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Disease on EC 3.5.4.37 - double-stranded RNA adenine deaminase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Lung Injury
ADAR1 p150 IN ALVEOLAR MACROPHAGE IS INVOLVED IN LPS-INDUCED LUNG INJURY.
Adenocarcinoma
Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progression.
Adenocarcinoma of Lung
Decrease in ADAR1 expression by exposure to cigarette smoke enhances susceptibility to oxidative stress.
Ribonuclease L mediates the cell-lethal phenotype of the double-stranded RNA editing enzyme ADAR1 in a human cell line.
Amyotrophic Lateral Sclerosis
A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology.
Deficient RNA-editing enzyme ADAR2 in an amyotrophic lateral sclerosis patient with a FUS(P525L) mutation.
Determination of editors at the novel A-to-I editing positions.
Anemia
Double-stranded RNA-specific adenosine deaminase 1 (ADAR1) promotes EIAV replication and infectivity.
Double-stranded-RNA-specific adenosine deaminase 1 (ADAR1) is proposed to contribute to the adaptation of equine infectious anemia virus from horses to donkeys.
Anhedonia
Cell type-specific in vivo expression of genes encoding signalling molecules in the brain in response to chronic mild stress and chronic treatment with fluoxetine.
Aortic Aneurysm
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Astrocytoma
ADAR RNA editing in human disease; more to it than meets the I.
ADAR2 editing activity in newly diagnosed versus relapsed pediatric high-grade astrocytomas.
ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis.
Down-regulation of RNA Editing in Pediatric Astrocytomas: ADAR2 EDITING ACTIVITY INHIBITS CELL MIGRATION AND PROLIFERATION.
Atherosclerosis
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Autoimmune Diseases
ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells.
Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs.
Adenosine-to-inosine RNA editing in the immune system: friend or foe?
Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development.
LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways.
Pediatric Evans syndrome is associated with a high frequency of potentially damaging variants in immune genes.
Blast Crisis
ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis.
ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia.
An RNA editing fingerprint of cancer stem cell reprogramming.
Borna Disease
ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus.
Brain Diseases
ADAR RNA editing in innate immune response phasing, in circadian clocks and in sleep.
Adenosine-to-inosine RNA editing in the immune system: friend or foe?
Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy.
Phenotypic Variation in Aicardi-Goutières Syndrome Explained by Cell-Specific IFN-Stimulated Gene Response and Cytokine Release.
Breast Neoplasms
8-Chloro-Adenosine Inhibits Proliferation of MDA-MB-231 and SK-BR-3 Breast Cancer Cells by Regulating ADAR1/p53 Signaling Pathway.
A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer.
ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage response.
ADAR1-mediated RNA-editing of 3'UTRs in breast cancer.
Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer.
Immune-related IncRNA LINC00944 responds to variations in ADAR1 levels and it is associated with breast cancer prognosis.
RNA-editing enzymes ADAR1 and ADAR2 coordinately regulate the editing and expression of Ctn RNA.
Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries.
Targeting DDX3X Triggers Antitumor Immunity via a dsRNA-Mediated Tumor-Intrinsic Type I Interferon Response.
Carcinogenesis
ADAR1 Editing and its Role in Cancer.
ADAR1-mediated 3' UTR editing and expression control of antiapoptosis genes fine-tunes cellular apoptosis response.
Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progression.
Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer.
Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis.
Metabolomic and Lipidomic Profiling Identifies The Role of the RNA Editing Pathway in Endometrial Carcinogenesis.
RNA editing enzyme adenosine deaminases acting on RNA 1 deficiency increases the sensitivity of non-small cell lung cancer cells to anlotinib by regulating CX3CR1-fractalkine expression.
RNA editing mediates the functional switch of COPA in a novel mechanism of hepatocarcinogenesis.
Carcinoma
ADAR1 overexpression is associated with cervical cancer progression and angiogenesis.
ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation.
ADAR2 functions as a tumor suppressor via editing IGFBP7 in esophageal squamous cell carcinoma.
Overexpression of ADAR1 into the cytoplasm correlates with a better prognosis of patients with oral squamous cells carcinoma.
RNA editing is induced by type I interferon in esophageal squamous cell carcinoma.
[Detection of ADAR1 mRNA expression in larynx carcinoma tissues]
Carcinoma, Hepatocellular
ADAR1 affects HCV infection by modulating innate immune response.
