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Literature summary for 3.6.1.28 extracted from

  • Hashitani, Y.; Cooper, J.R.
    The partial purification of thiamine triphosphatase from rat brain (1972), J. Biol. Chem., 247, 2117-2119.
    View publication on PubMed
Search for more literature for 3.6.1.28

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ 0.2 mM CaCl2, 50% inhibition Rattus norvegicus
F- 5 mM, 55% inhibition Rattus norvegicus
thiamine diphosphate 0.75 mM, 55% inhibition Rattus norvegicus
thiamine phosphate 0.75 mM, 12% inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2
-
 thiamine triphosphate
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
heart
-
 Rattus norvegicus
-
intestine
-
 Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.69
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + H2O at 13% of the activity with thiamine triphosphate Rattus norvegicus CDP + phosphate
-
 ?
GTP + H2O at 4% of the activity with thiamine triphosphate Rattus norvegicus GDP + phosphate
-
 ?
thiamine triphosphate + H2O
-
 Rattus norvegicus thiamine diphosphate + phosphate
-
 ?
UTP + H2O at 2% of the activity with thiamine triphosphate Rattus norvegicus UDP + phosphate
-
 ?