CaCl2, 50% inhibition
Ca2+
-
physiological concentrations markedly inhibit soluble TTPase
Ca2+
-
0.1-1.0 mM, in presence of Mg2+, soluble enzymem
chlorpromazine
-
1.0 mM, 61% loss of activity
chlorpromazine
-
microsomal and soluble enzyme
chlorpromazine
-
no inhibition in presence of Ca2+
deoxycholate
-
-
desipramine
-
-
desipramine
-
microsomal and soluble enzyme
thiamine diphosphate
-
0.75 mM, 55% inhibition
thiamine diphosphate
-
soluble enzyme, at levels of substrate 2 to 3 times Km, no inhibition of membrane-associated enzyme
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Barchi, R.L.; Braun, P.E.
A membrane-associated thiamine triphosphatase from rat brain. Properties of the enzyme
J. Biol. Chem.
247
7668-7673
1972
Rattus norvegicus
brenda
Hashitani, Y.; Cooper, J.R.
The partial purification of thiamine triphosphatase from rat brain
J. Biol. Chem.
247
2117-2119
1972
Rattus norvegicus
brenda
Barchi, R.L.; Braun, P.E.
Thiamine triphosphatase in the nervous system
Biochim. Biophys. Acta
255
402-405
1972
Rattus norvegicus
brenda
Iwata, H.; Baba, A.; Matsuda, T.; Terashita, Z.; Ishii, K.
Role of thiamine metabolism in the central nervous system. II. Effects of various agents on thiamine triphosphatase activity in rat brain
Jpn. J. Pharmacol.
24
825-829
1974
Rattus norvegicus
brenda
Iwata, H.; Baba, A.; Matsuda, T.
Role of thiamine metabolism in the central nervous system. I. Basic properties of thiamine triphosphatase in rat brain
Jpn. J. Pharmacol.
24
817-823
1974
Rattus norvegicus
brenda
Iwata, H.; Baba, A.; Matsuda, T.; Terashita, Z.
Properties of thiamine di- and triphosphatases in rat brain microsomes: effects of chlorpromazine
J. Neurochem.
24
1209-1213
1975
Rattus norvegicus
brenda
Matsuda, T.; Tonomura, H.; Baba, A.; Iwata, H.
Membrane-associated thiamine triphosphatase in rat skeletal muscle
Int. J. Biochem.
23
1111-1114
1991
Rattus norvegicus
brenda
Barchi, R.L.; Viale, R.O.
Membrane-associated thiamin triphosphatase. II. Activation by divalent cations
J. Biol. Chem.
251
193-197
1976
Rattus norvegicus
brenda
Barchi, R.L.
Membrane thiamine triphosphatase from rat brain: inhibition by ATP and ADP
J. Neurochem.
26
715-720
1976
Rattus norvegicus
brenda
Iwata, H.; Baba, A.; Matsuda, T.; Terashita, Z.
Some properties of the enzyme system degrading phosphorylated thiamines in the brain and the effect of chlorpromazine
Thiamine (Proc. Pap. U. S. -Jpn. Semin, 2. Meeting)
2. Meeting
213-221
1974
Rattus norvegicus
-
brenda
Barchi, R.L.
Thiamine triphosphatases in brain
Thiamine (Proc. Pap. U. S. -Jpn. Semin, 2. Meeting)
195-212
1974
Rattus norvegicus
-
brenda
Penttinen, H.K.; Uotila, L.
The relation of the soluble thiamine triphosphatase activity of various rat tissues to nonspecific phosphatases
Med. Biol.
59
177-184
1981
Rattus norvegicus
brenda
Ogawa, K.; Sakai, M.
Recent findings on ultracytochemistry of thiamin phosphatases
Ann. N. Y. Acad. Sci.
378
188-214
1982
Rattus norvegicus
brenda
Makarchikov, A.F.; Lakaye, B.; Gulyai, I.E.; Czerniecki, J.; Coumans, B.; Wins, P.; Grisar, T.; Bettendorff, L.
Thiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals
Cell. Mol. Life Sci.
60
1477-1488
2003
Bos taurus, Gallus gallus, Homo sapiens, quail, Rattus norvegicus, Sus scrofa
brenda
Czerniecki, J.; Chanas, G.; Verlaet, M.; Bettendorff, L.; Makarchikov, A.F.; Leprince, P.; Wins, P.; Grisar, T.; Lakaye, B.
Neuronal localization of the 25-kDa specific thiamine triphosphatase in rodent brain
Neuroscience
125
833-840
2004
Rattus norvegicus
brenda
Lakaye, B.; Verlaet, M.; Dubail, J.; Czerniecki, J.; Bontems, S.; Makarchikov, A.F.; Wins, P.; Piette, J.; Grisar, T.; Bettendorff, L.
Expression of 25 kDa thiamine triphosphatase in rodent tissues using quantitative PCR and characterization of its mRNA
Int. J. Biochem. Cell Biol.
36
2032-2041
2004
Mus musculus (Q8JZL3), Mus musculus, Rattus norvegicus
brenda
Kovacevic, Z.; Fu, D.; Richardson, D.R.
The iron-regulated metastasis suppressor, Ndrg-1: identification of novel molecular targets
Biochim. Biophys. Acta
1783
1981-1992
2008
Homo sapiens, Rattus norvegicus (Q8CGV7)
brenda