ADAR1 p110 Enhances Adhesion of Tumor Cells to Extracellular Matrix in Hepatocellular Carcinoma via Up-Regulating ITGA2 Expression.
ADAR1 promotes HBV replication through its deaminase domain.
ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers.
CDK13 RNA Over-Editing Mediated by ADAR1 Associates with Poor Prognosis of Hepatocellular Carcinoma Patients.
Carcinoma, Squamous Cell
ADAR1 overexpression is associated with cervical cancer progression and angiogenesis.
Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence.
RNA editing is induced by type I interferon in esophageal squamous cell carcinoma.
Cardiomyopathy, Dilated
Modulation of ADAR mRNA expression in patients with congenital heart defects.
Cardiotoxicity
ADAR2 increases in exercised heart and protects against myocardial infarction and doxorubicin-induced cardiotoxicity.
Carotid Artery Diseases
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Cervical Intraepithelial Neoplasia
ADAR1 overexpression is associated with cervical cancer progression and angiogenesis.
Chordoma
Overexpression of adenosine deaminase acting on RNA 1 in chordoma tissues is associated with chordoma pathogenesis by reducing miR?125a and miR?10a expression.
Colitis
ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity.
Colorectal Neoplasms
Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer.
LncRNA MEG3 acts a biomarker and regulates cell functions by targeting ADAR1 in colorectal cancer.
Coronary Artery Disease
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
COVID-19
RESIC: A Tool for Comprehensive Adenosine to Inosine RNA Editing Site Identification and Classification.
Dengue
MicroRNA profiling of human primary macrophages exposed to dengue virus identifies miRNA-3614-5p as antiviral and regulator of ADAR1 expression.
The interactomes of influenza virus NS1 and NS2 proteins identify new host factors and provide insights for ADAR1 playing a supportive role in virus replication.
Dermatomyositis
Clinical and serological features of dermatomyositis and systemic lupus erythematosus patients with autoantibodies to ADAR1.
double-stranded rna adenine deaminase deficiency
A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency.
ADAR1 deficiency protects against high-fat diet-induced obesity and insulin resistance in mice.
ADAR1 Facilitates KSHV Lytic Reactivation by Modulating the RLR-Dependent Signaling Pathway.
ADAR1 Is Required for Dendritic Cell Subset Homeostasis and Alveolar Macrophage Function.
ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner.
ADAR1 is vital for B cell lineage development in the mouse bone marrow.
ADAR1, inosine and the immune sensing system: distinguishing self from non-self.
c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells.
Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis.
Deficient RNA-editing enzyme ADAR2 in an amyotrophic lateral sclerosis patient with a FUS(P525L) mutation.
Hepatitis B virus evades immune recognition via RNA adenosine deaminase ADAR1-mediated viral RNA editing in hepatocytes.
Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells.
RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment.
RNA editing enzyme adenosine deaminases acting on RNA 1 deficiency increases the sensitivity of non-small cell lung cancer cells to anlotinib by regulating CX3CR1-fractalkine expression.
RNA editing of the Q/R site of GluA2 in different cultured cell lines that constitutively express different levels of RNA editing enzyme ADAR2.
RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR.
Specificity of ADAR-mediated RNA editing in newly identified targets.
Down Syndrome
Regulation of glutamate receptor RNA editing and ADAR mRNA expression in developing human normal and Down's syndrome brains.
Dystonia
Dyschromatosis symmetrica hereditaria associated with neurological disorders.
Dystonia, mental deterioration, and dyschromatosis symmetrica hereditaria in a family with ADAR1 mutation.
The RNA-editing enzyme ADAR1 controls innate immune responses to RNA.
Encephalitis
ADAR RNA editing in human disease; more to it than meets the I.
Encephalitis, Viral
Dyschromatosis symmetrica hereditaria by ADAR1 mutations and viral encephalitis: a hidden link?
Endometriosis
Aberrant Overexpression of RNA-Editing Enzyme ADAR1 Promotes the Progression of Endometriosis.
Epilepsy
ADAR RNA editing in human disease; more to it than meets the I.
Bi-allelic ADARB1 Variants Associated with Microcephaly, Intellectual Disability, and Seizures.
Biallelic variants in ADARB1, encoding a dsRNA-specific adenosine deaminase, cause a severe developmental and epileptic encephalopathy.
Novel Etiological and Therapeutic Strategies for Neurodiseases: RNA Editing Enzyme Abnormality in Sporadic Amyotrophic Lateral Sclerosis.
Novel exon of mammalian ADAR2 extends open reading frame.
Equine Infectious Anemia
Double-stranded RNA-specific adenosine deaminase 1 (ADAR1) promotes EIAV replication and infectivity.
Double-stranded-RNA-specific adenosine deaminase 1 (ADAR1) is proposed to contribute to the adaptation of equine infectious anemia virus from horses to donkeys.
Esophageal Neoplasms
ADAR1 Editing and its Role in Cancer.
ADARs and editing: The role of A-to-I RNA modification in cancer progression.
Esophageal Squamous Cell Carcinoma
ADAR2 functions as a tumor suppressor via editing IGFBP7 in esophageal squamous cell carcinoma.
RNA editing is induced by type I interferon in esophageal squamous cell carcinoma.
Ganglion Cysts
RNA editing enzyme ADAR2 is a mediator of neuropathic pain after peripheral nerve injury.
Glaucoma
Down-Regulation of the RNA Editing Enzyme ADAR2 Contributes to RGC Death in a Mouse Model of Glaucoma.
Glioblastoma
ADAR RNA editing in human disease; more to it than meets the I.
ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism.
ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis.
ADAR2/miR-589-3p axis controls glioblastoma cell migration/invasion.
ADARs and editing: The role of A-to-I RNA modification in cancer progression.
Adenosine Deaminase That Acts on RNA 3 (ADAR3) Binding to Glutamate Receptor Subunit B Pre-mRNA Inhibits RNA Editing in Glioblastoma.
Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma.
Glioma
Aberrant alternative splicing pattern of ADAR2 downregulates adenosine-to-inosine editing in glioma.
Abnormal expression of an ADAR2 alternative splicing variant in gliomas downregulates adenosine-to-inosine RNA editing.
Astrocytic insulin-like growth factor-1 prevents excitotoxic downregulation of adenosine deaminase acting on RNA in calcium dynamics.
Isolation and characterization of intranuclear ribonucleoprotein complexes associated with double-stranded RNA adenosine deaminase from brain cells: implications for RNA-editing and hypermutation of viral RNA in the CNS.
PTBP1 induces ADAR1 p110 isoform expression through IRES-like dependent translation control and influences cell proliferation in gliomas.
Splicing variants of ADAR2 and ADAR2-mediated RNA editing in glioma.
Heart Defects, Congenital
Modulation of ADAR mRNA expression in patients with congenital heart defects.
Heart Diseases
ADAR2 increases in exercised heart and protects against myocardial infarction and doxorubicin-induced cardiotoxicity.
Hemangioma
Two novel ADAR1 gene mutations in two patients with dyschromatosis symmetrical hereditaria from birth.
Hepatitis
Control of ADAR1 Editing of Hepatitis Delta Virus RNAs.
Crystallization and X-ray diffraction analysis of the Trp/amber editing site of hepatitis delta virus (+)RNA: a case of rational design.
Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection.
Effects of conserved RNA secondary structures on hepatitis delta virus genotype I RNA editing, replication, and virus production.
Enhancement of Replication of RNA Viruses by ADAR1 via RNA Editing and Inhibition of RNA-Activated Protein Kinase.
Hepatitis delta virus minimal substrates competent for editing by ADAR1 and ADAR2.
Increased RNA editing and inhibition of hepatitis delta virus replication by high-level expression of ADAR1 and ADAR2.
Inhibition of hepatitis delta virus RNA editing by short inhibitory RNA-mediated knockdown of ADAR1 but not ADAR2 expression.
Replicating hepatitis delta virus RNA is edited in the nucleus by the small form of ADAR1.
The fraction of RNA that folds into the correct branched secondary structure determines hepatitis delta virus type 3 RNA editing levels.
Hepatitis B
ADAR1 promotes HBV replication through its deaminase domain.
Adenosine deaminase acting on RNA-1 (ADAR1) inhibits hepatitis B virus (HBV) replication by enhancing microRNA-122 processing.
Hepatitis B, Chronic
Polymorphisms in ADAR1 gene affect response to interferon alpha based therapy for chronic hepatitis B in Han Chinese.
Hepatitis C
Adenosine deaminase acting on RNA-1 (ADAR1) inhibits hepatitis B virus (HBV) replication by enhancing microRNA-122 processing.
New antiviral pathway that mediates hepatitis C virus replicon interferon sensitivity through ADAR1.
Hirschsprung Disease
Lipopolysaccharide enhances ADAR2 which drives Hirschsprung's disease by impairing miR-142-3p biogenesis.
HIV Infections
ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication.
Hyperalgesia
RNA editing enzyme ADAR2 is a mediator of neuropathic pain after peripheral nerve injury.
Hyperglycemia
Hyperphagia-mediated obesity in transgenic mice misexpressing the RNA-editing enzyme ADAR2.
Hypersensitivity
IL6R-STAT3-ADAR1 (P150) interplay promotes oncogenicity in 1q21(amp) multiple myeloma.
Requirement of the RNA editing enzyme ADAR2 for normal physiology in mice.
Idiopathic Pulmonary Fibrosis
The Role of ADAR1 and ADAR2 in the Regulation of miRNA-21 in Idiopathic Pulmonary Fibrosis.
Immune System Diseases
Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1.
Infections
A comprehensive study on cellular RNA editing activity in response to infections with different subtypes of influenza a viruses.
A survey on cellular RNA editing activity in response to Candida albicans infections.
A-to-I editing of Malacoherpesviridae RNAs supports the antiviral role of ADAR1 in mollusks.
ADAR1 affects HCV infection by modulating innate immune response.
ADAR1 and PACT contribute to efficient translation of transcripts containing HIV-1 trans-activating response (TAR) element.
ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity.
ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus.
Adenosine Deaminase Acting on RNA 1 (ADAR1) Suppresses the Induction of Interferon by Measles Virus.
Adenosine Deaminase Acting on RNA 1 Associates with Orf Virus OV20.0 and Enhances Viral Replication.
Adenosine deaminase acting on RNA-1 (ADAR1) inhibits hepatitis B virus (HBV) replication by enhancing microRNA-122 processing.
Cloning and expression of Malabar grouper (Epinephelus malabaricus) ADAR1 gene in response to immune stimulants and nervous necrosis virus.
Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection.
Editing of Cellular Self-RNAs by Adenosine Deaminase ADAR1 Suppresses Innate Immune Stress Responses.
Expression of interferon-inducible RNA adenosine deaminase ADAR1 during pathogen infection and mouse embryo development involves tissue-selective promoter utilization and alternative splicing.
Host Response to Polyomavirus Infection Is Modulated by RNA Adenosine Deaminase ADAR1 but Not by ADAR2.
Hyperediting by ADAR1 of a new herpesvirus lncRNA during the lytic phase of the oncogenic Marek's disease virus.
Inhibition of hepatitis delta virus RNA editing by short inhibitory RNA-mediated knockdown of ADAR1 but not ADAR2 expression.
Janus effects of ADAR1 on CVB3-induced viral myocarditis at different infection stages.
MicroRNA editing facilitates immune elimination of HCMV infected cells.
RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages.
RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis.
Stress granule formation induced by measles virus is protein kinase PKR dependent and impaired by RNA adenosine deaminase ADAR1.
The role of RNA editing enzyme ADAR1 in human disease.
Influenza, Human
A comprehensive study on cellular RNA editing activity in response to infections with different subtypes of influenza a viruses.
ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus.
Double-stranded RNA adenosine deaminase ADAR-1-induced hypermutated genomes among inactivated seasonal influenza and live attenuated measles virus vaccines.
The interactomes of influenza virus NS1 and NS2 proteins identify new host factors and provide insights for ADAR1 playing a supportive role in virus replication.
The p150 Isoform of ADAR1 Blocks Sustained RLR signaling and Apoptosis during Influenza Virus Infection.
Insulin Resistance
ADAR1 deficiency protects against high-fat diet-induced obesity and insulin resistance in mice.
Insulinoma
Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis.
Intellectual Disability
Bi-allelic ADARB1 Variants Associated with Microcephaly, Intellectual Disability, and Seizures.
Leukemia
A-to-I RNA editing in leukemia stem cells - set ADAR1 on the radar.
Abnormal expression of ADAR1 isoforms in Chinese pediatric acute leukemias.
ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis.
ADARs and editing: The role of A-to-I RNA modification in cancer progression.
An RNA editing fingerprint of cancer stem cell reprogramming.
[ADAR1 Knockout Inhibits Notch1-induced T-ALL in Mice].
[Expression of ADAR1 Isoforms in Murine Acute T-ALL Leukemia Model.]
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis.
ADAR1 Editing and its Role in Cancer.
ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia.
Deletion of the RNA-editing enzyme ADAR1 causes regression of established chronic myelogenous leukemia in mice.
Leukemia, Myeloid
RNA editing signature during myeloid leukemia cell differentiation.
Leukemia, Myeloid, Acute
ADAR1 may be involved in the proliferation of acute myeloid leukemia cells via regulation of the Wnt pathway.
[Effect of ADAR1 on the development of MLL-AF9 induced murine AML].
Leukemia, T-Cell
Hyperediting of human T-cell leukemia virus type 2 and simian T-cell leukemia virus type 3 by the dsRNA adenosine deaminase ADAR-1.
Leukocytosis
Deletion of the RNA-editing enzyme ADAR1 causes regression of established chronic myelogenous leukemia in mice.
Liver Cirrhosis
A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma.
ADAR1 affects HCV infection by modulating innate immune response.
ADAR1 polymorphisms are related to severity of liver fibrosis in HIV/HCV-coinfected patients.
Liver Diseases
ADAR1 polymorphisms are related to severity of liver fibrosis in HIV/HCV-coinfected patients.
Liver Neoplasms
ADARs and editing: The role of A-to-I RNA modification in cancer progression.
Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries.
Lung Injury
ADAR1 is involved in the development of microvascular lung injury.
ADAR1 p150 IN ALVEOLAR MACROPHAGE IS INVOLVED IN LPS-INDUCED LUNG INJURY.
Endothelial cell-specific deficiency of the adenosine deaminase ADAR1 aggravates LPS-induced lung injury in mice via an MDA5-independent pathway.
Lung Neoplasms
ADARs and editing: The role of A-to-I RNA modification in cancer progression.
Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis.
Identification of novel deregulated RNA metabolism-related genes in non-small cell lung cancer.
Lupus Erythematosus, Systemic
Altered editing in RNA editing adenosine deaminase ADAR2 gene transcripts of systemic lupus erythematosus T lymphocytes.
Clinical and serological features of dermatomyositis and systemic lupus erythematosus patients with autoantibodies to ADAR1.
Lymphatic Metastasis
ADAR1 expression is associated with tumour-infiltrating lymphocytes in triple-negative breast cancer.
Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer.
Marek Disease
Hyperediting by ADAR1 of a new herpesvirus lncRNA during the lytic phase of the oncogenic Marek's disease virus.
Measles
Adenosine Deaminase Acting on RNA 1 (ADAR1) Suppresses the Induction of Interferon by Measles Virus.
Double-stranded RNA adenosine deaminase activity during measles virus infection.
Double-stranded RNA adenosine deaminase ADAR-1-induced hypermutated genomes among inactivated seasonal influenza and live attenuated measles virus vaccines.
Enhancement of Replication of RNA Viruses by ADAR1 via RNA Editing and Inhibition of RNA-Activated Protein Kinase.
RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR.
Stress granule formation induced by measles virus is protein kinase PKR dependent and impaired by RNA adenosine deaminase ADAR1.
Melanoma
A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme.
A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression.
ADAR1 regulates melanoma cell invasiveness by controlling beta3-integrin via microRNA-30 family members.
ADAR1-mediated regulation of melanoma invasion.
ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity.
ADAR1p150 regulates the biosynthesis and function of miRNA-149* in human melanoma.
Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex.
Endothelial cell-specific deficiency of the adenosine deaminase ADAR1 aggravates LPS-induced lung injury in mice via an MDA5-independent pathway.
MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth.
Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis.
RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain.
RNA modification of an RNA modifier prevents self-RNA sensing.
Mesothelioma
ADAR2 Regulates Malignant Behaviour of Mesothelioma Cells Independent of RNA-editing Activity.
Microcephaly
Bi-allelic ADARB1 Variants Associated with Microcephaly, Intellectual Disability, and Seizures.
Biallelic variants in ADARB1, encoding a dsRNA-specific adenosine deaminase, cause a severe developmental and epileptic encephalopathy.
Mouth Neoplasms
ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation.
Movement Disorders
Dystonia, mental deterioration, and dyschromatosis symmetrica hereditaria in a family with ADAR1 mutation.
Movement disorders in ADAR1 disease: Insights from a comprehensive cohort.
Muscular Diseases
Modulation of ADAR mRNA expression in patients with congenital heart defects.
Myocardial Infarction
ADAR2 increases in exercised heart and protects against myocardial infarction and doxorubicin-induced cardiotoxicity.
Myocarditis
Janus effects of ADAR1 on CVB3-induced viral myocarditis at different infection stages.
Neoplasm Metastasis
Aberrant overexpression of ADAR1 promotes gastric cancer progression by activating mTOR/p70S6K signaling.
ADAR1 expression is associated with tumour-infiltrating lymphocytes in triple-negative breast cancer.
ADAR1 p110 Enhances Adhesion of Tumor Cells to Extracellular Matrix in Hepatocellular Carcinoma via Up-Regulating ITGA2 Expression.
ADAR1-mediated regulation of melanoma invasion.
CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing.
Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer.
Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis.
RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer.
Neoplasms
A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma.
A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme.
A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression.
Aberrant overexpression of ADAR1 promotes gastric cancer progression by activating mTOR/p70S6K signaling.
Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer.
ADAR RNA editing in human disease; more to it than meets the I.
ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer.
ADAR1 and MicroRNA; A Hidden Crosstalk in Cancer.
ADAR1 Editing and its Role in Cancer.
ADAR1 expression is associated with tumour-infiltrating lymphocytes in triple-negative breast cancer.
ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism.
ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling.
ADAR1 is involved in the regulation of reprogramming human fibroblasts to induced pluripotent stem cells.
ADAR1 Is Required for Dendritic Cell Subset Homeostasis and Alveolar Macrophage Function.
ADAR1 overexpression is associated with cervical cancer progression and angiogenesis.
ADAR1 p110 Enhances Adhesion of Tumor Cells to Extracellular Matrix in Hepatocellular Carcinoma via Up-Regulating ITGA2 Expression.
ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation.
ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells.
ADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress.
ADAR1-mediated regulation of melanoma invasion.
ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity.
ADAR1-mediated RNA-editing of 3'UTRs in breast cancer.
ADAR1: A New Target for Immuno-oncology Therapy.
ADAR1p150 Forms a Complex with Dicer to Promote miRNA-222 Activity and Regulate PTEN Expression in CVB3-Induced Viral Myocarditis.
ADAR2 editing activity in newly diagnosed versus relapsed pediatric high-grade astrocytomas.
ADAR2 functions as a tumor suppressor via editing IGFBP7 in esophageal squamous cell carcinoma.
ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis.
ADARs and editing: The role of A-to-I RNA modification in cancer progression.
Adenosine Deaminase That Acts on RNA 3 (ADAR3) Binding to Glutamate Receptor Subunit B Pre-mRNA Inhibits RNA Editing in Glioblastoma.
Adenosine-to-inosine RNA editing in the immune system: friend or foe?
Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma.
Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma.
An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks.
Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition.
AZIN1 RNA editing confers cancer stemness and enhances oncogenic potential in colorectal cancer.
CDK13 RNA Over-Editing Mediated by ADAR1 Associates with Poor Prognosis of Hepatocellular Carcinoma Patients.
Combinatory RNA-Sequencing Analyses Reveal a Dual Mode of Gene Regulation by ADAR1 in Gastric Cancer.
Defining the functions of adenosine-to-inosine RNA editing through hematology.
Down-regulation of RNA Editing in Pediatric Astrocytomas: ADAR2 EDITING ACTIVITY INHIBITS CELL MIGRATION AND PROLIFERATION.
Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency.
Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer.
Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis.
High RIG-I expression in ovarian cancer associates with an immune-escape signature and poor clinical outcome.
High-throughput mutagenesis reveals unique structural features of human ADAR1.
Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells.
Immune-related IncRNA LINC00944 responds to variations in ADAR1 levels and it is associated with breast cancer prognosis.
Lipopolysaccharide enhances ADAR2 which drives Hirschsprung's disease by impairing miR-142-3p biogenesis.
Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade.
Metabolomic and Lipidomic Profiling Identifies The Role of the RNA Editing Pathway in Endometrial Carcinogenesis.
MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth.
Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma.
Overexpression of ADAR1 into the cytoplasm correlates with a better prognosis of patients with oral squamous cells carcinoma.
p150 ADAR1 isoform involved in maintenance of HeLa cell proliferation.
Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis.
RNA Editing by ADAR Adenosine Deaminases: From Molecular Plasticity of Neural Proteins to the Mechanisms of Human Cancer.
RNA Editing in Interferonopathies.
RNA editing mediates the functional switch of COPA in a novel mechanism of hepatocarcinogenesis.
Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries.
SINEs of cancer therapy success without ADAR1.
The aberrant expression of ADAR1 promotes resistance to BET inhibitors in pancreatic cancer by stabilizing c-Myc.
The role of RNA editing enzyme ADAR1 in human disease.
Widespread inosine-containing mRNA in lymphocytes regulated by ADAR1 in response to inflammation.
Nervous System Diseases
Dyschromatosis symmetrica hereditaria associated with neurological disorders.
Neuralgia
RNA editing enzyme ADAR2 is a mediator of neuropathic pain after peripheral nerve injury.
Neuroblastoma
Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.
Obesity
ADAR1 deficiency protects against high-fat diet-induced obesity and insulin resistance in mice.
Hyperactive hypothalamus, motivated and non-distractible chronic overeating in ADAR2 transgenic mice.
Hyperphagia-mediated obesity in transgenic mice misexpressing the RNA-editing enzyme ADAR2.
Pancreatic Neoplasms
The aberrant expression of ADAR1 promotes resistance to BET inhibitors in pancreatic cancer by stabilizing c-Myc.
Papillomavirus Infections
ADAR1 function affects HPV replication and is associated to recurrent human papillomavirus-induced dysplasia in HIV coinfected individuals.
Paralysis
A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity.
Adenosine-to-inosine genetic recoding is required in the adult-stage nervous system for coordinated behavior in Drosophila.
Paraplegia
Mutations in ADAR1, IFIH1, and RNASEH2B presenting as spastic paraplegia.
Peripheral Nerve Injuries
RNA editing enzyme ADAR2 is a mediator of neuropathic pain after peripheral nerve injury.
Persistent Infection
ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus.
Characterization of the 5'-flanking region of the human RNA-specific adenosine deaminase ADAR1 gene and identification of an interferon-inducible ADAR1 promoter.
Hepatitis B virus evades immune recognition via RNA adenosine deaminase ADAR1-mediated viral RNA editing in hepatocytes.
Host-dependent editing of SARS-CoV-2 in COVID-19 patients.
Pheochromocytoma
Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis.
Pigmentation Disorders
Decoupling expression and editing preferences of ADAR1 p150 and p110 isoforms.
Pneumonia
ADAR1 p150 IN ALVEOLAR MACROPHAGE IS INVOLVED IN LPS-INDUCED LUNG INJURY.
Polyomavirus Infections
Host Response to Polyomavirus Infection Is Modulated by RNA Adenosine Deaminase ADAR1 but Not by ADAR2.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[ADAR1 Knockout Inhibits Notch1-induced T-ALL in Mice].
[Expression of ADAR1 Isoforms in Murine Acute T-ALL Leukemia Model.]
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
[ADAR1 Knockout Inhibits Notch1-induced T-ALL in Mice].
[Expression of ADAR1 Isoforms in Murine Acute T-ALL Leukemia Model.]
Psoriasis
Novel ADAR1 mutations in three cases of psoriasis coexisting with dyschromatosis symmetrica hereditaria.
Pulmonary Edema
ADAR1 is involved in the development of microvascular lung injury.
Salmonella Infections
Analysis of A to I editing of miRNA in macrophages exposed to Salmonella.
Seizures
ADAR RNA editing in human disease; more to it than meets the I.
ADAR2 affects mRNA coding sequence edits with only modest effects on gene expression or splicing in vivo.
Adenosine-to-inosine genetic recoding is required in the adult-stage nervous system for coordinated behavior in Drosophila.
Seizure-induced neuronal apoptosis is related to dysregulation of the RNA-edited GluR2 subunit in the developing mouse brain.
Sepsis
ADAR1 Alleviates Inflammation in a Murine Sepsis Model via the ADAR1-miR-30a-SOCS3 Axis.
ADAR1 is targeted by miR-143 to regulate IL-1?-induced endothelial activation through the NF?B pathway.
ADAR1 prevents small intestinal injury from inflammation in a murine model of sepsis.
Assessing the potential function of ADAR1 in virus-associated sepsis.
Endothelial cell-specific deficiency of the adenosine deaminase ADAR1 aggravates LPS-induced lung injury in mice via an MDA5-independent pathway.
Skin Diseases
Five novel mutations in the ADAR1 gene associated with dyschromatosis symmetrica hereditaria.
Two novel mutations and evidence for haploinsufficiency of the ADAR gene in dyschromatosis symmetrica hereditaria.
Spasm
Decrease of mRNA Editing after Spinal Cord Injury is Caused by Down-regulation of ADAR2 that is Triggered by Inflammatory Response.
Spinal Cord Injuries
Decrease of mRNA Editing after Spinal Cord Injury is Caused by Down-regulation of ADAR2 that is Triggered by Inflammatory Response.
Squamous Cell Carcinoma of Head and Neck
ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation.
Stomach Neoplasms
Aberrant overexpression of ADAR1 promotes gastric cancer progression by activating mTOR/p70S6K signaling.
ADAR1 Suppresses Interferon Signaling in Gastric Cancer Cells by MicroRNA-302a-Mediated IRF9/STAT1 Regulation.
Combinatory RNA-Sequencing Analyses Reveal a Dual Mode of Gene Regulation by ADAR1 in Gastric Cancer.
Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer.
Stupor
Mutation in pre-mRNA adenosine deaminase markedly attenuates neuronal tolerance to O2 deprivation in Drosophila melanogaster.
Teratocarcinoma
Dramatic increase of the RNA editing for glutamate receptor subunits during terminal differentiation of clonal human neurons.
Thyroid Neoplasms
ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity.
An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks.
Tremor
A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity.
Triple Negative Breast Neoplasms
ADAR1 expression is associated with tumour-infiltrating lymphocytes in triple-negative breast cancer.
Correction to: Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer.
Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer.
Uterine Cervical Neoplasms
ADAR1 overexpression is associated with cervical cancer progression and angiogenesis.
Vascular Diseases
Adenosine-to-inosine Alu RNA editing controls the stability of the pro-inflammatory long noncoding RNA NEAT1 in atherosclerotic cardiovascular disease.
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Vesicular Stomatitis
Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection.
Enhancement of Replication of RNA Viruses by ADAR1 via RNA Editing and Inhibition of RNA-Activated Protein Kinase.
RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment.
Viremia
Host-dependent editing of SARS-CoV-2 in COVID-19 patients.
Virus Diseases
ADAR RNA editing in human disease; more to it than meets the I.
ADAR1 function affects HPV replication and is associated to recurrent human papillomavirus-induced dysplasia in HIV coinfected individuals.
ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication.
ADAR1 limits stress granule formation through both translation-dependent and translation-independent mechanisms.
ADAR1 Suppresses the Activation of Cytosolic RNA-Sensing Signaling Pathways to Protect the Liver from Ischemia/Reperfusion Injury.
ADAR1p150 Forms a Complex with Dicer to Promote miRNA-222 Activity and Regulate PTEN Expression in CVB3-Induced Viral Myocarditis.
Adenosine Deaminase Acting on RNA 1 (ADAR1) Suppresses the Induction of Interferon by Measles Virus.
Adenosine Deaminase Acting on RNA 1 Associates with Orf Virus OV20.0 and Enhances Viral Replication.
Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs.
Assessing the potential function of ADAR1 in virus-associated sepsis.
Double-stranded RNA adenosine deaminase activity during measles virus infection.
Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection.
Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection.
Enhancement of Replication of RNA Viruses by ADAR1 via RNA Editing and Inhibition of RNA-Activated Protein Kinase.
Functions of the RNA Editing Enzyme ADAR1 and Their Relevance to Human Diseases.
Janus effects of ADAR1 on CVB3-induced viral myocarditis at different infection stages.
Reovirus-mediated induction of ADAR1 (p150) minimally alters RNA editing patterns in discrete brain regions.
RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment.
RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR.
The p150 Isoform of ADAR1 Blocks Sustained RLR signaling and Apoptosis during Influenza Virus Infection.
Ubiquitin-dependent Turnover of Adenosine Deaminase Acting on RNA 1 (ADAR1) Is Required for Efficient Antiviral Activity of Type I Interferon.